KR20160060100A - 치환된 아미노피리미딘 화합물 및 이용 방법 - Google Patents

치환된 아미노피리미딘 화합물 및 이용 방법 Download PDF

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Publication number
KR20160060100A
KR20160060100A KR1020167010190A KR20167010190A KR20160060100A KR 20160060100 A KR20160060100 A KR 20160060100A KR 1020167010190 A KR1020167010190 A KR 1020167010190A KR 20167010190 A KR20167010190 A KR 20167010190A KR 20160060100 A KR20160060100 A KR 20160060100A
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South Korea
Prior art keywords
alkylene
heterocyclyl
cycloalkyl
alkyl
compound
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KR1020167010190A
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English (en)
Korean (ko)
Inventor
닝 시
량 왕
팅진 왕
Original Assignee
칼리토르 사이언시즈, 엘엘씨
선샤인 레이크 파르마 컴퍼니 리미티드
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Publication of KR20160060100A publication Critical patent/KR20160060100A/ko
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Immunology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Virology (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Transplantation (AREA)
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  • Molecular Biology (AREA)
  • Obesity (AREA)
KR1020167010190A 2013-09-22 2014-09-17 치환된 아미노피리미딘 화합물 및 이용 방법 Ceased KR20160060100A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361880974P 2013-09-22 2013-09-22
US61/880,974 2013-09-22
US201461983444P 2014-04-23 2014-04-23
US61/983,444 2014-04-23
PCT/US2014/055967 WO2015042078A2 (en) 2013-09-22 2014-09-17 Substituted aminopyrimidine compounds and methods of use

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KR20160060100A true KR20160060100A (ko) 2016-05-27

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KR1020167010190A Ceased KR20160060100A (ko) 2013-09-22 2014-09-17 치환된 아미노피리미딘 화합물 및 이용 방법
KR1020167010188A Ceased KR20160058889A (ko) 2013-09-22 2014-09-17 치환된 아미노피리미딘 화합물 및 이용 방법

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US (4) US9670194B2 (enExample)
EP (2) EP3046921A4 (enExample)
JP (2) JP6494633B2 (enExample)
KR (2) KR20160060100A (enExample)
AU (2) AU2014321420B2 (enExample)
BR (1) BR112016003229A8 (enExample)
CA (2) CA2918938C (enExample)
MX (2) MX2016003456A (enExample)
MY (2) MY184292A (enExample)
RU (2) RU2683793C2 (enExample)
SG (2) SG11201600028YA (enExample)
WO (3) WO2015042078A2 (enExample)

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CA2918938C (en) * 2013-09-22 2021-05-18 Calitor Sciences, Llc Substituted aminopyrimidine compounds and methods of use
JP6455995B2 (ja) * 2014-06-13 2019-01-23 ギリアード サイエンシーズ， インコーポレイテッド ホスファチジルイノシトール３−キナーゼ阻害剤
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