RU2732405C2 - Хиральные диарильные макроциклы в качестве модуляторов протеинкиназ - Google Patents
Хиральные диарильные макроциклы в качестве модуляторов протеинкиназ Download PDFInfo
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- RU2732405C2 RU2732405C2 RU2018103907A RU2018103907A RU2732405C2 RU 2732405 C2 RU2732405 C2 RU 2732405C2 RU 2018103907 A RU2018103907 A RU 2018103907A RU 2018103907 A RU2018103907 A RU 2018103907A RU 2732405 C2 RU2732405 C2 RU 2732405C2
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- alkyl
- nhs
- nhc
- calkyl
- cycloalkyl
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Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
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- Veterinary Medicine (AREA)
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- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Transplantation (AREA)
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- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562188043P | 2015-07-02 | 2015-07-02 | |
| US62/188,043 | 2015-07-02 | ||
| US201662353728P | 2016-06-23 | 2016-06-23 | |
| US62/353,728 | 2016-06-23 | ||
| PCT/US2016/040329 WO2017004342A1 (en) | 2015-07-02 | 2016-06-30 | Chiral diaryl macrocycles as modulators of protein kinases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2018103907A RU2018103907A (ru) | 2019-08-05 |
| RU2018103907A3 RU2018103907A3 (enExample) | 2019-10-07 |
| RU2732405C2 true RU2732405C2 (ru) | 2020-09-16 |
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2016
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- 2016-06-30 WO PCT/US2016/040329 patent/WO2017004342A1/en not_active Ceased
- 2016-06-30 MX MX2017017097A patent/MX2017017097A/es unknown
- 2016-06-30 KR KR1020187002777A patent/KR102599788B1/ko active Active
- 2016-06-30 CA CA2989327A patent/CA2989327A1/en active Pending
- 2016-06-30 RU RU2018103907A patent/RU2732405C2/ru active
- 2016-06-30 CN CN201680038613.1A patent/CN107735399B/zh active Active
- 2016-06-30 ES ES16818768T patent/ES2864839T3/es active Active
- 2016-06-30 AU AU2016287568A patent/AU2016287568B2/en not_active Ceased
- 2016-06-30 EP EP16818768.0A patent/EP3317285B1/en active Active
- 2016-07-01 TW TW105121035A patent/TW201716415A/zh unknown
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2017
- 2017-12-18 IL IL256377A patent/IL256377A/en unknown
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2019
- 2019-05-29 US US16/425,407 patent/US11008337B2/en active Active
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2020
- 2020-08-11 AU AU2020217336A patent/AU2020217336A1/en not_active Abandoned
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| US20190284209A1 (en) | 2019-09-19 |
| RU2018103907A3 (enExample) | 2019-10-07 |
| EP3317285A4 (en) | 2019-02-27 |
| KR20180023970A (ko) | 2018-03-07 |
| JP2018519343A (ja) | 2018-07-19 |
| US10316044B2 (en) | 2019-06-11 |
| RU2018103907A (ru) | 2019-08-05 |
| EP3317285B1 (en) | 2021-01-27 |
| US11008337B2 (en) | 2021-05-18 |
| AU2020217336A1 (en) | 2020-08-27 |
| CN107735399A (zh) | 2018-02-23 |
| US20180186813A1 (en) | 2018-07-05 |
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| EP3317285A1 (en) | 2018-05-09 |
| AU2016287568A1 (en) | 2018-01-04 |
| IL256377A (en) | 2018-02-28 |
| CA2989327A1 (en) | 2017-01-05 |
| WO2017004342A1 (en) | 2017-01-05 |
| AU2016287568B2 (en) | 2020-08-20 |
| ES2864839T3 (es) | 2021-10-14 |
| JP6871903B2 (ja) | 2021-05-19 |
| CN107735399B (zh) | 2021-01-26 |
| TW201716415A (zh) | 2017-05-16 |
| MX2017017097A (es) | 2018-05-23 |
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