RU2693382C2 - Лечение заболевания дыхательной системы - Google Patents
Лечение заболевания дыхательной системы Download PDFInfo
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- RU2693382C2 RU2693382C2 RU2015122027A RU2015122027A RU2693382C2 RU 2693382 C2 RU2693382 C2 RU 2693382C2 RU 2015122027 A RU2015122027 A RU 2015122027A RU 2015122027 A RU2015122027 A RU 2015122027A RU 2693382 C2 RU2693382 C2 RU 2693382C2
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Images
Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
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- Cardiology (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
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| US201261730749P | 2012-11-28 | 2012-11-28 | |
| US61/730,749 | 2012-11-28 | ||
| PCT/US2013/072038 WO2014085474A1 (en) | 2012-11-28 | 2013-11-26 | Treatment of pulmonary disease |
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| RU2015122027A RU2015122027A (ru) | 2017-01-10 |
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| RU2015122027A RU2693382C2 (ru) | 2012-11-28 | 2013-11-26 | Лечение заболевания дыхательной системы |
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| SG (1) | SG11201503697TA (https=) |
| TW (1) | TWI636786B (https=) |
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| SI3071696T1 (sl) | 2013-11-22 | 2019-11-29 | Mina Therapeutics Ltd | C/EBP alfa kratko delujoči RNA sestavki in postopki uporabe |
| WO2016045480A1 (zh) * | 2014-09-28 | 2016-03-31 | 上海源力生物技术有限公司 | 一种奥贝胆酸的制备方法 |
| US10538550B2 (en) | 2014-11-19 | 2020-01-21 | NZP UK Limited | 6.alpha.-alkyl-3,7-dione steroids as intermediates for the production of steroidal FXR modulators |
| US10131688B2 (en) | 2014-11-19 | 2018-11-20 | NZP UK Limited | 5.beta.-6-alkyl-7-hydroxy-3-one steroids as intermediates for the production of steroidal FXR modulators |
| TWI688571B (zh) * | 2014-11-19 | 2020-03-21 | 英商Ｎｚｐ英國有限公司 | 化合物（四） |
| KR102526631B1 (ko) * | 2014-11-19 | 2023-04-27 | 엔제트피 유케이 리미티드 | 스테로이드 fxr 조절인자를 제조하기 위한 중간체로서의 6-알킬-7-하이드록시-4-엔-3-온 스테로이드 |
| CN105348365A (zh) * | 2014-12-03 | 2016-02-24 | 四川百利药业有限责任公司 | 一种胆酸衍生物及其制备方法、药物组合物和用途 |
| CN105801653B (zh) * | 2014-12-30 | 2018-04-17 | 苏州晶云药物科技有限公司 | 奥贝胆酸的晶型a及其制备方法 |
| CZ2015504A3 (cs) * | 2015-07-16 | 2017-01-25 | Zentiva, K.S. | Krystalické formy obeticholové kyseliny |
| CN105085597B (zh) * | 2015-08-28 | 2017-03-29 | 成都百裕制药股份有限公司 | 一种无定型奥贝胆酸的制备方法 |
| EP3353189A4 (en) * | 2015-09-24 | 2019-06-19 | Intercept Pharmaceuticals, Inc. | METHOD AND INTERMEDIATE PRODUCTS FOR THE PREPARATION OF GALLENIC ACID DERIVATIVES |
| EP3981779A1 (en) * | 2015-10-07 | 2022-04-13 | Intercept Pharmaceuticals, Inc. | Farnesoid x receptor modulators |
| CN106589039B (zh) * | 2015-10-15 | 2019-12-17 | 苏州朗科生物技术股份有限公司 | 一种奥贝胆酸的制备方法及相关化合物 |
| CN106589038A (zh) * | 2015-10-15 | 2017-04-26 | 重庆医药工业研究院有限责任公司 | 一种制备3α,7α-二羟基-6α-乙基-5β-胆烷酸的方法 |
| CN106668027A (zh) * | 2015-11-05 | 2017-05-17 | 中美华世通生物医药科技（武汉）有限公司 | 奥贝胆酸药物组合物及其制备方法 |
| CN105399793A (zh) * | 2015-12-24 | 2016-03-16 | 北京康立生医药技术开发有限公司 | 一种胆烷酸的制备方法 |
| ES2909907T3 (es) | 2016-02-10 | 2022-05-10 | Dr Reddys Laboratories Ltd | Proceso de purificación que implica la sal de amina del ácido obeticólico |
| JPWO2017170858A1 (ja) * | 2016-03-31 | 2019-02-14 | インターセプト ファーマシューティカルズ， インコーポレイテッド | 溶出性に優れた経口製剤 |
| WO2017180577A1 (en) * | 2016-04-13 | 2017-10-19 | Intercept Pharmaceuticals, Inc. | Methods of treating cancer |
| GB201608776D0 (en) | 2016-05-18 | 2016-06-29 | Dextra Lab Ltd | Methods and compounds |
| GB201608777D0 (en) | 2016-05-18 | 2016-06-29 | Dextra Lab Ltd | Compounds |
| WO2017208165A1 (en) * | 2016-06-01 | 2017-12-07 | Dr. Reddy’S Laboratories Limited | Process for preparation of obeticholic acid |
| CN106046095B (zh) * | 2016-06-06 | 2017-02-22 | 南京理工大学 | 奥贝胆酸的合成方法 |
| CA3038534A1 (en) * | 2016-09-30 | 2018-04-05 | Intercept Pharmaceuticals, Inc. | Crystalline forms of a bile acid derivative |
| CN108117579A (zh) * | 2016-11-29 | 2018-06-05 | 昆明积大制药股份有限公司 | 奥贝胆酸及其中间体的制备方法 |
| TW201832768A (zh) * | 2017-03-07 | 2018-09-16 | 英特賽普醫藥品公司 | 治療癌症的方法 |
| WO2019048632A1 (en) | 2017-09-08 | 2019-03-14 | Mina Therapeutics Limited | STABILIZED COMPOSITIONS OF SMALL ACTIVATORY RNA (PARNA) OF HNF4A AND METHODS OF USE |
| KR20190030805A (ko) * | 2017-09-14 | 2019-03-25 | 경상대학교산학협력단 | 폐고혈압 예방 또는 치료용 흡입제, 및 이의 투여방법 |
| EP3705487B1 (en) * | 2017-11-02 | 2022-10-26 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Method for preparing cholic acid compound |
| KR20210038877A (ko) | 2018-07-25 | 2021-04-08 | 노파르티스 아게 | Nlrp3 인플라마좀 억제제 |
| AR119731A1 (es) | 2019-05-17 | 2022-01-05 | Novartis Ag | Inhibidores del inflamasoma nlrp3 |
| TW202122078A (zh) | 2019-09-06 | 2021-06-16 | 瑞士商諾華公司 | 使用lta4h抑制劑治療肝臟疾病之方法 |
| KR20220150270A (ko) | 2019-10-07 | 2022-11-10 | 칼리오페, 인크. | Gpr119 효능제 |
| TW202140440A (zh) | 2020-02-28 | 2021-11-01 | 美商克力歐普股份有限公司 | Gpr40激動劑 |
| CN113318114B (zh) * | 2020-02-28 | 2023-02-17 | 广州市赛普特医药科技股份有限公司 | 小分子化合物在治疗肺上皮细胞损伤和/或血管内皮细胞损伤介导的疾病中的用途 |
| WO2021236617A1 (en) | 2020-05-19 | 2021-11-25 | Kallyope, Inc. | Ampk activators |
| CN116390925A (zh) | 2020-06-26 | 2023-07-04 | 卡尔优普公司 | Ampk活化剂 |
| UY40374A (es) | 2022-08-03 | 2024-02-15 | Novartis Ag | Inhibidores de inflamasoma nlrp3 |
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2017
- 2017-07-18 US US15/652,777 patent/US20180064729A1/en not_active Abandoned
Patent Citations (3)
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| WO2008002573A2 (en) * | 2006-06-27 | 2008-01-03 | Intercept Pharmaceuticals, Inc. | Bile acid derivatives as fxr ligands for the prevention or treatment of fxr-mediated deseases or conditions |
| RU2424233C2 (ru) * | 2006-06-29 | 2011-07-20 | Ф.Хоффманн-Ля Рош Аг | Производные бензимидазола, методы их получения, применение их в качестве агонистов фарнезоид-х-рецептора (fxr) и содержащие их фармацевтические препараты |
| WO2011022838A1 (en) * | 2009-08-25 | 2011-03-03 | British Columbia Cancer Agency Branch | Polyhydroxylated bile acids for treatment of biliary disorders |
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| PELLICCIARI R. et al. "6α-Ethyl-Chenodeoxycholic Acid (6-ECDCA), a Potent and Selective FXR Agonist Endowed with Anticholestatic Activity".J. Med. Chem. 2002, Vol.45, No 17, pp.3569-3572, найдено 10.11.2017 из Интернет: http://pubs.acs.org/doi/pdf/10.1021/jm025529g. ZHANG L. et al. "FXR Protects Lung From Lipopolysacchatide-induced Acute injury". Molecular Endocrinology 2011 vol. 26, no.1, pp. 27-36. * |
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| NZ708501A (en) | 2019-03-29 |
| JP6270171B2 (ja) | 2018-01-31 |
| KR102106186B1 (ko) | 2020-05-04 |
| IL239025A0 (en) | 2015-07-30 |
| RU2015122027A (ru) | 2017-01-10 |
| CL2015001442A1 (es) | 2015-08-28 |
| BR112015012312A2 (pt) | 2017-07-11 |
| US20140148428A1 (en) | 2014-05-29 |
| TW201434469A (zh) | 2014-09-16 |
| WO2014085474A1 (en) | 2014-06-05 |
| JP2016500111A (ja) | 2016-01-07 |
| US20180064729A1 (en) | 2018-03-08 |
| PH12015501108B1 (en) | 2015-08-17 |
| KR20150089052A (ko) | 2015-08-04 |
| CA2891348A1 (en) | 2014-06-05 |
| CN104853758A (zh) | 2015-08-19 |
| HK1211844A1 (en) | 2016-06-03 |
| CA2891348C (en) | 2020-04-28 |
| AU2013352288A1 (en) | 2015-06-04 |
| PH12015501108A1 (en) | 2015-08-17 |
| AU2013352288B2 (en) | 2017-11-23 |
| MX2015006710A (es) | 2016-01-15 |
| IL239025B (en) | 2021-04-29 |
| SG11201503697TA (en) | 2015-06-29 |
| US20160213689A1 (en) | 2016-07-28 |
| EP2925328A1 (en) | 2015-10-07 |
| TWI636786B (zh) | 2018-10-01 |
| MY170802A (en) | 2019-08-28 |
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