CN107735399B - 作为蛋白质激酶的调节剂的手性二芳基大环 - Google Patents
作为蛋白质激酶的调节剂的手性二芳基大环 Download PDFInfo
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- CN107735399B CN107735399B CN201680038613.1A CN201680038613A CN107735399B CN 107735399 B CN107735399 B CN 107735399B CN 201680038613 A CN201680038613 A CN 201680038613A CN 107735399 B CN107735399 B CN 107735399B
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- C—CHEMISTRY; METALLURGY
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
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Landscapes
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- Neurology (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| US62/353,728 | 2016-06-23 | ||
| PCT/US2016/040329 WO2017004342A1 (en) | 2015-07-02 | 2016-06-30 | Chiral diaryl macrocycles as modulators of protein kinases |
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| ES2464461T3 (es) | 2008-09-22 | 2014-06-02 | Array Biopharma, Inc. | Compuestos de imidazo[1,2B]piridazina sustituidos como inhibidores de la TRK cinasa |
| SG196855A1 (en) | 2008-10-22 | 2014-02-13 | Array Biopharma Inc | Substituted pyrazolo[1,5-a]pyrimidine compounds as trk kinase inhibitors |
| AR077468A1 (es) | 2009-07-09 | 2011-08-31 | Array Biopharma Inc | Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa |
| AU2011256380C1 (en) | 2010-05-20 | 2016-09-08 | Array Biopharma Inc. | Macrocyclic compounds as Trk kinase inhibitors |
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- 2016-06-30 US US15/740,462 patent/US10316044B2/en active Active
- 2016-06-30 ES ES16818768T patent/ES2864839T3/es active Active
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- 2016-06-30 RU RU2018103907A patent/RU2732405C2/ru active
- 2016-06-30 JP JP2018500297A patent/JP6871903B2/ja active Active
- 2016-06-30 EP EP16818768.0A patent/EP3317285B1/en active Active
- 2016-06-30 MX MX2017017097A patent/MX2017017097A/es unknown
- 2016-06-30 KR KR1020187002777A patent/KR102599788B1/ko active Active
- 2016-06-30 CA CA2989327A patent/CA2989327A1/en active Pending
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015112806A2 (en) * | 2014-01-24 | 2015-07-30 | Tp Therapeutics, Inc. | Diaryl macrocycles as modulators of protein kinases |
| CN106170289A (zh) * | 2014-01-24 | 2016-11-30 | Tp生物医药公司 | 作为蛋白质激酶的调节剂的二芳基巨环 |
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| Publication number | Publication date |
|---|---|
| CN107735399A (zh) | 2018-02-23 |
| RU2018103907A3 (enExample) | 2019-10-07 |
| JP6871903B2 (ja) | 2021-05-19 |
| EP3317285B1 (en) | 2021-01-27 |
| US20190284209A1 (en) | 2019-09-19 |
| RU2732405C2 (ru) | 2020-09-16 |
| KR102599788B1 (ko) | 2023-11-07 |
| WO2017004342A1 (en) | 2017-01-05 |
| TW201716415A (zh) | 2017-05-16 |
| MX2017017097A (es) | 2018-05-23 |
| JP2018519343A (ja) | 2018-07-19 |
| IL256377A (en) | 2018-02-28 |
| US20180186813A1 (en) | 2018-07-05 |
| KR20180023970A (ko) | 2018-03-07 |
| US10316044B2 (en) | 2019-06-11 |
| AU2016287568A1 (en) | 2018-01-04 |
| RU2018103907A (ru) | 2019-08-05 |
| US11008337B2 (en) | 2021-05-18 |
| AU2020217336A1 (en) | 2020-08-27 |
| AU2016287568B2 (en) | 2020-08-20 |
| EP3317285A1 (en) | 2018-05-09 |
| CA2989327A1 (en) | 2017-01-05 |
| ES2864839T3 (es) | 2021-10-14 |
| EP3317285A4 (en) | 2019-02-27 |
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