RU2635917C2 - Имидазо[1, 2-b]пиридазиновые производные как ингибиторы киназ - Google Patents
Имидазо[1, 2-b]пиридазиновые производные как ингибиторы киназ Download PDFInfo
- Publication number
- RU2635917C2 RU2635917C2 RU2014153627A RU2014153627A RU2635917C2 RU 2635917 C2 RU2635917 C2 RU 2635917C2 RU 2014153627 A RU2014153627 A RU 2014153627A RU 2014153627 A RU2014153627 A RU 2014153627A RU 2635917 C2 RU2635917 C2 RU 2635917C2
- Authority
- RU
- Russia
- Prior art keywords
- group
- cancer
- compound according
- imidazo
- phenyl
- Prior art date
Links
- 150000004942 imidazo[1,2-b]pyridazines Chemical class 0.000 title 1
- 229940043355 kinase inhibitor Drugs 0.000 title 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract description 578
- 150000003839 salts Chemical class 0.000 claims abstract description 81
- 101000686031 Homo sapiens Proto-oncogene tyrosine-protein kinase ROS Proteins 0.000 claims abstract description 74
- 102100023347 Proto-oncogene tyrosine-protein kinase ROS Human genes 0.000 claims abstract description 73
- 206010028980 Neoplasm Diseases 0.000 claims abstract description 72
- 230000002401 inhibitory effect Effects 0.000 claims abstract description 26
- 230000002255 enzymatic effect Effects 0.000 claims abstract description 22
- 108091000080 Phosphotransferase Proteins 0.000 claims abstract description 13
- 102000020233 phosphotransferase Human genes 0.000 claims abstract description 13
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 3
- 238000000034 method Methods 0.000 claims description 133
- -1 amino, hydroxy Chemical group 0.000 claims description 118
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 71
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 50
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 48
- 108090000623 proteins and genes Proteins 0.000 claims description 46
- 229910052757 nitrogen Inorganic materials 0.000 claims description 39
- 230000014509 gene expression Effects 0.000 claims description 37
- 230000004927 fusion Effects 0.000 claims description 36
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 30
- 125000002206 pyridazin-3-yl group Chemical group [H]C1=C([H])C([H])=C(*)N=N1 0.000 claims description 29
- 125000004180 3-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(F)=C1[H] 0.000 claims description 28
- 125000005843 halogen group Chemical group 0.000 claims description 28
- 201000011510 cancer Diseases 0.000 claims description 25
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims description 24
- 239000004480 active ingredient Substances 0.000 claims description 23
- 125000003277 amino group Chemical group 0.000 claims description 23
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 23
- 101150035397 Ros1 gene Proteins 0.000 claims description 21
- 239000003814 drug Substances 0.000 claims description 19
- 125000001424 substituent group Chemical group 0.000 claims description 18
- 125000001931 aliphatic group Chemical group 0.000 claims description 17
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 17
- 125000000623 heterocyclic group Chemical group 0.000 claims description 17
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims description 16
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims description 15
- 125000004430 oxygen atom Chemical group O* 0.000 claims description 15
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 14
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 14
- 229940124597 therapeutic agent Drugs 0.000 claims description 14
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 13
- 206010060862 Prostate cancer Diseases 0.000 claims description 11
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 11
- 206010004593 Bile duct cancer Diseases 0.000 claims description 10
- 208000003174 Brain Neoplasms Diseases 0.000 claims description 10
- 208000026900 bile duct neoplasm Diseases 0.000 claims description 10
- 208000006990 cholangiocarcinoma Diseases 0.000 claims description 10
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 10
- 239000003112 inhibitor Substances 0.000 claims description 9
- ROFHSOCMQNVNGI-IBGZPJMESA-N (4s)-4-amino-1-[4-[6-[(3-fluorophenyl)methyl-methylamino]imidazo[1,2-b]pyridazin-3-yl]phenyl]pyrrolidin-2-one Chemical compound C1=CC2=NC=C(C=3C=CC(=CC=3)N3C(C[C@H](N)C3)=O)N2N=C1N(C)CC1=CC=CC(F)=C1 ROFHSOCMQNVNGI-IBGZPJMESA-N 0.000 claims description 8
- HEVHTYMYEMEBPX-HZPDHXFCSA-N 3-[4-[(2r)-2-aminopropoxy]phenyl]-n-[(1r)-1-(3-fluorophenyl)ethyl]imidazo[1,2-b]pyridazin-6-amine Chemical compound C1=CC(OC[C@H](N)C)=CC=C1C1=CN=C2N1N=C(N[C@H](C)C=1C=C(F)C=CC=1)C=C2 HEVHTYMYEMEBPX-HZPDHXFCSA-N 0.000 claims description 8
- 239000002246 antineoplastic agent Substances 0.000 claims description 8
- 206010006187 Breast cancer Diseases 0.000 claims description 7
- 208000026310 Breast neoplasm Diseases 0.000 claims description 7
- 206010009944 Colon cancer Diseases 0.000 claims description 7
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 7
- 206010033128 Ovarian cancer Diseases 0.000 claims description 7
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 7
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 7
- 206010039491 Sarcoma Diseases 0.000 claims description 7
- 125000000217 alkyl group Chemical group 0.000 claims description 7
- 201000010536 head and neck cancer Diseases 0.000 claims description 7
- 208000014829 head and neck neoplasm Diseases 0.000 claims description 7
- 201000005202 lung cancer Diseases 0.000 claims description 7
- 208000020816 lung neoplasm Diseases 0.000 claims description 7
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 7
- 201000001441 melanoma Diseases 0.000 claims description 7
- 201000002528 pancreatic cancer Diseases 0.000 claims description 7
- 208000008443 pancreatic carcinoma Diseases 0.000 claims description 7
- 229910052717 sulfur Inorganic materials 0.000 claims description 7
- 125000004434 sulfur atom Chemical group 0.000 claims description 7
- 206010073360 Appendix cancer Diseases 0.000 claims description 6
- 206010005003 Bladder cancer Diseases 0.000 claims description 6
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims description 6
- 206010051066 Gastrointestinal stromal tumour Diseases 0.000 claims description 6
- 208000007766 Kaposi sarcoma Diseases 0.000 claims description 6
- 208000008839 Kidney Neoplasms Diseases 0.000 claims description 6
- 206010025323 Lymphomas Diseases 0.000 claims description 6
- 206010027406 Mesothelioma Diseases 0.000 claims description 6
- 208000034578 Multiple myelomas Diseases 0.000 claims description 6
- 206010052399 Neuroendocrine tumour Diseases 0.000 claims description 6
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims description 6
- 206010035226 Plasma cell myeloma Diseases 0.000 claims description 6
- 206010038389 Renal cancer Diseases 0.000 claims description 6
- 208000021712 Soft tissue sarcoma Diseases 0.000 claims description 6
- 208000005718 Stomach Neoplasms Diseases 0.000 claims description 6
- 208000024313 Testicular Neoplasms Diseases 0.000 claims description 6
- 206010057644 Testis cancer Diseases 0.000 claims description 6
- 208000024770 Thyroid neoplasm Diseases 0.000 claims description 6
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims description 6
- 208000021780 appendiceal neoplasm Diseases 0.000 claims description 6
- 208000029742 colonic neoplasm Diseases 0.000 claims description 6
- 201000004101 esophageal cancer Diseases 0.000 claims description 6
- 206010017758 gastric cancer Diseases 0.000 claims description 6
- 201000011243 gastrointestinal stromal tumor Diseases 0.000 claims description 6
- 230000002489 hematologic effect Effects 0.000 claims description 6
- 201000010982 kidney cancer Diseases 0.000 claims description 6
- 208000032839 leukemia Diseases 0.000 claims description 6
- 201000007270 liver cancer Diseases 0.000 claims description 6
- 208000014018 liver neoplasm Diseases 0.000 claims description 6
- LLDWLXXSYWQNMD-UTKZUKDTSA-N n-[(1r)-1-(3-fluorophenyl)ethyl]-3-[4-[[(2s)-pyrrolidin-2-yl]methoxy]phenyl]imidazo[1,2-b]pyridazin-6-amine Chemical compound N([C@H](C)C=1C=C(F)C=CC=1)C(=NN12)C=CC1=NC=C2C(C=C1)=CC=C1OC[C@@H]1CCCN1 LLDWLXXSYWQNMD-UTKZUKDTSA-N 0.000 claims description 6
- 208000016065 neuroendocrine neoplasm Diseases 0.000 claims description 6
- 201000011519 neuroendocrine tumor Diseases 0.000 claims description 6
- 201000008968 osteosarcoma Diseases 0.000 claims description 6
- 201000011549 stomach cancer Diseases 0.000 claims description 6
- 201000003120 testicular cancer Diseases 0.000 claims description 6
- 201000002510 thyroid cancer Diseases 0.000 claims description 6
- 201000005112 urinary bladder cancer Diseases 0.000 claims description 6
- GEDXRUYMMKEYEI-BEFAXECRSA-N (3S)-1-[5-[6-[(1R)-1-(3-fluorophenyl)ethoxy]imidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl]pyrrolidin-3-amine Chemical compound N[C@H]1CCN(C1)C1=NC=C(C=C1)C1=CN=C2N1N=C(C=C2)O[C@H](C)C1=CC(=CC=C1)F GEDXRUYMMKEYEI-BEFAXECRSA-N 0.000 claims description 5
- RDYDLGQKCZBWIJ-UZLBHIALSA-N 3-[4-[(3S)-3-aminopyrrolidin-1-yl]phenyl]-N-[(1R)-1-(3-fluorophenyl)ethyl]imidazo[1,2-b]pyridazin-6-amine Chemical compound N[C@H]1CCN(C1)C1=CC=C(C=C1)C1=CN=C2N1N=C(C=C2)N[C@H](C)C1=CC(=CC=C1)F RDYDLGQKCZBWIJ-UZLBHIALSA-N 0.000 claims description 5
- 208000007860 Anus Neoplasms Diseases 0.000 claims description 5
- 206010008342 Cervix carcinoma Diseases 0.000 claims description 5
- 208000022072 Gallbladder Neoplasms Diseases 0.000 claims description 5
- 102000001253 Protein Kinase Human genes 0.000 claims description 5
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims description 5
- 125000003282 alkyl amino group Chemical group 0.000 claims description 5
- 125000006620 amino-(C1-C6) alkyl group Chemical group 0.000 claims description 5
- 201000011165 anus cancer Diseases 0.000 claims description 5
- 201000010881 cervical cancer Diseases 0.000 claims description 5
- 125000006310 cycloalkyl amino group Chemical group 0.000 claims description 5
- 201000010175 gallbladder cancer Diseases 0.000 claims description 5
- 125000005842 heteroatom Chemical group 0.000 claims description 5
- 108060006633 protein kinase Proteins 0.000 claims description 5
- XIQJHAMJWILELX-SFHVURJKSA-N (4s)-4-amino-1-[4-[6-[(3-fluorophenyl)methyl-methylamino]imidazo[1,2-b]pyridazin-3-yl]-3-methoxyphenyl]pyrrolidin-2-one Chemical compound COC1=CC(N2C(C[C@H](N)C2)=O)=CC=C1C(N1N=2)=CN=C1C=CC=2N(C)CC1=CC=CC(F)=C1 XIQJHAMJWILELX-SFHVURJKSA-N 0.000 claims description 4
- HEVHTYMYEMEBPX-JKSUJKDBSA-N 3-[4-[(2s)-2-aminopropoxy]phenyl]-n-[(1r)-1-(3-fluorophenyl)ethyl]imidazo[1,2-b]pyridazin-6-amine Chemical compound C1=CC(OC[C@@H](N)C)=CC=C1C1=CN=C2N1N=C(N[C@H](C)C=1C=C(F)C=CC=1)C=C2 HEVHTYMYEMEBPX-JKSUJKDBSA-N 0.000 claims description 4
- FQCGOBGLJQWKJA-UZLBHIALSA-N 3-[4-[[(2s)-azetidin-2-yl]methoxy]phenyl]-n-[(1r)-1-(3-fluorophenyl)ethyl]imidazo[1,2-b]pyridazin-6-amine Chemical compound N([C@H](C)C=1C=C(F)C=CC=1)C(=NN12)C=CC1=NC=C2C(C=C1)=CC=C1OC[C@@H]1CCN1 FQCGOBGLJQWKJA-UZLBHIALSA-N 0.000 claims description 4
- 125000006164 6-membered heteroaryl group Chemical group 0.000 claims description 4
- 229910052799 carbon Inorganic materials 0.000 claims description 4
- KEYUEZVISDYBTH-MRXNPFEDSA-N n-[(1r)-1-(3-fluorophenyl)ethyl]-3-[4-[2-(methylamino)ethoxy]phenyl]imidazo[1,2-b]pyridazin-6-amine Chemical compound C1=CC(OCCNC)=CC=C1C1=CN=C2N1N=C(N[C@H](C)C=1C=C(F)C=CC=1)C=C2 KEYUEZVISDYBTH-MRXNPFEDSA-N 0.000 claims description 4
- FNVZGBFSYRZMSY-FYZYNONXSA-N (4s)-4-amino-1-[4-[6-[(3-fluorophenyl)methyl-methylamino]imidazo[1,2-b]pyridazin-3-yl]phenyl]pyrrolidin-2-one;benzenesulfonic acid Chemical compound OS(=O)(=O)C1=CC=CC=C1.C1=CC2=NC=C(C=3C=CC(=CC=3)N3C(C[C@H](N)C3)=O)N2N=C1N(C)CC1=CC=CC(F)=C1 FNVZGBFSYRZMSY-FYZYNONXSA-N 0.000 claims description 3
- BQHPPNPYUMQTPW-FYZYNONXSA-N (4s)-4-amino-1-[4-[6-[(3-fluorophenyl)methyl-methylamino]imidazo[1,2-b]pyridazin-3-yl]phenyl]pyrrolidin-2-one;hexanedioic acid Chemical compound OC(=O)CCCCC(O)=O.C1=CC2=NC=C(C=3C=CC(=CC=3)N3C(C[C@H](N)C3)=O)N2N=C1N(C)CC1=CC=CC(F)=C1 BQHPPNPYUMQTPW-FYZYNONXSA-N 0.000 claims description 3
- DORJQZDOULKINH-QNBGGDODSA-N 3-[4-[(2r)-2-aminopropoxy]phenyl]-n-[(1r)-1-(3-fluorophenyl)ethyl]imidazo[1,2-b]pyridazin-6-amine;hexanedioic acid Chemical compound OC(=O)CCCCC(O)=O.C1=CC(OC[C@H](N)C)=CC=C1C1=CN=C2N1N=C(N[C@H](C)C=1C=C(F)C=CC=1)C=C2 DORJQZDOULKINH-QNBGGDODSA-N 0.000 claims description 3
- 125000006163 5-membered heteroaryl group Chemical group 0.000 claims description 3
- 208000002495 Uterine Neoplasms Diseases 0.000 claims description 3
- 125000001072 heteroaryl group Chemical group 0.000 claims description 3
- 206010046766 uterine cancer Diseases 0.000 claims description 3
- ZUGFMWBTUQRHSE-QNBGGDODSA-N 3-[4-[(2r)-2-aminopropoxy]phenyl]-n-[(1r)-1-(3-fluorophenyl)ethyl]imidazo[1,2-b]pyridazin-6-amine;methanesulfonic acid Chemical compound CS(O)(=O)=O.C1=CC(OC[C@H](N)C)=CC=C1C1=CN=C2N1N=C(N[C@H](C)C=1C=C(F)C=CC=1)C=C2 ZUGFMWBTUQRHSE-QNBGGDODSA-N 0.000 claims description 2
- ZGFLWZPQLIXFGY-PXPMWPIZSA-N Cl.N[C@H]1CCN(C1)C1=CC=C(C=C1)C1=CN=C2N1N=C(C=C2)O[C@H](C)C2=CC(=CC=C2)F Chemical compound Cl.N[C@H]1CCN(C1)C1=CC=C(C=C1)C1=CN=C2N1N=C(C=C2)O[C@H](C)C2=CC(=CC=C2)F ZGFLWZPQLIXFGY-PXPMWPIZSA-N 0.000 claims description 2
- 125000004432 carbon atom Chemical group C* 0.000 claims description 2
- 125000001425 triazolyl group Chemical group 0.000 claims 2
- ACNFQZFMWCSGRR-HOOCCGKBSA-N O.OS(=O)(=O)c1ccccc1.C[C@@H](Oc1ccc2ncc(-c3ccc(cc3)N3C[C@@H](N)CC3=O)n2n1)c1cccc(F)c1 Chemical compound O.OS(=O)(=O)c1ccccc1.C[C@@H](Oc1ccc2ncc(-c3ccc(cc3)N3C[C@@H](N)CC3=O)n2n1)c1cccc(F)c1 ACNFQZFMWCSGRR-HOOCCGKBSA-N 0.000 claims 1
- JEGUKCSWCFPDGT-UHFFFAOYSA-N h2o hydrate Chemical compound O.O JEGUKCSWCFPDGT-UHFFFAOYSA-N 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- LETVJWLLIMJADE-UHFFFAOYSA-N pyridazin-3-amine Chemical compound NC1=CC=CN=N1 LETVJWLLIMJADE-UHFFFAOYSA-N 0.000 claims 1
- 210000004291 uterus Anatomy 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 25
- 239000000126 substance Substances 0.000 abstract description 9
- VTVRXITWWZGKHV-UHFFFAOYSA-N imidazo[1,2-b]pyridazine Chemical group N1=CC=CC2=NC=CN21 VTVRXITWWZGKHV-UHFFFAOYSA-N 0.000 abstract description 3
- 238000005160 1H NMR spectroscopy Methods 0.000 description 335
- 239000000243 solution Substances 0.000 description 268
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 258
- 239000000203 mixture Substances 0.000 description 211
- 238000006243 chemical reaction Methods 0.000 description 144
- 230000002829 reductive effect Effects 0.000 description 118
- YMWUJEATGCHHMB-UHFFFAOYSA-N dichloromethane Substances ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 117
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 107
- 239000002904 solvent Substances 0.000 description 96
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 72
- 238000010898 silica gel chromatography Methods 0.000 description 71
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 67
- 238000002330 electrospray ionisation mass spectrometry Methods 0.000 description 64
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 60
- 239000012044 organic layer Substances 0.000 description 60
- OAYLNYINCPYISS-UHFFFAOYSA-N ethyl acetate;hexane Chemical compound CCCCCC.CCOC(C)=O OAYLNYINCPYISS-UHFFFAOYSA-N 0.000 description 54
- 238000001816 cooling Methods 0.000 description 49
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 48
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 47
- 238000005259 measurement Methods 0.000 description 46
- 239000007858 starting material Substances 0.000 description 45
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 44
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 41
- 239000012267 brine Substances 0.000 description 40
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 39
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 39
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 39
- NXQGGXCHGDYOHB-UHFFFAOYSA-L cyclopenta-1,4-dien-1-yl(diphenyl)phosphane;dichloropalladium;iron(2+) Chemical compound [Fe+2].Cl[Pd]Cl.[CH-]1C=CC(P(C=2C=CC=CC=2)C=2C=CC=CC=2)=C1.[CH-]1C=CC(P(C=2C=CC=CC=2)C=2C=CC=CC=2)=C1 NXQGGXCHGDYOHB-UHFFFAOYSA-L 0.000 description 34
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 33
- 239000010410 layer Substances 0.000 description 30
- 229920006395 saturated elastomer Polymers 0.000 description 30
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 29
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 28
- 238000001914 filtration Methods 0.000 description 27
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 24
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 24
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 24
- 235000017557 sodium bicarbonate Nutrition 0.000 description 24
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 24
- 239000007787 solid Substances 0.000 description 24
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 22
- 238000000605 extraction Methods 0.000 description 22
- 230000005764 inhibitory process Effects 0.000 description 22
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 21
- 210000004027 cell Anatomy 0.000 description 21
- 239000000741 silica gel Substances 0.000 description 20
- 229910002027 silica gel Inorganic materials 0.000 description 20
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 18
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 18
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 16
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 16
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 16
- DYHSDKLCOJIUFX-UHFFFAOYSA-N tert-butoxycarbonyl anhydride Chemical compound CC(C)(C)OC(=O)OC(=O)OC(C)(C)C DYHSDKLCOJIUFX-UHFFFAOYSA-N 0.000 description 16
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 description 15
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 15
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 14
- 238000012360 testing method Methods 0.000 description 13
- 230000000259 anti-tumor effect Effects 0.000 description 12
- 125000001153 fluoro group Chemical group F* 0.000 description 12
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 10
- 102100035108 High affinity nerve growth factor receptor Human genes 0.000 description 10
- 150000001412 amines Chemical class 0.000 description 10
- 230000010261 cell growth Effects 0.000 description 10
- 239000012043 crude product Substances 0.000 description 10
- 230000037361 pathway Effects 0.000 description 10
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 description 10
- 238000002360 preparation method Methods 0.000 description 10
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 10
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 10
- VHYFNPMBLIVWCW-UHFFFAOYSA-N 4-Dimethylaminopyridine Chemical compound CN(C)C1=CC=NC=C1 VHYFNPMBLIVWCW-UHFFFAOYSA-N 0.000 description 9
- 102100035080 BDNF/NT-3 growth factors receptor Human genes 0.000 description 9
- 101000596896 Homo sapiens BDNF/NT-3 growth factors receptor Proteins 0.000 description 9
- 101000596894 Homo sapiens High affinity nerve growth factor receptor Proteins 0.000 description 9
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 9
- 102100029166 NT-3 growth factor receptor Human genes 0.000 description 9
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 9
- 239000007864 aqueous solution Substances 0.000 description 9
- 230000035578 autophosphorylation Effects 0.000 description 9
- WORJEOGGNQDSOE-UHFFFAOYSA-N chloroform;methanol Chemical compound OC.ClC(Cl)Cl WORJEOGGNQDSOE-UHFFFAOYSA-N 0.000 description 9
- 125000006239 protecting group Chemical group 0.000 description 9
- 239000012312 sodium hydride Substances 0.000 description 9
- 229910000104 sodium hydride Inorganic materials 0.000 description 9
- 108010064892 trkC Receptor Proteins 0.000 description 9
- GZFGOTFRPZRKDS-UHFFFAOYSA-N 4-bromophenol Chemical compound OC1=CC=C(Br)C=C1 GZFGOTFRPZRKDS-UHFFFAOYSA-N 0.000 description 8
- JGFZNNIVVJXRND-UHFFFAOYSA-N N,N-Diisopropylethylamine (DIPEA) Chemical compound CCN(C(C)C)C(C)C JGFZNNIVVJXRND-UHFFFAOYSA-N 0.000 description 8
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 description 8
- WGQKYBSKWIADBV-UHFFFAOYSA-N benzylamine Chemical compound NCC1=CC=CC=C1 WGQKYBSKWIADBV-UHFFFAOYSA-N 0.000 description 8
- 239000003153 chemical reaction reagent Substances 0.000 description 8
- 239000000706 filtrate Substances 0.000 description 8
- 229910052731 fluorine Inorganic materials 0.000 description 8
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 8
- 229910000041 hydrogen chloride Inorganic materials 0.000 description 8
- 239000003921 oil Substances 0.000 description 8
- 235000019198 oils Nutrition 0.000 description 8
- 229910000029 sodium carbonate Inorganic materials 0.000 description 8
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 7
- 239000007995 HEPES buffer Substances 0.000 description 7
- 229920002472 Starch Polymers 0.000 description 7
- DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 description 7
- WGLUMOCWFMKWIL-UHFFFAOYSA-N dichloromethane;methanol Chemical compound OC.ClCCl WGLUMOCWFMKWIL-UHFFFAOYSA-N 0.000 description 7
- 239000012046 mixed solvent Substances 0.000 description 7
- 208000002154 non-small cell lung carcinoma Diseases 0.000 description 7
- 230000026731 phosphorylation Effects 0.000 description 7
- 238000006366 phosphorylation reaction Methods 0.000 description 7
- 229910000027 potassium carbonate Inorganic materials 0.000 description 7
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 7
- 239000008107 starch Substances 0.000 description 7
- 235000019698 starch Nutrition 0.000 description 7
- 239000000725 suspension Substances 0.000 description 7
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 description 7
- IEQAICDLOKRSRL-UHFFFAOYSA-N 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-dodecoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol Chemical compound CCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO IEQAICDLOKRSRL-UHFFFAOYSA-N 0.000 description 6
- 230000003321 amplification Effects 0.000 description 6
- 238000004458 analytical method Methods 0.000 description 6
- 125000004429 atom Chemical group 0.000 description 6
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 6
- 150000001642 boronic acid derivatives Chemical class 0.000 description 6
- GKIRPKYJQBWNGO-OCEACIFDSA-N clomifene Chemical compound C1=CC(OCCN(CC)CC)=CC=C1C(\C=1C=CC=CC=1)=C(\Cl)C1=CC=CC=C1 GKIRPKYJQBWNGO-OCEACIFDSA-N 0.000 description 6
- 238000006911 enzymatic reaction Methods 0.000 description 6
- 230000001965 increasing effect Effects 0.000 description 6
- INQOMBQAUSQDDS-UHFFFAOYSA-N iodomethane Chemical compound IC INQOMBQAUSQDDS-UHFFFAOYSA-N 0.000 description 6
- 238000003199 nucleic acid amplification method Methods 0.000 description 6
- KJIFKLIQANRMOU-UHFFFAOYSA-N oxidanium;4-methylbenzenesulfonate Chemical compound O.CC1=CC=C(S(O)(=O)=O)C=C1 KJIFKLIQANRMOU-UHFFFAOYSA-N 0.000 description 6
- SCVFZCLFOSHCOH-UHFFFAOYSA-M potassium acetate Chemical compound [K+].CC([O-])=O SCVFZCLFOSHCOH-UHFFFAOYSA-M 0.000 description 6
- 239000000843 powder Substances 0.000 description 6
- 239000012279 sodium borohydride Substances 0.000 description 6
- 229910000033 sodium borohydride Inorganic materials 0.000 description 6
- FVAUCKIRQBBSSJ-UHFFFAOYSA-M sodium iodide Chemical compound [Na+].[I-] FVAUCKIRQBBSSJ-UHFFFAOYSA-M 0.000 description 6
- 239000000758 substrate Substances 0.000 description 6
- 230000004083 survival effect Effects 0.000 description 6
- 239000003826 tablet Substances 0.000 description 6
- YMRKXEHMYMXSCW-UHFFFAOYSA-N tert-butyl N-[3-methyl-5-oxo-1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]pyrrolidin-3-yl]carbamate Chemical compound CC(C)(C)OC(=O)NC1(C)CN(C(=O)C1)c1ccc(cc1)B1OC(C)(C)C(C)(C)O1 YMRKXEHMYMXSCW-UHFFFAOYSA-N 0.000 description 6
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 6
- RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical compound C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 description 6
- MEKOFIRRDATTAG-UHFFFAOYSA-N 2,2,5,8-tetramethyl-3,4-dihydrochromen-6-ol Chemical compound C1CC(C)(C)OC2=C1C(C)=C(O)C=C2C MEKOFIRRDATTAG-UHFFFAOYSA-N 0.000 description 5
- WDFQBORIUYODSI-UHFFFAOYSA-N 4-bromoaniline Chemical compound NC1=CC=C(Br)C=C1 WDFQBORIUYODSI-UHFFFAOYSA-N 0.000 description 5
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 5
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 description 5
- 108010025020 Nerve Growth Factor Proteins 0.000 description 5
- 229940100198 alkylating agent Drugs 0.000 description 5
- 239000002168 alkylating agent Substances 0.000 description 5
- 235000019270 ammonium chloride Nutrition 0.000 description 5
- 238000003556 assay Methods 0.000 description 5
- ZADPBFCGQRWHPN-UHFFFAOYSA-N boronic acid Chemical compound OBO ZADPBFCGQRWHPN-UHFFFAOYSA-N 0.000 description 5
- FJDQFPXHSGXQBY-UHFFFAOYSA-L caesium carbonate Chemical compound [Cs+].[Cs+].[O-]C([O-])=O FJDQFPXHSGXQBY-UHFFFAOYSA-L 0.000 description 5
- 229910000024 caesium carbonate Inorganic materials 0.000 description 5
- 229910052801 chlorine Inorganic materials 0.000 description 5
- 125000001309 chloro group Chemical group Cl* 0.000 description 5
- 238000005859 coupling reaction Methods 0.000 description 5
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 5
- 230000001419 dependent effect Effects 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 239000012299 nitrogen atmosphere Substances 0.000 description 5
- 125000003226 pyrazolyl group Chemical group 0.000 description 5
- 125000005412 pyrazyl group Chemical group 0.000 description 5
- 125000004076 pyridyl group Chemical group 0.000 description 5
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 description 4
- QDHRSLFSDGCJFX-UHFFFAOYSA-N 3-fluorobenzyl alcohol Chemical compound OCC1=CC=CC(F)=C1 QDHRSLFSDGCJFX-UHFFFAOYSA-N 0.000 description 4
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 4
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 4
- 108010007457 Extracellular Signal-Regulated MAP Kinases Proteins 0.000 description 4
- 108010010803 Gelatin Proteins 0.000 description 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- 101001082627 Homo sapiens HLA class II histocompatibility antigen gamma chain Proteins 0.000 description 4
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 4
- BAVYZALUXZFZLV-UHFFFAOYSA-N Methylamine Chemical compound NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 description 4
- 229920001213 Polysorbate 20 Polymers 0.000 description 4
- 108010017324 STAT3 Transcription Factor Proteins 0.000 description 4
- 102100024040 Signal transducer and activator of transcription 3 Human genes 0.000 description 4
- 102100033019 Tyrosine-protein phosphatase non-receptor type 11 Human genes 0.000 description 4
- 101710116241 Tyrosine-protein phosphatase non-receptor type 11 Proteins 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 4
- 239000001361 adipic acid Substances 0.000 description 4
- 235000011037 adipic acid Nutrition 0.000 description 4
- IPWKHHSGDUIRAH-UHFFFAOYSA-N bis(pinacolato)diboron Chemical compound O1C(C)(C)C(C)(C)OB1B1OC(C)(C)C(C)(C)O1 IPWKHHSGDUIRAH-UHFFFAOYSA-N 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- MKRTXPORKIRPDG-UHFFFAOYSA-N diphenylphosphoryl azide Chemical compound C=1C=CC=CC=1P(=O)(N=[N+]=[N-])C1=CC=CC=C1 MKRTXPORKIRPDG-UHFFFAOYSA-N 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 239000000839 emulsion Substances 0.000 description 4
- 238000011156 evaluation Methods 0.000 description 4
- 125000000524 functional group Chemical group 0.000 description 4
- 239000008273 gelatin Substances 0.000 description 4
- 229920000159 gelatin Polymers 0.000 description 4
- 235000019322 gelatine Nutrition 0.000 description 4
- 235000011852 gelatine desserts Nutrition 0.000 description 4
- 239000008103 glucose Substances 0.000 description 4
- DCLWNTIANRACSB-UHFFFAOYSA-N imidazo[1,2-b]pyridazin-6-amine Chemical compound N1=C(N)C=CC2=NC=CN21 DCLWNTIANRACSB-UHFFFAOYSA-N 0.000 description 4
- 239000008101 lactose Substances 0.000 description 4
- 239000003446 ligand Substances 0.000 description 4
- 230000002503 metabolic effect Effects 0.000 description 4
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 description 4
- 239000000546 pharmaceutical excipient Substances 0.000 description 4
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 4
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 4
- NROKBHXJSPEDAR-UHFFFAOYSA-M potassium fluoride Chemical compound [F-].[K+] NROKBHXJSPEDAR-UHFFFAOYSA-M 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 238000000746 purification Methods 0.000 description 4
- 102000005962 receptors Human genes 0.000 description 4
- 108020003175 receptors Proteins 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- 239000012089 stop solution Substances 0.000 description 4
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 4
- 229910000404 tripotassium phosphate Inorganic materials 0.000 description 4
- 235000019798 tripotassium phosphate Nutrition 0.000 description 4
- LMDZBCPBFSXMTL-UHFFFAOYSA-N 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide Substances CCN=C=NCCCN(C)C LMDZBCPBFSXMTL-UHFFFAOYSA-N 0.000 description 3
- ASOKPJOREAFHNY-UHFFFAOYSA-N 1-Hydroxybenzotriazole Chemical compound C1=CC=C2N(O)N=NC2=C1 ASOKPJOREAFHNY-UHFFFAOYSA-N 0.000 description 3
- WNWHHMBRJJOGFJ-UHFFFAOYSA-N 16-methylheptadecan-1-ol Chemical class CC(C)CCCCCCCCCCCCCCCO WNWHHMBRJJOGFJ-UHFFFAOYSA-N 0.000 description 3
- FPQQSJJWHUJYPU-UHFFFAOYSA-N 3-(dimethylamino)propyliminomethylidene-ethylazanium;chloride Chemical compound Cl.CCN=C=NCCCN(C)C FPQQSJJWHUJYPU-UHFFFAOYSA-N 0.000 description 3
- IHNUIZIYKJTMNB-UHFFFAOYSA-N 5-(1-hydroxyethyl)-2-methylpyrazole-3-carbonitrile Chemical compound CC(O)C=1C=C(C#N)N(C)N=1 IHNUIZIYKJTMNB-UHFFFAOYSA-N 0.000 description 3
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 3
- 239000005995 Aluminium silicate Substances 0.000 description 3
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- FDOURIWQJDBXAF-UHFFFAOYSA-N ClC1=CC(=NN1C)C(C)O Chemical compound ClC1=CC(=NN1C)C(C)O FDOURIWQJDBXAF-UHFFFAOYSA-N 0.000 description 3
- 102000007665 Extracellular Signal-Regulated MAP Kinases Human genes 0.000 description 3
- VSHXUPVCLGZGOU-UHFFFAOYSA-N FC1=NC=C(C=C1C(C)O)F Chemical compound FC1=NC=C(C=C1C(C)O)F VSHXUPVCLGZGOU-UHFFFAOYSA-N 0.000 description 3
- 102100030595 HLA class II histocompatibility antigen gamma chain Human genes 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- SJRJJKPEHAURKC-UHFFFAOYSA-N N-Methylmorpholine Chemical compound CN1CCOCC1 SJRJJKPEHAURKC-UHFFFAOYSA-N 0.000 description 3
- UFPQAKXKPBXADS-UHFFFAOYSA-N NC1(CC(N(C1)C1=CC=C(C=C1)C1=CN=C2N1N=C(C=C2)N(C)CC1=CC(=CC=C1)F)=O)C Chemical compound NC1(CC(N(C1)C1=CC=C(C=C1)C1=CN=C2N1N=C(C=C2)N(C)CC1=CC(=CC=C1)F)=O)C UFPQAKXKPBXADS-UHFFFAOYSA-N 0.000 description 3
- XQOMKCDERFDPHL-UHFFFAOYSA-N NC1(CC(N(C1)C1=CC=C(C=C1)C1=CN=C2N1N=C(C=C2)N(C)CC=1C=NC=C(C=1)F)=O)C Chemical compound NC1(CC(N(C1)C1=CC=C(C=C1)C1=CN=C2N1N=C(C=C2)N(C)CC=1C=NC=C(C=1)F)=O)C XQOMKCDERFDPHL-UHFFFAOYSA-N 0.000 description 3
- 102000007072 Nerve Growth Factors Human genes 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- OKJPEAGHQZHRQV-UHFFFAOYSA-N Triiodomethane Natural products IC(I)I OKJPEAGHQZHRQV-UHFFFAOYSA-N 0.000 description 3
- 230000004913 activation Effects 0.000 description 3
- 230000002411 adverse Effects 0.000 description 3
- 235000012211 aluminium silicate Nutrition 0.000 description 3
- 239000003098 androgen Substances 0.000 description 3
- 239000005557 antagonist Substances 0.000 description 3
- 239000003242 anti bacterial agent Substances 0.000 description 3
- 229940088710 antibiotic agent Drugs 0.000 description 3
- 238000013459 approach Methods 0.000 description 3
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 3
- JFDZBHWFFUWGJE-UHFFFAOYSA-N benzonitrile Chemical compound N#CC1=CC=CC=C1 JFDZBHWFFUWGJE-UHFFFAOYSA-N 0.000 description 3
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 3
- 239000011230 binding agent Substances 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000003054 catalyst Substances 0.000 description 3
- 239000007795 chemical reaction product Substances 0.000 description 3
- 210000000349 chromosome Anatomy 0.000 description 3
- 239000011248 coating agent Substances 0.000 description 3
- 229940110456 cocoa butter Drugs 0.000 description 3
- 235000019868 cocoa butter Nutrition 0.000 description 3
- 238000004440 column chromatography Methods 0.000 description 3
- 125000001028 difluoromethyl group Chemical group [H]C(F)(F)* 0.000 description 3
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 description 3
- 239000007884 disintegrant Substances 0.000 description 3
- 230000012010 growth Effects 0.000 description 3
- 230000009422 growth inhibiting effect Effects 0.000 description 3
- 150000004677 hydrates Chemical class 0.000 description 3
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 description 3
- 239000000367 immunologic factor Substances 0.000 description 3
- 150000007529 inorganic bases Chemical class 0.000 description 3
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 3
- NXPHGHWWQRMDIA-UHFFFAOYSA-M magnesium;carbanide;bromide Chemical compound [CH3-].[Mg+2].[Br-] NXPHGHWWQRMDIA-UHFFFAOYSA-M 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 235000011056 potassium acetate Nutrition 0.000 description 3
- 230000035484 reaction time Effects 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 230000019491 signal transduction Effects 0.000 description 3
- 239000012453 solvate Substances 0.000 description 3
- ROEMZCLHRRRKGF-YUMQZZPRSA-N tert-butyl (2s,4s)-4-fluoro-2-(hydroxymethyl)pyrrolidine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1C[C@@H](F)C[C@H]1CO ROEMZCLHRRRKGF-YUMQZZPRSA-N 0.000 description 3
- BZUBYWOANCHCFS-UHFFFAOYSA-N tert-butyl N-(3-methyl-5-oxopyrrolidin-3-yl)carbamate Chemical compound CC(C)(C)OC(=O)NC1(C)CNC(=O)C1 BZUBYWOANCHCFS-UHFFFAOYSA-N 0.000 description 3
- 125000001981 tert-butyldimethylsilyl group Chemical group [H]C([H])([H])[Si]([H])(C([H])([H])[H])[*]C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 3
- 125000000335 thiazolyl group Chemical group 0.000 description 3
- 238000004809 thin layer chromatography Methods 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 230000004614 tumor growth Effects 0.000 description 3
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 description 3
- LSPHULWDVZXLIL-UHFFFAOYSA-N (+/-)-Camphoric acid Chemical compound CC1(C)C(C(O)=O)CCC1(C)C(O)=O LSPHULWDVZXLIL-UHFFFAOYSA-N 0.000 description 2
- CYPYTURSJDMMMP-WVCUSYJESA-N (1e,4e)-1,5-diphenylpenta-1,4-dien-3-one;palladium Chemical compound [Pd].[Pd].C=1C=CC=CC=1\C=C\C(=O)\C=C\C1=CC=CC=C1.C=1C=CC=CC=1\C=C\C(=O)\C=C\C1=CC=CC=C1.C=1C=CC=CC=1\C=C\C(=O)\C=C\C1=CC=CC=C1 CYPYTURSJDMMMP-WVCUSYJESA-N 0.000 description 2
- MXFZBCMCPBVPLV-SSEXGKCCSA-N (2R)-3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]-2-(tritylamino)propan-1-ol Chemical compound CC1(OB(OC1(C)C)C1=CC=C(OC[C@@H](CO)NC(C2=CC=CC=C2)(C2=CC=CC=C2)C2=CC=CC=C2)C=C1)C MXFZBCMCPBVPLV-SSEXGKCCSA-N 0.000 description 2
- KZPYGQFFRCFCPP-UHFFFAOYSA-N 1,1'-bis(diphenylphosphino)ferrocene Chemical compound [Fe+2].C1=CC=C[C-]1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=C[C-]1P(C=1C=CC=CC=1)C1=CC=CC=C1 KZPYGQFFRCFCPP-UHFFFAOYSA-N 0.000 description 2
- KAONHJHECZKGCC-UHFFFAOYSA-N 1-[5-fluoro-2-(triazol-2-yl)phenyl]ethanol Chemical compound CC(O)C1=CC(F)=CC=C1N1N=CC=N1 KAONHJHECZKGCC-UHFFFAOYSA-N 0.000 description 2
- JAHNSTQSQJOJLO-UHFFFAOYSA-N 2-(3-fluorophenyl)-1h-imidazole Chemical compound FC1=CC=CC(C=2NC=CN=2)=C1 JAHNSTQSQJOJLO-UHFFFAOYSA-N 0.000 description 2
- OZMLUMPWPFZWTP-UHFFFAOYSA-N 2-(tributyl-$l^{5}-phosphanylidene)acetonitrile Chemical compound CCCCP(CCCC)(CCCC)=CC#N OZMLUMPWPFZWTP-UHFFFAOYSA-N 0.000 description 2
- 125000004777 2-fluoroethyl group Chemical group [H]C([H])(F)C([H])([H])* 0.000 description 2
- QSECPQCFCWVBKM-UHFFFAOYSA-N 2-iodoethanol Chemical compound OCCI QSECPQCFCWVBKM-UHFFFAOYSA-N 0.000 description 2
- YOETUEMZNOLGDB-UHFFFAOYSA-N 2-methylpropyl carbonochloridate Chemical compound CC(C)COC(Cl)=O YOETUEMZNOLGDB-UHFFFAOYSA-N 0.000 description 2
- PFHPKMPWBFJZEY-UHFFFAOYSA-N 3-bromo-6-chloroimidazo[1,2-b]pyridazine Chemical compound N1=C(Cl)C=CC2=NC=C(Br)N21 PFHPKMPWBFJZEY-UHFFFAOYSA-N 0.000 description 2
- AOJJSUZBOXZQNB-VTZDEGQISA-N 4'-epidoxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-VTZDEGQISA-N 0.000 description 2
- BICZJRAGTCRORZ-UHFFFAOYSA-N 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol Chemical compound O1C(C)(C)C(C)(C)OB1C1=CC=C(O)C=C1 BICZJRAGTCRORZ-UHFFFAOYSA-N 0.000 description 2
- WOVKYSAHUYNSMH-RRKCRQDMSA-N 5-bromodeoxyuridine Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(Br)=C1 WOVKYSAHUYNSMH-RRKCRQDMSA-N 0.000 description 2
- KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 2
- MWTLVHAEIKPJRB-NRFANRHFSA-N C(C1=CC=CC=C1)NC=1C=CC=2N(N1)C(=CN2)C2=CC(=CC=C2)OC[C@H]2N(CCC2)C Chemical compound C(C1=CC=CC=C1)NC=1C=CC=2N(N1)C(=CN2)C2=CC(=CC=C2)OC[C@H]2N(CCC2)C MWTLVHAEIKPJRB-NRFANRHFSA-N 0.000 description 2
- OZJQUBCBLXNWKH-NRFANRHFSA-N C(C1=CC=CC=C1)NC=1C=CC=2N(N1)C(=CN2)C2=CC=C(C=C2)OCC[C@H]2NCCC2 Chemical compound C(C1=CC=CC=C1)NC=1C=CC=2N(N1)C(=CN2)C2=CC=C(C=C2)OCC[C@H]2NCCC2 OZJQUBCBLXNWKH-NRFANRHFSA-N 0.000 description 2
- FSXHLZSGRLXUKO-FQEVSTJZSA-N C(C1=CC=CC=C1)NC=1C=CC=2N(N1)C(=CN2)C2=CC=C(C=C2)OC[C@H]2NCCC2 Chemical compound C(C1=CC=CC=C1)NC=1C=CC=2N(N1)C(=CN2)C2=CC=C(C=C2)OC[C@H]2NCCC2 FSXHLZSGRLXUKO-FQEVSTJZSA-N 0.000 description 2
- AEKFYPGTZCHYJD-QFIPXVFZSA-N C(C1=CC=CC=C1)NC=1C=CC=2N(N1)C(=CN2)C=2C=C(OC[C@H]1N(CCC1)CCO)C=CC2 Chemical compound C(C1=CC=CC=C1)NC=1C=CC=2N(N1)C(=CN2)C=2C=C(OC[C@H]1N(CCC1)CCO)C=CC2 AEKFYPGTZCHYJD-QFIPXVFZSA-N 0.000 description 2
- FIHHWVQAQINZCU-KRWDZBQOSA-N CC(C)(C)OC(=O)N1CCC[C@H]1COc1ccc(cc1)B1OC(C)(C)C(C)(C)O1 Chemical compound CC(C)(C)OC(=O)N1CCC[C@H]1COc1ccc(cc1)B1OC(C)(C)C(C)(C)O1 FIHHWVQAQINZCU-KRWDZBQOSA-N 0.000 description 2
- YBHNUCGAXUGTRH-LBPRGKRZSA-N CC(C)(C)OC(=O)N[C@@H]1CN(C(=O)C1)c1ccc(Br)cc1C#N Chemical compound CC(C)(C)OC(=O)N[C@@H]1CN(C(=O)C1)c1ccc(Br)cc1C#N YBHNUCGAXUGTRH-LBPRGKRZSA-N 0.000 description 2
- KTYOHTCDAJZHGD-GOSISDBHSA-N CN(CCCOC1=CC=C(C=C1)C1=CN=C2N1N=C(C=C2)N[C@H](C)C2=CC(=CC=C2)F)C Chemical compound CN(CCCOC1=CC=C(C=C1)C1=CN=C2N1N=C(C=C2)N[C@H](C)C2=CC(=CC=C2)F)C KTYOHTCDAJZHGD-GOSISDBHSA-N 0.000 description 2
- XYJZINXCWSAFEJ-QGZVFWFLSA-N CN(CCOC1=CC=C(C=C1)C1=CN=C2N1N=C(C=C2)N[C@H](C)C2=CC(=CC=C2)F)C Chemical compound CN(CCOC1=CC=C(C=C1)C1=CN=C2N1N=C(C=C2)N[C@H](C)C2=CC(=CC=C2)F)C XYJZINXCWSAFEJ-QGZVFWFLSA-N 0.000 description 2
- MNMKXTFJUKSNCX-MRXNPFEDSA-N CN(CCOC1=CC=C(C=N1)C1=CN=C2N1N=C(C=C2)N[C@H](C)C2=CC(=CC=C2)F)C Chemical compound CN(CCOC1=CC=C(C=N1)C1=CN=C2N1N=C(C=C2)N[C@H](C)C2=CC(=CC=C2)F)C MNMKXTFJUKSNCX-MRXNPFEDSA-N 0.000 description 2
- ARNJQSVLOGGAQS-SFHVURJKSA-N CN(Cc1cccnc1)c1ccc2ncc(-c3ccc(cc3)N3C[C@@H](N)CC3=O)n2n1 Chemical compound CN(Cc1cccnc1)c1ccc2ncc(-c3ccc(cc3)N3C[C@@H](N)CC3=O)n2n1 ARNJQSVLOGGAQS-SFHVURJKSA-N 0.000 description 2
- YGXYAZFEULFPHL-YTJLLHSVSA-N COc1ccc(cc1)[C@H](C)N1CC(C)(CC1=O)C(=O)OC(C)(C)C Chemical compound COc1ccc(cc1)[C@H](C)N1CC(C)(CC1=O)C(=O)OC(C)(C)C YGXYAZFEULFPHL-YTJLLHSVSA-N 0.000 description 2
- IUFUBRZVLYHNAF-MYHCZTBNSA-N COc1ccc(cc1)[C@H](C)N1CC(C)(CC1=O)C(O)=O Chemical compound COc1ccc(cc1)[C@H](C)N1CC(C)(CC1=O)C(O)=O IUFUBRZVLYHNAF-MYHCZTBNSA-N 0.000 description 2
- IEVXQZXOTOZOTL-XORNHQRDSA-N C[C@@H](Nc1ccc2ncc(-c3ccc(O[C@@H]4CCC[C@@H]4N)cc3)n2n1)c1cccc(F)c1 Chemical compound C[C@@H](Nc1ccc2ncc(-c3ccc(O[C@@H]4CCC[C@@H]4N)cc3)n2n1)c1cccc(F)c1 IEVXQZXOTOZOTL-XORNHQRDSA-N 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- OKTJSMMVPCPJKN-NJFSPNSNSA-N Carbon-14 Chemical compound [14C] OKTJSMMVPCPJKN-NJFSPNSNSA-N 0.000 description 2
- IAZDPXIOMUYVGZ-WFGJKAKNSA-N Dimethyl sulfoxide Chemical compound [2H]C([2H])([2H])S(=O)C([2H])([2H])[2H] IAZDPXIOMUYVGZ-WFGJKAKNSA-N 0.000 description 2
- ROSDSFDQCJNGOL-UHFFFAOYSA-N Dimethylamine Chemical compound CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 description 2
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 description 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
- SWLOJGMBZVQDNN-UHFFFAOYSA-N FC(N1N=NC(=C1)C(C)O)F Chemical compound FC(N1N=NC(=C1)C(C)O)F SWLOJGMBZVQDNN-UHFFFAOYSA-N 0.000 description 2
- OBYVZCKNTMUKHN-OAQYLSRUSA-N FC=1C=C(C=CC1)CN(C=1C=CC=2N(N1)C(=CN2)C2=CC=C(C=C2)O[C@H]2CNCC2)C Chemical compound FC=1C=C(C=CC1)CN(C=1C=CC=2N(N1)C(=CN2)C2=CC=C(C=C2)O[C@H]2CNCC2)C OBYVZCKNTMUKHN-OAQYLSRUSA-N 0.000 description 2
- OMAZPUFUUNZUEG-HXUWFJFHSA-N FC=1C=C(C=CC1)COC=1C=CC=2N(N1)C(=CN2)C2=CC=C(C=C2)OC[C@@H]2NCCC2 Chemical compound FC=1C=C(C=CC1)COC=1C=CC=2N(N1)C(=CN2)C2=CC=C(C=C2)OC[C@@H]2NCCC2 OMAZPUFUUNZUEG-HXUWFJFHSA-N 0.000 description 2
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 2
- 208000034951 Genetic Translocation Diseases 0.000 description 2
- 229920001543 Laminarin Polymers 0.000 description 2
- 239000012359 Methanesulfonyl chloride Substances 0.000 description 2
- NWIBSHFKIJFRCO-WUDYKRTCSA-N Mytomycin Chemical compound C1N2C(C(C(C)=C(N)C3=O)=O)=C3[C@@H](COC(N)=O)[C@@]2(OC)[C@@H]2[C@H]1N2 NWIBSHFKIJFRCO-WUDYKRTCSA-N 0.000 description 2
- SFYZGPXAENSQOA-XLLULAGJSA-N NC1(CC(N(C1)[C@@H](C)C1=CC=C(C=C1)OC)=O)C Chemical compound NC1(CC(N(C1)[C@@H](C)C1=CC=C(C=C1)OC)=O)C SFYZGPXAENSQOA-XLLULAGJSA-N 0.000 description 2
- XVQKNGSMWZSJGF-UHFFFAOYSA-N NC1CC(N(C1)C1=CC=C(C=C1)C1=CN=C2N1N=C(C=C2)N(C)CC2=CC(=CC=C2)Cl)=O Chemical compound NC1CC(N(C1)C1=CC=C(C=C1)C1=CN=C2N1N=C(C=C2)N(C)CC2=CC(=CC=C2)Cl)=O XVQKNGSMWZSJGF-UHFFFAOYSA-N 0.000 description 2
- SLKDTGQQCOPQOS-UHFFFAOYSA-N NC1CC(N(C1)C1=CC=C(C=C1)C1=CN=C2N1N=C(C=C2)NCC2=CC=CC=C2)=O Chemical compound NC1CC(N(C1)C1=CC=C(C=C1)C1=CN=C2N1N=C(C=C2)NCC2=CC=CC=C2)=O SLKDTGQQCOPQOS-UHFFFAOYSA-N 0.000 description 2
- SZLJNFFTYNOYEP-UHFFFAOYSA-N NC1CC(N(C1)C1=CC=C(C=C1)C1=CN=C2N1N=C(C=C2)OCC2=CC(=CC=C2)F)=O Chemical compound NC1CC(N(C1)C1=CC=C(C=C1)C1=CN=C2N1N=C(C=C2)OCC2=CC(=CC=C2)F)=O SZLJNFFTYNOYEP-UHFFFAOYSA-N 0.000 description 2
- 238000005481 NMR spectroscopy Methods 0.000 description 2
- LYNANKCCXCMGHV-IBGZPJMESA-N N[C@H]1CC(N(C1)C1=CC=C(C=C1)C1=CN=C2N1N=C(C=C2)N(C)CC2=CC=CC=C2)=O Chemical compound N[C@H]1CC(N(C1)C1=CC=C(C=C1)C1=CN=C2N1N=C(C=C2)N(C)CC2=CC=CC=C2)=O LYNANKCCXCMGHV-IBGZPJMESA-N 0.000 description 2
- LRMLXELRZXDWFB-APWZRJJASA-N N[C@H]1CC(N(C1)C1=CC=C(C=C1)C1=CN=C2N1N=C(C=C2)N[C@H](C)C2=CC=CC=C2)=O Chemical compound N[C@H]1CC(N(C1)C1=CC=C(C=C1)C1=CN=C2N1N=C(C=C2)N[C@H](C)C2=CC=CC=C2)=O LRMLXELRZXDWFB-APWZRJJASA-N 0.000 description 2
- QSKCPBUYMPEAEL-IBGZPJMESA-N N[C@H]1CC(N(C1)C1=CC=C(C=C1)C1=CN=C2N1N=C(C=C2)OCC=2C=C(C#N)C=CC2)=O Chemical compound N[C@H]1CC(N(C1)C1=CC=C(C=C1)C1=CN=C2N1N=C(C=C2)OCC=2C=C(C#N)C=CC2)=O QSKCPBUYMPEAEL-IBGZPJMESA-N 0.000 description 2
- 102000015336 Nerve Growth Factor Human genes 0.000 description 2
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical group [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
- 108091006576 SLC34A2 Proteins 0.000 description 2
- 101150046784 Slc34a2 gene Proteins 0.000 description 2
- PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 description 2
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 2
- 102100038437 Sodium-dependent phosphate transport protein 2B Human genes 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- NKANXQFJJICGDU-QPLCGJKRSA-N Tamoxifen Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=CC=C1 NKANXQFJJICGDU-QPLCGJKRSA-N 0.000 description 2
- YZCKVEUIGOORGS-NJFSPNSNSA-N Tritium Chemical compound [3H] YZCKVEUIGOORGS-NJFSPNSNSA-N 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- RJURFGZVJUQBHK-UHFFFAOYSA-N actinomycin D Natural products CC1OC(=O)C(C(C)C)N(C)C(=O)CN(C)C(=O)C2CCCN2C(=O)C(C(C)C)NC(=O)C1NC(=O)C1=C(N)C(=O)C(C)=C2OC(C(C)=CC=C3C(=O)NC4C(=O)NC(C(N5CCCC5C(=O)N(C)CC(=O)N(C)C(C(C)C)C(=O)OC4C)=O)C(C)C)=C3N=C21 RJURFGZVJUQBHK-UHFFFAOYSA-N 0.000 description 2
- 238000007792 addition Methods 0.000 description 2
- 239000008272 agar Substances 0.000 description 2
- 235000010419 agar Nutrition 0.000 description 2
- 150000001298 alcohols Chemical class 0.000 description 2
- 229910052786 argon Inorganic materials 0.000 description 2
- 239000012300 argon atmosphere Substances 0.000 description 2
- 229940077388 benzenesulfonate Drugs 0.000 description 2
- SRSXLGNVWSONIS-UHFFFAOYSA-M benzenesulfonate Chemical compound [O-]S(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-M 0.000 description 2
- SRSXLGNVWSONIS-UHFFFAOYSA-N benzenesulfonic acid Chemical compound OS(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-N 0.000 description 2
- 229940092714 benzenesulfonic acid Drugs 0.000 description 2
- 238000001574 biopsy Methods 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- YNHIGQDRGKUECZ-UHFFFAOYSA-L bis(triphenylphosphine)palladium(ii) dichloride Chemical compound [Cl-].[Cl-].[Pd+2].C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 YNHIGQDRGKUECZ-UHFFFAOYSA-L 0.000 description 2
- XJHCXCQVJFPJIK-UHFFFAOYSA-M caesium fluoride Chemical compound [F-].[Cs+] XJHCXCQVJFPJIK-UHFFFAOYSA-M 0.000 description 2
- 229910000019 calcium carbonate Inorganic materials 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 239000000470 constituent Substances 0.000 description 2
- GBRBMTNGQBKBQE-UHFFFAOYSA-L copper;diiodide Chemical compound I[Cu]I GBRBMTNGQBKBQE-UHFFFAOYSA-L 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- 238000010828 elution Methods 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- SRCZQMGIVIYBBJ-UHFFFAOYSA-N ethoxyethane;ethyl acetate Chemical compound CCOCC.CCOC(C)=O SRCZQMGIVIYBBJ-UHFFFAOYSA-N 0.000 description 2
- UREBWPXBXRYXRJ-UHFFFAOYSA-N ethyl acetate;methanol Chemical compound OC.CCOC(C)=O UREBWPXBXRYXRJ-UHFFFAOYSA-N 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- 101150016193 fig gene Proteins 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 125000004216 fluoromethyl group Chemical group [H]C([H])(F)* 0.000 description 2
- 239000008098 formaldehyde solution Substances 0.000 description 2
- 108020001507 fusion proteins Proteins 0.000 description 2
- 102000037865 fusion proteins Human genes 0.000 description 2
- 208000005017 glioblastoma Diseases 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 2
- 239000005457 ice water Substances 0.000 description 2
- 150000005233 imidazopyridazines Chemical group 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 239000000543 intermediate Substances 0.000 description 2
- ZCYVEMRRCGMTRW-YPZZEJLDSA-N iodine-125 Chemical compound [125I] ZCYVEMRRCGMTRW-YPZZEJLDSA-N 0.000 description 2
- 229940044173 iodine-125 Drugs 0.000 description 2
- 125000004491 isohexyl group Chemical group C(CCC(C)C)* 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- DBTMGCOVALSLOR-VPNXCSTESA-N laminarin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)OC1O[C@@H]1[C@@H](O)C(O[C@H]2[C@@H]([C@@H](CO)OC(O)[C@@H]2O)O)O[C@H](CO)[C@H]1O DBTMGCOVALSLOR-VPNXCSTESA-N 0.000 description 2
- KWGKDLIKAYFUFQ-UHFFFAOYSA-M lithium chloride Chemical compound [Li+].[Cl-] KWGKDLIKAYFUFQ-UHFFFAOYSA-M 0.000 description 2
- ZCSHNCUQKCANBX-UHFFFAOYSA-N lithium diisopropylamide Chemical compound [Li+].CC(C)[N-]C(C)C ZCSHNCUQKCANBX-UHFFFAOYSA-N 0.000 description 2
- 239000000314 lubricant Substances 0.000 description 2
- 238000004020 luminiscence type Methods 0.000 description 2
- 239000002609 medium Substances 0.000 description 2
- GLVAUDGFNGKCSF-UHFFFAOYSA-N mercaptopurine Chemical compound S=C1NC=NC2=C1NC=N2 GLVAUDGFNGKCSF-UHFFFAOYSA-N 0.000 description 2
- 108020004999 messenger RNA Proteins 0.000 description 2
- 229940098779 methanesulfonic acid Drugs 0.000 description 2
- QARBMVPHQWIHKH-UHFFFAOYSA-N methanesulfonyl chloride Chemical compound CS(Cl)(=O)=O QARBMVPHQWIHKH-UHFFFAOYSA-N 0.000 description 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 2
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 description 2
- LVHBHZANLOWSRM-UHFFFAOYSA-N methylenebutanedioic acid Natural products OC(=O)CC(=C)C(O)=O LVHBHZANLOWSRM-UHFFFAOYSA-N 0.000 description 2
- 230000035772 mutation Effects 0.000 description 2
- 229940053128 nerve growth factor Drugs 0.000 description 2
- 210000000653 nervous system Anatomy 0.000 description 2
- 230000000508 neurotrophic effect Effects 0.000 description 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 150000007530 organic bases Chemical class 0.000 description 2
- 230000002018 overexpression Effects 0.000 description 2
- NFHFRUOZVGFOOS-UHFFFAOYSA-N palladium;triphenylphosphane Chemical compound [Pd].C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 NFHFRUOZVGFOOS-UHFFFAOYSA-N 0.000 description 2
- 239000006187 pill Substances 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 239000011698 potassium fluoride Substances 0.000 description 2
- 235000003270 potassium fluoride Nutrition 0.000 description 2
- FYRHIOVKTDQVFC-UHFFFAOYSA-M potassium phthalimide Chemical compound [K+].C1=CC=C2C(=O)[N-]C(=O)C2=C1 FYRHIOVKTDQVFC-UHFFFAOYSA-M 0.000 description 2
- 210000002307 prostate Anatomy 0.000 description 2
- 230000029983 protein stabilization Effects 0.000 description 2
- 230000017854 proteolysis Effects 0.000 description 2
- QJZUKDFHGGYHMC-UHFFFAOYSA-N pyridine-3-carbaldehyde Chemical compound O=CC1=CC=CN=C1 QJZUKDFHGGYHMC-UHFFFAOYSA-N 0.000 description 2
- 150000003222 pyridines Chemical class 0.000 description 2
- 238000012552 review Methods 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 2
- 235000012239 silicon dioxide Nutrition 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 235000009518 sodium iodide Nutrition 0.000 description 2
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 2
- 239000012321 sodium triacetoxyborohydride Substances 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- 239000000829 suppository Substances 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- VTSTTXZPYYAMHI-KRWDZBQOSA-N tert-butyl (2S)-2-[[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]sulfanylmethyl]pyrrolidine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCC[C@H]1CSc1ccc(cc1)B1OC(C)(C)C(C)(C)O1 VTSTTXZPYYAMHI-KRWDZBQOSA-N 0.000 description 2
- MXPOLUPSEVGAAS-VIFPVBQESA-N tert-butyl (2s)-2-(2-hydroxyethyl)pyrrolidine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCC[C@H]1CCO MXPOLUPSEVGAAS-VIFPVBQESA-N 0.000 description 2
- BFFLLBPMZCIGRM-QMMMGPOBSA-N tert-butyl (2s)-2-(hydroxymethyl)pyrrolidine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCC[C@H]1CO BFFLLBPMZCIGRM-QMMMGPOBSA-N 0.000 description 2
- QSHLBDDCJBXAMS-UHFFFAOYSA-N tert-butyl 4-[[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]methyl]piperidine-1-carboxylate Chemical compound C1CN(C(=O)OC(C)(C)C)CCC1COC1=CC=C(B2OC(C)(C)C(C)(C)O2)C=C1 QSHLBDDCJBXAMS-UHFFFAOYSA-N 0.000 description 2
- OYNXETRYPQQPQV-HNNXBMFYSA-N tert-butyl N-[(3S)-1-[3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-5-oxopyrrolidin-3-yl]carbamate Chemical compound Cc1cc(ccc1B1OC(C)(C)C(C)(C)O1)N1C[C@H](CC1=O)NC(=O)OC(C)(C)C OYNXETRYPQQPQV-HNNXBMFYSA-N 0.000 description 2
- JCJZKLAPICPVLC-HNNXBMFYSA-N tert-butyl N-[(3S)-5-oxo-1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]pyrrolidin-3-yl]carbamate Chemical compound CC(C)(C)OC(=O)N[C@@H]1CN(C(=O)C1)c1ccc(cc1)B1OC(C)(C)C(C)(C)O1 JCJZKLAPICPVLC-HNNXBMFYSA-N 0.000 description 2
- WUDWIXOFYZGSSL-UHFFFAOYSA-N tert-butyl N-[1-[[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]methyl]cyclopropyl]carbamate Chemical compound CC(C)(C)OC(=O)NC1(COc2ccc(cc2)B2OC(C)(C)C(C)(C)O2)CC1 WUDWIXOFYZGSSL-UHFFFAOYSA-N 0.000 description 2
- PTYOQXKKNOBVIK-UHFFFAOYSA-N tert-butyl N-[2-oxo-1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]pyrrolidin-3-yl]carbamate Chemical compound CC(C)(C)OC(=O)NC1CCN(C1=O)c1ccc(cc1)B1OC(C)(C)C(C)(C)O1 PTYOQXKKNOBVIK-UHFFFAOYSA-N 0.000 description 2
- JCJZKLAPICPVLC-UHFFFAOYSA-N tert-butyl N-[5-oxo-1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]pyrrolidin-3-yl]carbamate Chemical compound CC(C)(C)OC(=O)NC1CN(C(=O)C1)c1ccc(cc1)B1OC(C)(C)C(C)(C)O1 JCJZKLAPICPVLC-UHFFFAOYSA-N 0.000 description 2
- HTHIEFBWGSTHTJ-UHFFFAOYSA-N tert-butyl N-[[5-oxo-1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]pyrrolidin-3-yl]methyl]carbamate Chemical compound CC(C)(C)OC(=O)NCC1CN(C(=O)C1)c1ccc(cc1)B1OC(C)(C)C(C)(C)O1 HTHIEFBWGSTHTJ-UHFFFAOYSA-N 0.000 description 2
- ZMVBSGDCHJGJDD-UHFFFAOYSA-N tert-butyl N-cyclopropyl-N-[2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]ethyl]carbamate Chemical compound CC(C)(C)OC(=O)N(CCOc1ccc(cc1)B1OC(C)(C)C(C)(C)O1)C1CC1 ZMVBSGDCHJGJDD-UHFFFAOYSA-N 0.000 description 2
- QKSQWQOAUQFORH-UHFFFAOYSA-N tert-butyl n-[(2-methylpropan-2-yl)oxycarbonylimino]carbamate Chemical compound CC(C)(C)OC(=O)N=NC(=O)OC(C)(C)C QKSQWQOAUQFORH-UHFFFAOYSA-N 0.000 description 2
- PFHVTCWJHBHEFA-LURJTMIESA-N tert-butyl n-[(3s)-5-oxopyrrolidin-3-yl]carbamate Chemical compound CC(C)(C)OC(=O)N[C@@H]1CNC(=O)C1 PFHVTCWJHBHEFA-LURJTMIESA-N 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- FPGGTKZVZWFYPV-UHFFFAOYSA-M tetrabutylammonium fluoride Chemical compound [F-].CCCC[N+](CCCC)(CCCC)CCCC FPGGTKZVZWFYPV-UHFFFAOYSA-M 0.000 description 2
- 229940126585 therapeutic drug Drugs 0.000 description 2
- WYWHKKSPHMUBEB-UHFFFAOYSA-N tioguanine Chemical compound N1C(N)=NC(=S)C2=C1N=CN2 WYWHKKSPHMUBEB-UHFFFAOYSA-N 0.000 description 2
- 230000005758 transcription activity Effects 0.000 description 2
- 229910052723 transition metal Inorganic materials 0.000 description 2
- 150000003624 transition metals Chemical class 0.000 description 2
- 238000013519 translation Methods 0.000 description 2
- TUQOTMZNTHZOKS-UHFFFAOYSA-N tributylphosphine Chemical compound CCCCP(CCCC)CCCC TUQOTMZNTHZOKS-UHFFFAOYSA-N 0.000 description 2
- QAEDZJGFFMLHHQ-UHFFFAOYSA-N trifluoroacetic anhydride Chemical compound FC(F)(F)C(=O)OC(=O)C(F)(F)F QAEDZJGFFMLHHQ-UHFFFAOYSA-N 0.000 description 2
- 229910052722 tritium Inorganic materials 0.000 description 2
- 210000004881 tumor cell Anatomy 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- CXNIUSPIQKWYAI-UHFFFAOYSA-N xantphos Chemical compound C=12OC3=C(P(C=4C=CC=CC=4)C=4C=CC=CC=4)C=CC=C3C(C)(C)C2=CC=CC=1P(C=1C=CC=CC=1)C1=CC=CC=C1 CXNIUSPIQKWYAI-UHFFFAOYSA-N 0.000 description 2
- ASNVMKIDRJZXQZ-ZCFIWIBFSA-N (1r)-1-(3-fluorophenyl)ethanamine Chemical compound C[C@@H](N)C1=CC=CC(F)=C1 ASNVMKIDRJZXQZ-ZCFIWIBFSA-N 0.000 description 1
- YESOPGLEIJQAEF-ZCFIWIBFSA-N (1r)-1-(3-fluorophenyl)ethanol Chemical compound C[C@@H](O)C1=CC=CC(F)=C1 YESOPGLEIJQAEF-ZCFIWIBFSA-N 0.000 description 1
- ZFSXKSSWYSZPGQ-TYSVMGFPSA-N (1r,2r)-2-aminocyclopentan-1-ol;hydrochloride Chemical compound Cl.N[C@@H]1CCC[C@H]1O ZFSXKSSWYSZPGQ-TYSVMGFPSA-N 0.000 description 1
- JTDGKQNNPKXKII-ZETCQYMHSA-N (1s)-1-(4-methoxyphenyl)ethanamine Chemical compound COC1=CC=C([C@H](C)N)C=C1 JTDGKQNNPKXKII-ZETCQYMHSA-N 0.000 description 1
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Polymers OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 1
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 1
- LLHOYOCAAURYRL-NTSWFWBYSA-N (2r,3s)-3-hydroxy-2-[(2-methylpropan-2-yl)oxycarbonylamino]butanoic acid Chemical compound C[C@H](O)[C@H](C(O)=O)NC(=O)OC(C)(C)C LLHOYOCAAURYRL-NTSWFWBYSA-N 0.000 description 1
- NWZSZGALRFJKBT-KNIFDHDWSA-N (2s)-2,6-diaminohexanoic acid;(2s)-2-hydroxybutanedioic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O.NCCCC[C@H](N)C(O)=O NWZSZGALRFJKBT-KNIFDHDWSA-N 0.000 description 1
- LLHOYOCAAURYRL-RITPCOANSA-N (2s,3r)-3-hydroxy-2-[(2-methylpropan-2-yl)oxycarbonylamino]butanoic acid Chemical compound C[C@@H](O)[C@@H](C(O)=O)NC(=O)OC(C)(C)C LLHOYOCAAURYRL-RITPCOANSA-N 0.000 description 1
- YGWZXQOYEBWUTH-BQBZGAKWSA-N (2s,4s)-4-fluoro-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid Chemical compound CC(C)(C)OC(=O)N1C[C@@H](F)C[C@H]1C(O)=O YGWZXQOYEBWUTH-BQBZGAKWSA-N 0.000 description 1
- SUAFQFLEPLALCC-WSCVZUBPSA-N (4s)-4-amino-1-[4-[6-[(1r)-1-(3-fluorophenyl)ethoxy]imidazo[1,2-b]pyridazin-3-yl]phenyl]pyrrolidin-2-one;2-hydroxypropanoic acid Chemical compound CC(O)C(O)=O.O([C@H](C)C=1C=C(F)C=CC=1)C(=NN12)C=CC1=NC=C2C(C=C1)=CC=C1N1C[C@@H](N)CC1=O SUAFQFLEPLALCC-WSCVZUBPSA-N 0.000 description 1
- WYZOVPAERLAKCG-WSCVZUBPSA-N (4s)-4-amino-1-[4-[6-[(1r)-1-(3-fluorophenyl)ethoxy]imidazo[1,2-b]pyridazin-3-yl]phenyl]pyrrolidin-2-one;hexanedioic acid Chemical compound OC(=O)CCCCC(O)=O.O([C@H](C)C=1C=C(F)C=CC=1)C(=NN12)C=CC1=NC=C2C(C=C1)=CC=C1N1C[C@@H](N)CC1=O WYZOVPAERLAKCG-WSCVZUBPSA-N 0.000 description 1
- KMSKQZKKOZQFFG-YXRRJAAWSA-N (7S,9S)-7-[[(2R,4S,5S,6S)-4-amino-6-methyl-5-[[(2R)-2-oxanyl]oxy]-2-oxanyl]oxy]-6,9,11-trihydroxy-9-(2-hydroxy-1-oxoethyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione Chemical compound O([C@H]1[C@@H](N)C[C@@H](O[C@H]1C)O[C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@@H]1CCCCO1 KMSKQZKKOZQFFG-YXRRJAAWSA-N 0.000 description 1
- FDKXTQMXEQVLRF-ZHACJKMWSA-N (E)-dacarbazine Chemical compound CN(C)\N=N\c1[nH]cnc1C(N)=O FDKXTQMXEQVLRF-ZHACJKMWSA-N 0.000 description 1
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- MOWXJLUYGFNTAL-DEOSSOPVSA-N (s)-[2-chloro-4-fluoro-5-(7-morpholin-4-ylquinazolin-4-yl)phenyl]-(6-methoxypyridazin-3-yl)methanol Chemical compound N1=NC(OC)=CC=C1[C@@H](O)C1=CC(C=2C3=CC=C(C=C3N=CN=2)N2CCOCC2)=C(F)C=C1Cl MOWXJLUYGFNTAL-DEOSSOPVSA-N 0.000 description 1
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 description 1
- SWJPEBQEEAHIGZ-UHFFFAOYSA-N 1,4-dibromobenzene Chemical compound BrC1=CC=C(Br)C=C1 SWJPEBQEEAHIGZ-UHFFFAOYSA-N 0.000 description 1
- HLAFIZUVVWJAKL-UHFFFAOYSA-N 1-(2,5-difluorophenyl)ethanone Chemical compound CC(=O)C1=CC(F)=CC=C1F HLAFIZUVVWJAKL-UHFFFAOYSA-N 0.000 description 1
- NPYLCUURNHMXHV-UHFFFAOYSA-N 1-(2,5-difluoropyridin-3-yl)ethanone Chemical compound CC(=O)C1=CC(F)=CN=C1F NPYLCUURNHMXHV-UHFFFAOYSA-N 0.000 description 1
- MYBLAOJMRYYKMS-RTRLPJTCSA-N 1-(2-chloroethyl)-1-nitroso-3-[(3r,4r,5s,6r)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]urea Chemical compound OC[C@H]1OC(O)[C@H](NC(=O)N(CCCl)N=O)[C@@H](O)[C@@H]1O MYBLAOJMRYYKMS-RTRLPJTCSA-N 0.000 description 1
- ZPNLAQVYPIAHTO-UHFFFAOYSA-N 1-(3-chlorophenyl)-n-methylmethanamine Chemical compound CNCC1=CC=CC(Cl)=C1 ZPNLAQVYPIAHTO-UHFFFAOYSA-N 0.000 description 1
- ZXWCKKSSCIFVBT-UHFFFAOYSA-N 1-(3-fluorophenyl)-n-methylmethanamine Chemical compound CNCC1=CC=CC(F)=C1 ZXWCKKSSCIFVBT-UHFFFAOYSA-N 0.000 description 1
- NYPDNSSFCQKXQG-UHFFFAOYSA-N 1-(4-bromophenyl)-4-(hydroxymethyl)pyrrolidin-2-one Chemical compound O=C1CC(CO)CN1C1=CC=C(Br)C=C1 NYPDNSSFCQKXQG-UHFFFAOYSA-N 0.000 description 1
- MDFOXHGBFTXKQL-UHFFFAOYSA-N 1-(4-bromophenyl)-5-oxopyrrolidine-3-carboxylic acid Chemical compound O=C1CC(C(=O)O)CN1C1=CC=C(Br)C=C1 MDFOXHGBFTXKQL-UHFFFAOYSA-N 0.000 description 1
- KJLSIALJLABLNZ-UHFFFAOYSA-N 1-(4-chloro-5-fluoropyridin-3-yl)-n-methylmethanamine Chemical compound CNCC1=CN=CC(F)=C1Cl KJLSIALJLABLNZ-UHFFFAOYSA-N 0.000 description 1
- IDPURXSQCKYKIJ-UHFFFAOYSA-N 1-(4-methoxyphenyl)methanamine Chemical compound COC1=CC=C(CN)C=C1 IDPURXSQCKYKIJ-UHFFFAOYSA-N 0.000 description 1
- HGNUKWYVPBUQMW-UHFFFAOYSA-N 1-(5-chloro-1-methylpyrazol-3-yl)ethanone Chemical compound CC(=O)C=1C=C(Cl)N(C)N=1 HGNUKWYVPBUQMW-UHFFFAOYSA-N 0.000 description 1
- XEEHTMHSKNSCIW-UHFFFAOYSA-N 1-(5-chloropyridin-3-yl)ethanol Chemical compound CC(O)C1=CN=CC(Cl)=C1 XEEHTMHSKNSCIW-UHFFFAOYSA-N 0.000 description 1
- OPMTZWDRLGAXNM-UHFFFAOYSA-N 1-(5-fluoropyridin-3-yl)ethanol Chemical compound CC(O)C1=CN=CC(F)=C1 OPMTZWDRLGAXNM-UHFFFAOYSA-N 0.000 description 1
- JBOIQIRJYOXYDQ-FTNKSUMCSA-N 1-[(1s)-1-(4-methoxyphenyl)ethyl]-5-oxopyrrolidine-3-carboxylic acid Chemical compound C1=CC(OC)=CC=C1[C@H](C)N1C(=O)CC(C(O)=O)C1 JBOIQIRJYOXYDQ-FTNKSUMCSA-N 0.000 description 1
- DSKCOVBHIFAJRI-UHFFFAOYSA-N 1-[(2-methylpropan-2-yl)oxycarbonylamino]cyclopropane-1-carboxylic acid Chemical compound CC(C)(C)OC(=O)NC1(C(O)=O)CC1 DSKCOVBHIFAJRI-UHFFFAOYSA-N 0.000 description 1
- ZOFNXTQEFNKSGH-UHFFFAOYSA-N 1-[5-fluoro-2-(triazol-2-yl)phenyl]ethanone Chemical compound CC(=O)C1=CC(F)=CC=C1N1N=CC=N1 ZOFNXTQEFNKSGH-UHFFFAOYSA-N 0.000 description 1
- 102100025573 1-alkyl-2-acetylglycerophosphocholine esterase Human genes 0.000 description 1
- QSQOGKONVJDRNH-UHFFFAOYSA-N 1-bromo-4-iodo-2-methylbenzene Chemical compound CC1=CC(I)=CC=C1Br QSQOGKONVJDRNH-UHFFFAOYSA-N 0.000 description 1
- DDGRAFHHXYIQQR-UHFFFAOYSA-N 1-chloro-3-(chloromethyl)benzene Chemical compound ClCC1=CC=CC(Cl)=C1 DDGRAFHHXYIQQR-UHFFFAOYSA-N 0.000 description 1
- 125000004066 1-hydroxyethyl group Chemical group [H]OC([H])([*])C([H])([H])[H] 0.000 description 1
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 1
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- BFPYWIDHMRZLRN-UHFFFAOYSA-N 17alpha-ethynyl estradiol Natural products OC1=CC=C2C3CCC(C)(C(CC4)(O)C#C)C4C3CCC2=C1 BFPYWIDHMRZLRN-UHFFFAOYSA-N 0.000 description 1
- QWENRTYMTSOGBR-UHFFFAOYSA-N 1H-1,2,3-Triazole Chemical compound C=1C=NNN=1 QWENRTYMTSOGBR-UHFFFAOYSA-N 0.000 description 1
- 125000000453 2,2,2-trichloroethyl group Chemical group [H]C([H])(*)C(Cl)(Cl)Cl 0.000 description 1
- 125000004206 2,2,2-trifluoroethyl group Chemical group [H]C([H])(*)C(F)(F)F 0.000 description 1
- 125000004778 2,2-difluoroethyl group Chemical group [H]C([H])(*)C([H])(F)F 0.000 description 1
- WYZLYWUZERABRL-UHFFFAOYSA-N 2,4-dibromobutanoyl chloride Chemical compound ClC(=O)C(Br)CCBr WYZLYWUZERABRL-UHFFFAOYSA-N 0.000 description 1
- BAQVNWTUOKQWBV-UHFFFAOYSA-N 2,5-difluoro-n-methoxy-n-methylpyridine-3-carboxamide Chemical compound CON(C)C(=O)C1=CC(F)=CN=C1F BAQVNWTUOKQWBV-UHFFFAOYSA-N 0.000 description 1
- NEDDADJKOLQIJZ-UHFFFAOYSA-N 2,5-difluoropyridine-3-carboxylic acid Chemical compound OC(=O)C1=CC(F)=CN=C1F NEDDADJKOLQIJZ-UHFFFAOYSA-N 0.000 description 1
- JNYAEWCLZODPBN-UHFFFAOYSA-N 2-(1,2-dihydroxyethyl)oxolane-3,4-diol Polymers OCC(O)C1OCC(O)C1O JNYAEWCLZODPBN-UHFFFAOYSA-N 0.000 description 1
- GDWKIRLZWQQMIE-QMMMGPOBSA-N 2-[(2s)-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidin-2-yl]acetic acid Chemical compound CC(C)(C)OC(=O)N1CCC[C@H]1CC(O)=O GDWKIRLZWQQMIE-QMMMGPOBSA-N 0.000 description 1
- NLMKTBGFQGKQEV-UHFFFAOYSA-N 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-hexadecoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol Chemical compound CCCCCCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO NLMKTBGFQGKQEV-UHFFFAOYSA-N 0.000 description 1
- 125000000022 2-aminoethyl group Chemical group [H]C([*])([H])C([H])([H])N([H])[H] 0.000 description 1
- 125000001340 2-chloroethyl group Chemical group [H]C([H])(Cl)C([H])([H])* 0.000 description 1
- 125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 description 1
- 125000004493 2-methylbut-1-yl group Chemical group CC(C*)CC 0.000 description 1
- NDMPLJNOPCLANR-UHFFFAOYSA-N 3,4-dihydroxy-15-(4-hydroxy-18-methoxycarbonyl-5,18-seco-ibogamin-18-yl)-16-methoxy-1-methyl-6,7-didehydro-aspidospermidine-3-carboxylic acid methyl ester Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 NDMPLJNOPCLANR-UHFFFAOYSA-N 0.000 description 1
- HCDMJFOHIXMBOV-UHFFFAOYSA-N 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(morpholin-4-ylmethyl)-4,7-dihydropyrrolo[4,5]pyrido[1,2-d]pyrimidin-2-one Chemical compound C=1C2=C3N(CC)C(=O)N(C=4C(=C(OC)C=C(OC)C=4F)F)CC3=CN=C2NC=1CN1CCOCC1 HCDMJFOHIXMBOV-UHFFFAOYSA-N 0.000 description 1
- YMXIIVIQLHYKOT-UHFFFAOYSA-N 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline Chemical group O1C(C)(C)C(C)(C)OB1C1=CC=CC(N)=C1 YMXIIVIQLHYKOT-UHFFFAOYSA-N 0.000 description 1
- BYHQTRFJOGIQAO-GOSISDBHSA-N 3-(4-bromophenyl)-8-[(2R)-2-hydroxypropyl]-1-[(3-methoxyphenyl)methyl]-1,3,8-triazaspiro[4.5]decan-2-one Chemical compound C[C@H](CN1CCC2(CC1)CN(C(=O)N2CC3=CC(=CC=C3)OC)C4=CC=C(C=C4)Br)O BYHQTRFJOGIQAO-GOSISDBHSA-N 0.000 description 1
- PCOFIIVWHXIDGT-UHFFFAOYSA-N 3-(hydroxymethyl)benzonitrile Chemical compound OCC1=CC=CC(C#N)=C1 PCOFIIVWHXIDGT-UHFFFAOYSA-N 0.000 description 1
- CMUNCGSSECCERB-XXBNENTESA-N 3-[4-[[(2S)-1-tert-butylazetidin-2-yl]methoxy]phenyl]-6-[(1R)-1-(3-fluorophenyl)ethoxy]imidazo[1,2-b]pyridazine Chemical compound C(C)(C)(C)N1[C@@H](CC1)COC1=CC=C(C=C1)C1=CN=C2N1N=C(C=C2)O[C@H](C)C1=CC(=CC=C1)F CMUNCGSSECCERB-XXBNENTESA-N 0.000 description 1
- QUUGICKQIQTLKC-UHFFFAOYSA-N 3-bromo-1-(4-bromophenyl)pyrrolidin-2-one Chemical compound O=C1C(Br)CCN1C1=CC=C(Br)C=C1 QUUGICKQIQTLKC-UHFFFAOYSA-N 0.000 description 1
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 1
- VAEZZQWJTQBXSI-UHFFFAOYSA-N 4-[6-(benzylamino)imidazo[1,2-b]pyridazin-3-yl]phenol Chemical compound C(C1=CC=CC=C1)NC=1C=CC=2N(N1)C(=CN2)C2=CC=C(C=C2)O VAEZZQWJTQBXSI-UHFFFAOYSA-N 0.000 description 1
- 125000004042 4-aminobutyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H] 0.000 description 1
- FTBCOQFMQSTCQQ-UHFFFAOYSA-N 4-bromobenzenethiol Chemical compound SC1=CC=C(Br)C=C1 FTBCOQFMQSTCQQ-UHFFFAOYSA-N 0.000 description 1
- 125000004800 4-bromophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Br 0.000 description 1
- BEQUUSCRAKEKQM-UHFFFAOYSA-N 4-chloro-3-fluoropyridine Chemical compound FC1=CN=CC=C1Cl BEQUUSCRAKEKQM-UHFFFAOYSA-N 0.000 description 1
- BQRNVJRDXKKHRB-UHFFFAOYSA-N 4-chloro-5-fluoropyridine-3-carbaldehyde Chemical compound FC1=CN=CC(C=O)=C1Cl BQRNVJRDXKKHRB-UHFFFAOYSA-N 0.000 description 1
- 125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 description 1
- MPDJPMRNZWAXBR-UHFFFAOYSA-N 5-acetyl-2-methylpyrazole-3-carbonitrile Chemical compound CC(=O)C=1C=C(C#N)N(C)N=1 MPDJPMRNZWAXBR-UHFFFAOYSA-N 0.000 description 1
- GYCNHFWRPJXTSB-UHFFFAOYSA-N 5-bromo-2-fluorobenzonitrile Chemical compound FC1=CC=C(Br)C=C1C#N GYCNHFWRPJXTSB-UHFFFAOYSA-N 0.000 description 1
- WGOLHUGPTDEKCF-UHFFFAOYSA-N 5-bromopyridin-2-amine Chemical compound NC1=CC=C(Br)C=N1 WGOLHUGPTDEKCF-UHFFFAOYSA-N 0.000 description 1
- KXFLDFBYTWSMPV-UHFFFAOYSA-N 5-chloro-1-methylpyrazole-3-carboxylic acid Chemical compound CN1N=C(C(O)=O)C=C1Cl KXFLDFBYTWSMPV-UHFFFAOYSA-N 0.000 description 1
- QQWUGDVOUVUTOY-UHFFFAOYSA-N 5-chloro-N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine Chemical compound COC1=CC(N2CCC(CC2)N2CCN(C)CC2)=CC=C1NC(N=1)=NC=C(Cl)C=1NC1=CC=CC=C1S(=O)(=O)C(C)C QQWUGDVOUVUTOY-UHFFFAOYSA-N 0.000 description 1
- KCBWAFJCKVKYHO-UHFFFAOYSA-N 6-(4-cyclopropyl-6-methoxypyrimidin-5-yl)-1-[[4-[1-propan-2-yl-4-(trifluoromethyl)imidazol-2-yl]phenyl]methyl]pyrazolo[3,4-d]pyrimidine Chemical compound C1(CC1)C1=NC=NC(=C1C1=NC=C2C(=N1)N(N=C2)CC1=CC=C(C=C1)C=1N(C=C(N=1)C(F)(F)F)C(C)C)OC KCBWAFJCKVKYHO-UHFFFAOYSA-N 0.000 description 1
- NKGPJODWTZCHGF-KQYNXXCUSA-N 6-thioinosinic acid Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC=NC(S)=C2N=C1 NKGPJODWTZCHGF-KQYNXXCUSA-N 0.000 description 1
- STQGQHZAVUOBTE-UHFFFAOYSA-N 7-Cyan-hept-2t-en-4,6-diinsaeure Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)=O)CC1OC1CC(N)C(O)C(C)O1 STQGQHZAVUOBTE-UHFFFAOYSA-N 0.000 description 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- 244000215068 Acacia senegal Species 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Natural products OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 1
- 108010024976 Asparaginase Proteins 0.000 description 1
- 241000416162 Astragalus gummifer Species 0.000 description 1
- NOWKCMXCCJGMRR-UHFFFAOYSA-N Aziridine Chemical compound C1CN1 NOWKCMXCCJGMRR-UHFFFAOYSA-N 0.000 description 1
- MLDQJTXFUGDVEO-UHFFFAOYSA-N BAY-43-9006 Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=CC(NC(=O)NC=3C=C(C(Cl)=CC=3)C(F)(F)F)=CC=2)=C1 MLDQJTXFUGDVEO-UHFFFAOYSA-N 0.000 description 1
- WOVKYSAHUYNSMH-UHFFFAOYSA-N BROMODEOXYURIDINE Natural products C1C(O)C(CO)OC1N1C(=O)NC(=O)C(Br)=C1 WOVKYSAHUYNSMH-UHFFFAOYSA-N 0.000 description 1
- 229920001342 Bakelite® Polymers 0.000 description 1
- 239000005711 Benzoic acid Substances 0.000 description 1
- 108010006654 Bleomycin Proteins 0.000 description 1
- WPNYZRSHMXVENT-UHFFFAOYSA-N BrC(C(=O)NC1=CC=C(C=C1)Br)CCBr Chemical compound BrC(C(=O)NC1=CC=C(C=C1)Br)CCBr WPNYZRSHMXVENT-UHFFFAOYSA-N 0.000 description 1
- GVYYBQQIBKMKEU-UHFFFAOYSA-N BrC1=CC=C(C=C1)N1C(C(CC1)N1C(C2=CC=CC=C2C1=O)=O)=O Chemical compound BrC1=CC=C(C=C1)N1C(C(CC1)N1C(C2=CC=CC=C2C1=O)=O)=O GVYYBQQIBKMKEU-UHFFFAOYSA-N 0.000 description 1
- OYOQWCDTJILSLH-UHFFFAOYSA-N BrC1=CC=C(C=C1)N1CC(CC1=O)CN1C(C2=CC=CC=C2C1=O)=O Chemical compound BrC1=CC=C(C=C1)N1CC(CC1=O)CN1C(C2=CC=CC=C2C1=O)=O OYOQWCDTJILSLH-UHFFFAOYSA-N 0.000 description 1
- NPDBXKDPTZQCHY-UHFFFAOYSA-N BrC1=CC=C(OCC(C)N(C(OC(C)(C)C)=O)C)C=C1 Chemical compound BrC1=CC=C(OCC(C)N(C(OC(C)(C)C)=O)C)C=C1 NPDBXKDPTZQCHY-UHFFFAOYSA-N 0.000 description 1
- TXAIIEAXIDWHIV-AREMUKBSSA-N BrC1=CC=C(OC[C@@H](CO)NC(C2=CC=CC=C2)(C2=CC=CC=C2)C2=CC=CC=C2)C=C1 Chemical compound BrC1=CC=C(OC[C@@H](CO)NC(C2=CC=CC=C2)(C2=CC=CC=C2)C2=CC=CC=C2)C=C1 TXAIIEAXIDWHIV-AREMUKBSSA-N 0.000 description 1
- YCIAJWJSLFMFTB-UHFFFAOYSA-N BrC1=CN=C2N1N=C(C=C2)N(C)CC2=CC(=CC=C2)Cl Chemical compound BrC1=CN=C2N1N=C(C=C2)N(C)CC2=CC(=CC=C2)Cl YCIAJWJSLFMFTB-UHFFFAOYSA-N 0.000 description 1
- BNVVYVYAWUFMBX-UHFFFAOYSA-N BrC1=CN=C2N1N=C(C=C2)N(C)CC2=CC(=CC=C2)F Chemical compound BrC1=CN=C2N1N=C(C=C2)N(C)CC2=CC(=CC=C2)F BNVVYVYAWUFMBX-UHFFFAOYSA-N 0.000 description 1
- SKBDBEYPCMQTES-UHFFFAOYSA-N BrC1=CN=C2N1N=C(C=C2)N(C)CC=2C=NC=C(C2Cl)F Chemical compound BrC1=CN=C2N1N=C(C=C2)N(C)CC=2C=NC=C(C2Cl)F SKBDBEYPCMQTES-UHFFFAOYSA-N 0.000 description 1
- BJISZLHAVGHQAU-UHFFFAOYSA-N BrC1=CN=C2N1N=C(C=C2)N(CC=2C=NC=CC2)C Chemical compound BrC1=CN=C2N1N=C(C=C2)N(CC=2C=NC=CC2)C BJISZLHAVGHQAU-UHFFFAOYSA-N 0.000 description 1
- ISHZINVVYSFPEJ-SECBINFHSA-N BrC1=CN=C2N1N=C(C=C2)N[C@H](C)C2=CC(=CC=C2)F Chemical compound BrC1=CN=C2N1N=C(C=C2)N[C@H](C)C2=CC(=CC=C2)F ISHZINVVYSFPEJ-SECBINFHSA-N 0.000 description 1
- HEIDUHNKJDBPTI-SNVBAGLBSA-N BrC1=CN=C2N1N=C(C=C2)N[C@H](C)C2=CC=CC=C2 Chemical compound BrC1=CN=C2N1N=C(C=C2)N[C@H](C)C2=CC=CC=C2 HEIDUHNKJDBPTI-SNVBAGLBSA-N 0.000 description 1
- NPFLHVYJNOKJQK-UHFFFAOYSA-N BrC1=CN=C2N1N=C(C=C2)OC(C)C=2C(=NC=C(C2)F)F Chemical compound BrC1=CN=C2N1N=C(C=C2)OC(C)C=2C(=NC=C(C2)F)F NPFLHVYJNOKJQK-UHFFFAOYSA-N 0.000 description 1
- IMVVCOXMWSWBPG-UHFFFAOYSA-N BrC1=CN=C2N1N=C(C=C2)OCC2=CC(=CC=C2)F Chemical compound BrC1=CN=C2N1N=C(C=C2)OCC2=CC(=CC=C2)F IMVVCOXMWSWBPG-UHFFFAOYSA-N 0.000 description 1
- SXQCPYOMFRIWHC-SECBINFHSA-N BrC1=CN=C2N1N=C(C=C2)O[C@H](C)C2=CC(=CC=C2)F Chemical compound BrC1=CN=C2N1N=C(C=C2)O[C@H](C)C2=CC(=CC=C2)F SXQCPYOMFRIWHC-SECBINFHSA-N 0.000 description 1
- 102000004219 Brain-derived neurotrophic factor Human genes 0.000 description 1
- 108090000715 Brain-derived neurotrophic factor Proteins 0.000 description 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 1
- COVZYZSDYWQREU-UHFFFAOYSA-N Busulfan Chemical compound CS(=O)(=O)OCCCCOS(C)(=O)=O COVZYZSDYWQREU-UHFFFAOYSA-N 0.000 description 1
- KAKZBPTYRLMSJV-UHFFFAOYSA-N Butadiene Chemical group C=CC=C KAKZBPTYRLMSJV-UHFFFAOYSA-N 0.000 description 1
- YKWYPHMCUWJXDX-UHFFFAOYSA-N C(C1=CC=CC=C1)N(C=1C=CC=2N(N1)C(=CN2)Br)C Chemical compound C(C1=CC=CC=C1)N(C=1C=CC=2N(N1)C(=CN2)Br)C YKWYPHMCUWJXDX-UHFFFAOYSA-N 0.000 description 1
- KWOXVIQJPCHCCY-UHFFFAOYSA-N C(C1=CC=CC=C1)NC=1C=CC=2N(N1)C(=CN2)Br Chemical compound C(C1=CC=CC=C1)NC=1C=CC=2N(N1)C(=CN2)Br KWOXVIQJPCHCCY-UHFFFAOYSA-N 0.000 description 1
- JXORVLXDYOJQAW-LJQANCHMSA-N C(NC1=NN2C(C=C1)=NC=C2C1=CC=C(OC[C@@H]2CCNC2)C=C1)C1=CC=CC=C1 Chemical compound C(NC1=NN2C(C=C1)=NC=C2C1=CC=C(OC[C@@H]2CCNC2)C=C1)C1=CC=CC=C1 JXORVLXDYOJQAW-LJQANCHMSA-N 0.000 description 1
- SBSYNSRYFDXOOC-FQEVSTJZSA-N C(NC1=NN2C(C=C1)=NC=C2C1=CC=CC(OC[C@@H]2CCCN2)=C1)C1=CC=CC=C1 Chemical compound C(NC1=NN2C(C=C1)=NC=C2C1=CC=CC(OC[C@@H]2CCCN2)=C1)C1=CC=CC=C1 SBSYNSRYFDXOOC-FQEVSTJZSA-N 0.000 description 1
- BPVDIYFXDQHZQR-HXUWFJFHSA-N C(NC1=NN2C(C=C1)=NC=C2C1=CC=CC(O[C@@H]2CCNC2)=C1)C1=CC=CC=C1 Chemical compound C(NC1=NN2C(C=C1)=NC=C2C1=CC=CC(O[C@@H]2CCNC2)=C1)C1=CC=CC=C1 BPVDIYFXDQHZQR-HXUWFJFHSA-N 0.000 description 1
- GBDHHMAYHRQEMX-HXUWFJFHSA-N C(Nc1ccc2ncc(-c3ccc(O[C@@H]4CCNC4)cc3)n2n1)c1ccccc1 Chemical compound C(Nc1ccc2ncc(-c3ccc(O[C@@H]4CCNC4)cc3)n2n1)c1ccccc1 GBDHHMAYHRQEMX-HXUWFJFHSA-N 0.000 description 1
- HQVJPKYAJNHEHV-NQIIRXRSSA-N C1(=CC=CC=C1)[C@@H](C)NC=1C=CC=2N(N1)C(=CN2)C2=CC=C(C=C2)OC[C@H]2NCCC2 Chemical compound C1(=CC=CC=C1)[C@@H](C)NC=1C=CC=2N(N1)C(=CN2)C2=CC=C(C=C2)OC[C@H]2NCCC2 HQVJPKYAJNHEHV-NQIIRXRSSA-N 0.000 description 1
- OQOYMXJORZTQKS-UHFFFAOYSA-N CC(C)(C)OC(=O)N1CC(C1)Oc1ccc(cc1)B1OC(C)(C)C(C)(C)O1 Chemical compound CC(C)(C)OC(=O)N1CC(C1)Oc1ccc(cc1)B1OC(C)(C)C(C)(C)O1 OQOYMXJORZTQKS-UHFFFAOYSA-N 0.000 description 1
- ZJCNXSGPDYORFU-IUCAKERBSA-N CC(C)(C)OC(=O)N1C[C@@H](F)C[C@H]1COS(C)(=O)=O Chemical compound CC(C)(C)OC(=O)N1C[C@@H](F)C[C@H]1COS(C)(=O)=O ZJCNXSGPDYORFU-IUCAKERBSA-N 0.000 description 1
- XEGWLZLIRMWDFR-STQMWFEESA-N CC(C)(C)OC(=O)N1C[C@@H](F)C[C@H]1COc1ccc(Br)cc1 Chemical compound CC(C)(C)OC(=O)N1C[C@@H](F)C[C@H]1COc1ccc(Br)cc1 XEGWLZLIRMWDFR-STQMWFEESA-N 0.000 description 1
- YTNGNHTYMCMXIC-UHFFFAOYSA-N CC(C)(C)OC(=O)NC1(COc2ccc(Br)cc2)CC1 Chemical compound CC(C)(C)OC(=O)NC1(COc2ccc(Br)cc2)CC1 YTNGNHTYMCMXIC-UHFFFAOYSA-N 0.000 description 1
- IKQNVQGSRPFAGF-UHFFFAOYSA-N CC(C)(C)OC(=O)NC1CCN(C1=O)c1ccc(Br)cc1 Chemical compound CC(C)(C)OC(=O)NC1CCN(C1=O)c1ccc(Br)cc1 IKQNVQGSRPFAGF-UHFFFAOYSA-N 0.000 description 1
- UEGSXFDJHQQGTG-UHFFFAOYSA-N CC(C)(C)OC(=O)NC1CN(C(=O)C1)c1ccc(Br)cc1 Chemical compound CC(C)(C)OC(=O)NC1CN(C(=O)C1)c1ccc(Br)cc1 UEGSXFDJHQQGTG-UHFFFAOYSA-N 0.000 description 1
- UEGSXFDJHQQGTG-LLVKDONJSA-N CC(C)(C)OC(=O)N[C@H]1CN(C(=O)C1)c1ccc(Br)cc1 Chemical compound CC(C)(C)OC(=O)N[C@H]1CN(C(=O)C1)c1ccc(Br)cc1 UEGSXFDJHQQGTG-LLVKDONJSA-N 0.000 description 1
- HEVHTYMYEMEBPX-OEMAIJDKSA-N CC(N)COc1ccc(cc1)-c1cnc2ccc(N[C@H](C)c3cccc(F)c3)nn12 Chemical compound CC(N)COc1ccc(cc1)-c1cnc2ccc(N[C@H](C)c3cccc(F)c3)nn12 HEVHTYMYEMEBPX-OEMAIJDKSA-N 0.000 description 1
- QYUPEIASEFPJAU-FUBQLUNQSA-N CC(OC1=NN2C(C=C1)=NC=C2C1=CC=C(N2C[C@@H](N)CC2=O)C(C)=C1)C1=CC(F)=CN=C1 Chemical compound CC(OC1=NN2C(C=C1)=NC=C2C1=CC=C(N2C[C@@H](N)CC2=O)C(C)=C1)C1=CC(F)=CN=C1 QYUPEIASEFPJAU-FUBQLUNQSA-N 0.000 description 1
- UJNNYPZNGXKGDQ-WMCAAGNKSA-N CC(Oc1ccc2ncc(-c3ccc(cc3)N3C[C@@H](N)CC3=O)n2n1)c1cccc(F)c1F Chemical compound CC(Oc1ccc2ncc(-c3ccc(cc3)N3C[C@@H](N)CC3=O)n2n1)c1cccc(F)c1F UJNNYPZNGXKGDQ-WMCAAGNKSA-N 0.000 description 1
- ZLCJDXLVQVPASE-IBGZPJMESA-N CC1=CC=C(F)C=C1COC1=NN2C(C=C1)=NC=C2C1=CC=C(C=C1)N1C[C@@H](N)CC1=O Chemical compound CC1=CC=C(F)C=C1COC1=NN2C(C=C1)=NC=C2C1=CC=C(C=C1)N1C[C@@H](N)CC1=O ZLCJDXLVQVPASE-IBGZPJMESA-N 0.000 description 1
- FUABWVZDAZGCBY-FQEVSTJZSA-N CCN(CC1=CC(F)=CC=C1)C1=NN2C(C=C1)=NC=C2C1=CC=C(C=C1)N1C[C@@H](N)CC1=O Chemical compound CCN(CC1=CC(F)=CC=C1)C1=NN2C(C=C1)=NC=C2C1=CC=C(C=C1)N1C[C@@H](N)CC1=O FUABWVZDAZGCBY-FQEVSTJZSA-N 0.000 description 1
- FTTKBANOJMLBIW-FQEVSTJZSA-N CCN(CC1=CC=CC=C1)C1=NN2C(C=C1)=NC=C2C1=CC=C(C=C1)N1C[C@@H](N)CC1=O Chemical compound CCN(CC1=CC=CC=C1)C1=NN2C(C=C1)=NC=C2C1=CC=C(C=C1)N1C[C@@H](N)CC1=O FTTKBANOJMLBIW-FQEVSTJZSA-N 0.000 description 1
- MIVARRVDQMRTSE-NRFANRHFSA-N CN(CC1=CC(F)=CC=C1)C1=NN2C(C=C1)=NC=C2C1=CC=C(OC[C@@H]2CCCN2)C=C1 Chemical compound CN(CC1=CC(F)=CC=C1)C1=NN2C(C=C1)=NC=C2C1=CC=C(OC[C@@H]2CCCN2)C=C1 MIVARRVDQMRTSE-NRFANRHFSA-N 0.000 description 1
- FURFADGYFGGGBE-IBGZPJMESA-N CN(CC1=CC(F)=CN=C1)C1=NN2C(C=C1)=NC=C2C1=CC=C(N2C[C@@H](N)CC2=O)C(=C1)C#N Chemical compound CN(CC1=CC(F)=CN=C1)C1=NN2C(C=C1)=NC=C2C1=CC=C(N2C[C@@H](N)CC2=O)C(=C1)C#N FURFADGYFGGGBE-IBGZPJMESA-N 0.000 description 1
- LWPYXLFDZCSISO-IBGZPJMESA-N CN(Cc1cc(F)cc(F)c1)c1ccc2ncc(-c3ccc(cc3)N3C[C@@H](N)CC3=O)n2n1 Chemical compound CN(Cc1cc(F)cc(F)c1)c1ccc2ncc(-c3ccc(cc3)N3C[C@@H](N)CC3=O)n2n1 LWPYXLFDZCSISO-IBGZPJMESA-N 0.000 description 1
- YAOPFFRCEYWGGB-UHFFFAOYSA-N COC(=O)C1(C)CN(Cc2ccc(OC)cc2)C(=O)C1 Chemical compound COC(=O)C1(C)CN(Cc2ccc(OC)cc2)C(=O)C1 YAOPFFRCEYWGGB-UHFFFAOYSA-N 0.000 description 1
- PCBZRNYXXCIELG-WYFCWLEVSA-N COC1=CC=C(C[C@H](NC(=O)OC2CCCC3(C2)OOC2(O3)C3CC4CC(C3)CC2C4)C(=O)N[C@@H]2[C@@H](CO)O[C@H]([C@@H]2O)N2C=NC3=C2N=CN=C3N(C)C)C=C1 Chemical compound COC1=CC=C(C[C@H](NC(=O)OC2CCCC3(C2)OOC2(O3)C3CC4CC(C3)CC2C4)C(=O)N[C@@H]2[C@@H](CO)O[C@H]([C@@H]2O)N2C=NC3=C2N=CN=C3N(C)C)C=C1 PCBZRNYXXCIELG-WYFCWLEVSA-N 0.000 description 1
- WUOSQXAUYKSZTL-UHFFFAOYSA-N COc1ccc(CN2CC(C)(CC2=O)C(O)=O)cc1 Chemical compound COc1ccc(CN2CC(C)(CC2=O)C(O)=O)cc1 WUOSQXAUYKSZTL-UHFFFAOYSA-N 0.000 description 1
- MQPKWTJIHJTNDG-NBFOIZRFSA-N COc1ccc(cc1)[C@H](C)N1CC(CC1=O)C(=O)OC(C)(C)C Chemical compound COc1ccc(cc1)[C@H](C)N1CC(CC1=O)C(=O)OC(C)(C)C MQPKWTJIHJTNDG-NBFOIZRFSA-N 0.000 description 1
- ZGEPJQFRZAXTQM-UWGSCQAASA-N CS(O)(=O)=O.CS(O)(=O)=O.C[C@@H](N)COc1ccc(cc1)-c1cnc2ccc(N[C@H](C)c3cccc(F)c3)nn12 Chemical compound CS(O)(=O)=O.CS(O)(=O)=O.C[C@@H](N)COc1ccc(cc1)-c1cnc2ccc(N[C@H](C)c3cccc(F)c3)nn12 ZGEPJQFRZAXTQM-UWGSCQAASA-N 0.000 description 1
- QRZLVDCHVGWTPM-QZTJIDSGSA-N C[C@@H](NC1=NN2C(C=C1)=NC=C2C1=CC=C(OC[C@@H]2CCNC2)C=C1)C1=CC(F)=CC=C1 Chemical compound C[C@@H](NC1=NN2C(C=C1)=NC=C2C1=CC=C(OC[C@@H]2CCNC2)C=C1)C1=CC(F)=CC=C1 QRZLVDCHVGWTPM-QZTJIDSGSA-N 0.000 description 1
- LXSHMEFVGKOPBA-KDOFPFPSSA-N C[C@@H](Nc1ccc2ncc(-c3ccc(N4C[C@@H](N)CC4=O)c(F)c3)n2n1)c1cccc(F)c1 Chemical compound C[C@@H](Nc1ccc2ncc(-c3ccc(N4C[C@@H](N)CC4=O)c(F)c3)n2n1)c1cccc(F)c1 LXSHMEFVGKOPBA-KDOFPFPSSA-N 0.000 description 1
- FHBHXNZHLOJDPS-OAHLLOKOSA-N C[C@@H](Nc1ccc2ncc(-c3ccc(OC4CNC4)cc3)n2n1)c1cccc(F)c1 Chemical compound C[C@@H](Nc1ccc2ncc(-c3ccc(OC4CNC4)cc3)n2n1)c1cccc(F)c1 FHBHXNZHLOJDPS-OAHLLOKOSA-N 0.000 description 1
- PLVBUDUWVILKCR-MRXNPFEDSA-N C[C@@H](Nc1ccc2ncc(-c3ccc(OCC4(N)CC4)cc3)n2n1)c1cccc(F)c1 Chemical compound C[C@@H](Nc1ccc2ncc(-c3ccc(OCC4(N)CC4)cc3)n2n1)c1cccc(F)c1 PLVBUDUWVILKCR-MRXNPFEDSA-N 0.000 description 1
- WYEKYAISUNTPNR-MRXNPFEDSA-N C[C@@H](Nc1ccc2ncc(-c3ccc(OCC4CNC4)cc3)n2n1)c1cccc(F)c1 Chemical compound C[C@@H](Nc1ccc2ncc(-c3ccc(OCC4CNC4)cc3)n2n1)c1cccc(F)c1 WYEKYAISUNTPNR-MRXNPFEDSA-N 0.000 description 1
- YHEXMBUKTFFKQJ-MRXNPFEDSA-N C[C@@H](Nc1ccc2ncc(-c3ccc(OCCCN)cc3)n2n1)c1cccc(F)c1 Chemical compound C[C@@H](Nc1ccc2ncc(-c3ccc(OCCCN)cc3)n2n1)c1cccc(F)c1 YHEXMBUKTFFKQJ-MRXNPFEDSA-N 0.000 description 1
- IGVRCKYCFGWQSN-OAHLLOKOSA-N C[C@@H](Nc1ccc2ncc(-c3ccc(OCCN)cc3)n2n1)c1cccc(F)c1 Chemical compound C[C@@H](Nc1ccc2ncc(-c3ccc(OCCN)cc3)n2n1)c1cccc(F)c1 IGVRCKYCFGWQSN-OAHLLOKOSA-N 0.000 description 1
- NNZINGYTQYXVCS-QGZVFWFLSA-N C[C@@H](Nc1ccc2ncc(-c3ccc(OCCNC4CC4)cc3)n2n1)c1cccc(F)c1 Chemical compound C[C@@H](Nc1ccc2ncc(-c3ccc(OCCNC4CC4)cc3)n2n1)c1cccc(F)c1 NNZINGYTQYXVCS-QGZVFWFLSA-N 0.000 description 1
- AHBGYNUPYBINDK-QGZVFWFLSA-N C[C@@H](Nc1ccc2ncc(-c3ccc(OCCNCCO)cc3)n2n1)c1cccc(F)c1 Chemical compound C[C@@H](Nc1ccc2ncc(-c3ccc(OCCNCCO)cc3)n2n1)c1cccc(F)c1 AHBGYNUPYBINDK-QGZVFWFLSA-N 0.000 description 1
- GXLPATSYFRMQBK-BEFAXECRSA-N C[C@@H](Nc1ccc2ncc(-c3ccc(OC[C@@H](N)CO)cc3)n2n1)c1cccc(F)c1 Chemical compound C[C@@H](Nc1ccc2ncc(-c3ccc(OC[C@@H](N)CO)cc3)n2n1)c1cccc(F)c1 GXLPATSYFRMQBK-BEFAXECRSA-N 0.000 description 1
- DLPGZALEJXVOND-CZAAIQMYSA-N C[C@@H](Nc1ccc2ncc(-c3ccc(OC[C@@H]4C[C@H](F)CN4)cc3)n2n1)c1cccc(F)c1 Chemical compound C[C@@H](Nc1ccc2ncc(-c3ccc(OC[C@@H]4C[C@H](F)CN4)cc3)n2n1)c1cccc(F)c1 DLPGZALEJXVOND-CZAAIQMYSA-N 0.000 description 1
- GXLPATSYFRMQBK-DNVCBOLYSA-N C[C@@H](Nc1ccc2ncc(-c3ccc(OC[C@H](N)CO)cc3)n2n1)c1cccc(F)c1 Chemical compound C[C@@H](Nc1ccc2ncc(-c3ccc(OC[C@H](N)CO)cc3)n2n1)c1cccc(F)c1 GXLPATSYFRMQBK-DNVCBOLYSA-N 0.000 description 1
- IEVXQZXOTOZOTL-FQQGMQMYSA-N C[C@@H](Nc1ccc2ncc(-c3ccc(O[C@@H]4CCC[C@H]4N)cc3)n2n1)c1cccc(F)c1 Chemical compound C[C@@H](Nc1ccc2ncc(-c3ccc(O[C@@H]4CCC[C@H]4N)cc3)n2n1)c1cccc(F)c1 IEVXQZXOTOZOTL-FQQGMQMYSA-N 0.000 description 1
- DHECRPIXZSWCQM-IIBYNOLFSA-N C[C@@H](Nc1ccc2ncc(-c3ccc(O[C@@H]4CCNC4)cc3)n2n1)c1cccc(F)c1 Chemical compound C[C@@H](Nc1ccc2ncc(-c3ccc(O[C@@H]4CCNC4)cc3)n2n1)c1cccc(F)c1 DHECRPIXZSWCQM-IIBYNOLFSA-N 0.000 description 1
- IEVXQZXOTOZOTL-VZPUWSDOSA-N C[C@@H](Nc1ccc2ncc(-c3ccc(O[C@H]4CCC[C@H]4N)cc3)n2n1)c1cccc(F)c1 Chemical compound C[C@@H](Nc1ccc2ncc(-c3ccc(O[C@H]4CCC[C@H]4N)cc3)n2n1)c1cccc(F)c1 IEVXQZXOTOZOTL-VZPUWSDOSA-N 0.000 description 1
- GNOWOHHCTGUWJT-NQIIRXRSSA-N C[C@@H](Nc1ccc2ncc(-c3ccc(SC[C@@H]4CCCN4)cc3)n2n1)c1ccccc1 Chemical compound C[C@@H](Nc1ccc2ncc(-c3ccc(SC[C@@H]4CCCN4)cc3)n2n1)c1ccccc1 GNOWOHHCTGUWJT-NQIIRXRSSA-N 0.000 description 1
- KBVPFMBDQZRTLF-PBHICJAKSA-N C[C@@H](Nc1ccc2ncc(-c3ccc(cc3F)N3C[C@@H](N)CC3=O)n2n1)c1cccc(F)c1 Chemical compound C[C@@H](Nc1ccc2ncc(-c3ccc(cc3F)N3C[C@@H](N)CC3=O)n2n1)c1cccc(F)c1 KBVPFMBDQZRTLF-PBHICJAKSA-N 0.000 description 1
- MCSDYUREYQKRRG-WHSLLNHNSA-N C[C@@H](O)[C@H](N)COc1ccc(cc1)-c1cnc2ccc(N[C@H](C)c3cccc(F)c3)nn12 Chemical compound C[C@@H](O)[C@H](N)COc1ccc(cc1)-c1cnc2ccc(N[C@H](C)c3cccc(F)c3)nn12 MCSDYUREYQKRRG-WHSLLNHNSA-N 0.000 description 1
- HJWWUSZVNRISGR-UTKZUKDTSA-N C[C@@H](OC1=NN2C(C=C1)=NC=C2C1=CC=C(OC[C@@H]2CCCN2)C=C1)C1=CC(F)=CC=C1 Chemical compound C[C@@H](OC1=NN2C(C=C1)=NC=C2C1=CC=C(OC[C@@H]2CCCN2)C=C1)C1=CC(F)=CC=C1 HJWWUSZVNRISGR-UTKZUKDTSA-N 0.000 description 1
- MCSDYUREYQKRRG-XFQAVAEZSA-N C[C@H](O)[C@@H](N)COc1ccc(cc1)-c1cnc2ccc(N[C@H](C)c3cccc(F)c3)nn12 Chemical compound C[C@H](O)[C@@H](N)COc1ccc(cc1)-c1cnc2ccc(N[C@H](C)c3cccc(F)c3)nn12 MCSDYUREYQKRRG-XFQAVAEZSA-N 0.000 description 1
- FVLVBPDQNARYJU-XAHDHGMMSA-N C[C@H]1CCC(CC1)NC(=O)N(CCCl)N=O Chemical compound C[C@H]1CCC(CC1)NC(=O)N(CCCl)N=O FVLVBPDQNARYJU-XAHDHGMMSA-N 0.000 description 1
- KLWPJMFMVPTNCC-UHFFFAOYSA-N Camptothecin Natural products CCC1(O)C(=O)OCC2=C1C=C3C4Nc5ccccc5C=C4CN3C2=O KLWPJMFMVPTNCC-UHFFFAOYSA-N 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 201000009030 Carcinoma Diseases 0.000 description 1
- DLGOEMSEDOSKAD-UHFFFAOYSA-N Carmustine Chemical compound ClCCNC(=O)N(N=O)CCCl DLGOEMSEDOSKAD-UHFFFAOYSA-N 0.000 description 1
- UCHBOGDKZNYWSE-NSHDSACASA-N Cc1cc(ccc1Br)N1C[C@H](CC1=O)NC(=O)OC(C)(C)C Chemical compound Cc1cc(ccc1Br)N1C[C@H](CC1=O)NC(=O)OC(C)(C)C UCHBOGDKZNYWSE-NSHDSACASA-N 0.000 description 1
- RURLVUZRUFHCJO-UHFFFAOYSA-N Chromomycin A3 Natural products COC(C1Cc2cc3cc(OC4CC(OC(=O)C)C(OC5CC(O)C(OC)C(C)O5)C(C)O4)c(C)c(O)c3c(O)c2C(=O)C1OC6CC(OC7CC(C)(O)C(OC(=O)C)C(C)O7)C(O)C(C)O6)C(=O)C(O)C(C)O RURLVUZRUFHCJO-UHFFFAOYSA-N 0.000 description 1
- VMRISFUBMMZDQX-UHFFFAOYSA-N ClC1=CC(=NN1C)C(=O)N(C)OC Chemical compound ClC1=CC(=NN1C)C(=O)N(C)OC VMRISFUBMMZDQX-UHFFFAOYSA-N 0.000 description 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 description 1
- HTJDQJBWANPRPF-UHFFFAOYSA-N Cyclopropylamine Chemical compound NC1CC1 HTJDQJBWANPRPF-UHFFFAOYSA-N 0.000 description 1
- UHDGCWIWMRVCDJ-CCXZUQQUSA-N Cytarabine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1 UHDGCWIWMRVCDJ-CCXZUQQUSA-N 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- 238000000018 DNA microarray Methods 0.000 description 1
- 108010092160 Dactinomycin Proteins 0.000 description 1
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 description 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 1
- 238000002965 ELISA Methods 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 206010014733 Endometrial cancer Diseases 0.000 description 1
- 206010014759 Endometrial neoplasm Diseases 0.000 description 1
- HTIJFSOGRVMCQR-UHFFFAOYSA-N Epirubicin Natural products COc1cccc2C(=O)c3c(O)c4CC(O)(CC(OC5CC(N)C(=O)C(C)O5)c4c(O)c3C(=O)c12)C(=O)CO HTIJFSOGRVMCQR-UHFFFAOYSA-N 0.000 description 1
- 239000004593 Epoxy Substances 0.000 description 1
- BFPYWIDHMRZLRN-SLHNCBLASA-N Ethinyl estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 BFPYWIDHMRZLRN-SLHNCBLASA-N 0.000 description 1
- 101150073473 Etv6 gene Proteins 0.000 description 1
- 102100020903 Ezrin Human genes 0.000 description 1
- OMAZPUFUUNZUEG-FQEVSTJZSA-N FC1=CC=CC(COC2=NN3C(C=C2)=NC=C3C2=CC=C(OC[C@@H]3CCCN3)C=C2)=C1 Chemical compound FC1=CC=CC(COC2=NN3C(C=C2)=NC=C3C2=CC=C(OC[C@@H]3CCCN3)C=C2)=C1 OMAZPUFUUNZUEG-FQEVSTJZSA-N 0.000 description 1
- AQTCVEDHZLMPHQ-HXUWFJFHSA-N FC1=CC=CC(COC2=NN3C(C=C2)=NC=C3C2=CC=C(O[C@@H]3CCNC3)C=C2)=C1 Chemical compound FC1=CC=CC(COC2=NN3C(C=C2)=NC=C3C2=CC=C(O[C@@H]3CCNC3)C=C2)=C1 AQTCVEDHZLMPHQ-HXUWFJFHSA-N 0.000 description 1
- DIWQVYSWGUPVON-QGZVFWFLSA-N FC=1C=C(C=CC1)[C@@H](C)OC=1C=CC=2N(N1)C(=CN2)C2=CC=C(C=C2)OC2CCNCC2 Chemical compound FC=1C=C(C=CC1)[C@@H](C)OC=1C=CC=2N(N1)C(=CN2)C2=CC=C(C=C2)OC2CCNCC2 DIWQVYSWGUPVON-QGZVFWFLSA-N 0.000 description 1
- NPDRLAMGJGZJIB-QGZVFWFLSA-N FC=1C=C(C=CC=1)[C@@H](C)NC=1C=CC=2N(N=1)C(=CN=2)C1=CC(=CC=C1)OCCCNC Chemical compound FC=1C=C(C=CC=1)[C@@H](C)NC=1C=CC=2N(N=1)C(=CN=2)C1=CC(=CC=C1)OCCCNC NPDRLAMGJGZJIB-QGZVFWFLSA-N 0.000 description 1
- MZLXAPDXSQRJLB-MRXNPFEDSA-N FC=1C=C(C=CC=1)[C@@H](C)NC=1C=CC=2N(N=1)C(=CN=2)C1=CC(=CC=C1)OCCNC Chemical compound FC=1C=C(C=CC=1)[C@@H](C)NC=1C=CC=2N(N=1)C(=CN=2)C1=CC(=CC=C1)OCCNC MZLXAPDXSQRJLB-MRXNPFEDSA-N 0.000 description 1
- RRTLJHSCAASNJW-UTKZUKDTSA-N FC=1C=C(C=CC=1)[C@@H](C)NC=1C=CC=2N(N=1)C(=CN=2)C1=CC(=CC=C1)OC[C@H]1NCCC1 Chemical compound FC=1C=C(C=CC=1)[C@@H](C)NC=1C=CC=2N(N=1)C(=CN=2)C1=CC(=CC=C1)OC[C@H]1NCCC1 RRTLJHSCAASNJW-UTKZUKDTSA-N 0.000 description 1
- UWRVQXPYHVTKLV-ZYMOGRSISA-N FC=1C=C(C=CC=1)[C@@H](C)NC=1C=CC=2N(N=1)C(=CN=2)C1=CC=C(C=C1)OCC(C)NC Chemical compound FC=1C=C(C=CC=1)[C@@H](C)NC=1C=CC=2N(N=1)C(=CN=2)C1=CC=C(C=C1)OCC(C)NC UWRVQXPYHVTKLV-ZYMOGRSISA-N 0.000 description 1
- ISXRYVJOVKBIKB-VGSWGCGISA-N FC=1C=C(C=CC=1)[C@@H](C)NC=1C=CC=2N(N=1)C(=CN=2)C=1C=CC(=C(C#N)C=1)OC[C@H]1NCCC1 Chemical compound FC=1C=C(C=CC=1)[C@@H](C)NC=1C=CC=2N(N=1)C(=CN=2)C=1C=CC(=C(C#N)C=1)OC[C@H]1NCCC1 ISXRYVJOVKBIKB-VGSWGCGISA-N 0.000 description 1
- PUAMGDUEIWYILP-OAHLLOKOSA-N FC=1C=C(C=CC=1)[C@@H](C)NC=1C=CC=2N(N=1)C(=CN=2)C=1C=NC(=CC=1)OCCNC Chemical compound FC=1C=C(C=CC=1)[C@@H](C)NC=1C=CC=2N(N=1)C(=CN=2)C=1C=NC(=CC=1)OCCNC PUAMGDUEIWYILP-OAHLLOKOSA-N 0.000 description 1
- ADCRVMPJTPEOLM-XPGWFJOJSA-N FC=1C=C(C=CC=1)[C@@H](C)NC=1C=CC=2N(N=1)C(=CN=2)C=1C=NC(=CC=1)OC[C@H]1NC[C@H](C1)F Chemical compound FC=1C=C(C=CC=1)[C@@H](C)NC=1C=CC=2N(N=1)C(=CN=2)C=1C=NC(=CC=1)OC[C@H]1NC[C@H](C1)F ADCRVMPJTPEOLM-XPGWFJOJSA-N 0.000 description 1
- UFXMZDJQZJJAHF-BEFAXECRSA-N FC=1C=C(C=NC=1)[C@@H](C)OC=1C=CC=2N(N=1)C(=CN=2)C1=CC=C(C=C1)N1C(C[C@@H](C1)NC)=O Chemical compound FC=1C=C(C=NC=1)[C@@H](C)OC=1C=CC=2N(N=1)C(=CN=2)C1=CC=C(C=C1)N1C(C[C@@H](C1)NC)=O UFXMZDJQZJJAHF-BEFAXECRSA-N 0.000 description 1
- KRHYYFGTRYWZRS-UHFFFAOYSA-N Fluorane Chemical compound F KRHYYFGTRYWZRS-UHFFFAOYSA-N 0.000 description 1
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 description 1
- DCXXMTOCNZCJGO-UHFFFAOYSA-N Glycerol trioctadecanoate Natural products CCCCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC DCXXMTOCNZCJGO-UHFFFAOYSA-N 0.000 description 1
- 102100021181 Golgi phosphoprotein 3 Human genes 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- 101000854648 Homo sapiens Ezrin Proteins 0.000 description 1
- 101001040734 Homo sapiens Golgi phosphoprotein 3 Proteins 0.000 description 1
- 101001017855 Homo sapiens Leucine-rich repeats and immunoglobulin-like domains protein 3 Proteins 0.000 description 1
- 101000874179 Homo sapiens Syndecan-1 Proteins 0.000 description 1
- 101000850794 Homo sapiens Tropomyosin alpha-3 chain Proteins 0.000 description 1
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 description 1
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical class NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 description 1
- CIWBSHSKHKDKBQ-JLAZNSOCSA-M L-ascorbate Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] CIWBSHSKHKDKBQ-JLAZNSOCSA-M 0.000 description 1
- 150000000994 L-ascorbates Chemical class 0.000 description 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical class NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 1
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 description 1
- 239000005411 L01XE02 - Gefitinib Substances 0.000 description 1
- 239000005551 L01XE03 - Erlotinib Substances 0.000 description 1
- 239000002147 L01XE04 - Sunitinib Substances 0.000 description 1
- 239000005511 L01XE05 - Sorafenib Substances 0.000 description 1
- 239000002136 L01XE07 - Lapatinib Substances 0.000 description 1
- XNRVGTHNYCNCFF-UHFFFAOYSA-N Lapatinib ditosylate monohydrate Chemical compound O.CC1=CC=C(S(O)(=O)=O)C=C1.CC1=CC=C(S(O)(=O)=O)C=C1.O1C(CNCCS(=O)(=O)C)=CC=C1C1=CC=C(N=CN=C2NC=3C=C(Cl)C(OCC=4C=C(F)C=CC=4)=CC=3)C2=C1 XNRVGTHNYCNCFF-UHFFFAOYSA-N 0.000 description 1
- 102100033284 Leucine-rich repeats and immunoglobulin-like domains protein 3 Human genes 0.000 description 1
- GQYIWUVLTXOXAJ-UHFFFAOYSA-N Lomustine Chemical compound ClCCN(N=O)C(=O)NC1CCCCC1 GQYIWUVLTXOXAJ-UHFFFAOYSA-N 0.000 description 1
- 238000000134 MTT assay Methods 0.000 description 1
- 231100000002 MTT assay Toxicity 0.000 description 1
- FQISKWAFAHGMGT-SGJOWKDISA-M Methylprednisolone sodium succinate Chemical compound [Na+].C([C@@]12C)=CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2[C@@H](O)C[C@]2(C)[C@@](O)(C(=O)COC(=O)CCC([O-])=O)CC[C@H]21 FQISKWAFAHGMGT-SGJOWKDISA-M 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 208000005927 Myosarcoma Diseases 0.000 description 1
- DQHWJOGBYMMGED-UHFFFAOYSA-N N-benzyl-3-[4-[tert-butyl(dimethyl)silyl]oxyphenyl]imidazo[1,2-b]pyridazin-6-amine Chemical compound C(C1=CC=CC=C1)NC=1C=CC=2N(N1)C(=CN2)C2=CC=C(C=C2)O[Si](C)(C)C(C)(C)C DQHWJOGBYMMGED-UHFFFAOYSA-N 0.000 description 1
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 description 1
- PLWQVWUZZPOHLZ-QRWLVFNGSA-N N1[C@@H](CC1)COC=1C=C(C=C(C=1)F)C1=CN=C2N1N=C(C=C2)N[C@H](C)C1=CC(=CC=C1)F Chemical compound N1[C@@H](CC1)COC=1C=C(C=C(C=1)F)C1=CN=C2N1N=C(C=C2)N[C@H](C)C1=CC(=CC=C1)F PLWQVWUZZPOHLZ-QRWLVFNGSA-N 0.000 description 1
- SQECEEZNIYHZBQ-UZLBHIALSA-N N1[C@@H](CC1)COC=1C=C(C=CC=1)C1=CN=C2N1N=C(C=C2)N[C@H](C)C1=CC(=CC=C1)F Chemical compound N1[C@@H](CC1)COC=1C=C(C=CC=1)C1=CN=C2N1N=C(C=C2)N[C@H](C)C1=CC(=CC=C1)F SQECEEZNIYHZBQ-UZLBHIALSA-N 0.000 description 1
- CUOFSCWYNKVGRQ-BEFAXECRSA-N N1[C@@H](CC1)COC=1C=C(C=CC=1F)C1=CN=C2N1N=C(C=C2)N[C@H](C)C1=CC(=CC=C1)F Chemical compound N1[C@@H](CC1)COC=1C=C(C=CC=1F)C1=CN=C2N1N=C(C=C2)N[C@H](C)C1=CC(=CC=C1)F CUOFSCWYNKVGRQ-BEFAXECRSA-N 0.000 description 1
- XWYQHTIHHDVVQH-UHFFFAOYSA-N NC1(CC(N(C1)C1=CC=C(C=C1)C1=CN=C2N1N=C(C=C2)N(C)CC=1C=NC=C(C=1)Cl)=O)C Chemical compound NC1(CC(N(C1)C1=CC=C(C=C1)C1=CN=C2N1N=C(C=C2)N(C)CC=1C=NC=C(C=1)Cl)=O)C XWYQHTIHHDVVQH-UHFFFAOYSA-N 0.000 description 1
- WWETYMBQGBQQHI-UHFFFAOYSA-N NC1(CC(N(C1)CC1=CC=C(C=C1)OC)=O)C Chemical compound NC1(CC(N(C1)CC1=CC=C(C=C1)OC)=O)C WWETYMBQGBQQHI-UHFFFAOYSA-N 0.000 description 1
- YXXCYJFEHPUIPC-UHFFFAOYSA-N NC1C(N(CC1)C1=CC=C(C=C1)C1=CN=C2N1N=C(C=C2)OCC1=CC(=CC=C1)F)=O Chemical compound NC1C(N(CC1)C1=CC=C(C=C1)C1=CN=C2N1N=C(C=C2)OCC1=CC(=CC=C1)F)=O YXXCYJFEHPUIPC-UHFFFAOYSA-N 0.000 description 1
- ROFHSOCMQNVNGI-UHFFFAOYSA-N NC1CC(N(C1)C1=CC=C(C=C1)C1=CN=C2N1N=C(C=C2)N(C)CC1=CC(=CC=C1)F)=O Chemical compound NC1CC(N(C1)C1=CC=C(C=C1)C1=CN=C2N1N=C(C=C2)N(C)CC1=CC(=CC=C1)F)=O ROFHSOCMQNVNGI-UHFFFAOYSA-N 0.000 description 1
- ACSBJDNLBNQQCA-UHFFFAOYSA-N NCC1CC(N(C1)C1=CC=C(C=C1)C1=CN=C2N1N=C(C=C2)OCC1=CC(=CC=C1)F)=O Chemical compound NCC1CC(N(C1)C1=CC=C(C=C1)C1=CN=C2N1N=C(C=C2)OCC1=CC(=CC=C1)F)=O ACSBJDNLBNQQCA-UHFFFAOYSA-N 0.000 description 1
- ARAYWFNSURRLSG-MRXNPFEDSA-N NCCCOC=1C=C(C=CC=1)C1=CN=C2N1N=C(C=C2)N[C@H](C)C1=CC(=CC=C1)F Chemical compound NCCCOC=1C=C(C=CC=1)C1=CN=C2N1N=C(C=C2)N[C@H](C)C1=CC(=CC=C1)F ARAYWFNSURRLSG-MRXNPFEDSA-N 0.000 description 1
- SZXHLXIUGSOOSR-UHFFFAOYSA-N NCCOC1=CC=C(C=C1)C1=CN=C2C=CC(OCC3=CC(F)=CC=C3)=NN12 Chemical compound NCCOC1=CC=C(C=C1)C1=CN=C2C=CC(OCC3=CC(F)=CC=C3)=NN12 SZXHLXIUGSOOSR-UHFFFAOYSA-N 0.000 description 1
- 101150111783 NTRK1 gene Proteins 0.000 description 1
- 101150117329 NTRK3 gene Proteins 0.000 description 1
- IHIIBNLKRNVRKW-OXQOHEQNSA-N N[C@@H](COC1=CC=C(C=C1)C1=CN=C2N1N=C(C=C2)N[C@H](C)C1=CC(=CC=C1)F)CC Chemical compound N[C@@H](COC1=CC=C(C=C1)C1=CN=C2N1N=C(C=C2)N[C@H](C)C1=CC(=CC=C1)F)CC IHIIBNLKRNVRKW-OXQOHEQNSA-N 0.000 description 1
- XFMUNUGRBVFEHS-HUUCEWRRSA-N N[C@@H](COC1=CC=C(C=N1)C1=CN=C2N1N=C(C=C2)N[C@H](C)C1=CC(=CC=C1)F)C Chemical compound N[C@@H](COC1=CC=C(C=N1)C1=CN=C2N1N=C(C=C2)N[C@H](C)C1=CC(=CC=C1)F)C XFMUNUGRBVFEHS-HUUCEWRRSA-N 0.000 description 1
- XTEPTPUTCLFBSA-HZPDHXFCSA-N N[C@@H](COC=1C=C(C=CC=1)C1=CN=C2N1N=C(C=C2)N[C@H](C)C1=CC(=CC=C1)F)C Chemical compound N[C@@H](COC=1C=C(C=CC=1)C1=CN=C2N1N=C(C=C2)N[C@H](C)C1=CC(=CC=C1)F)C XTEPTPUTCLFBSA-HZPDHXFCSA-N 0.000 description 1
- IHIIBNLKRNVRKW-UZLBHIALSA-N N[C@H](COC1=CC=C(C=C1)C1=CN=C2N1N=C(C=C2)N[C@H](C)C1=CC(=CC=C1)F)CC Chemical compound N[C@H](COC1=CC=C(C=C1)C1=CN=C2N1N=C(C=C2)N[C@H](C)C1=CC(=CC=C1)F)CC IHIIBNLKRNVRKW-UZLBHIALSA-N 0.000 description 1
- XFMUNUGRBVFEHS-LSDHHAIUSA-N N[C@H](COC1=CC=C(C=N1)C1=CN=C2N1N=C(C=C2)N[C@H](C)C1=CC(=CC=C1)F)C Chemical compound N[C@H](COC1=CC=C(C=N1)C1=CN=C2N1N=C(C=C2)N[C@H](C)C1=CC(=CC=C1)F)C XFMUNUGRBVFEHS-LSDHHAIUSA-N 0.000 description 1
- XTEPTPUTCLFBSA-JKSUJKDBSA-N N[C@H](COC=1C=C(C=CC=1)C1=CN=C2N1N=C(C=C2)N[C@H](C)C1=CC(=CC=C1)F)C Chemical compound N[C@H](COC=1C=C(C=CC=1)C1=CN=C2N1N=C(C=C2)N[C@H](C)C1=CC(=CC=C1)F)C XTEPTPUTCLFBSA-JKSUJKDBSA-N 0.000 description 1
- UAXHJFKKIGPHPL-FQEVSTJZSA-N N[C@H]1CC(N(C1)C1=C(C#N)C=C(C=C1)C1=CN=C2N1N=C(C=C2)N(C)CC1=CC(=CC=C1)F)=O Chemical compound N[C@H]1CC(N(C1)C1=C(C#N)C=C(C=C1)C1=CN=C2N1N=C(C=C2)N(C)CC1=CC(=CC=C1)F)=O UAXHJFKKIGPHPL-FQEVSTJZSA-N 0.000 description 1
- PTYQKSNTVHVNOR-SFHVURJKSA-N N[C@H]1CC(N(C1)C1=C(C=C(C=C1)C1=CN=C2N1N=C(C=C2)N(C)CC1=CC(=CC=C1)F)F)=O Chemical compound N[C@H]1CC(N(C1)C1=C(C=C(C=C1)C1=CN=C2N1N=C(C=C2)N(C)CC1=CC(=CC=C1)F)F)=O PTYQKSNTVHVNOR-SFHVURJKSA-N 0.000 description 1
- JPYGXAHRDNAXEU-DYVFJYSZSA-N N[C@H]1CC(N(C1)C1=C(C=C(C=C1)C1=CN=C2N1N=C(C=C2)O[C@H](C)C=1C=NC=C(C=1)F)F)=O Chemical compound N[C@H]1CC(N(C1)C1=C(C=C(C=C1)C1=CN=C2N1N=C(C=C2)O[C@H](C)C=1C=NC=C(C=1)F)F)=O JPYGXAHRDNAXEU-DYVFJYSZSA-N 0.000 description 1
- RZZHHASZAJISAU-CJNGLKHVSA-N N[C@H]1CC(N(C1)C1=CC(=C(C=C1)C1=CN=C2N1N=C(C=C2)O[C@H](C)C=1C=NC=C(C=1)F)F)=O Chemical compound N[C@H]1CC(N(C1)C1=CC(=C(C=C1)C1=CN=C2N1N=C(C=C2)O[C@H](C)C=1C=NC=C(C=1)F)F)=O RZZHHASZAJISAU-CJNGLKHVSA-N 0.000 description 1
- YTKIIKOTVQBACJ-KRWDZBQOSA-N N[C@H]1CC(N(C1)C1=CC=C(C=C1)C1=CN=C2N1N=C(C=C2)N(C)CC1=C(C(=CC=C1)F)F)=O Chemical compound N[C@H]1CC(N(C1)C1=CC=C(C=C1)C1=CN=C2N1N=C(C=C2)N(C)CC1=C(C(=CC=C1)F)F)=O YTKIIKOTVQBACJ-KRWDZBQOSA-N 0.000 description 1
- ZOOBHNSVEZIMBX-SFHVURJKSA-N N[C@H]1CC(N(C1)C1=CC=C(C=C1)C1=CN=C2N1N=C(C=C2)N(C)CC1=C(C=CC(=C1)F)Cl)=O Chemical compound N[C@H]1CC(N(C1)C1=CC=C(C=C1)C1=CN=C2N1N=C(C=C2)N(C)CC1=C(C=CC(=C1)F)Cl)=O ZOOBHNSVEZIMBX-SFHVURJKSA-N 0.000 description 1
- LYIQEWRSSMPQTG-SFHVURJKSA-N N[C@H]1CC(N(C1)C1=CC=C(C=C1)C1=CN=C2N1N=C(C=C2)N(C)CC1=C(C=CC(=C1)F)F)=O Chemical compound N[C@H]1CC(N(C1)C1=CC=C(C=C1)C1=CN=C2N1N=C(C=C2)N(C)CC1=C(C=CC(=C1)F)F)=O LYIQEWRSSMPQTG-SFHVURJKSA-N 0.000 description 1
- OAKKVLFTNLCZBP-SFHVURJKSA-N N[C@H]1CC(N(C1)C1=CC=C(C=C1)C1=CN=C2N1N=C(C=C2)N(C)CC=1C=NC=C(C=1)Cl)=O Chemical compound N[C@H]1CC(N(C1)C1=CC=C(C=C1)C1=CN=C2N1N=C(C=C2)N(C)CC=1C=NC=C(C=1)Cl)=O OAKKVLFTNLCZBP-SFHVURJKSA-N 0.000 description 1
- LTANOCHPLSYTPW-SFHVURJKSA-N N[C@H]1CC(N(C1)C1=CC=C(C=C1)C1=CN=C2N1N=C(C=C2)N(C)CC=1C=NC=C(C=1)F)=O Chemical compound N[C@H]1CC(N(C1)C1=CC=C(C=C1)C1=CN=C2N1N=C(C=C2)N(C)CC=1C=NC=C(C=1)F)=O LTANOCHPLSYTPW-SFHVURJKSA-N 0.000 description 1
- GWVCYKQAZQTYBF-JRZJBTRGSA-N N[C@H]1CC(N(C1)C1=CC=C(C=C1)C1=CN=C2N1N=C(C=C2)OC(C)C1=C(C=CC(=C1)F)F)=O Chemical compound N[C@H]1CC(N(C1)C1=CC=C(C=C1)C1=CN=C2N1N=C(C=C2)OC(C)C1=C(C=CC(=C1)F)F)=O GWVCYKQAZQTYBF-JRZJBTRGSA-N 0.000 description 1
- BXWGKCYLSXXFLS-CVMIBEPCSA-N N[C@H]1CC(N(C1)C1=CC=C(C=C1)C1=CN=C2N1N=C(C=C2)OC(C)C1=C(C=CC(=C1)F)N1N=CC=N1)=O Chemical compound N[C@H]1CC(N(C1)C1=CC=C(C=C1)C1=CN=C2N1N=C(C=C2)OC(C)C1=C(C=CC(=C1)F)N1N=CC=N1)=O BXWGKCYLSXXFLS-CVMIBEPCSA-N 0.000 description 1
- TUBICTYHHIXKPH-WUJWULDRSA-N N[C@H]1CC(N(C1)C1=CC=C(C=C1)C1=CN=C2N1N=C(C=C2)OC(C)C1=NN(C(=C1)Cl)C)=O Chemical compound N[C@H]1CC(N(C1)C1=CC=C(C=C1)C1=CN=C2N1N=C(C=C2)OC(C)C1=NN(C(=C1)Cl)C)=O TUBICTYHHIXKPH-WUJWULDRSA-N 0.000 description 1
- SZLJNFFTYNOYEP-SFHVURJKSA-N N[C@H]1CC(N(C1)C1=CC=C(C=C1)C1=CN=C2N1N=C(C=C2)OCC1=CC(=CC=C1)F)=O Chemical compound N[C@H]1CC(N(C1)C1=CC=C(C=C1)C1=CN=C2N1N=C(C=C2)OCC1=CC(=CC=C1)F)=O SZLJNFFTYNOYEP-SFHVURJKSA-N 0.000 description 1
- BTIRONZTPUCNAX-INIZCTEOSA-N N[C@H]1CC(N(C1)C1=NC=C(C=C1)C1=CN=C2N1N=C(C=C2)N(C)CC1=C(C(=CC=C1)F)F)=O Chemical compound N[C@H]1CC(N(C1)C1=NC=C(C=C1)C1=CN=C2N1N=C(C=C2)N(C)CC1=C(C(=CC=C1)F)F)=O BTIRONZTPUCNAX-INIZCTEOSA-N 0.000 description 1
- SYEWWVGYBGJNMP-KRWDZBQOSA-N N[C@H]1CC(N(C1)C1=NC=C(C=C1)C1=CN=C2N1N=C(C=C2)N(C)CC1=C(C=CC(=C1)F)F)=O Chemical compound N[C@H]1CC(N(C1)C1=NC=C(C=C1)C1=CN=C2N1N=C(C=C2)N(C)CC1=C(C=CC(=C1)F)F)=O SYEWWVGYBGJNMP-KRWDZBQOSA-N 0.000 description 1
- CTOFUYOZLWIYNP-SFHVURJKSA-N N[C@H]1CC(N(C1)C1=NC=C(C=C1)C1=CN=C2N1N=C(C=C2)N(C)CC1=CC(=CC=C1)F)=O Chemical compound N[C@H]1CC(N(C1)C1=NC=C(C=C1)C1=CN=C2N1N=C(C=C2)N(C)CC1=CC(=CC=C1)F)=O CTOFUYOZLWIYNP-SFHVURJKSA-N 0.000 description 1
- 108700019961 Neoplasm Genes Proteins 0.000 description 1
- 102000048850 Neoplasm Genes Human genes 0.000 description 1
- 206010029260 Neuroblastoma Diseases 0.000 description 1
- 102100033857 Neurotrophin-4 Human genes 0.000 description 1
- 238000000636 Northern blotting Methods 0.000 description 1
- 101150056950 Ntrk2 gene Proteins 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 229930012538 Paclitaxel Natural products 0.000 description 1
- 108010057150 Peplomycin Proteins 0.000 description 1
- 229920001214 Polysorbate 60 Polymers 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 102000001708 Protein Isoforms Human genes 0.000 description 1
- 108010029485 Protein Isoforms Proteins 0.000 description 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 description 1
- 239000012980 RPMI-1640 medium Substances 0.000 description 1
- AHHFEZNOXOZZQA-ZEBDFXRSSA-N Ranimustine Chemical compound CO[C@H]1O[C@H](CNC(=O)N(CCCl)N=O)[C@@H](O)[C@H](O)[C@H]1O AHHFEZNOXOZZQA-ZEBDFXRSSA-N 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 108090000873 Receptor Protein-Tyrosine Kinases Proteins 0.000 description 1
- 229920001800 Shellac Polymers 0.000 description 1
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
- 238000002105 Southern blotting Methods 0.000 description 1
- 102100035721 Syndecan-1 Human genes 0.000 description 1
- 229940123237 Taxane Drugs 0.000 description 1
- WFWLQNSHRPWKFK-UHFFFAOYSA-N Tegafur Chemical compound O=C1NC(=O)C(F)=CN1C1OCCC1 WFWLQNSHRPWKFK-UHFFFAOYSA-N 0.000 description 1
- FOCVUCIESVLUNU-UHFFFAOYSA-N Thiotepa Chemical compound C1CN1P(N1CC1)(=S)N1CC1 FOCVUCIESVLUNU-UHFFFAOYSA-N 0.000 description 1
- IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 description 1
- 101150043385 Tpm3 gene Proteins 0.000 description 1
- 229920001615 Tragacanth Polymers 0.000 description 1
- 102000005937 Tropomyosin Human genes 0.000 description 1
- 108010030743 Tropomyosin Proteins 0.000 description 1
- 102100033080 Tropomyosin alpha-3 chain Human genes 0.000 description 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 1
- 241001069823 UR2 sarcoma virus Species 0.000 description 1
- JXLYSJRDGCGARV-WWYNWVTFSA-N Vinblastine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@](O)(CC)C[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C JXLYSJRDGCGARV-WWYNWVTFSA-N 0.000 description 1
- 229940122803 Vinca alkaloid Drugs 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 235000010724 Wisteria floribunda Nutrition 0.000 description 1
- LXRZVMYMQHNYJB-UNXOBOICSA-N [(1R,2S,4R)-4-[[5-[4-[(1R)-7-chloro-1,2,3,4-tetrahydroisoquinolin-1-yl]-5-methylthiophene-2-carbonyl]pyrimidin-4-yl]amino]-2-hydroxycyclopentyl]methyl sulfamate Chemical compound CC1=C(C=C(S1)C(=O)C1=C(N[C@H]2C[C@H](O)[C@@H](COS(N)(=O)=O)C2)N=CN=C1)[C@@H]1NCCC2=C1C=C(Cl)C=C2 LXRZVMYMQHNYJB-UNXOBOICSA-N 0.000 description 1
- RLEIFUHYMILCOD-UHFFFAOYSA-N [1-(4-bromophenyl)-5-oxopyrrolidin-3-yl]methyl methanesulfonate Chemical compound O=C1CC(COS(=O)(=O)C)CN1C1=CC=C(Br)C=C1 RLEIFUHYMILCOD-UHFFFAOYSA-N 0.000 description 1
- 229940124532 absorption promoter Drugs 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- ZOZKYEHVNDEUCO-XUTVFYLZSA-N aceglatone Chemical compound O1C(=O)[C@H](OC(C)=O)[C@@H]2OC(=O)[C@@H](OC(=O)C)[C@@H]21 ZOZKYEHVNDEUCO-XUTVFYLZSA-N 0.000 description 1
- 229950002684 aceglatone Drugs 0.000 description 1
- 150000001242 acetic acid derivatives Chemical class 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- USZYSDMBJDPRIF-SVEJIMAYSA-N aclacinomycin A Chemical compound O([C@H]1[C@@H](O)C[C@@H](O[C@H]1C)O[C@H]1[C@H](C[C@@H](O[C@H]1C)O[C@H]1C[C@]([C@@H](C2=CC=3C(=O)C4=CC=CC(O)=C4C(=O)C=3C(O)=C21)C(=O)OC)(O)CC)N(C)C)[C@H]1CCC(=O)[C@H](C)O1 USZYSDMBJDPRIF-SVEJIMAYSA-N 0.000 description 1
- 229960004176 aclarubicin Drugs 0.000 description 1
- RJURFGZVJUQBHK-IIXSONLDSA-N actinomycin D Chemical compound C[C@H]1OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@@H]2CCCN2C(=O)[C@@H](C(C)C)NC(=O)[C@H]1NC(=O)C1=C(N)C(=O)C(C)=C2OC(C(C)=CC=C3C(=O)N[C@@H]4C(=O)N[C@@H](C(N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)=O)C(C)C)=C3N=C21 RJURFGZVJUQBHK-IIXSONLDSA-N 0.000 description 1
- WNLRTRBMVRJNCN-UHFFFAOYSA-L adipate(2-) Chemical compound [O-]C(=O)CCCCC([O-])=O WNLRTRBMVRJNCN-UHFFFAOYSA-L 0.000 description 1
- 239000003463 adsorbent Substances 0.000 description 1
- 229940045714 alkyl sulfonate alkylating agent Drugs 0.000 description 1
- 230000029936 alkylation Effects 0.000 description 1
- 238000005804 alkylation reaction Methods 0.000 description 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
- 229940024606 amino acid Drugs 0.000 description 1
- 125000004202 aminomethyl group Chemical group [H]N([H])C([H])([H])* 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-N ammonia Natural products N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 1
- 239000003817 anthracycline antibiotic agent Substances 0.000 description 1
- 210000000436 anus Anatomy 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
- 125000000637 arginyl group Chemical class N[C@@H](CCCNC(N)=N)C(=O)* 0.000 description 1
- 125000005228 aryl sulfonate group Chemical group 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 229940009098 aspartate Drugs 0.000 description 1
- 238000011914 asymmetric synthesis Methods 0.000 description 1
- VSRXQHXAPYXROS-UHFFFAOYSA-N azanide;cyclobutane-1,1-dicarboxylic acid;platinum(2+) Chemical compound [NH2-].[NH2-].[Pt+2].OC(=O)C1(C(O)=O)CCC1 VSRXQHXAPYXROS-UHFFFAOYSA-N 0.000 description 1
- 125000002393 azetidinyl group Chemical group 0.000 description 1
- 125000004069 aziridinyl group Chemical group 0.000 description 1
- 239000004637 bakelite Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000000440 bentonite Substances 0.000 description 1
- 229910000278 bentonite Inorganic materials 0.000 description 1
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
- 235000010233 benzoic acid Nutrition 0.000 description 1
- 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 description 1
- 229960002537 betamethasone Drugs 0.000 description 1
- UREBDLICKHMUKA-DVTGEIKXSA-N betamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-DVTGEIKXSA-N 0.000 description 1
- 229960000397 bevacizumab Drugs 0.000 description 1
- 229960001561 bleomycin Drugs 0.000 description 1
- OYVAGSVQBOHSSS-UAPAGMARSA-O bleomycin A2 Chemical compound N([C@H](C(=O)N[C@H](C)[C@@H](O)[C@H](C)C(=O)N[C@@H]([C@H](O)C)C(=O)NCCC=1SC=C(N=1)C=1SC=C(N=1)C(=O)NCCC[S+](C)C)[C@@H](O[C@H]1[C@H]([C@@H](O)[C@H](O)[C@H](CO)O1)O[C@@H]1[C@H]([C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O1)O)C=1N=CNC=1)C(=O)C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C OYVAGSVQBOHSSS-UAPAGMARSA-O 0.000 description 1
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 1
- 239000004327 boric acid Substances 0.000 description 1
- UWTDFICHZKXYAC-UHFFFAOYSA-N boron;oxolane Chemical compound [B].C1CCOC1 UWTDFICHZKXYAC-UHFFFAOYSA-N 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 125000005997 bromomethyl group Chemical group 0.000 description 1
- 229950004398 broxuridine Drugs 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 229960002092 busulfan Drugs 0.000 description 1
- 125000004106 butoxy group Chemical group [*]OC([H])([H])C([H])([H])C(C([H])([H])[H])([H])[H] 0.000 description 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- LSPHULWDVZXLIL-QUBYGPBYSA-N camphoric acid Chemical compound CC1(C)[C@H](C(O)=O)CC[C@]1(C)C(O)=O LSPHULWDVZXLIL-QUBYGPBYSA-N 0.000 description 1
- 229940127093 camptothecin Drugs 0.000 description 1
- VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical compound C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 150000001721 carbon Chemical group 0.000 description 1
- 229960004562 carboplatin Drugs 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 229960005243 carmustine Drugs 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 230000010307 cell transformation Effects 0.000 description 1
- 239000012094 cell viability reagent Substances 0.000 description 1
- 238000012054 celltiter-glo Methods 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 235000010980 cellulose Nutrition 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 229960005395 cetuximab Drugs 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 229960004630 chlorambucil Drugs 0.000 description 1
- JCKYGMPEJWAADB-UHFFFAOYSA-N chlorambucil Chemical compound OC(=O)CCCC1=CC=C(N(CCCl)CCCl)C=C1 JCKYGMPEJWAADB-UHFFFAOYSA-N 0.000 description 1
- VUHJZBBCZGVNDZ-TTYLFXKOSA-N chlormadinone Chemical compound C1=C(Cl)C2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)C)(O)[C@@]1(C)CC2 VUHJZBBCZGVNDZ-TTYLFXKOSA-N 0.000 description 1
- 229960003996 chlormadinone Drugs 0.000 description 1
- PSEHHVRCDVOTID-NAVXHOJHSA-N chloro-bis[(1s,3s,4r,5s)-4,6,6-trimethyl-3-bicyclo[3.1.1]heptanyl]borane Chemical compound C([C@@H]([C@H]1C)B(Cl)[C@@H]2[C@@H](C)[C@@]3(C[C@](C2)(C3(C)C)[H])[H])[C@]2([H])C(C)(C)[C@@]1([H])C2 PSEHHVRCDVOTID-NAVXHOJHSA-N 0.000 description 1
- RCTFHBWTYQOVGJ-UHFFFAOYSA-N chloroform;dichloromethane Chemical compound ClCCl.ClC(Cl)Cl RCTFHBWTYQOVGJ-UHFFFAOYSA-N 0.000 description 1
- 125000004218 chloromethyl group Chemical group [H]C([H])(Cl)* 0.000 description 1
- ZYVSOIYQKUDENJ-WKSBCEQHSA-N chromomycin A3 Chemical compound O([C@@H]1C[C@@H](O[C@H](C)[C@@H]1OC(C)=O)OC=1C=C2C=C3C[C@H]([C@@H](C(=O)C3=C(O)C2=C(O)C=1C)O[C@@H]1O[C@H](C)[C@@H](O)[C@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](O[C@@H]3O[C@@H](C)[C@H](OC(C)=O)[C@@](C)(O)C3)C2)C1)[C@H](OC)C(=O)[C@@H](O)[C@@H](C)O)[C@@H]1C[C@@H](O)[C@@H](OC)[C@@H](C)O1 ZYVSOIYQKUDENJ-WKSBCEQHSA-N 0.000 description 1
- 230000008711 chromosomal rearrangement Effects 0.000 description 1
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 description 1
- 229960004316 cisplatin Drugs 0.000 description 1
- 150000001860 citric acid derivatives Chemical class 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 239000012050 conventional carrier Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 description 1
- 229910000366 copper(II) sulfate Inorganic materials 0.000 description 1
- 150000001923 cyclic compounds Chemical class 0.000 description 1
- 125000006311 cyclobutyl amino group Chemical group [H]N(*)C1([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 1
- 125000006312 cyclopentyl amino group Chemical group [H]N(*)C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 1
- 229960004397 cyclophosphamide Drugs 0.000 description 1
- 125000006317 cyclopropyl amino group Chemical group 0.000 description 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 description 1
- 229960000684 cytarabine Drugs 0.000 description 1
- 229960003901 dacarbazine Drugs 0.000 description 1
- 229960000640 dactinomycin Drugs 0.000 description 1
- STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 description 1
- 229960000975 daunorubicin Drugs 0.000 description 1
- 238000010908 decantation Methods 0.000 description 1
- FMGSKLZLMKYGDP-USOAJAOKSA-N dehydroepiandrosterone Chemical compound C1[C@@H](O)CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CC=C21 FMGSKLZLMKYGDP-USOAJAOKSA-N 0.000 description 1
- 229960001251 denosumab Drugs 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 229910052805 deuterium Inorganic materials 0.000 description 1
- 229960003957 dexamethasone Drugs 0.000 description 1
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 description 1
- 238000002059 diagnostic imaging Methods 0.000 description 1
- 125000004915 dibutylamino group Chemical group C(CCC)N(CCCC)* 0.000 description 1
- 125000004772 dichloromethyl group Chemical group [H]C(Cl)(Cl)* 0.000 description 1
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 1
- FAMRKDQNMBBFBR-BQYQJAHWSA-N diethyl azodicarboxylate Substances CCOC(=O)\N=N\C(=O)OCC FAMRKDQNMBBFBR-BQYQJAHWSA-N 0.000 description 1
- 125000001664 diethylamino group Chemical group [H]C([H])([H])C([H])([H])N(*)C([H])([H])C([H])([H])[H] 0.000 description 1
- NLORYLAYLIXTID-ISLYRVAYSA-N diethylstilbestrol diphosphate Chemical compound C=1C=C(OP(O)(O)=O)C=CC=1C(/CC)=C(\CC)C1=CC=C(OP(O)(O)=O)C=C1 NLORYLAYLIXTID-ISLYRVAYSA-N 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 description 1
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 1
- 125000004914 dipropylamino group Chemical group C(CC)N(CCC)* 0.000 description 1
- VSJKWCGYPAHWDS-UHFFFAOYSA-N dl-camptothecin Natural products C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)C5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-UHFFFAOYSA-N 0.000 description 1
- 229960003668 docetaxel Drugs 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 229960004679 doxorubicin Drugs 0.000 description 1
- 239000008298 dragée Substances 0.000 description 1
- 210000005069 ears Anatomy 0.000 description 1
- 239000003974 emollient agent Substances 0.000 description 1
- 239000002662 enteric coated tablet Substances 0.000 description 1
- 229960001904 epirubicin Drugs 0.000 description 1
- AAKJLRGGTJKAMG-UHFFFAOYSA-N erlotinib Chemical compound C=12C=C(OCCOC)C(OCCOC)=CC2=NC=NC=1NC1=CC=CC(C#C)=C1 AAKJLRGGTJKAMG-UHFFFAOYSA-N 0.000 description 1
- 229960001433 erlotinib Drugs 0.000 description 1
- CCIVGXIOQKPBKL-UHFFFAOYSA-M ethanesulfonate Chemical compound CCS([O-])(=O)=O CCIVGXIOQKPBKL-UHFFFAOYSA-M 0.000 description 1
- 229960002568 ethinylestradiol Drugs 0.000 description 1
- ZKQFHRVKCYFVCN-UHFFFAOYSA-N ethoxyethane;hexane Chemical compound CCOCC.CCCCCC ZKQFHRVKCYFVCN-UHFFFAOYSA-N 0.000 description 1
- DUGSTTIFTRKIBL-UHFFFAOYSA-N ethyl 3-acetyl-1h-pyrazole-5-carboxylate Chemical compound CCOC(=O)C=1C=C(C(C)=O)NN=1 DUGSTTIFTRKIBL-UHFFFAOYSA-N 0.000 description 1
- FQKCNTHLJQQWTA-UHFFFAOYSA-N ethyl 5-acetyl-2-methylpyrazole-3-carboxylate Chemical compound CCOC(=O)C1=CC(C(C)=O)=NN1C FQKCNTHLJQQWTA-UHFFFAOYSA-N 0.000 description 1
- PQVSTLUFSYVLTO-UHFFFAOYSA-N ethyl n-ethoxycarbonylcarbamate Chemical compound CCOC(=O)NC(=O)OCC PQVSTLUFSYVLTO-UHFFFAOYSA-N 0.000 description 1
- FAMRKDQNMBBFBR-UHFFFAOYSA-N ethyl n-ethoxycarbonyliminocarbamate Chemical compound CCOC(=O)N=NC(=O)OCC FAMRKDQNMBBFBR-UHFFFAOYSA-N 0.000 description 1
- XTHFKEDIFFGKHM-UHFFFAOYSA-N ethylene glycol dimethyl ether Natural products COCCOC XTHFKEDIFFGKHM-UHFFFAOYSA-N 0.000 description 1
- VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 description 1
- 229960005420 etoposide Drugs 0.000 description 1
- 239000007941 film coated tablet Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 229960002949 fluorouracil Drugs 0.000 description 1
- 239000004052 folic acid antagonist Substances 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 235000019253 formic acid Nutrition 0.000 description 1
- 229960000297 fosfestrol Drugs 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- VZCYOOQTPOCHFL-OWOJBTEDSA-L fumarate(2-) Chemical class [O-]C(=O)\C=C\C([O-])=O VZCYOOQTPOCHFL-OWOJBTEDSA-L 0.000 description 1
- 125000002541 furyl group Chemical group 0.000 description 1
- 210000000232 gallbladder Anatomy 0.000 description 1
- 229960002584 gefitinib Drugs 0.000 description 1
- XGALLCVXEZPNRQ-UHFFFAOYSA-N gefitinib Chemical compound C=12C=C(OCCCN3CCOCC3)C(OC)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 XGALLCVXEZPNRQ-UHFFFAOYSA-N 0.000 description 1
- 229930195712 glutamate Natural products 0.000 description 1
- 125000005456 glyceride group Chemical group 0.000 description 1
- 150000002332 glycine derivatives Chemical class 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 230000009036 growth inhibition Effects 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 201000005787 hematologic cancer Diseases 0.000 description 1
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 description 1
- 125000005549 heteroarylene group Chemical group 0.000 description 1
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000001245 hexylamino group Chemical group [H]N([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(C([H])([H])[H])([H])[H] 0.000 description 1
- 125000003707 hexyloxy group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])O* 0.000 description 1
- 238000009396 hybridization Methods 0.000 description 1
- IKDUDTNKRLTJSI-UHFFFAOYSA-N hydrazine monohydrate Substances O.NN IKDUDTNKRLTJSI-UHFFFAOYSA-N 0.000 description 1
- 229960000890 hydrocortisone Drugs 0.000 description 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 1
- 239000008172 hydrogenated vegetable oil Substances 0.000 description 1
- USZLCYNVCCDPLQ-UHFFFAOYSA-N hydron;n-methoxymethanamine;chloride Chemical compound Cl.CNOC USZLCYNVCCDPLQ-UHFFFAOYSA-N 0.000 description 1
- HOMGKSMUEGBAAB-UHFFFAOYSA-N ifosfamide Chemical compound ClCCNP1(=O)OCCCN1CCCl HOMGKSMUEGBAAB-UHFFFAOYSA-N 0.000 description 1
- 229960001101 ifosfamide Drugs 0.000 description 1
- 239000012216 imaging agent Substances 0.000 description 1
- 229960003685 imatinib mesylate Drugs 0.000 description 1
- YLMAHDNUQAMNNX-UHFFFAOYSA-N imatinib methanesulfonate Chemical compound CS(O)(=O)=O.C1CN(C)CCN1CC1=CC=C(C(=O)NC=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)C=C1 YLMAHDNUQAMNNX-UHFFFAOYSA-N 0.000 description 1
- 125000002883 imidazolyl group Chemical group 0.000 description 1
- 238000012744 immunostaining Methods 0.000 description 1
- DBIGHPPNXATHOF-UHFFFAOYSA-N improsulfan Chemical compound CS(=O)(=O)OCCCNCCCOS(C)(=O)=O DBIGHPPNXATHOF-UHFFFAOYSA-N 0.000 description 1
- 229950008097 improsulfan Drugs 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 229960000905 indomethacin Drugs 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 229960000598 infliximab Drugs 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 125000002510 isobutoxy group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])O* 0.000 description 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 125000005921 isopentoxy group Chemical group 0.000 description 1
- 125000001972 isopentyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000003253 isopropoxy group Chemical group [H]C([H])([H])C([H])(O*)C([H])([H])[H] 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 238000011901 isothermal amplification Methods 0.000 description 1
- 150000003854 isothiazoles Chemical class 0.000 description 1
- 125000001786 isothiazolyl group Chemical group 0.000 description 1
- 239000000644 isotonic solution Substances 0.000 description 1
- 230000000155 isotopic effect Effects 0.000 description 1
- 125000000842 isoxazolyl group Chemical group 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 229960004891 lapatinib Drugs 0.000 description 1
- 238000007834 ligase chain reaction Methods 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 239000012280 lithium aluminium hydride Substances 0.000 description 1
- 229940040692 lithium hydroxide monohydrate Drugs 0.000 description 1
- GLXDVVHUTZTUQK-UHFFFAOYSA-M lithium hydroxide monohydrate Substances [Li+].O.[OH-] GLXDVVHUTZTUQK-UHFFFAOYSA-M 0.000 description 1
- 229960002247 lomustine Drugs 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 150000002688 maleic acid derivatives Chemical class 0.000 description 1
- 150000004701 malic acid derivatives Chemical class 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- FRQMUZJSZHZSGN-HBNHAYAOSA-N medroxyprogesterone Chemical compound C([C@@]12C)CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2CC[C@]2(C)[C@@](O)(C(C)=O)CC[C@H]21 FRQMUZJSZHZSGN-HBNHAYAOSA-N 0.000 description 1
- 229960004616 medroxyprogesterone Drugs 0.000 description 1
- 229960001924 melphalan Drugs 0.000 description 1
- SGDBTWWWUNNDEQ-LBPRGKRZSA-N melphalan Chemical compound OC(=O)[C@@H](N)CC1=CC=C(N(CCCl)CCCl)C=C1 SGDBTWWWUNNDEQ-LBPRGKRZSA-N 0.000 description 1
- 229960001428 mercaptopurine Drugs 0.000 description 1
- 229960000485 methotrexate Drugs 0.000 description 1
- ADCKODZETBTRLR-MHZLTWQESA-N methyl (2s)-3-(4-bromophenoxy)-2-(tritylamino)propanoate Chemical compound C([C@@H](C(=O)OC)NC(C=1C=CC=CC=1)(C=1C=CC=CC=1)C=1C=CC=CC=1)OC1=CC=C(Br)C=C1 ADCKODZETBTRLR-MHZLTWQESA-N 0.000 description 1
- YNIPPRDEXJUZDV-UHFFFAOYSA-N methyl 1-[(4-methoxyphenyl)methyl]-5-oxopyrrolidine-3-carboxylate Chemical compound O=C1CC(C(=O)OC)CN1CC1=CC=C(OC)C=C1 YNIPPRDEXJUZDV-UHFFFAOYSA-N 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 229960004584 methylprednisolone Drugs 0.000 description 1
- 229960004857 mitomycin Drugs 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 201000002077 muscle cancer Diseases 0.000 description 1
- DILRJUIACXKSQE-UHFFFAOYSA-N n',n'-dimethylethane-1,2-diamine Chemical compound CN(C)CCN DILRJUIACXKSQE-UHFFFAOYSA-N 0.000 description 1
- RIWRFSMVIUAEBX-UHFFFAOYSA-N n-methyl-1-phenylmethanamine Chemical compound CNCC1=CC=CC=C1 RIWRFSMVIUAEBX-UHFFFAOYSA-N 0.000 description 1
- MCSAQVGDZLPTBS-UHFFFAOYSA-N n-methyl-1-pyridin-3-ylmethanamine Chemical compound CNCC1=CC=CN=C1 MCSAQVGDZLPTBS-UHFFFAOYSA-N 0.000 description 1
- 125000003506 n-propoxy group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])O* 0.000 description 1
- 229960004719 nandrolone Drugs 0.000 description 1
- NPAGDVCDWIYMMC-IZPLOLCNSA-N nandrolone Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 NPAGDVCDWIYMMC-IZPLOLCNSA-N 0.000 description 1
- 125000001971 neopentyl group Chemical group [H]C([*])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 210000000944 nerve tissue Anatomy 0.000 description 1
- 229950010203 nimotuzumab Drugs 0.000 description 1
- 229960001420 nimustine Drugs 0.000 description 1
- VFEDRRNHLBGPNN-UHFFFAOYSA-N nimustine Chemical compound CC1=NC=C(CNC(=O)N(CCCl)N=O)C(N)=N1 VFEDRRNHLBGPNN-UHFFFAOYSA-N 0.000 description 1
- 150000002823 nitrates Chemical class 0.000 description 1
- OSTGTTZJOCZWJG-UHFFFAOYSA-N nitrosourea Chemical compound NC(=O)N=NO OSTGTTZJOCZWJG-UHFFFAOYSA-N 0.000 description 1
- 238000000655 nuclear magnetic resonance spectrum Methods 0.000 description 1
- 238000010534 nucleophilic substitution reaction Methods 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 230000002246 oncogenic effect Effects 0.000 description 1
- 125000002734 organomagnesium group Chemical group 0.000 description 1
- 150000002903 organophosphorus compounds Chemical class 0.000 description 1
- 229960001756 oxaliplatin Drugs 0.000 description 1
- DWAFYCQODLXJNR-BNTLRKBRSA-L oxaliplatin Chemical compound O1C(=O)C(=O)O[Pt]11N[C@@H]2CCCC[C@H]2N1 DWAFYCQODLXJNR-BNTLRKBRSA-L 0.000 description 1
- 125000002971 oxazolyl group Chemical group 0.000 description 1
- 125000003566 oxetanyl group Chemical group 0.000 description 1
- 150000005623 oxindoles Chemical class 0.000 description 1
- 125000000466 oxiranyl group Chemical group 0.000 description 1
- BSCHIACBONPEOB-UHFFFAOYSA-N oxolane;hydrate Chemical compound O.C1CCOC1 BSCHIACBONPEOB-UHFFFAOYSA-N 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229960005244 oxymetholone Drugs 0.000 description 1
- ICMWWNHDUZJFDW-DHODBPELSA-N oxymetholone Chemical compound C([C@@H]1CC2)C(=O)\C(=C/O)C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@](C)(O)[C@@]2(C)CC1 ICMWWNHDUZJFDW-DHODBPELSA-N 0.000 description 1
- ICMWWNHDUZJFDW-UHFFFAOYSA-N oxymetholone Natural products C1CC2CC(=O)C(=CO)CC2(C)C2C1C1CCC(C)(O)C1(C)CC2 ICMWWNHDUZJFDW-UHFFFAOYSA-N 0.000 description 1
- 101800002712 p27 Proteins 0.000 description 1
- 229960001592 paclitaxel Drugs 0.000 description 1
- 229910052763 palladium Inorganic materials 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 125000003538 pentan-3-yl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000004115 pentoxy group Chemical group [*]OC([H])([H])C([H])([H])C([H])([H])C(C([H])([H])[H])([H])[H] 0.000 description 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
- 125000004894 pentylamino group Chemical group C(CCCC)N* 0.000 description 1
- QIMGFXOHTOXMQP-GFAGFCTOSA-N peplomycin Chemical compound N([C@H](C(=O)N[C@H](C)[C@@H](O)[C@H](C)C(=O)N[C@@H]([C@H](O)C)C(=O)NCCC=1SC=C(N=1)C=1SC=C(N=1)C(=O)NCCCN[C@@H](C)C=1C=CC=CC=1)[C@@H](O[C@H]1[C@H]([C@@H](O)[C@H](O)[C@H](CO)O1)O[C@@H]1[C@H]([C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O1)O)C=1NC=NC=1)C(=O)C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C QIMGFXOHTOXMQP-GFAGFCTOSA-N 0.000 description 1
- 229950003180 peplomycin Drugs 0.000 description 1
- VLTRZXGMWDSKGL-UHFFFAOYSA-N perchloric acid Chemical class OCl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-N 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- DNUTZBZXLPWRJG-UHFFFAOYSA-M piperidine-1-carboxylate Chemical compound [O-]C(=O)N1CCCCC1 DNUTZBZXLPWRJG-UHFFFAOYSA-M 0.000 description 1
- 229960000952 pipobroman Drugs 0.000 description 1
- NJBFOOCLYDNZJN-UHFFFAOYSA-N pipobroman Chemical compound BrCCC(=O)N1CCN(C(=O)CCBr)CC1 NJBFOOCLYDNZJN-UHFFFAOYSA-N 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 229910000160 potassium phosphate Inorganic materials 0.000 description 1
- 235000011009 potassium phosphates Nutrition 0.000 description 1
- 229960002847 prasterone Drugs 0.000 description 1
- 229960005205 prednisolone Drugs 0.000 description 1
- OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- CPTBDICYNRMXFX-UHFFFAOYSA-N procarbazine Chemical compound CNNCC1=CC=C(C(=O)NC(C)C)C=C1 CPTBDICYNRMXFX-UHFFFAOYSA-N 0.000 description 1
- 229960000624 procarbazine Drugs 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- VVWRJUBEIPHGQF-UHFFFAOYSA-N propan-2-yl n-propan-2-yloxycarbonyliminocarbamate Chemical compound CC(C)OC(=O)N=NC(=O)OC(C)C VVWRJUBEIPHGQF-UHFFFAOYSA-N 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 208000023958 prostate neoplasm Diseases 0.000 description 1
- XFTQRUTUGRCSGO-UHFFFAOYSA-N pyrazin-2-amine Chemical class NC1=CN=CC=N1 XFTQRUTUGRCSGO-UHFFFAOYSA-N 0.000 description 1
- 150000003217 pyrazoles Chemical class 0.000 description 1
- 125000004942 pyridazin-6-yl group Chemical group N1=NC=CC=C1* 0.000 description 1
- 125000002098 pyridazinyl group Chemical group 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 125000005551 pyridylene group Chemical group 0.000 description 1
- 125000000714 pyrimidinyl group Chemical group 0.000 description 1
- NYCVCXMSZNOGDH-UHFFFAOYSA-N pyrrolidine-1-carboxylic acid Chemical compound OC(=O)N1CCCC1 NYCVCXMSZNOGDH-UHFFFAOYSA-N 0.000 description 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 description 1
- 125000000168 pyrrolyl group Chemical group 0.000 description 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 229960002185 ranimustine Drugs 0.000 description 1
- 102000027426 receptor tyrosine kinases Human genes 0.000 description 1
- 108091008598 receptor tyrosine kinases Proteins 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 229960004641 rituximab Drugs 0.000 description 1
- 239000012047 saturated solution Substances 0.000 description 1
- 125000005920 sec-butoxy group Chemical group 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 229960003440 semustine Drugs 0.000 description 1
- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
- 239000004208 shellac Substances 0.000 description 1
- 235000013874 shellac Nutrition 0.000 description 1
- 229940113147 shellac Drugs 0.000 description 1
- 235000020374 simple syrup Nutrition 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 1
- 235000019345 sodium thiosulphate Nutrition 0.000 description 1
- MRTAVLDNYYEJHK-UHFFFAOYSA-M sodium;2-chloro-2,2-difluoroacetate Chemical compound [Na+].[O-]C(=O)C(F)(F)Cl MRTAVLDNYYEJHK-UHFFFAOYSA-M 0.000 description 1
- 229960003787 sorafenib Drugs 0.000 description 1
- JNYAEWCLZODPBN-CTQIIAAMSA-N sorbitan Polymers OCC(O)C1OCC(O)[C@@H]1O JNYAEWCLZODPBN-CTQIIAAMSA-N 0.000 description 1
- 229960001052 streptozocin Drugs 0.000 description 1
- ZSJLQEPLLKMAKR-GKHCUFPYSA-N streptozocin Chemical compound O=NN(C)C(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O ZSJLQEPLLKMAKR-GKHCUFPYSA-N 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 150000003890 succinate salts Chemical class 0.000 description 1
- 239000007940 sugar coated tablet Substances 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- WINHZLLDWRZWRT-ATVHPVEESA-N sunitinib Chemical compound CCN(CC)CCNC(=O)C1=C(C)NC(\C=C/2C3=CC(F)=CC=C3NC\2=O)=C1C WINHZLLDWRZWRT-ATVHPVEESA-N 0.000 description 1
- 229960001796 sunitinib Drugs 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 229960001603 tamoxifen Drugs 0.000 description 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 1
- WFWLQNSHRPWKFK-ZCFIWIBFSA-N tegafur Chemical compound O=C1NC(=O)C(F)=CN1[C@@H]1OCCC1 WFWLQNSHRPWKFK-ZCFIWIBFSA-N 0.000 description 1
- 229960001674 tegafur Drugs 0.000 description 1
- NRUKOCRGYNPUPR-QBPJDGROSA-N teniposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@@H](OC[C@H]4O3)C=3SC=CC=3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 NRUKOCRGYNPUPR-QBPJDGROSA-N 0.000 description 1
- 229960001278 teniposide Drugs 0.000 description 1
- 125000004213 tert-butoxy group Chemical group [H]C([H])([H])C(O*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- FIHHWVQAQINZCU-QGZVFWFLSA-N tert-butyl (2R)-2-[[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]methyl]pyrrolidine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCC[C@@H]1COc1ccc(cc1)B1OC(C)(C)C(C)(C)O1 FIHHWVQAQINZCU-QGZVFWFLSA-N 0.000 description 1
- CICVHMLALVKTCM-SFHVURJKSA-N tert-butyl (2S)-2-[[2-cyano-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]methyl]pyrrolidine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCC[C@H]1COc1ccc(cc1C#N)B1OC(C)(C)C(C)(C)O1 CICVHMLALVKTCM-SFHVURJKSA-N 0.000 description 1
- LTGRJWDGMKVYRW-HNNXBMFYSA-N tert-butyl (2S)-2-[[2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]methyl]azetidine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CC[C@H]1COc1ccc(cc1F)B1OC(C)(C)C(C)(C)O1 LTGRJWDGMKVYRW-HNNXBMFYSA-N 0.000 description 1
- MEUQNSOHQFQLHF-HNNXBMFYSA-N tert-butyl (2S)-2-[[2-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]methyl]azetidine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CC[C@H]1COc1cc(ccc1F)B1OC(C)(C)C(C)(C)O1 MEUQNSOHQFQLHF-HNNXBMFYSA-N 0.000 description 1
- FVIFFUDJAWQAPD-KRWDZBQOSA-N tert-butyl (2S)-2-[[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]methyl]pyrrolidine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCC[C@H]1COc1cccc(c1)B1OC(C)(C)C(C)(C)O1 FVIFFUDJAWQAPD-KRWDZBQOSA-N 0.000 description 1
- WQGHAHVIIDEJQF-INIZCTEOSA-N tert-butyl (2S)-2-[[3-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]methyl]azetidine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CC[C@H]1COc1cc(F)cc(c1)B1OC(C)(C)C(C)(C)O1 WQGHAHVIIDEJQF-INIZCTEOSA-N 0.000 description 1
- LUXGCVWMAQUWFZ-INIZCTEOSA-N tert-butyl (2S)-2-[[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]methyl]azetidine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CC[C@H]1COc1ccc(cc1)B1OC(C)(C)C(C)(C)O1 LUXGCVWMAQUWFZ-INIZCTEOSA-N 0.000 description 1
- XLJYRURLRGYZKO-ZDUSSCGKSA-N tert-butyl (2s)-2-[(4-bromophenoxy)methyl]pyrrolidine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCC[C@H]1COC1=CC=C(Br)C=C1 XLJYRURLRGYZKO-ZDUSSCGKSA-N 0.000 description 1
- MHSXECLZNNMHIA-ZDUSSCGKSA-N tert-butyl (2s)-2-[(4-bromophenyl)sulfanylmethyl]pyrrolidine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCC[C@H]1CSC1=CC=C(Br)C=C1 MHSXECLZNNMHIA-ZDUSSCGKSA-N 0.000 description 1
- SHUBPFFKEVYIBS-QGZVFWFLSA-N tert-butyl (3R)-3-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]pyrrolidine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CC[C@H](C1)Oc1cccc(c1)B1OC(C)(C)C(C)(C)O1 SHUBPFFKEVYIBS-QGZVFWFLSA-N 0.000 description 1
- OEJSTZCLXILPAN-MRXNPFEDSA-N tert-butyl (3R)-3-[[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]methyl]pyrrolidine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CC[C@@H](COc2ccc(cc2)B2OC(C)(C)C(C)(C)O2)C1 OEJSTZCLXILPAN-MRXNPFEDSA-N 0.000 description 1
- SGHPXNIINLLSMV-QGZVFWFLSA-N tert-butyl (3r)-3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]pyrrolidine-1-carboxylate Chemical compound C1N(C(=O)OC(C)(C)C)CC[C@H]1OC1=CC=C(B2OC(C)(C)C(C)(C)O2)C=C1 SGHPXNIINLLSMV-QGZVFWFLSA-N 0.000 description 1
- LFBDCEDHEZFPKE-UHFFFAOYSA-N tert-butyl 3-[[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]methyl]azetidine-1-carboxylate Chemical compound C1N(C(=O)OC(C)(C)C)CC1COC1=CC=C(B2OC(C)(C)C(C)(C)O2)C=C1 LFBDCEDHEZFPKE-UHFFFAOYSA-N 0.000 description 1
- CTEDVGRUGMPBHE-UHFFFAOYSA-N tert-butyl 4-(hydroxymethyl)piperidine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCC(CO)CC1 CTEDVGRUGMPBHE-UHFFFAOYSA-N 0.000 description 1
- RXNQBVRCZIYUJK-UHFFFAOYSA-N tert-butyl 4-(methylsulfonyloxymethyl)piperidine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCC(COS(C)(=O)=O)CC1 RXNQBVRCZIYUJK-UHFFFAOYSA-N 0.000 description 1
- AUYNXTKHUQFAQZ-UHFFFAOYSA-N tert-butyl 4-[(4-bromophenoxy)methyl]piperidine-1-carboxylate Chemical compound C1CN(C(=O)OC(C)(C)C)CCC1COC1=CC=C(Br)C=C1 AUYNXTKHUQFAQZ-UHFFFAOYSA-N 0.000 description 1
- XPNSYBYHVPMAET-UHFFFAOYSA-N tert-butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]piperidine-1-carboxylate Chemical compound C1CN(C(=O)OC(C)(C)C)CCC1OC1=CC=C(B2OC(C)(C)C(C)(C)O2)C=C1 XPNSYBYHVPMAET-UHFFFAOYSA-N 0.000 description 1
- UFZBTLKKGGVEDN-UHFFFAOYSA-N tert-butyl N-(2-hydroxyethyl)-N-[2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]ethyl]carbamate Chemical compound CC(C)(C)OC(=O)N(CCO)CCOc1ccc(cc1)B1OC(C)(C)C(C)(C)O1 UFZBTLKKGGVEDN-UHFFFAOYSA-N 0.000 description 1
- PTLJFDZAMPQWRX-MSOLQXFVSA-N tert-butyl N-[(1R,2S)-2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]cyclopentyl]carbamate Chemical compound CC(C)(C)OC(=O)N[C@@H]1CCC[C@@H]1Oc1ccc(cc1)B1OC(C)(C)C(C)(C)O1 PTLJFDZAMPQWRX-MSOLQXFVSA-N 0.000 description 1
- PTLJFDZAMPQWRX-ZWKOTPCHSA-N tert-butyl N-[(1S,2R)-2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]cyclopentyl]carbamate Chemical compound CC(C)(C)OC(=O)N[C@H]1CCC[C@H]1Oc1ccc(cc1)B1OC(C)(C)C(C)(C)O1 PTLJFDZAMPQWRX-ZWKOTPCHSA-N 0.000 description 1
- FCQSUXOFMQUQOE-INIZCTEOSA-N tert-butyl N-[(3S)-1-[2-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-5-oxopyrrolidin-3-yl]carbamate Chemical compound Cc1cc(ccc1N1C[C@H](CC1=O)NC(=O)OC(C)(C)C)B1OC(C)(C)C(C)(C)O1 FCQSUXOFMQUQOE-INIZCTEOSA-N 0.000 description 1
- HTCYYQFNCRCSDN-AWEZNQCLSA-N tert-butyl N-[(3S)-1-[3-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-5-oxopyrrolidin-3-yl]carbamate Chemical compound COc1cc(ccc1B1OC(C)(C)C(C)(C)O1)N1C[C@H](CC1=O)NC(=O)OC(C)(C)C HTCYYQFNCRCSDN-AWEZNQCLSA-N 0.000 description 1
- QDDHLMZPMRGJDU-HNNXBMFYSA-N tert-butyl N-[(3S)-5-oxo-1-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]pyrrolidin-3-yl]carbamate Chemical compound CC(C)(C)OC(=O)N[C@@H]1CN(C(=O)C1)c1cccc(c1)B1OC(C)(C)C(C)(C)O1 QDDHLMZPMRGJDU-HNNXBMFYSA-N 0.000 description 1
- KVIQXHUFUSBFJH-UHFFFAOYSA-N tert-butyl N-[3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]propyl]carbamate Chemical compound C1=CC(OCCCNC(=O)OC(C)(C)C)=CC=C1B1OC(C)(C)C(C)(C)O1 KVIQXHUFUSBFJH-UHFFFAOYSA-N 0.000 description 1
- DWLIVAUGBKFQDZ-UHFFFAOYSA-N tert-butyl N-methyl-N-[2-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]ethyl]carbamate Chemical compound CN(CCOc1cccc(c1)B1OC(C)(C)C(C)(C)O1)C(=O)OC(C)(C)C DWLIVAUGBKFQDZ-UHFFFAOYSA-N 0.000 description 1
- YTIUQCFYODSGKN-UHFFFAOYSA-N tert-butyl N-methyl-N-[3-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]propyl]carbamate Chemical compound CN(CCCOc1cccc(c1)B1OC(C)(C)C(C)(C)O1)C(=O)OC(C)(C)C YTIUQCFYODSGKN-UHFFFAOYSA-N 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- CGZQRJSADXRRKN-HTQZYQBOSA-N tert-butyl n-[(1r,2r)-2-hydroxycyclopentyl]carbamate Chemical compound CC(C)(C)OC(=O)N[C@@H]1CCC[C@H]1O CGZQRJSADXRRKN-HTQZYQBOSA-N 0.000 description 1
- PFHVTCWJHBHEFA-ZCFIWIBFSA-N tert-butyl n-[(3r)-5-oxopyrrolidin-3-yl]carbamate Chemical compound CC(C)(C)OC(=O)N[C@H]1CNC(=O)C1 PFHVTCWJHBHEFA-ZCFIWIBFSA-N 0.000 description 1
- HFMAZNJKNNRONT-UHFFFAOYSA-N tert-butyl n-[1-(hydroxymethyl)cyclopropyl]carbamate Chemical compound CC(C)(C)OC(=O)NC1(CO)CC1 HFMAZNJKNNRONT-UHFFFAOYSA-N 0.000 description 1
- NCYYXYWUMGGMPM-UHFFFAOYSA-N tert-butyl n-[2-(4-bromophenoxy)ethyl]-n-cyclopropylcarbamate Chemical compound C1CC1N(C(=O)OC(C)(C)C)CCOC1=CC=C(Br)C=C1 NCYYXYWUMGGMPM-UHFFFAOYSA-N 0.000 description 1
- GXCVCYPGZBKJQB-UHFFFAOYSA-N tert-butyl n-[2-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]ethyl]carbamate Chemical compound CC(C)(C)OC(=O)NCCOC1=CC=CC(B2OC(C)(C)C(C)(C)O2)=C1 GXCVCYPGZBKJQB-UHFFFAOYSA-N 0.000 description 1
- NGKGVDKSWLOSRW-UHFFFAOYSA-N tert-butyl n-[2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]ethyl]carbamate Chemical compound C1=CC(OCCNC(=O)OC(C)(C)C)=CC=C1B1OC(C)(C)C(C)(C)O1 NGKGVDKSWLOSRW-UHFFFAOYSA-N 0.000 description 1
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 description 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 description 1
- 125000003507 tetrahydrothiofenyl group Chemical group 0.000 description 1
- 125000004632 tetrahydrothiopyranyl group Chemical group S1C(CCCC1)* 0.000 description 1
- CZDYPVPMEAXLPK-UHFFFAOYSA-N tetramethylsilane Chemical compound C[Si](C)(C)C CZDYPVPMEAXLPK-UHFFFAOYSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 125000005557 thiazolylene group Chemical group 0.000 description 1
- 125000001544 thienyl group Chemical group 0.000 description 1
- 125000005556 thienylene group Chemical group 0.000 description 1
- 125000002053 thietanyl group Chemical group 0.000 description 1
- 229960001196 thiotepa Drugs 0.000 description 1
- 229960003087 tioguanine Drugs 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 101150023860 tpr gene Proteins 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 230000005945 translocation Effects 0.000 description 1
- 229960000575 trastuzumab Drugs 0.000 description 1
- 229960005294 triamcinolone Drugs 0.000 description 1
- GFNANZIMVAIWHM-OBYCQNJPSA-N triamcinolone Chemical compound O=C1C=C[C@]2(C)[C@@]3(F)[C@@H](O)C[C@](C)([C@@]([C@H](O)C4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 GFNANZIMVAIWHM-OBYCQNJPSA-N 0.000 description 1
- 125000003866 trichloromethyl group Chemical group ClC(Cl)(Cl)* 0.000 description 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical compound [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 description 1
- JLTRXTDYQLMHGR-UHFFFAOYSA-N trimethylaluminium Chemical compound C[Al](C)C JLTRXTDYQLMHGR-UHFFFAOYSA-N 0.000 description 1
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
- 102000003390 tumor necrosis factor Human genes 0.000 description 1
- 229940121358 tyrosine kinase inhibitor Drugs 0.000 description 1
- 239000005483 tyrosine kinase inhibitor Substances 0.000 description 1
- 229960003048 vinblastine Drugs 0.000 description 1
- JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 description 1
- 229960004528 vincristine Drugs 0.000 description 1
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 description 1
- UGGWPQSBPIFKDZ-KOTLKJBCSA-N vindesine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(N)=O)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1N=C1[C]2C=CC=C1 UGGWPQSBPIFKDZ-KOTLKJBCSA-N 0.000 description 1
- 229960004355 vindesine Drugs 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 238000001262 western blot Methods 0.000 description 1
- 229910052727 yttrium Inorganic materials 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012127079 | 2012-06-04 | ||
| JP2012-127079 | 2012-06-04 | ||
| PCT/JP2013/065328 WO2013183578A1 (ja) | 2012-06-04 | 2013-06-03 | キナーゼ阻害剤としてのイミダゾ[１，２－ｂ]ピリダジン誘導体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2014153627A RU2014153627A (ru) | 2016-08-10 |
| RU2635917C2 true RU2635917C2 (ru) | 2017-11-17 |
Family
ID=49711970
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2014153627A RU2635917C2 (ru) | 2012-06-04 | 2013-06-03 | Имидазо[1, 2-b]пиридазиновые производные как ингибиторы киназ |
Country Status (32)
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2821941C2 (ru) * | 2018-03-02 | 2024-06-28 | Оцука Фармасьютикал Ко., Лтд. | Фармацевтические соединения |
| US12037345B2 (en) | 2018-07-24 | 2024-07-16 | Taiho Pharmaceutical Co., Ltd. | Heterobicyclic compounds for inhibiting the activity of SHP2 |
| US12458640B2 (en) | 2019-08-20 | 2025-11-04 | Otsuka Pharmaceutical Co., Ltd. | Pyrazolo[3,4-b]pyrazine SHP2 phosphatase inhibitors |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102224153B (zh) | 2008-09-22 | 2014-04-30 | 阵列生物制药公司 | 作为trk激酶抑制剂的取代的咪唑并[1，2-b]哒嗪化合物 |
| PL3372605T3 (pl) | 2008-10-22 | 2022-03-07 | Array Biopharma Inc. | Podstawione związki pirazolo[1,5-a]pirymidynowe jako inhibitory kinaz trk |
| AR077468A1 (es) | 2009-07-09 | 2011-08-31 | Array Biopharma Inc | Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa |
| HUE044025T2 (hu) | 2010-05-20 | 2019-09-30 | Array Biopharma Inc | Makrociklusos vegyületek mint TRK-kináz inhibitorok |
| WO2013180183A1 (ja) | 2012-05-30 | 2013-12-05 | 日本新薬株式会社 | 芳香族複素環誘導体及び医薬 |
| EA032255B1 (ru) * | 2014-03-27 | 2019-04-30 | Янссен Фармацевтика Нв | ЗАМЕЩЕННЫЕ ПРОИЗВОДНЫЕ 4,5,6,7-ТЕТРАГИДРОПИРАЗОЛО[1,5-a]ПИРАЗИНА И ПРОИЗВОДНЫЕ 5,6,7,8-ТЕТРАГИДРО-4H-ПИРАЗОЛО[1,5-a][1,4]ДИАЗЕПИНА В КАЧЕСТВЕ ИНГИБИТОРОВ Ros1 |
| JP6527167B2 (ja) * | 2014-03-27 | 2019-06-05 | ヤンセン ファーマシューティカ エヌ．ベー． | ＲＯＳ１阻害剤としての置換４，５，６，７−テトラヒドロ−ピラゾロ［１，５−ａ］ピリミジン誘導体および２，３−ジヒドロ−１Ｈ−イミダゾ［１，２−ｂ］ピラゾール誘導体 |
| EP3906921A1 (en) * | 2014-04-25 | 2021-11-10 | Exelixis, Inc. | Method of treating lung adenocarcinoma |
| PT3699181T (pt) | 2014-11-16 | 2023-04-05 | Array Biopharma Inc | Forma cristalina de hidrogenossulfato de (s)-n-(5-((r)-2-(2,5-difluorofenil)-pirrolidin-1-il)-pirazolo[1,5-a]pirimidin-3-il)-3-hidroxipirrolidina-1-carboxamida |
| HK1253093A1 (zh) | 2015-06-01 | 2019-06-06 | Loxo Oncology Inc. | 诊断和治疗癌症的方法 |
| US10919875B2 (en) | 2015-06-18 | 2021-02-16 | 89Bio Ltd | Substituted 4-benzyl and 4-benzoyl piperidine derivatives |
| CN107847765B (zh) | 2015-06-18 | 2021-05-04 | 89生物有限公司 | 1,4-取代的哌啶衍生物 |
| ES2857081T3 (es) | 2015-07-16 | 2021-09-28 | Array Biopharma Inc | Compuestos de pirazolo[1,5-a]piridina sustituidos como inhibidores de la quinasa ret |
| JP2018534296A (ja) | 2015-10-26 | 2018-11-22 | ロクソ オンコロジー， インコーポレイテッドＬｏｘｏ Ｏｎｃｏｌｏｇｙ， Ｉｎｃ． | Ｔｒｋ阻害薬耐性がんにおける点変異およびそれに関連する方法 |
| CN106854174A (zh) * | 2015-12-08 | 2017-06-16 | 湖南华腾制药有限公司 | 一种4位取代哌啶衍生物的制备方法 |
| US10045991B2 (en) | 2016-04-04 | 2018-08-14 | Loxo Oncology, Inc. | Methods of treating pediatric cancers |
| HRP20241295T1 (hr) | 2016-04-04 | 2024-12-06 | Loxo Oncology, Inc. | Postupci za liječenje pedijatrijskih karcinoma |
| CU20180125A7 (es) | 2016-04-04 | 2019-05-03 | Loxo Oncology Inc | Formulaciones líquidas de (s)-n-(5-((r)-2-(2,5-difluorofenil) -pirrolidin-1-il)-pirazolo[1,5-alpirimidin-3-il)-3 hidroxipirrolidina-1-carboxamida |
| MX392604B (es) | 2016-05-18 | 2025-03-24 | Array Biopharma Inc | Procesos para la preparacion de (s)-n-(5-((r)-2-(2,5-difluorofenil)pirrolidin-1-il)-pirazolo[1,5-a]pirimidin-3-il)-3-hidroxipirrolidin-1-carboxamida y sales del mismo. |
| CN107400082A (zh) * | 2016-05-19 | 2017-11-28 | 湖南华腾制药有限公司 | 一种取代哌啶衍生物的制备方法 |
| TWI704148B (zh) | 2016-10-10 | 2020-09-11 | 美商亞雷生物製藥股份有限公司 | 作為ｒｅｔ激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物 |
| JOP20190077A1 (ar) | 2016-10-10 | 2019-04-09 | Array Biopharma Inc | مركبات بيرازولو [1، 5-a]بيريدين بها استبدال كمثبطات كيناز ret |
| JOP20190072A1 (ar) * | 2016-10-13 | 2019-04-07 | Glaxosmithkline Ip Dev Ltd | مشتقات 1، 3 سيكلوبوتان ثنائي الاستبدال أو آزيتيدين كمثبطات للإنزيم المخلق للبروستاجلاندين d المكون للدم |
| JOP20190092A1 (ar) | 2016-10-26 | 2019-04-25 | Array Biopharma Inc | عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها |
| WO2018136663A1 (en) | 2017-01-18 | 2018-07-26 | Array Biopharma, Inc. | Ret inhibitors |
| ES2948194T3 (es) | 2017-01-18 | 2023-09-01 | Array Biopharma Inc | Compuestos de pirazolo[1,5-a]pirazina sustituida como inhibidores de la cinasa RET |
| PL3597648T3 (pl) * | 2017-03-14 | 2023-07-24 | Daiichi Sankyo Company, Limited | METODA WYTWARZANIA 3,6-DIPODSTAWIONEJ POCHODNEJ IMIDAZO[1, 2-b]PIRYDAZYNY |
| JOP20190213A1 (ar) | 2017-03-16 | 2019-09-16 | Array Biopharma Inc | مركبات حلقية ضخمة كمثبطات لكيناز ros1 |
| US10180422B1 (en) | 2017-08-22 | 2019-01-15 | Scripps Health | Methods of treating a neuroendocrine tumor |
| TWI791053B (zh) | 2017-10-10 | 2023-02-01 | 美商亞雷生物製藥股份有限公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之結晶形式及其醫藥組合物 |
| TWI812649B (zh) | 2017-10-10 | 2023-08-21 | 美商絡速藥業公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之調配物 |
| MA50456A (fr) | 2017-10-26 | 2020-09-02 | Array Biopharma Inc | Formulations d'un inhibiteur de kinase trk macrocyclique |
| CN109748902B (zh) * | 2017-11-02 | 2020-11-06 | 杭州科巢生物科技有限公司 | 一种盐酸安罗替尼的制备方法 |
| JP7041265B2 (ja) * | 2017-11-29 | 2022-03-23 | ソウル大学校産学協力団 | 抗－ｒｏｓ１抗体およびその用途 |
| CN108129288B (zh) * | 2017-12-27 | 2021-01-22 | 上海毕得医药科技股份有限公司 | 一种反式-3-羟基环丁基甲酸的合成方法 |
| TW201932464A (zh) | 2018-01-18 | 2019-08-16 | 美商亞雷生物製藥股份有限公司 | 作為ret激酶抑制劑之經取代吡唑基[4,3-c]吡啶化合物 |
| US11603374B2 (en) | 2018-01-18 | 2023-03-14 | Array Biopharma Inc. | Substituted pyrrolo[2,3-d]pyrimidines compounds as ret kinase inhibitors |
| CA3087578C (en) | 2018-01-18 | 2023-08-08 | Array Biopharma Inc. | Substituted pyrazolo[3,4-d]pyrimidine compounds as ret kinase inhibitors |
| EP3773725A1 (en) | 2018-03-29 | 2021-02-17 | Loxo Oncology Inc. | Treatment of trk-associated cancers |
| KR102612513B1 (ko) | 2018-07-31 | 2023-12-12 | 록쏘 온콜로지, 인코포레이티드 | (s)-5-아미노-3-(4-((5-플루오로-2-메톡시벤즈아미도)메틸)페닐)-1-(1,1,1-트리플루오로프로판-2-일)-1h-피라졸-4-카르복스아미드의 분무-건조된 분산물 및 제제 |
| EP3849986B1 (en) | 2018-09-10 | 2022-06-08 | Array Biopharma, Inc. | Fused heterocyclic compounds as ret kinase inhibitors |
| CN113474337A (zh) | 2018-12-19 | 2021-10-01 | 奥瑞生物药品公司 | 作为fgfr抑制剂用于治疗癌症的7-((3，5-二甲氧基苯基)氨基)喹喔啉衍生物 |
| WO2020131627A1 (en) | 2018-12-19 | 2020-06-25 | Array Biopharma Inc. | Substituted pyrazolo[1,5-a]pyridine compounds as inhibitors of fgfr tyrosine kinases |
| US12240855B2 (en) | 2019-03-06 | 2025-03-04 | Daiichi Sankyo Company, Limited | Pyrrolopyrazole derivative |
| MX2021009863A (es) | 2019-03-21 | 2021-11-12 | Onxeo | Una molecula dbait en combinacion con inhibidor de quinasa para el tratamiento del cancer. |
| KR102731401B1 (ko) * | 2019-05-08 | 2024-11-15 | 티와이케이 메디슨즈, 인코포레이티드 | 키나아제 억제제로 사용되는 화합물 및 이의 응용 |
| WO2021089791A1 (en) | 2019-11-08 | 2021-05-14 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| TW202200589A (zh) | 2020-05-28 | 2022-01-01 | 瑞士商諾華公司 | Ｍｌｌ１抑制劑及抗癌劑 |
| CN114957259A (zh) * | 2021-02-25 | 2022-08-30 | 南京明德新药研发有限公司 | 氰基取代的芳香双环类化合物及其应用 |
| JP2024525230A (ja) * | 2021-07-01 | 2024-07-10 | アンハート セラピューティクス（ハンチョウ）コーポレーション，リミテッド | ３－｛４－［（２ｒ）－２－アミノプロポキシ］フェニル｝－ｎ－［（１ｒ）－１－（３－フルオロフェニル）エチル］イミダゾ［１，２－ｂ］ピリダジン－６－アミンおよびその塩の結晶形態 |
| AU2022459411A1 (en) * | 2022-05-18 | 2024-11-21 | Nuvation Bio Inc. | Method for producing 3,6-disubstituted-imidazo[1,2-b]pyridazine compounds |
| CN114989176B (zh) * | 2022-07-08 | 2024-08-27 | 深圳市新樾生物科技有限公司 | 咪唑并哒嗪类衍生物及其应用 |
| CN115197115B (zh) * | 2022-08-25 | 2024-11-08 | 成都金博汇康医药科技有限公司 | 一种手性5-氧代吡咯烷-3-甲酸的制备方法与应用 |
| CN117659020A (zh) * | 2022-09-07 | 2024-03-08 | 苏州朗睿生物医药有限公司 | 一种咪唑并[1,2-b]哒嗪衍生物及其制备方法和用途 |
| CN117659043A (zh) | 2022-09-07 | 2024-03-08 | 苏州朗睿生物医药有限公司 | 一种大环咪唑并[1,2-b]哒嗪衍生物及其制备方法和用途 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007147646A1 (de) * | 2006-06-21 | 2007-12-27 | Bayer Schering Pharma Aktiengesellschaft | OXO-SUBSTITUIERTE IMIDAZO[1,2b]PYRIDAZINE, DEREN HERSTELLUNG UND VERWENDUNG ALS ARZNEIMITTEL |
| WO2008058126A2 (en) * | 2006-11-06 | 2008-05-15 | Supergen, Inc. | Imidazo[1,2-b]pyridazine and pyrazolo[1,5-a]pyrimidine derivatives and their use as protein kinase inhibitors |
| RU2009120389A (ru) * | 2006-10-30 | 2010-12-10 | Новартис АГ (CH) | Гетероциклические соединения в качестве противовоспалительных агентов |
| EA201001774A1 (ru) * | 2008-05-13 | 2011-06-30 | Айрм Ллк | Конденсированные азотсодержащие гетероциклы и содержащие их композиции в качестве ингибиторов киназы |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6399780B1 (en) | 1999-08-20 | 2002-06-04 | Cephalon, Inc. | Isomeric fused pyrrolocarbazoles and isoindolones |
| WO2002020513A1 (en) | 2000-09-01 | 2002-03-14 | Glaxo Group Limited | Oxindole derivatives |
| WO2002020479A1 (en) | 2000-09-01 | 2002-03-14 | Glaxo Group Limited | Substituted oxindole derivatives as tyrosine kinase inhibitors |
| JP2003231687A (ja) | 2002-02-04 | 2003-08-19 | Japan Tobacco Inc | ピラゾリル縮合環化合物及びその医薬用途 |
| MY141220A (en) | 2003-11-17 | 2010-03-31 | Astrazeneca Ab | Pyrazole derivatives as inhibitors of receptor tyrosine kinases |
| WO2005103010A2 (en) | 2004-04-21 | 2005-11-03 | Astrazeneca Ab | Pyrazole derivatives useful for the treatment of cancer |
| EP1832588A4 (en) | 2004-12-28 | 2009-09-02 | Takeda Pharmaceutical | CONDENSED IMIDAZOLE COMPOUND AND ITS USE |
| HUE025671T2 (en) | 2005-02-04 | 2016-04-28 | Astrazeneca Ab | Pyrazolylaminopyridine derivatives useful as kinase inhibitors |
| ES2308731T3 (es) | 2005-02-16 | 2008-12-01 | Astrazeneca Ab | Compuestos quimicos. |
| EP1853602B1 (en) | 2005-02-16 | 2010-07-14 | AstraZeneca AB | Chemical compounds |
| WO2007013673A1 (en) | 2005-07-29 | 2007-02-01 | Astellas Pharma Inc. | Fused heterocycles as lck inhibitors |
| CN101208339B (zh) * | 2005-08-01 | 2010-12-29 | 霍夫曼-拉罗奇有限公司 | 杂环苄基氨基衍生物，它们的制备以及作为药剂的应用 |
| DE102005042742A1 (de) | 2005-09-02 | 2007-03-08 | Schering Ag | Substituierte Imidazo[1,2b]pyridazine als Kinase-Inhibitoren, deren Herstellung und Verwendung als Arzneimittel |
| WO2008072682A1 (ja) * | 2006-12-15 | 2008-06-19 | Daiichi Sankyo Company, Limited | イミダゾ［１，２－ｂ］ピリダジン誘導体 |
| JP2009227599A (ja) * | 2008-03-21 | 2009-10-08 | Daiichi Sankyo Co Ltd | イミダゾピリダジン誘導体 |
| CN102224153B (zh) * | 2008-09-22 | 2014-04-30 | 阵列生物制药公司 | 作为trk激酶抑制剂的取代的咪唑并[1，2-b]哒嗪化合物 |
| KR101147550B1 (ko) | 2009-10-22 | 2012-05-17 | 한국과학기술연구원 | 단백질 키나아제 저해활성을 가지는 2,7-치환된 티에노［3,2-ｄ］피리미딘 화합물 |
| WO2012005299A1 (ja) | 2010-07-07 | 2012-01-12 | 日本新薬株式会社 | Ｒｏｓチロシンキナーゼ阻害剤 |
| WO2012125667A1 (en) | 2011-03-17 | 2012-09-20 | Merck Sharp & Dohme Corp. | TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF |
-
2013
- 2013-05-31 TW TW102119261A patent/TWI585088B/zh active
- 2013-06-03 JP JP2014519977A patent/JP5814467B2/ja active Active
- 2013-06-03 CA CA2874819A patent/CA2874819C/en active Active
- 2013-06-03 PT PT138013206T patent/PT2857404T/pt unknown
- 2013-06-03 KR KR1020147033351A patent/KR101781255B1/ko active Active
- 2013-06-03 CN CN201380041498.XA patent/CN104520300B/zh active Active
- 2013-06-03 PL PL13801320T patent/PL2857404T3/pl unknown
- 2013-06-03 DK DK13801320.6T patent/DK2857404T3/en active
- 2013-06-03 SG SG11201408052WA patent/SG11201408052WA/en unknown
- 2013-06-03 NO NO13801320A patent/NO2857404T3/no unknown
- 2013-06-03 EP EP13801320.6A patent/EP2857404B1/en active Active
- 2013-06-03 LT LTEP13801320.6T patent/LT2857404T/lt unknown
- 2013-06-03 SI SI201330798T patent/SI2857404T1/sl unknown
- 2013-06-03 HR HRP20171724TT patent/HRP20171724T1/hr unknown
- 2013-06-03 HU HUE13801320A patent/HUE037221T2/hu unknown
- 2013-06-03 BR BR112014029851-3A patent/BR112014029851B1/pt active IP Right Grant
- 2013-06-03 RS RS20171198A patent/RS56625B1/sr unknown
- 2013-06-03 ES ES13801320.6T patent/ES2648228T3/es active Active
- 2013-06-03 US US14/378,318 patent/US9187489B2/en active Active
- 2013-06-03 AU AU2013272701A patent/AU2013272701B2/en active Active
- 2013-06-03 MX MX2014014803A patent/MX357021B/es active IP Right Grant
- 2013-06-03 NZ NZ702574A patent/NZ702574A/en unknown
- 2013-06-03 IN IN2497MUN2014 patent/IN2014MN02497A/en unknown
- 2013-06-03 SM SM20170539T patent/SMT201700539T1/it unknown
- 2013-06-03 MY MYPI2014003346A patent/MY170326A/en unknown
- 2013-06-03 RU RU2014153627A patent/RU2635917C2/ru active
- 2013-06-03 WO PCT/JP2013/065328 patent/WO2013183578A1/ja not_active Ceased
-
2014
- 2014-12-02 ZA ZA2014/08843A patent/ZA201408843B/en unknown
- 2014-12-04 IL IL236075A patent/IL236075A/en active IP Right Grant
- 2014-12-04 PH PH12014502721A patent/PH12014502721A1/en unknown
- 2014-12-30 CO CO14286593A patent/CO7160119A2/es unknown
-
2015
- 2015-10-29 US US14/926,973 patent/US9751887B2/en active Active
-
2017
- 2017-11-15 CY CY20171101204T patent/CY1119607T1/el unknown
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007147646A1 (de) * | 2006-06-21 | 2007-12-27 | Bayer Schering Pharma Aktiengesellschaft | OXO-SUBSTITUIERTE IMIDAZO[1,2b]PYRIDAZINE, DEREN HERSTELLUNG UND VERWENDUNG ALS ARZNEIMITTEL |
| RU2009120389A (ru) * | 2006-10-30 | 2010-12-10 | Новартис АГ (CH) | Гетероциклические соединения в качестве противовоспалительных агентов |
| WO2008058126A2 (en) * | 2006-11-06 | 2008-05-15 | Supergen, Inc. | Imidazo[1,2-b]pyridazine and pyrazolo[1,5-a]pyrimidine derivatives and their use as protein kinase inhibitors |
| EA201001774A1 (ru) * | 2008-05-13 | 2011-06-30 | Айрм Ллк | Конденсированные азотсодержащие гетероциклы и содержащие их композиции в качестве ингибиторов киназы |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2821941C2 (ru) * | 2018-03-02 | 2024-06-28 | Оцука Фармасьютикал Ко., Лтд. | Фармацевтические соединения |
| US12037345B2 (en) | 2018-07-24 | 2024-07-16 | Taiho Pharmaceutical Co., Ltd. | Heterobicyclic compounds for inhibiting the activity of SHP2 |
| US12458640B2 (en) | 2019-08-20 | 2025-11-04 | Otsuka Pharmaceutical Co., Ltd. | Pyrazolo[3,4-b]pyrazine SHP2 phosphatase inhibitors |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2635917C2 (ru) | Имидазо[1, 2-b]пиридазиновые производные как ингибиторы киназ | |
| US9980952B2 (en) | Modulators of methyl modifying enzymes, compositions and uses thereof | |
| DK2625175T3 (en) | Crystalline (R) - (E) -2- (4- (2- (5- (1- (3,5-dichloropyridine-4-yl) ethoxy) -1H-indazol-3-yl) vinyl) -1H- pYRAZOLE-1-YL) ETHANOL AND USE THEREOF AS FGFR-INHIBITOR | |
| JP2022518860A (ja) | 免疫調節剤、組成物およびその使用方法 | |
| KR20180081790A (ko) | Ntrk 관련 장애의 치료에 유용한 화합물 및 조성물 | |
| EP3405192A1 (en) | Bruton's tyrosine kinase inhibitors | |
| US20220289732A1 (en) | Heterocyclic wdr5 inhibitors as anti-cancer compounds | |
| EP3601264A1 (en) | Bruton's tyrosine kinase inhibitors | |
| EP3694331A1 (en) | Indazolyl-spiro[2.3]hexane-carbonitrile derivatives as lrrk2 inhibitors, pharmaceutical compositions, and uses thereof | |
| EP4141003A1 (en) | Pyrazolo[1,5-a]pyridine derivative, preparation method therefor, and composition and use thereof | |
| CN118139846A (zh) | 一种egfr小分子抑制剂、含其的药物组合物及其用途 | |
| HK1207374B (en) | Imidazo[1,2-b]pyridazine derivatives as kinase inhibitors | |
| TW202510871A (zh) | 經取代之雙環化合物 | |
| EP4308096A1 (en) | Heteroaroyl amides as lrrk2 inhibitors, pharmaceutical compositions, and uses thereof | |
| KR20230142350A (ko) | 에틸 피페리딘 트리아졸로 트리아진 유도체, 이의 제조방법 및 이를 포함하는 암의 예방 또는 치료용 약학적 조성물 | |
| EA041461B1 (ru) | Ингибиторы тирозинкиназы брутона |