CN104853758A - 肺部疾病的治疗 - Google Patents

肺部疾病的治疗 Download PDF

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Publication number
CN104853758A
CN104853758A CN201380061734.4A CN201380061734A CN104853758A CN 104853758 A CN104853758 A CN 104853758A CN 201380061734 A CN201380061734 A CN 201380061734A CN 104853758 A CN104853758 A CN 104853758A
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China
Prior art keywords
compound
lung
pulmonary
hydrogen
pharmaceutically acceptable
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Pending
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CN201380061734.4A
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English (en)
Chinese (zh)
Inventor
M·普鲁赞斯基
卢西亚诺·阿多里尼
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yingte Saipute Pharmaceuticals Co
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Yingte Saipute Pharmaceuticals Co
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49753520&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN104853758(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Yingte Saipute Pharmaceuticals Co filed Critical Yingte Saipute Pharmaceuticals Co
Publication of CN104853758A publication Critical patent/CN104853758A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201380061734.4A 2012-11-28 2013-11-26 肺部疾病的治疗 Pending CN104853758A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261730749P 2012-11-28 2012-11-28
US61/730,749 2012-11-28
PCT/US2013/072038 WO2014085474A1 (en) 2012-11-28 2013-11-26 Treatment of pulmonary disease

Publications (1)

Publication Number Publication Date
CN104853758A true CN104853758A (zh) 2015-08-19

Family

ID=49753520

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201380061734.4A Pending CN104853758A (zh) 2012-11-28 2013-11-26 肺部疾病的治疗

Country Status (19)

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US (3) US20140148428A1 (https=)
EP (1) EP2925328A1 (https=)
JP (1) JP6270171B2 (https=)
KR (1) KR102106186B1 (https=)
CN (1) CN104853758A (https=)
AU (1) AU2013352288B2 (https=)
BR (1) BR112015012312A2 (https=)
CA (1) CA2891348C (https=)
CL (1) CL2015001442A1 (https=)
HK (1) HK1211844A1 (https=)
IL (1) IL239025B (https=)
MX (1) MX2015006710A (https=)
MY (1) MY170802A (https=)
NZ (1) NZ708501A (https=)
PH (1) PH12015501108A1 (https=)
RU (1) RU2693382C2 (https=)
SG (1) SG11201503697TA (https=)
TW (1) TWI636786B (https=)
WO (1) WO2014085474A1 (https=)

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CN105085597A (zh) * 2015-08-28 2015-11-25 成都百裕科技制药有限公司 一种无定型奥贝胆酸的制备方法
CN105399793A (zh) * 2015-12-24 2016-03-16 北京康立生医药技术开发有限公司 一种胆烷酸的制备方法
CN106046095A (zh) * 2016-06-06 2016-10-26 南京理工大学 奥贝胆酸的合成方法
CN106589038A (zh) * 2015-10-15 2017-04-26 重庆医药工业研究院有限责任公司 一种制备3α,7α-二羟基-6α-乙基-5β-胆烷酸的方法
CN106589039A (zh) * 2015-10-15 2017-04-26 苏州朗科生物技术有限公司 一种奥贝胆酸的制备方法及相关化合物
CN109071452A (zh) * 2016-04-13 2018-12-21 英特塞普特医药品公司 治疗癌症的方法
CN109415405A (zh) * 2016-06-01 2019-03-01 雷迪博士实验室有限公司 制备奥贝胆酸的方法
CN113318114A (zh) * 2020-02-28 2021-08-31 广州市赛普特医药科技股份有限公司 小分子化合物在治疗肺上皮细胞损伤和/或血管内皮细胞损伤介导的疾病中的用途

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TW202122078A (zh) 2019-09-06 2021-06-16 瑞士商諾華公司 使用lta4h抑制劑治療肝臟疾病之方法
KR20220150270A (ko) 2019-10-07 2022-11-10 칼리오페, 인크. Gpr119 효능제
TW202140440A (zh) 2020-02-28 2021-11-01 美商克力歐普股份有限公司 Gpr40激動劑
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Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105085597B (zh) * 2015-08-28 2017-03-29 成都百裕制药股份有限公司 一种无定型奥贝胆酸的制备方法
CN105085597A (zh) * 2015-08-28 2015-11-25 成都百裕科技制药有限公司 一种无定型奥贝胆酸的制备方法
CN106589039B (zh) * 2015-10-15 2019-12-17 苏州朗科生物技术股份有限公司 一种奥贝胆酸的制备方法及相关化合物
CN106589038A (zh) * 2015-10-15 2017-04-26 重庆医药工业研究院有限责任公司 一种制备3α,7α-二羟基-6α-乙基-5β-胆烷酸的方法
CN106589039A (zh) * 2015-10-15 2017-04-26 苏州朗科生物技术有限公司 一种奥贝胆酸的制备方法及相关化合物
CN105399793A (zh) * 2015-12-24 2016-03-16 北京康立生医药技术开发有限公司 一种胆烷酸的制备方法
CN109071452A (zh) * 2016-04-13 2018-12-21 英特塞普特医药品公司 治疗癌症的方法
CN109415405A (zh) * 2016-06-01 2019-03-01 雷迪博士实验室有限公司 制备奥贝胆酸的方法
CN106046095B (zh) * 2016-06-06 2017-02-22 南京理工大学 奥贝胆酸的合成方法
CN106046095A (zh) * 2016-06-06 2016-10-26 南京理工大学 奥贝胆酸的合成方法
CN113318114A (zh) * 2020-02-28 2021-08-31 广州市赛普特医药科技股份有限公司 小分子化合物在治疗肺上皮细胞损伤和/或血管内皮细胞损伤介导的疾病中的用途
WO2021170073A1 (zh) * 2020-02-28 2021-09-02 广州市赛普特医药科技股份有限公司 小分子化合物在治疗肺上皮细胞损伤和/或血管内皮细胞损伤介导的疾病中的用途
US12594282B2 (en) 2020-02-28 2026-04-07 Guangzhou Cellprotek Pharmaceutical Co., Ltd. Use of small molecule compounds in the treatment of diseases mediated by lung epithelial cell injury and/or vascular endothelial cell injury

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NZ708501A (en) 2019-03-29
RU2693382C2 (ru) 2019-07-02
JP6270171B2 (ja) 2018-01-31
KR102106186B1 (ko) 2020-05-04
IL239025A0 (en) 2015-07-30
RU2015122027A (ru) 2017-01-10
CL2015001442A1 (es) 2015-08-28
BR112015012312A2 (pt) 2017-07-11
US20140148428A1 (en) 2014-05-29
TW201434469A (zh) 2014-09-16
WO2014085474A1 (en) 2014-06-05
JP2016500111A (ja) 2016-01-07
US20180064729A1 (en) 2018-03-08
PH12015501108B1 (en) 2015-08-17
KR20150089052A (ko) 2015-08-04
CA2891348A1 (en) 2014-06-05
HK1211844A1 (en) 2016-06-03
CA2891348C (en) 2020-04-28
AU2013352288A1 (en) 2015-06-04
PH12015501108A1 (en) 2015-08-17
AU2013352288B2 (en) 2017-11-23
MX2015006710A (es) 2016-01-15
IL239025B (en) 2021-04-29
SG11201503697TA (en) 2015-06-29
US20160213689A1 (en) 2016-07-28
EP2925328A1 (en) 2015-10-07
TWI636786B (zh) 2018-10-01
MY170802A (en) 2019-08-28

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