TN2015000028A1 - Nep inhibitors for treating diseases characterized by atrial enlargement or remodeling - Google Patents

Nep inhibitors for treating diseases characterized by atrial enlargement or remodeling

Info

Publication number
TN2015000028A1
TN2015000028A1 TNP2015000028A TN2015000028A TN2015000028A1 TN 2015000028 A1 TN2015000028 A1 TN 2015000028A1 TN P2015000028 A TNP2015000028 A TN P2015000028A TN 2015000028 A TN2015000028 A TN 2015000028A TN 2015000028 A1 TN2015000028 A1 TN 2015000028A1
Authority
TN
Tunisia
Prior art keywords
drug
pro
remodeling
nep inhibitor
pharmaceutically acceptable
Prior art date
Application number
TNP2015000028A
Other languages
English (en)
French (fr)
Inventor
Christoph Schumacher
Thomas Holbro
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49000959&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TN2015000028(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of TN2015000028A1 publication Critical patent/TN2015000028A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TNP2015000028A 2012-08-24 2015-01-19 Nep inhibitors for treating diseases characterized by atrial enlargement or remodeling TN2015000028A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261692911P 2012-08-24 2012-08-24
PCT/EP2013/067472 WO2014029848A1 (en) 2012-08-24 2013-08-22 Nep inhibitors for treating diseases characterized by atrial enlargement or remodeling

Publications (1)

Publication Number Publication Date
TN2015000028A1 true TN2015000028A1 (en) 2016-06-29

Family

ID=49000959

Family Applications (1)

Application Number Title Priority Date Filing Date
TNP2015000028A TN2015000028A1 (en) 2012-08-24 2015-01-19 Nep inhibitors for treating diseases characterized by atrial enlargement or remodeling

Country Status (26)

Country Link
US (3) US9517226B2 (enExample)
EP (2) EP3943084A1 (enExample)
JP (4) JP6482462B2 (enExample)
KR (2) KR102159601B1 (enExample)
CN (2) CN108685889A (enExample)
AU (1) AU2013304949C1 (enExample)
BR (1) BR112015003067A2 (enExample)
CA (1) CA2882771C (enExample)
CL (1) CL2015000426A1 (enExample)
DK (1) DK2887961T3 (enExample)
ES (1) ES2879550T3 (enExample)
HU (1) HUE054885T2 (enExample)
IL (1) IL237114B (enExample)
MA (1) MA37850A1 (enExample)
MX (1) MX378867B (enExample)
NZ (1) NZ704604A (enExample)
PH (1) PH12015500375A1 (enExample)
PL (1) PL2887961T3 (enExample)
PT (1) PT2887961T (enExample)
RU (1) RU2667643C2 (enExample)
SG (1) SG11201500256UA (enExample)
SI (1) SI2887961T1 (enExample)
TN (1) TN2015000028A1 (enExample)
TW (1) TWI634887B (enExample)
WO (1) WO2014029848A1 (enExample)
ZA (1) ZA201500262B (enExample)

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EP1852108A1 (en) 2006-05-04 2007-11-07 Boehringer Ingelheim Pharma GmbH & Co.KG DPP IV inhibitor formulations
PE20140960A1 (es) 2008-04-03 2014-08-15 Boehringer Ingelheim Int Formulaciones que comprenden un inhibidor de dpp4
US20200155558A1 (en) 2018-11-20 2020-05-21 Boehringer Ingelheim International Gmbh Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
US9034883B2 (en) 2010-11-15 2015-05-19 Boehringer Ingelheim International Gmbh Vasoprotective and cardioprotective antidiabetic therapy
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Also Published As

Publication number Publication date
PL2887961T3 (pl) 2021-11-08
IL237114A0 (en) 2015-03-31
CA2882771C (en) 2021-02-23
CL2015000426A1 (es) 2015-10-02
BR112015003067A2 (pt) 2017-07-04
IL237114B (en) 2020-10-29
US20150190376A1 (en) 2015-07-09
RU2018126749A3 (enExample) 2021-12-28
WO2014029848A1 (en) 2014-02-27
US11135192B2 (en) 2021-10-05
RU2015110240A (ru) 2016-10-20
SI2887961T1 (sl) 2021-08-31
JP6482462B2 (ja) 2019-03-13
HUE054885T2 (hu) 2021-10-28
CA2882771A1 (en) 2014-02-27
KR20150046039A (ko) 2015-04-29
US20180200218A1 (en) 2018-07-19
ZA201500262B (en) 2016-09-28
MX378867B (es) 2025-03-11
JP2022020624A (ja) 2022-02-01
CN104602711A (zh) 2015-05-06
PH12015500375A1 (en) 2015-04-20
AU2013304949A1 (en) 2015-02-05
US20170049738A1 (en) 2017-02-23
JP2019069954A (ja) 2019-05-09
MX2015002432A (es) 2015-06-22
HK1205930A1 (en) 2015-12-31
US9517226B2 (en) 2016-12-13
KR20200111822A (ko) 2020-09-29
US9937143B2 (en) 2018-04-10
PT2887961T (pt) 2021-07-28
SG11201500256UA (en) 2015-04-29
RU2018126749A (ru) 2019-03-12
EP2887961A1 (en) 2015-07-01
EP3943084A1 (en) 2022-01-26
RU2667643C2 (ru) 2018-09-21
TWI634887B (zh) 2018-09-11
KR102159601B1 (ko) 2020-09-28
MA37850A1 (fr) 2018-07-31
NZ704604A (en) 2018-06-29
JP7407508B2 (ja) 2024-01-04
JP2023159114A (ja) 2023-10-31
JP2015526458A (ja) 2015-09-10
CN108685889A (zh) 2018-10-23
AU2013304949C1 (en) 2020-12-24
EP2887961B1 (en) 2021-04-28
TW201414471A (zh) 2014-04-16
ES2879550T3 (es) 2021-11-22
DK2887961T3 (da) 2021-07-19
AU2013304949B2 (en) 2016-08-11

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