RU2667643C2 - Ингибиторы nep для лечения заболеваний, характеризующихся увеличением или ремоделированием предсердия - Google Patents

Ингибиторы nep для лечения заболеваний, характеризующихся увеличением или ремоделированием предсердия Download PDF

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RU2667643C2
RU2667643C2 RU2015110240A RU2015110240A RU2667643C2 RU 2667643 C2 RU2667643 C2 RU 2667643C2 RU 2015110240 A RU2015110240 A RU 2015110240A RU 2015110240 A RU2015110240 A RU 2015110240A RU 2667643 C2 RU2667643 C2 RU 2667643C2
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prodrug
nep inhibitor
amino
heart failure
patients
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RU2015110240A
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Russian (ru)
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RU2015110240A (ru
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Кристоф ШУМАХЕР
Томас ХОЛЬБРО
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Новартис Аг
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
RU2015110240A 2012-08-24 2013-08-22 Ингибиторы nep для лечения заболеваний, характеризующихся увеличением или ремоделированием предсердия RU2667643C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261692911P 2012-08-24 2012-08-24
US61/692,911 2012-08-24
PCT/EP2013/067472 WO2014029848A1 (en) 2012-08-24 2013-08-22 Nep inhibitors for treating diseases characterized by atrial enlargement or remodeling

Related Child Applications (1)

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RU2018126749A Division RU2809222C2 (ru) 2012-08-24 2018-07-20 Ингибиторы nep для лечения заболеваний, характеризующихся увеличением или ремоделированием предсердия

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RU2015110240A RU2015110240A (ru) 2016-10-20
RU2667643C2 true RU2667643C2 (ru) 2018-09-21

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JP (4) JP6482462B2 (enExample)
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CN (2) CN108685889A (enExample)
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PT (1) PT2887961T (enExample)
RU (1) RU2667643C2 (enExample)
SG (1) SG11201500256UA (enExample)
SI (1) SI2887961T1 (enExample)
TN (1) TN2015000028A1 (enExample)
TW (1) TWI634887B (enExample)
WO (1) WO2014029848A1 (enExample)
ZA (1) ZA201500262B (enExample)

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RUILOPE LM et al. Blood-pressure reduction with LCZ696, a novel dual-acting inhibitor of the angiotensin II receptor and neprilysin: a randomized, double-blind, placebo-controlled active comparator study. Lancet 2010 Apr 10; 375(9722): 1255-66 [он лайн] [найдено 27.07.2017] (найдено из интернет: www.ncbi.nlm.nih.gov/pubmed/23066416). *
RUILOPE LM et al. Blood-pressure reduction with LCZ696, a novel dual-acting inhibitor of the angiotensin II receptor and neprilysin: a randomized, double-blind, placebo-controlled active comparator study. Lancet 2010 Apr 10; 375(9722): 1255-66 [он лайн] [найдено 27.07.2017] (найдено из интернет: www.ncbi.nlm.nih.gov/pubmed/23066416). КАМЫШНИКОВА Л.А. и др. Лечение диастолической дисфункции при хронической сердечной недостаточности. Научные ведомости. Серия Медицина. Фармация. 2010, N4(75), вып.9, с.11, 2-й абзац. HUANG GY et al. Clinical characteristics and risk factors for peripartum cardiomyopathy. Afr.health Sci. 2012 Mar; 12(1): 26-31 [он лайн] [найдено 27.07.2017] (найдено из интернет:www.ncbi.nlm.nih.gov/pubmed/23066416). *
КАМЫШНИКОВА Л.А. и др. Лечение диастолической дисфункции при хронической сердечной недостаточности. Научные ведомости. Серия Медицина. Фармация. 2010, N4(75), вып.9, с.11, 2-й абзац. *

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PL2887961T3 (pl) 2021-11-08
IL237114A0 (en) 2015-03-31
CA2882771C (en) 2021-02-23
CL2015000426A1 (es) 2015-10-02
BR112015003067A2 (pt) 2017-07-04
IL237114B (en) 2020-10-29
US20150190376A1 (en) 2015-07-09
RU2018126749A3 (enExample) 2021-12-28
WO2014029848A1 (en) 2014-02-27
US11135192B2 (en) 2021-10-05
RU2015110240A (ru) 2016-10-20
SI2887961T1 (sl) 2021-08-31
JP6482462B2 (ja) 2019-03-13
HUE054885T2 (hu) 2021-10-28
CA2882771A1 (en) 2014-02-27
KR20150046039A (ko) 2015-04-29
US20180200218A1 (en) 2018-07-19
ZA201500262B (en) 2016-09-28
MX378867B (es) 2025-03-11
JP2022020624A (ja) 2022-02-01
CN104602711A (zh) 2015-05-06
PH12015500375A1 (en) 2015-04-20
AU2013304949A1 (en) 2015-02-05
US20170049738A1 (en) 2017-02-23
JP2019069954A (ja) 2019-05-09
MX2015002432A (es) 2015-06-22
HK1205930A1 (en) 2015-12-31
US9517226B2 (en) 2016-12-13
KR20200111822A (ko) 2020-09-29
US9937143B2 (en) 2018-04-10
PT2887961T (pt) 2021-07-28
SG11201500256UA (en) 2015-04-29
RU2018126749A (ru) 2019-03-12
EP2887961A1 (en) 2015-07-01
EP3943084A1 (en) 2022-01-26
TWI634887B (zh) 2018-09-11
KR102159601B1 (ko) 2020-09-28
MA37850A1 (fr) 2018-07-31
NZ704604A (en) 2018-06-29
JP7407508B2 (ja) 2024-01-04
JP2023159114A (ja) 2023-10-31
JP2015526458A (ja) 2015-09-10
CN108685889A (zh) 2018-10-23
AU2013304949C1 (en) 2020-12-24
EP2887961B1 (en) 2021-04-28
TW201414471A (zh) 2014-04-16
TN2015000028A1 (en) 2016-06-29
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DK2887961T3 (da) 2021-07-19
AU2013304949B2 (en) 2016-08-11

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