RU2621039C1 - Полициклические производные, способ их получения и их фармацевтическое применение - Google Patents
Полициклические производные, способ их получения и их фармацевтическое применение Download PDFInfo
- Publication number
- RU2621039C1 RU2621039C1 RU2014132158A RU2014132158A RU2621039C1 RU 2621039 C1 RU2621039 C1 RU 2621039C1 RU 2014132158 A RU2014132158 A RU 2014132158A RU 2014132158 A RU2014132158 A RU 2014132158A RU 2621039 C1 RU2621039 C1 RU 2621039C1
- Authority
- RU
- Russia
- Prior art keywords
- compound
- mmol
- formula
- cycloalkyl
- oxy
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/80—Radicals substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Furan Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210008286.9 | 2012-01-12 | ||
| CN201210008286 | 2012-01-12 | ||
| PCT/CN2012/087606 WO2013104257A1 (zh) | 2012-01-12 | 2012-12-27 | 多环类衍生物、其制备方法及其在医药上的应用 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2621039C1 true RU2621039C1 (ru) | 2017-05-31 |
Family
ID=48781054
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2014132158A RU2621039C1 (ru) | 2012-01-12 | 2012-12-27 | Полициклические производные, способ их получения и их фармацевтическое применение |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US9139548B2 (enExample) |
| EP (1) | EP2803664B1 (enExample) |
| JP (1) | JP6122871B2 (enExample) |
| KR (1) | KR102036547B1 (enExample) |
| CN (1) | CN103429581B (enExample) |
| AU (1) | AU2012365706B2 (enExample) |
| BR (1) | BR112014016648B1 (enExample) |
| CA (1) | CA2860353A1 (enExample) |
| MX (1) | MX357780B (enExample) |
| RU (1) | RU2621039C1 (enExample) |
| TW (1) | TWI588136B (enExample) |
| UA (1) | UA115975C2 (enExample) |
| WO (1) | WO2013104257A1 (enExample) |
| ZA (1) | ZA201404625B (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2852177C1 (ru) * | 2020-09-10 | 2025-12-04 | Аб Фарма Лтд. | Бензокислородсодержащее гетероциклическое соединение и его применение в медицине |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015062486A1 (en) * | 2013-10-31 | 2015-05-07 | Sunshine Lake Pharma Co., Ltd. | Biphenyl compounds and uses thereof |
| CN104650055A (zh) * | 2013-11-22 | 2015-05-27 | 山东轩竹医药科技有限公司 | 芳香多环羧酸衍生物 |
| CN104788412B (zh) * | 2014-01-22 | 2017-02-15 | 山东轩竹医药科技有限公司 | 芳香多环羧酸衍生物 |
| WO2016019587A1 (en) | 2014-08-08 | 2016-02-11 | Merck Sharp & Dohme Corp. | [7, 6]-fused bicyclic antidiabetic compounds |
| US10100042B2 (en) | 2014-08-08 | 2018-10-16 | Merck Sharp & Dohme Corp. | [5,6]—fused bicyclic antidiabetic compounds |
| WO2016022742A1 (en) | 2014-08-08 | 2016-02-11 | Merck Sharp & Dohme Corp. | Antidiabetic bicyclic compounds |
| WO2016022448A1 (en) | 2014-08-08 | 2016-02-11 | Merck Sharp & Dohme Corp. | Antidiabetic bicyclic compounds |
| WO2016059042A1 (de) | 2014-10-14 | 2016-04-21 | Basf Se | Verwendung von hexadeca-8,15-dienal als aromachemikalie |
| CN106478616B (zh) * | 2015-08-27 | 2020-05-12 | 江苏恒瑞医药股份有限公司 | 一种gpr40激动剂的结晶形式及其制备方法 |
| CN108236609B (zh) * | 2016-12-27 | 2022-10-21 | 江苏恒瑞医药股份有限公司 | 一种gpr40激动剂药物组合物及其制备方法 |
| CN108236611A (zh) * | 2016-12-27 | 2018-07-03 | 江苏恒瑞医药股份有限公司 | 两种化合物联合在制备治疗糖尿病药物中的用途 |
| BR102018007822A2 (pt) | 2017-04-20 | 2018-11-06 | Gilead Sciences, Inc. | composto, métodos para inibir pd-1, pd-l1 e/ou interação de pd-1/pd-l1 e para tratamento de câncer, composição farmacêutica, e, kit para tratamento de ou prevenção de câncer ou uma doença ou condição |
| WO2019160882A1 (en) | 2018-02-13 | 2019-08-22 | Gilead Sciences, Inc. | Pd-1/pd-l1 inhibitors |
| KR102591947B1 (ko) | 2018-04-19 | 2023-10-25 | 길리애드 사이언시즈, 인코포레이티드 | Pd-1/pd-l1 억제제 |
| PE20210642A1 (es) | 2018-07-13 | 2021-03-23 | Gilead Sciences Inc | Inhibidores de pd-1/pd-l1 |
| US11236085B2 (en) | 2018-10-24 | 2022-02-01 | Gilead Sciences, Inc. | PD-1/PD-L1 inhibitors |
| JP2022552655A (ja) | 2019-10-07 | 2022-12-19 | キャリーオペ，インク． | Ｇｐｒ１１９アゴニスト |
| MX2022010548A (es) | 2020-02-28 | 2022-09-23 | Kallyope Inc | Agonistas de gpr40. |
| MX2022014505A (es) | 2020-05-19 | 2022-12-13 | Kallyope Inc | Activadores de la ampk. |
| CA3183575A1 (en) | 2020-06-26 | 2021-12-30 | Iyassu Sebhat | Ampk activators |
| CN114163426B (zh) * | 2020-09-10 | 2024-03-19 | 上海爱博医药科技有限公司 | 苯并含氧杂环类化合物及其医药应用 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2138498C1 (ru) * | 1994-07-22 | 1999-09-27 | Бык Гульден Ломберг Хемише Фабрик Гмбх | Дигидробензофураны, способ их получения и фармацевтическая композиция на их основе |
| US20060258722A1 (en) * | 2003-05-30 | 2006-11-16 | Takeda Pharmaceutical Company., Ltd. | Condensed ring compound |
| US20070244155A1 (en) * | 2006-03-14 | 2007-10-18 | Amgen Inc. | Bicyclic carboxylic acid derivatives useful for treating metabolic disorders |
| US20110313003A1 (en) * | 2010-06-16 | 2011-12-22 | Metabolex, Inc. | Gpr120 receptor agonists and uses thereof |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007502815A (ja) | 2003-08-20 | 2007-02-15 | イーライ リリー アンド カンパニー | Ｐｐａｒ調節因子 |
| WO2005051890A1 (en) | 2003-11-19 | 2005-06-09 | Smithkline Beecham Corporation | Aminophenylcyclopropyl carboxylic acids and derivatives as agonists to gpr40 |
| JP4074616B2 (ja) * | 2003-12-25 | 2008-04-09 | 武田薬品工業株式会社 | ３−（４−ベンジルオキシフェニル）プロパン酸誘導体 |
| US7456218B2 (en) * | 2003-12-25 | 2008-11-25 | Takeda Pharmaceutical Company Limited | 3-(4-benzyloxyphenyl) propanoic acid derivatives |
| WO2005087710A1 (ja) * | 2004-03-15 | 2005-09-22 | Takeda Pharmaceutical Company Limited | アミノフェニルプロパン酸誘導体 |
| WO2005115384A2 (en) * | 2004-05-25 | 2005-12-08 | Metabolex, Inc. | Bicyclic, substituted triazoles as modulators of ppar and methods of their preparation |
| AU2007265966B2 (en) | 2006-06-27 | 2012-05-17 | Takeda Pharmaceutical Company Limited | Fused cyclic compounds |
| EA022417B1 (ru) * | 2008-10-21 | 2015-12-30 | Саймабэй Терапевтикс, Инк. | Арильные агонисты рецептора gpr120 и их применение |
| AR074760A1 (es) * | 2008-12-18 | 2011-02-09 | Metabolex Inc | Agonistas del receptor gpr120 y usos de los mismos en medicamentos para el tratamiento de diabetes y el sindrome metabolico. |
| CN102333757B (zh) | 2009-01-30 | 2014-11-26 | 富山化学工业株式会社 | N-酰基邻氨基苯甲酸衍生物或其盐 |
| KR20120022801A (ko) * | 2009-04-22 | 2012-03-12 | 아스텔라스세이야쿠 가부시키가이샤 | 카르복실산 화합물 |
| US20120172351A1 (en) | 2009-06-09 | 2012-07-05 | Nobuyuki Negoro | Novel fused cyclic compound and use thereof |
| CN102153553A (zh) | 2010-02-11 | 2011-08-17 | 山东轩竹医药科技有限公司 | 含有氨基磺酰胺基氮杂环丁烷的口服碳青霉烯化合物 |
-
2012
- 2012-12-27 EP EP12865081.9A patent/EP2803664B1/en not_active Not-in-force
- 2012-12-27 RU RU2014132158A patent/RU2621039C1/ru not_active IP Right Cessation
- 2012-12-27 AU AU2012365706A patent/AU2012365706B2/en not_active Ceased
- 2012-12-27 UA UAA201408867A patent/UA115975C2/uk unknown
- 2012-12-27 US US14/371,123 patent/US9139548B2/en not_active Expired - Fee Related
- 2012-12-27 BR BR112014016648-0A patent/BR112014016648B1/pt not_active IP Right Cessation
- 2012-12-27 WO PCT/CN2012/087606 patent/WO2013104257A1/zh not_active Ceased
- 2012-12-27 MX MX2014008125A patent/MX357780B/es active IP Right Grant
- 2012-12-27 CA CA2860353A patent/CA2860353A1/en not_active Abandoned
- 2012-12-27 KR KR1020147022007A patent/KR102036547B1/ko not_active Expired - Fee Related
- 2012-12-27 JP JP2014551505A patent/JP6122871B2/ja active Active
- 2012-12-27 CN CN201280011690.XA patent/CN103429581B/zh active Active
-
2013
- 2013-01-09 TW TW102100678A patent/TWI588136B/zh not_active IP Right Cessation
-
2014
- 2014-06-24 ZA ZA2014/04625A patent/ZA201404625B/en unknown
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2138498C1 (ru) * | 1994-07-22 | 1999-09-27 | Бык Гульден Ломберг Хемише Фабрик Гмбх | Дигидробензофураны, способ их получения и фармацевтическая композиция на их основе |
| US20060258722A1 (en) * | 2003-05-30 | 2006-11-16 | Takeda Pharmaceutical Company., Ltd. | Condensed ring compound |
| US20070244155A1 (en) * | 2006-03-14 | 2007-10-18 | Amgen Inc. | Bicyclic carboxylic acid derivatives useful for treating metabolic disorders |
| US20110313003A1 (en) * | 2010-06-16 | 2011-12-22 | Metabolex, Inc. | Gpr120 receptor agonists and uses thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2852177C1 (ru) * | 2020-09-10 | 2025-12-04 | Аб Фарма Лтд. | Бензокислородсодержащее гетероциклическое соединение и его применение в медицине |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2012365706B2 (en) | 2015-08-20 |
| BR112014016648A2 (pt) | 2017-06-13 |
| UA115975C2 (uk) | 2018-01-25 |
| CN103429581B (zh) | 2015-08-26 |
| BR112014016648B1 (pt) | 2020-10-27 |
| JP6122871B2 (ja) | 2017-04-26 |
| TW201329058A (zh) | 2013-07-16 |
| JP2015503595A (ja) | 2015-02-02 |
| US20150005282A1 (en) | 2015-01-01 |
| WO2013104257A1 (zh) | 2013-07-18 |
| ZA201404625B (en) | 2015-11-25 |
| US9139548B2 (en) | 2015-09-22 |
| EP2803664B1 (en) | 2018-11-21 |
| HK1188781A1 (zh) | 2014-05-16 |
| CA2860353A1 (en) | 2013-07-18 |
| TWI588136B (zh) | 2017-06-21 |
| AU2012365706A1 (en) | 2014-07-24 |
| EP2803664A4 (en) | 2015-10-28 |
| KR20140117498A (ko) | 2014-10-07 |
| BR112014016648A8 (pt) | 2017-07-04 |
| MX357780B (es) | 2018-07-24 |
| EP2803664A1 (en) | 2014-11-19 |
| CN103429581A (zh) | 2013-12-04 |
| KR102036547B1 (ko) | 2019-10-25 |
| MX2014008125A (es) | 2014-09-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20201228 |