RU92004381A - Производные 2-замещенного сахарина как ингибиторы протеолитических ферментов - Google Patents

Производные 2-замещенного сахарина как ингибиторы протеолитических ферментов

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Publication number
RU92004381A
RU92004381A RU92004381/04A RU92004381A RU92004381A RU 92004381 A RU92004381 A RU 92004381A RU 92004381/04 A RU92004381/04 A RU 92004381/04A RU 92004381 A RU92004381 A RU 92004381A RU 92004381 A RU92004381 A RU 92004381A
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Russia
Prior art keywords
substituted
proteolytic enzymes
sakharin
inhibitors
derivatives
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RU92004381/04A
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English (en)
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RU2101281C1 (ru
Inventor
Поль Данлэп Ричард
Уоррен Боаз Нейл
Джозеф Мьюра Альберт
Джон Хласта Денниз
Чиманлал Десай Ранджит
Сабраманьям Чакрапони
Гамильтон Лэйтимер Ли
Пиэтт Лодж Эрик
Original Assignee
Стерлинг Уинтроп Инк.
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Priority claimed from US07/793,033 external-priority patent/US5236917A/en
Application filed by Стерлинг Уинтроп Инк. filed Critical Стерлинг Уинтроп Инк.
Publication of RU92004381A publication Critical patent/RU92004381A/ru
Application granted granted Critical
Publication of RU2101281C1 publication Critical patent/RU2101281C1/ru

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Claims (1)

  1. Предложены 2-замещенные сахарины, которые ингибируют ферментативную активность протеолитических ферментов, пригодные для лечения дегенеративных заболеваний и имеющие формулу
    Figure 00000001

    где L является -O-, -S-, -SO- или -SO2-; m и n каждый независимо равен 0 или 1; R1 представляет собой фенил, гетероцикл, или замещенный гетероцикл, или когда L является -O-, а n равно 1, то R1 представляет собой циклогептатриенон-2 ил, или когда L является -S-, а n равно 1, то R1 представляет собой цианогруппу или /низший алкокси/-тиокарбонил, или когда L является -SO2, а n равно 1, то R1 представляет собой низший алкил или трифторметил; R2 представляет собой водород, /низший алкокси/-карбонил, фенил или фенилтиогруппу; а R3 и R4 каждый является водородом или различными заместителями.
RU92004381A 1991-11-15 1992-11-13 Производное 2-замещенного сахарина и фармацевтическая композиция, проявляющая ингибиторную активность против эластазы RU2101281C1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/793,033 US5236917A (en) 1989-05-04 1991-11-15 Saccharin derivatives useful as proteolytic enzyme inhibitors and compositions and method of use thereof
US793033 1991-11-15

Publications (2)

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RU92004381A true RU92004381A (ru) 1995-05-20
RU2101281C1 RU2101281C1 (ru) 1998-01-10

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US (5) US5236917A (ru)
EP (1) EP0542372A1 (ru)
JP (1) JPH05194444A (ru)
KR (1) KR930010015A (ru)
AU (1) AU654581B2 (ru)
CA (1) CA2079822A1 (ru)
CZ (1) CZ339092A3 (ru)
FI (1) FI925167A (ru)
HU (2) HUT66873A (ru)
IL (1) IL103748A (ru)
MX (1) MX9206008A (ru)
MY (1) MY107740A (ru)
NO (1) NO303119B1 (ru)
NZ (1) NZ244446A (ru)
RU (1) RU2101281C1 (ru)
SG (1) SG55181A1 (ru)
TW (1) TW221433B (ru)

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