RU2693487C2 - Пептиды, способные реактивировать мутанты р53 - Google Patents
Пептиды, способные реактивировать мутанты р53 Download PDFInfo
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
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- C—CHEMISTRY; METALLURGY
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- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
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| CN105112377B (zh) * | 2015-09-25 | 2018-10-30 | 福州迈新生物技术开发有限公司 | 一株分泌抗p53单克隆抗体的杂交瘤细胞株及其应用 |
| RU2762089C2 (ru) * | 2016-02-04 | 2021-12-15 | Иеда Рисеч Энд Девелопмент Ко. Лтд. | ПЕПТИДЫ И ИХ ПРИМЕНЕНИЕ В ЛЕЧЕНИИ ЗАБОЛЕВАНИЙ, НАРУШЕНИЙ ИЛИ СОСТОЯНИЙ, АССОЦИИРОВАННЫХ С МУТАНТНЫМ р53 |
| US20220251159A1 (en) * | 2016-02-04 | 2022-08-11 | Yeda Research And Development Co., Ltd | Peptides and use of same in the treatment of diseases, disroders or conditions associated with a mutant p53 |
| MX421596B (es) * | 2017-09-29 | 2025-03-14 | Us Health | Receptores de celulas t que reconocen p53 mutado |
| CA3084369A1 (en) | 2017-12-07 | 2019-06-13 | Reven, Llc | Compositions and methods for the treatment of metabolic conditions |
| WO2019116376A1 (en) * | 2017-12-17 | 2019-06-20 | Yeda Research And Development Co. Ltd. | Cop9 signalosome (csn) complex modulators and uses thereof |
| WO2019134070A1 (en) * | 2018-01-02 | 2019-07-11 | Rui Jin Hospital, Shanghai Jiao Tong University School Of Medicine | Panda as novel therapeutic |
| WO2019134650A1 (en) * | 2018-01-02 | 2019-07-11 | Rui Jin Hospital, Shanghai Jiao Tong University School Of Medicine | Mp53 rescue compounds and methods of treating a p53 disorder |
| JP2022536708A (ja) * | 2019-06-12 | 2022-08-18 | リーベン アイピー ホールディングカンパニー リミテッド ライアビリティ カンパニー | がん患者の予後を改善する方法および組成物 |
| JP7402026B2 (ja) | 2019-11-27 | 2023-12-20 | 株式会社小松製作所 | 作業機械の制御システム、作業機械、作業機械の制御方法 |
| US20230127559A1 (en) | 2020-03-16 | 2023-04-27 | Yeda Research And Development Co. Ltd. | Peptide analogs and use of same in treating diseases, disorders or conditions associated with mutant p53 protein |
| CN111574591B (zh) * | 2020-04-29 | 2021-09-21 | 西安交通大学医学院第一附属医院 | 一种多肽及其合成方法 |
| CN113750246B (zh) * | 2020-06-04 | 2023-12-05 | 华南理工大学 | ZIF-8纳米材料在降解广谱突变p53蛋白中的应用 |
| CN111686127B (zh) * | 2020-06-04 | 2022-02-15 | 华南理工大学 | 锌铁纳米材料在降解突变p53蛋白中的应用 |
| WO2021262483A1 (en) * | 2020-06-24 | 2021-12-30 | Pmv Pharmaceuticals, Inc. | METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION |
| JP2024501840A (ja) * | 2020-12-21 | 2024-01-16 | アラウヌス バイオサイエンシズ， インコーポレイテッド | ペプチダーゼ切断可能基質およびその同定方法ならびにその使用方法 |
| CN112921032A (zh) * | 2020-12-29 | 2021-06-08 | 苏州中科先进技术研究院有限公司 | 一种引物对、探针、试剂盒及其使用方法 |
| CN115466786A (zh) * | 2021-06-11 | 2022-12-13 | 上海交通大学医学院附属瑞金医院 | 一种筛选适合用p53复活药物治疗p53异常相关疾病病人的方法 |
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| US5294605A (en) | 1990-07-19 | 1994-03-15 | The Scripps Research Institute | Amphiphilic peptide compositions and analogues thereof |
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| US6184205B1 (en) | 1994-07-22 | 2001-02-06 | University Of North Carolina At Chapel Hill | GRB2 SH3 binding peptides and methods of isolating and using same |
| US6169073B1 (en) * | 1995-02-16 | 2001-01-02 | Bayer Corporation | Peptides and peptidomimetics with structural similarity to human p53 that activate p53 function |
| US5877282A (en) | 1996-09-20 | 1999-03-02 | Bristol-Myers Squibb Company | Peptide inhibitors of nuclear protein translocation having nuclear localization sequences and methods of use thereof |
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| CA2600370A1 (en) * | 2005-03-14 | 2006-09-14 | Board Of Regents Of The University Of Texas System | Bioactive fus1 peptides and nanoparticle-polypeptide complexes |
| US8877201B2 (en) * | 2007-10-25 | 2014-11-04 | Wake Forest University Health Sciences | Bordetella outer-membrane protein antigens and methods of making and using the same |
| US8287845B2 (en) * | 2008-12-18 | 2012-10-16 | E I Du Pont De Nemours And Company | Hair-binding peptides |
| WO2013036208A1 (en) * | 2011-09-09 | 2013-03-14 | Agency For Science, Technology And Research | P53 activating peptides |
| US9657064B2 (en) * | 2012-09-13 | 2017-05-23 | Les Hopitaux Universitaires De Geneve | Cell penetrating peptides |
| WO2015019318A1 (en) | 2013-08-07 | 2015-02-12 | Yeda Research And Development Co. Ltd. | Peptides capable of reactivating p53 mutants |
| RU2762089C2 (ru) | 2016-02-04 | 2021-12-15 | Иеда Рисеч Энд Девелопмент Ко. Лтд. | ПЕПТИДЫ И ИХ ПРИМЕНЕНИЕ В ЛЕЧЕНИИ ЗАБОЛЕВАНИЙ, НАРУШЕНИЙ ИЛИ СОСТОЯНИЙ, АССОЦИИРОВАННЫХ С МУТАНТНЫМ р53 |
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2014
- 2014-08-07 WO PCT/IB2014/063777 patent/WO2015019318A1/en not_active Ceased
- 2014-08-07 HU HUE14834903A patent/HUE049292T2/hu unknown
- 2014-08-07 JP JP2016532782A patent/JP6554099B2/ja not_active Expired - Fee Related
- 2014-08-07 CN CN201480053550.8A patent/CN105579464B/zh not_active Expired - Fee Related
- 2014-08-07 EP EP14834903.8A patent/EP3030571B1/en active Active
- 2014-08-07 BR BR112016002721-3A patent/BR112016002721A2/pt not_active Application Discontinuation
- 2014-08-07 RU RU2016106583A patent/RU2693487C2/ru active
- 2014-08-07 CA CA2920147A patent/CA2920147C/en active Active
- 2014-08-07 ES ES14834903T patent/ES2795982T3/es active Active
- 2014-08-07 RU RU2019119609A patent/RU2721423C2/ru active
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2016
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- 2016-02-04 IL IL243944A patent/IL243944B/en active IP Right Grant
- 2016-02-04 AU AU2016200713A patent/AU2016200713B2/en not_active Ceased
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- 2017-10-29 US US15/796,811 patent/US10336789B2/en active Active
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Patent Citations (4)
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| RU2181772C2 (ru) * | 1994-12-30 | 2002-04-27 | Рон-Пуленк Агрошими | Синтез гамма-линоленовой кислоты под действием дельта-6-десатуразы |
| WO2003072600A2 (en) * | 2002-01-23 | 2003-09-04 | Gardner, Rebecca, Katherine | Methods of screening molecular libraries for active molecules that restore the function of target proteins and peptides that restore the function of mutant p53 |
| WO2009112075A1 (en) * | 2008-03-13 | 2009-09-17 | Universita' Degli Studi Di Trieste | Peptides and aptamers thereof as specific modulators of mutant p53 function |
| WO2013040142A2 (en) * | 2011-09-16 | 2013-03-21 | Iogenetics, Llc | Bioinformatic processes for determination of peptide binding |
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