RU2640485C2 - Комбинированное лечение рака - Google Patents

Комбинированное лечение рака Download PDF

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Publication number
RU2640485C2
RU2640485C2 RU2014119713A RU2014119713A RU2640485C2 RU 2640485 C2 RU2640485 C2 RU 2640485C2 RU 2014119713 A RU2014119713 A RU 2014119713A RU 2014119713 A RU2014119713 A RU 2014119713A RU 2640485 C2 RU2640485 C2 RU 2640485C2
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cancer
azd5363
pharmaceutically acceptable
combination
acceptable salt
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RU2014119713A
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English (en)
Russian (ru)
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RU2014119713A (ru
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Барри Роберт Дэвис
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Астразенека Аб
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
RU2014119713A 2011-11-30 2012-11-30 Комбинированное лечение рака RU2640485C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161564975P 2011-11-30 2011-11-30
US61/564,975 2011-11-30
PCT/GB2012/052969 WO2013079964A1 (en) 2011-11-30 2012-11-30 Combination treatment of cancer

Publications (2)

Publication Number Publication Date
RU2014119713A RU2014119713A (ru) 2016-01-27
RU2640485C2 true RU2640485C2 (ru) 2018-01-09

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RU2014119713A RU2640485C2 (ru) 2011-11-30 2012-11-30 Комбинированное лечение рака

Country Status (26)

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US (2) US20140329786A1 (OSRAM)
EP (1) EP2785349B2 (OSRAM)
JP (1) JP6309454B2 (OSRAM)
KR (1) KR102035361B1 (OSRAM)
CN (1) CN103945849B (OSRAM)
AU (2) AU2012321110B2 (OSRAM)
CA (1) CA2856646C (OSRAM)
CY (1) CY1122624T1 (OSRAM)
DK (1) DK2785349T4 (OSRAM)
ES (1) ES2762250T5 (OSRAM)
FI (1) FI2785349T4 (OSRAM)
HR (1) HRP20191982T4 (OSRAM)
HU (1) HUE046667T2 (OSRAM)
IL (1) IL232530B (OSRAM)
LT (1) LT2785349T (OSRAM)
MX (1) MX367640B (OSRAM)
MY (1) MY175800A (OSRAM)
PH (1) PH12014500943A1 (OSRAM)
PL (1) PL2785349T5 (OSRAM)
PT (1) PT2785349T (OSRAM)
RS (1) RS59493B2 (OSRAM)
RU (1) RU2640485C2 (OSRAM)
SG (1) SG11201401471PA (OSRAM)
SI (1) SI2785349T2 (OSRAM)
SM (1) SMT201900708T1 (OSRAM)
WO (1) WO2013079964A1 (OSRAM)

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EP2393827B1 (en) 2009-02-05 2015-10-07 Tokai Pharmaceuticals, Inc. Novel prodrugs of steroidal cyp17 inhibitors/antiandrogens
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JOP20200097A1 (ar) 2013-01-15 2017-06-16 Aragon Pharmaceuticals Inc معدل مستقبل أندروجين واستخداماته
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SG11201600525XA (en) 2013-08-12 2016-02-26 Tokai Pharmaceuticals Inc Biomarkers for treatment of neoplastic disorders using androgen-targeted therapies
WO2015049649A1 (en) * 2013-10-01 2015-04-09 Gbglaxosmithkline Intellectual Property (No.2) Limited Combination
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TWI726969B (zh) 2016-01-11 2021-05-11 比利時商健生藥品公司 用作雄性激素受體拮抗劑之經取代之硫尿囊素衍生物
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AU2017376704B2 (en) * 2016-12-16 2021-08-05 Kangpu Biopharmaceuticals, Ltd. Composition, application thereof and treatment method
CN107670048B (zh) * 2017-08-30 2019-04-26 南京明臻医药科技有限公司 具有协同抗癌活性的中间体药物和聚乙二醇偶联协同抗癌药物、及其制备方法和应用
AU2018335391A1 (en) * 2017-09-22 2020-03-26 AustinPx, LLC Abiraterone-cyclic oligomer pharmaceutical formulations and methods of formation and administration thereof
UA129105C2 (uk) 2017-10-16 2025-01-15 Арагон Фармасьютикалз, Інк. Антиандрогени для лікування неметастатичного резистентного до кастрації раку передміхурової залози
CN108486041A (zh) * 2018-03-28 2018-09-04 华南农业大学 PI3K/Akt信号通路在鸡胚成纤维细胞内对马立克氏病毒增殖的应用及其检测方法
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GODBOLE AM et al. New insights into the androgen-targeted therapies and epigenetic therapies in prostate cancer. Prostate cancer. 2011; 2011:918707 Epub 2011 Oct. 12 [он лайн] [найдено 07.07.2016] (Найдено из Интернет: www.ncbi.nlm.nih.gov/pubmed/22111003). КРАТКИЙ КУРС МОЛЕКУЛЯРНОЙ ФАРМАКОЛОГИИ. Под ред. П.В.Сергеева, М., 1975, с.10. Д.Г. ГРЭХАМ-СМИТ и др. Оксфордский справочник по клинической фармакологии и фармакотерапии. М.: Медицина 2000 с.136-137, с.149-150 раздел 10.6. OKEGAVA T. et al. Alterantive antiandrogen therapy in patients with castration-resistant prostate cancer: a single-center experience. Int.J.Urol. 2010 Nov;17(11): 950-5 Реферат [он лайн] [найдено 07.07.2016] (Найдено из Интернет: www.ncbi.nlm.nih.gov/pubmed/20807265). *
OKEGAVA T. et al. Alterantive antiandrogen therapy in patients with castration-resistant prostate cancer: a single-center experience. Int.J.Urol. 2010 Nov;17(11): 950-5 Реферат [он лайн] [найдено 07.07.2016] (Найдено из Интернет: www.ncbi.nlm.nih.gov/pubmed/20807265). *
Д.Г. ГРЭХАМ-СМИТ и др. Оксфордский справочник по клинической фармакологии и фармакотерапии. М.: Медицина 2000 с.136-137, с.149-150 раздел 10.6. *

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