RU2675105C9 - Замещенные аминопиримидиновые соединения и способы их использования - Google Patents

Замещенные аминопиримидиновые соединения и способы их использования Download PDF

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RU2675105C9
RU2675105C9 RU2016114866A RU2016114866A RU2675105C9 RU 2675105 C9 RU2675105 C9 RU 2675105C9 RU 2016114866 A RU2016114866 A RU 2016114866A RU 2016114866 A RU2016114866 A RU 2016114866A RU 2675105 C9 RU2675105 C9 RU 2675105C9
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compound
compounds
alkylene
alkyl
disease
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RU2016114866A
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RU2016114866A (ru
RU2675105C2 (ru
RU2016114866A3 (enExample
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Нин Си
Лян ВАН
Цзупин У
Сюэцзинь ФЭН
Яньцзюнь У
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Саншайн Лейк Фарма Ко., Лтд.
Калитор Сайенсез, ЛЛС
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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RU2016114866A 2013-09-22 2014-09-17 Замещенные аминопиримидиновые соединения и способы их использования RU2675105C9 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361880974P 2013-09-22 2013-09-22
US61/880,974 2013-09-22
US201461983444P 2014-04-23 2014-04-23
US61/983,444 2014-04-23
PCT/US2014/055966 WO2015042077A1 (en) 2013-09-22 2014-09-17 Substituted aminopyrimidine compounds and methods of use

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RU2016114866A RU2016114866A (ru) 2017-10-25
RU2016114866A3 RU2016114866A3 (enExample) 2018-06-25
RU2675105C2 RU2675105C2 (ru) 2018-12-17
RU2675105C9 true RU2675105C9 (ru) 2019-01-09

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RU2016115082A RU2683793C2 (ru) 2013-09-22 2014-09-17 Замещенные аминопиримидиновые соединения и способы их использования

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US (4) US9657007B2 (enExample)
EP (2) EP3046563B1 (enExample)
JP (2) JP6494633B2 (enExample)
KR (2) KR20160058889A (enExample)
AU (2) AU2014321420B2 (enExample)
BR (1) BR112016003229A8 (enExample)
CA (2) CA2920059A1 (enExample)
MX (2) MX2016003457A (enExample)
MY (2) MY176421A (enExample)
RU (2) RU2675105C9 (enExample)
SG (2) SG11201600707QA (enExample)
WO (3) WO2015042078A2 (enExample)

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US9657007B2 (en) * 2013-09-22 2017-05-23 Calitor Sciences, Llc Substituted aminopyrimidine compounds and methods of use
EA201692267A1 (ru) 2014-06-13 2017-06-30 Джилид Сайэнс, Инк. Ингибиторы фосфатидилинозитол-3-киназы
SG11201609527PA (en) 2014-06-13 2016-12-29 Gilead Sciences Inc Quinazolinone derivatives as phosphatidylinositol 3-kinase inhibitors
MX2016016530A (es) * 2014-06-13 2017-03-27 Gilead Sciences Inc Inhibidores de fosfatidilinositol 3-quinasa.
AU2015274635B2 (en) 2014-06-13 2018-04-19 Gilead Sciences, Inc. Phosphatidylinositol 3-kinase inhibitors
KR20170082490A (ko) 2014-07-04 2017-07-14 루핀 리미티드 Pi3k 억제제로서 퀴놀리지논 유도체
CN105924433B (zh) * 2015-02-28 2020-12-22 广东东阳光药业有限公司 取代的氨基嘧啶类化合物及其使用方法和用途
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