DK2887961T3 - Nep-inhibitorer til behandling af sygdomme, der er kendetegnet ved atrieforstørrelse eller -remodellering - Google Patents

Nep-inhibitorer til behandling af sygdomme, der er kendetegnet ved atrieforstørrelse eller -remodellering Download PDF

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Publication number
DK2887961T3
DK2887961T3 DK13750725.7T DK13750725T DK2887961T3 DK 2887961 T3 DK2887961 T3 DK 2887961T3 DK 13750725 T DK13750725 T DK 13750725T DK 2887961 T3 DK2887961 T3 DK 2887961T3
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DK
Denmark
Prior art keywords
atri
remodeling
magnification
treatment
diseases characterized
Prior art date
Application number
DK13750725.7T
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Danish (da)
English (en)
Inventor
Christoph Schumacher
Thomas Holbro
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49000959&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2887961(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
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Publication of DK2887961T3 publication Critical patent/DK2887961T3/da

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK13750725.7T 2012-08-24 2013-08-22 Nep-inhibitorer til behandling af sygdomme, der er kendetegnet ved atrieforstørrelse eller -remodellering DK2887961T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261692911P 2012-08-24 2012-08-24
PCT/EP2013/067472 WO2014029848A1 (en) 2012-08-24 2013-08-22 Nep inhibitors for treating diseases characterized by atrial enlargement or remodeling

Publications (1)

Publication Number Publication Date
DK2887961T3 true DK2887961T3 (da) 2021-07-19

Family

ID=49000959

Family Applications (1)

Application Number Title Priority Date Filing Date
DK13750725.7T DK2887961T3 (da) 2012-08-24 2013-08-22 Nep-inhibitorer til behandling af sygdomme, der er kendetegnet ved atrieforstørrelse eller -remodellering

Country Status (26)

Country Link
US (3) US9517226B2 (enExample)
EP (2) EP3943084A1 (enExample)
JP (4) JP6482462B2 (enExample)
KR (2) KR102159601B1 (enExample)
CN (2) CN108685889A (enExample)
AU (1) AU2013304949C1 (enExample)
BR (1) BR112015003067A2 (enExample)
CA (1) CA2882771C (enExample)
CL (1) CL2015000426A1 (enExample)
DK (1) DK2887961T3 (enExample)
ES (1) ES2879550T3 (enExample)
HU (1) HUE054885T2 (enExample)
IL (1) IL237114B (enExample)
MA (1) MA37850A1 (enExample)
MX (1) MX378867B (enExample)
NZ (1) NZ704604A (enExample)
PH (1) PH12015500375A1 (enExample)
PL (1) PL2887961T3 (enExample)
PT (1) PT2887961T (enExample)
RU (1) RU2667643C2 (enExample)
SG (1) SG11201500256UA (enExample)
SI (1) SI2887961T1 (enExample)
TN (1) TN2015000028A1 (enExample)
TW (1) TWI634887B (enExample)
WO (1) WO2014029848A1 (enExample)
ZA (1) ZA201500262B (enExample)

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EP1852108A1 (en) 2006-05-04 2007-11-07 Boehringer Ingelheim Pharma GmbH & Co.KG DPP IV inhibitor formulations
PE20140960A1 (es) 2008-04-03 2014-08-15 Boehringer Ingelheim Int Formulaciones que comprenden un inhibidor de dpp4
US20200155558A1 (en) 2018-11-20 2020-05-21 Boehringer Ingelheim International Gmbh Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
US9034883B2 (en) 2010-11-15 2015-05-19 Boehringer Ingelheim International Gmbh Vasoprotective and cardioprotective antidiabetic therapy
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EP2990800A1 (en) * 2014-08-29 2016-03-02 Fundació Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol Neprilysin as heartfailure (HF) prognostic marker
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CN103079554A (zh) * 2010-08-24 2013-05-01 诺华有限公司 在接受抗凝血剂疗法的哺乳动物中治疗高血压和/或预防或治疗心力衰竭
RU2667643C2 (ru) 2012-08-24 2018-09-21 Новартис Аг Ингибиторы nep для лечения заболеваний, характеризующихся увеличением или ремоделированием предсердия

Also Published As

Publication number Publication date
PL2887961T3 (pl) 2021-11-08
IL237114A0 (en) 2015-03-31
CA2882771C (en) 2021-02-23
CL2015000426A1 (es) 2015-10-02
BR112015003067A2 (pt) 2017-07-04
IL237114B (en) 2020-10-29
US20150190376A1 (en) 2015-07-09
RU2018126749A3 (enExample) 2021-12-28
WO2014029848A1 (en) 2014-02-27
US11135192B2 (en) 2021-10-05
RU2015110240A (ru) 2016-10-20
SI2887961T1 (sl) 2021-08-31
JP6482462B2 (ja) 2019-03-13
HUE054885T2 (hu) 2021-10-28
CA2882771A1 (en) 2014-02-27
KR20150046039A (ko) 2015-04-29
US20180200218A1 (en) 2018-07-19
ZA201500262B (en) 2016-09-28
MX378867B (es) 2025-03-11
JP2022020624A (ja) 2022-02-01
CN104602711A (zh) 2015-05-06
PH12015500375A1 (en) 2015-04-20
AU2013304949A1 (en) 2015-02-05
US20170049738A1 (en) 2017-02-23
JP2019069954A (ja) 2019-05-09
MX2015002432A (es) 2015-06-22
HK1205930A1 (en) 2015-12-31
US9517226B2 (en) 2016-12-13
KR20200111822A (ko) 2020-09-29
US9937143B2 (en) 2018-04-10
PT2887961T (pt) 2021-07-28
SG11201500256UA (en) 2015-04-29
RU2018126749A (ru) 2019-03-12
EP2887961A1 (en) 2015-07-01
EP3943084A1 (en) 2022-01-26
RU2667643C2 (ru) 2018-09-21
TWI634887B (zh) 2018-09-11
KR102159601B1 (ko) 2020-09-28
MA37850A1 (fr) 2018-07-31
NZ704604A (en) 2018-06-29
JP7407508B2 (ja) 2024-01-04
JP2023159114A (ja) 2023-10-31
JP2015526458A (ja) 2015-09-10
CN108685889A (zh) 2018-10-23
AU2013304949C1 (en) 2020-12-24
EP2887961B1 (en) 2021-04-28
TW201414471A (zh) 2014-04-16
TN2015000028A1 (en) 2016-06-29
ES2879550T3 (es) 2021-11-22
AU2013304949B2 (en) 2016-08-11

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