RU2662941C2 - Очистка рентгеноконтрастных веществ - Google Patents

Очистка рентгеноконтрастных веществ Download PDF

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Publication number
RU2662941C2
RU2662941C2 RU2015121502A RU2015121502A RU2662941C2 RU 2662941 C2 RU2662941 C2 RU 2662941C2 RU 2015121502 A RU2015121502 A RU 2015121502A RU 2015121502 A RU2015121502 A RU 2015121502A RU 2662941 C2 RU2662941 C2 RU 2662941C2
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RU
Russia
Prior art keywords
dimeric
membrane
crude product
retentate
monomeric
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RU2015121502A
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English (en)
Russian (ru)
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RU2015121502A (ru
Inventor
Ян СЕРВЕНКА
Миккель ТАНИНГ
Андреас ОЛССОН
Кристиан ГЛОГАРД
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ДжиИ Хелткер АС
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Publication of RU2015121502A publication Critical patent/RU2015121502A/ru
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C07C231/24—Separation; Purification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0438—Organic X-ray contrast-enhancing agent comprising an iodinated group or an iodine atom, e.g. iopamidol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
RU2015121502A 2012-12-19 2013-11-19 Очистка рентгеноконтрастных веществ RU2662941C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12198020.5 2012-12-19
EP12198020 2012-12-19
PCT/US2013/070699 WO2014099214A1 (en) 2012-12-19 2013-11-19 Purification of x-ray contrast agents

Publications (2)

Publication Number Publication Date
RU2015121502A RU2015121502A (ru) 2017-01-26
RU2662941C2 true RU2662941C2 (ru) 2018-07-31

Family

ID=47458704

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2015121502A RU2662941C2 (ru) 2012-12-19 2013-11-19 Очистка рентгеноконтрастных веществ

Country Status (15)

Country Link
US (1) US9938233B2 (enExample)
EP (1) EP2935204B1 (enExample)
JP (2) JP6342421B2 (enExample)
KR (1) KR102180250B1 (enExample)
CN (1) CN104854080B (enExample)
AU (1) AU2013364113B2 (enExample)
CA (1) CA2890449C (enExample)
ES (1) ES2690128T3 (enExample)
HU (1) HUE039458T2 (enExample)
IN (1) IN2015DN03980A (enExample)
NZ (1) NZ708503A (enExample)
PL (1) PL2935204T3 (enExample)
RU (1) RU2662941C2 (enExample)
SG (1) SG11201504201RA (enExample)
WO (1) WO2014099214A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6342421B2 (ja) 2012-12-19 2018-06-13 ジーイー・ヘルスケア・アクスイェ・セルスカプ Ｘ線造影剤の精製
KR101699539B1 (ko) * 2015-12-30 2017-02-13 (주)솔레이어 나노 여과 모듈 및 이를 이용한 농축 방법
CN113121377A (zh) * 2019-12-31 2021-07-16 江苏汉邦科技有限公司 碘克沙醇的纯化方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5221485A (en) * 1991-12-03 1993-06-22 Mallinckrodt Medical, Inc. Purification of X-ray contrast agent, magnetic resonance imaging agent, or radiopharmaceuticals using reverse osmosis
WO1997030735A2 (en) * 1996-02-23 1997-08-28 Bracco S.P.A. A process for the purification of opacifying contrast agents
RU2135462C1 (ru) * 1993-07-30 1999-08-27 Брэкко Интернэшнл Б.В. Способ кристаллизации иопамидола
WO2009091758A1 (en) * 2008-01-14 2009-07-23 Mallinckrodt Inc. Process for the preparation of iosimenol
WO2011063551A1 (en) * 2009-11-26 2011-06-03 Hovione China Holding Limited Preparation and purification of iodixanol

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5447635A (en) * 1991-02-26 1995-09-05 Bracco International B.V. Process of concentration and purification of organic compounds
IT1248741B (it) * 1991-02-26 1995-01-26 Bracco Spa Processo di concentrazione e di purificazione di composti organici
DE69416015D1 (de) 1993-02-26 1999-03-04 Createrra Inc Verfahren zur Herstellung von Substanzen zur Reinigung von Wasser
US5811581A (en) 1994-08-04 1998-09-22 Dibra S.P.A. Process for the purification of opacifying contrast agents
US6425885B1 (en) 1999-12-20 2002-07-30 Ultradent Products, Inc. Hydraulic syringe
NO20043305D0 (no) 2004-08-09 2004-08-09 Amersham Health As Preparation of lodixanol
NO20053676D0 (no) 2005-07-29 2005-07-29 Amersham Health As Crystallisation Process
NO20055643D0 (no) * 2005-11-29 2005-11-29 Amersham Health As Preparation of lodixanol
DK2178568T3 (da) 2007-07-12 2014-07-21 Ge Healthcare As Kontrastmidler
US20110021823A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As Processing crude iodixanol mixture by nanofiltration
JP2014511344A (ja) 2010-12-21 2014-05-15 ジーイー・ヘルスケア・アクスイェ・セルスカプ 造影剤を含む組成物の脱塩
JP6342421B2 (ja) 2012-12-19 2018-06-13 ジーイー・ヘルスケア・アクスイェ・セルスカプ Ｘ線造影剤の精製

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5221485A (en) * 1991-12-03 1993-06-22 Mallinckrodt Medical, Inc. Purification of X-ray contrast agent, magnetic resonance imaging agent, or radiopharmaceuticals using reverse osmosis
RU2135462C1 (ru) * 1993-07-30 1999-08-27 Брэкко Интернэшнл Б.В. Способ кристаллизации иопамидола
WO1997030735A2 (en) * 1996-02-23 1997-08-28 Bracco S.P.A. A process for the purification of opacifying contrast agents
WO2009091758A1 (en) * 2008-01-14 2009-07-23 Mallinckrodt Inc. Process for the preparation of iosimenol
WO2011063551A1 (en) * 2009-11-26 2011-06-03 Hovione China Holding Limited Preparation and purification of iodixanol

Also Published As

Publication number Publication date
CA2890449C (en) 2020-12-29
SG11201504201RA (en) 2015-07-30
AU2013364113B2 (en) 2018-01-18
JP2018115193A (ja) 2018-07-26
KR102180250B1 (ko) 2020-11-18
US20160304440A1 (en) 2016-10-20
CN104854080B (zh) 2018-07-03
ES2690128T3 (es) 2018-11-19
CA2890449A1 (en) 2014-06-26
AU2013364113A1 (en) 2015-05-28
EP2935204B1 (en) 2018-09-05
US9938233B2 (en) 2018-04-10
IN2015DN03980A (enExample) 2015-10-02
EP2935204A4 (en) 2016-08-17
PL2935204T3 (pl) 2018-12-31
JP6342421B2 (ja) 2018-06-13
CN104854080A (zh) 2015-08-19
HUE039458T2 (hu) 2019-01-28
RU2015121502A (ru) 2017-01-26
KR20150094639A (ko) 2015-08-19
NZ708503A (en) 2019-08-30
WO2014099214A1 (en) 2014-06-26
JP2016503054A (ja) 2016-02-01
EP2935204A1 (en) 2015-10-28

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