RU94042907A - Производные имидазопиридина, способ их получения, фармацевтическая композиция и способ ее получения - Google Patents
Производные имидазопиридина, способ их получения, фармацевтическая композиция и способ ее полученияInfo
- Publication number
- RU94042907A RU94042907A RU94042907/04A RU94042907A RU94042907A RU 94042907 A RU94042907 A RU 94042907A RU 94042907/04 A RU94042907/04 A RU 94042907/04A RU 94042907 A RU94042907 A RU 94042907A RU 94042907 A RU94042907 A RU 94042907A
- Authority
- RU
- Russia
- Prior art keywords
- synthesis
- preparing
- pharmaceutical composition
- imidazopyridine derivatives
- proposed
- Prior art date
Links
- 125000004857 imidazopyridinyl group Chemical class N1C(=NC2=C1C=CC=N2)* 0.000 title claims abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 102000005862 Angiotensin II Human genes 0.000 claims abstract 2
- 101800000733 Angiotensin-2 Proteins 0.000 claims abstract 2
- 206010019280 Heart failures Diseases 0.000 claims abstract 2
- 206010020571 Hyperaldosteronism Diseases 0.000 claims abstract 2
- 206010020772 Hypertension Diseases 0.000 claims abstract 2
- CZGUSIXMZVURDU-JZXHSEFVSA-N Ile(5)-angiotensin II Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C([O-])=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=[NH2+])NC(=O)[C@@H]([NH3+])CC([O-])=O)C(C)C)C1=CC=C(O)C=C1 CZGUSIXMZVURDU-JZXHSEFVSA-N 0.000 claims abstract 2
- 229950006323 angiotensin ii Drugs 0.000 claims abstract 2
- 230000003042 antagnostic effect Effects 0.000 claims abstract 2
- 230000004410 intraocular pressure Effects 0.000 claims abstract 2
- 150000003839 salts Chemical class 0.000 claims abstract 2
- 210000003169 central nervous system Anatomy 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 0 *Cc(cc1)ccc1NC1=C(*)CCC=C1 Chemical compound *Cc(cc1)ccc1NC1=C(*)CCC=C1 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4341453A DE4341453A1 (de) | 1993-12-06 | 1993-12-06 | Imidazopyridine |
| DEP4341453.2 | 1993-12-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU94042907A true RU94042907A (ru) | 1996-10-20 |
Family
ID=6504241
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU94042907/04A RU94042907A (ru) | 1993-12-06 | 1994-12-05 | Производные имидазопиридина, способ их получения, фармацевтическая композиция и способ ее получения |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5532276A (OSRAM) |
| EP (1) | EP0657452A1 (OSRAM) |
| JP (1) | JPH07196656A (OSRAM) |
| KR (1) | KR950018006A (OSRAM) |
| CN (1) | CN1109056A (OSRAM) |
| AU (1) | AU7919094A (OSRAM) |
| CA (1) | CA2137213A1 (OSRAM) |
| CZ (1) | CZ304694A3 (OSRAM) |
| DE (1) | DE4341453A1 (OSRAM) |
| HU (1) | HUT72595A (OSRAM) |
| NO (1) | NO944689L (OSRAM) |
| PL (1) | PL306127A1 (OSRAM) |
| RU (1) | RU94042907A (OSRAM) |
| SK (1) | SK149294A3 (OSRAM) |
| TW (1) | TW294665B (OSRAM) |
| ZA (1) | ZA949664B (OSRAM) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5798364A (en) * | 1992-03-26 | 1998-08-25 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Imidazopyridines |
| US6348380B1 (en) * | 2000-08-25 | 2002-02-19 | Micron Technology, Inc. | Use of dilute steam ambient for improvement of flash devices |
| AP1822A (en) * | 2002-02-14 | 2008-01-30 | Pharmacia Corp | Substituted pyridinones as modulators of P38 MAP kinase. |
| EP1537114B8 (en) * | 2002-08-07 | 2007-10-03 | Novartis AG | Organic compounds as agents for the treatment of aldosterone mediated conditions |
| KR20050122220A (ko) | 2003-03-25 | 2005-12-28 | 다케다 샌디에고, 인코포레이티드 | 디펩티딜 펩티다제 억제제 |
| EP1625122A1 (en) | 2003-05-14 | 2006-02-15 | Takeda San Diego, Inc. | Dipeptidyl peptidase inhibitors |
| US7169926B1 (en) | 2003-08-13 | 2007-01-30 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| KR20060041309A (ko) | 2003-08-13 | 2006-05-11 | 다케다 야쿠힌 고교 가부시키가이샤 | ４-피리미돈 유도체 및 펩티딜 펩티다제 저해제로서의 그의용도 |
| US7678909B1 (en) | 2003-08-13 | 2010-03-16 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| US7790734B2 (en) | 2003-09-08 | 2010-09-07 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| US7732446B1 (en) | 2004-03-11 | 2010-06-08 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| EA013427B1 (ru) | 2004-03-15 | 2010-04-30 | Такеда Фармасьютикал Компани Лимитед | Ингибиторы дипептидилпептидазы |
| JP2008501714A (ja) | 2004-06-04 | 2008-01-24 | 武田薬品工業株式会社 | ジペプチジルペプチダーゼインヒビター |
| WO2006019965A2 (en) | 2004-07-16 | 2006-02-23 | Takeda San Diego, Inc. | Dipeptidyl peptidase inhibitors |
| AU2005277137A1 (en) * | 2004-08-23 | 2006-03-02 | Wyeth | Pyrrolo-naphthyl acids as PAI-1 inhibitors |
| JP2008510815A (ja) | 2004-08-23 | 2008-04-10 | ワイス | 血栓症および心臓血管疾患の治療にて有用な調節剤であるプラスミノゲン活性化因子阻害剤１型（ｐａｉ−１）としてのオキサゾロ−ナフチル酸 |
| AU2005277139A1 (en) | 2004-08-23 | 2006-03-02 | Wyeth | Thiazolo-naphthyl acids as inhibitors of plasminogen activator inhibitor-1 |
| EP1828192B1 (en) | 2004-12-21 | 2014-12-03 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| PT1942898E (pt) | 2005-09-14 | 2011-12-20 | Takeda Pharmaceutical | Inibidores da dipeptidilpeptidase para o tratamento da diabetes |
| CN101360723A (zh) | 2005-09-16 | 2009-02-04 | 武田药品工业株式会社 | 制备嘧啶二酮衍生物的方法 |
| WO2007112347A1 (en) | 2006-03-28 | 2007-10-04 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| US8324383B2 (en) | 2006-09-13 | 2012-12-04 | Takeda Pharmaceutical Company Limited | Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile |
| TW200838536A (en) | 2006-11-29 | 2008-10-01 | Takeda Pharmaceutical | Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor |
| US8093236B2 (en) | 2007-03-13 | 2012-01-10 | Takeda Pharmaceuticals Company Limited | Weekly administration of dipeptidyl peptidase inhibitors |
| WO2009123241A1 (ja) * | 2008-03-31 | 2009-10-08 | 株式会社レナサイエンス | プラスミノーゲンアクチベーターインヒビター－１阻害剤 |
| JP5730190B2 (ja) * | 2009-03-31 | 2015-06-03 | 株式会社レナサイエンス | プラスミノーゲンアクチベーターインヒビター−１阻害剤 |
| US10092537B2 (en) | 2013-04-15 | 2018-10-09 | Renascience Co., Ltd. | Use for PAI-1 inhibitor |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL94390A (en) * | 1989-05-30 | 1996-03-31 | Merck & Co Inc | The 6-membered trans-nitrogen-containing heterocycles are compressed with imidazo and pharmaceutical preparations containing them |
| DE4110019C2 (de) * | 1991-03-27 | 2000-04-13 | Merck Patent Gmbh | Imidazopyridine, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen |
| US5332750A (en) * | 1991-09-04 | 1994-07-26 | Merck Patent Gesellschaft Mit Beschrankter Haftung | 1,2-dihydro-2-oxopyridines |
| DE4141788A1 (de) * | 1991-12-18 | 1993-06-24 | Merck Patent Gmbh | Imidazopyridine |
| DE4208304A1 (de) * | 1992-03-16 | 1993-09-23 | Merck Patent Gmbh | 2-oxochinolinderivate |
| DE4211474A1 (de) * | 1992-04-06 | 1993-10-07 | Merck Patent Gmbh | Imidazopyridine |
| DE4305602A1 (de) * | 1992-06-17 | 1993-12-23 | Merck Patent Gmbh | Imidazopyridine |
| DE4225835A1 (de) * | 1992-08-05 | 1994-02-10 | Merck Patent Gmbh | Verfahren zur Herstellung von Imidazopyridinen |
| DE4242459A1 (de) * | 1992-12-16 | 1994-06-23 | Merck Patent Gmbh | Imidazopyridine |
-
1993
- 1993-12-06 DE DE4341453A patent/DE4341453A1/de not_active Withdrawn
-
1994
- 1994-11-23 EP EP94118416A patent/EP0657452A1/de not_active Withdrawn
- 1994-12-01 HU HU9403451A patent/HUT72595A/hu unknown
- 1994-12-02 TW TW083111242A patent/TW294665B/zh active
- 1994-12-02 AU AU79190/94A patent/AU7919094A/en not_active Abandoned
- 1994-12-02 CA CA002137213A patent/CA2137213A1/en not_active Abandoned
- 1994-12-05 SK SK1492-94A patent/SK149294A3/sk unknown
- 1994-12-05 RU RU94042907/04A patent/RU94042907A/ru unknown
- 1994-12-05 NO NO944689A patent/NO944689L/no unknown
- 1994-12-05 KR KR1019940032795A patent/KR950018006A/ko not_active Withdrawn
- 1994-12-05 CZ CZ943046A patent/CZ304694A3/cs unknown
- 1994-12-05 PL PL94306127A patent/PL306127A1/xx unknown
- 1994-12-05 US US08/353,309 patent/US5532276A/en not_active Expired - Fee Related
- 1994-12-05 ZA ZA949664A patent/ZA949664B/xx unknown
- 1994-12-05 CN CN94119893A patent/CN1109056A/zh active Pending
- 1994-12-06 JP JP6302170A patent/JPH07196656A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| HUT72595A (en) | 1996-05-28 |
| EP0657452A1 (de) | 1995-06-14 |
| US5532276A (en) | 1996-07-02 |
| NO944689L (no) | 1995-06-07 |
| ZA949664B (en) | 1995-08-15 |
| PL306127A1 (en) | 1995-06-12 |
| CA2137213A1 (en) | 1995-06-07 |
| CN1109056A (zh) | 1995-09-27 |
| NO944689D0 (no) | 1994-12-05 |
| AU7919094A (en) | 1995-06-15 |
| TW294665B (OSRAM) | 1997-01-01 |
| SK149294A3 (en) | 1995-07-11 |
| KR950018006A (ko) | 1995-07-22 |
| HU9403451D0 (en) | 1995-02-28 |
| DE4341453A1 (de) | 1995-06-08 |
| CZ304694A3 (en) | 1995-08-16 |
| JPH07196656A (ja) | 1995-08-01 |
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