RU2672873C2 - Ингибиторы гликозидаз и их применения - Google Patents

Ингибиторы гликозидаз и их применения Download PDF

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RU2672873C2
RU2672873C2 RU2015120556A RU2015120556A RU2672873C2 RU 2672873 C2 RU2672873 C2 RU 2672873C2 RU 2015120556 A RU2015120556 A RU 2015120556A RU 2015120556 A RU2015120556 A RU 2015120556A RU 2672873 C2 RU2672873 C2 RU 2672873C2
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Prior art keywords
tetrahydro
thiopyrano
diol
thiazole
hydroxymethyl
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RU2015120556A
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Russian (ru)
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RU2015120556A (ru
Inventor
Рамеш КАУЛ
Эрнест Дж. МАКИЧЕРН
Дэвид Дж. ВОКАЛЬДО
Юаньси ЧЖОУ
Цюнь Дан
Гарольд Дж. СЕЛНИК
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Алектос Терапьютикс Инк.
Мерк Шарп И Доум Корп.
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42Oxazoles
    • A61K31/424Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/06Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing nitrogen as ring hetero atoms

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Transplantation (AREA)
RU2015120556A 2012-10-31 2013-10-30 Ингибиторы гликозидаз и их применения RU2672873C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261720708P 2012-10-31 2012-10-31
US61/720,708 2012-10-31
PCT/CA2013/050822 WO2014067003A1 (en) 2012-10-31 2013-10-30 Glycosidase inhibitors and uses thereof

Publications (2)

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RU2015120556A RU2015120556A (ru) 2016-12-20
RU2672873C2 true RU2672873C2 (ru) 2018-11-20

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US (1) US9695197B2 (https=)
EP (1) EP2914604A4 (https=)
JP (2) JP2015534991A (https=)
KR (1) KR20150079711A (https=)
CN (1) CN104837845B (https=)
AU (1) AU2013337570B2 (https=)
BR (1) BR112015009638A2 (https=)
CA (1) CA2890115A1 (https=)
RU (1) RU2672873C2 (https=)
WO (1) WO2014067003A1 (https=)

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WO2012129651A1 (en) 2011-03-31 2012-10-04 Alectos Therapeutics Inc. Selective glycosidase inhibitors and uses thereof
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BR112015009638A2 (pt) 2017-07-04
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