CN103429581B - 多环类衍生物、其制备方法及其在医药上的应用 - Google Patents

多环类衍生物、其制备方法及其在医药上的应用 Download PDF

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Publication number
CN103429581B
CN103429581B CN201280011690.XA CN201280011690A CN103429581B CN 103429581 B CN103429581 B CN 103429581B CN 201280011690 A CN201280011690 A CN 201280011690A CN 103429581 B CN103429581 B CN 103429581B
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alkyl
compound
dihydrobenzofuran
yloxy
general formula
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Chinese (zh)
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CN103429581A (zh
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杨方龙
董庆
韩吉慧
王春飞
张羚
王阳
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Jiangsu Hengrui Medicine Co Ltd
Shanghai Hengrui Pharmaceutical Co Ltd
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Jiangsu Hengrui Medicine Co Ltd
Shanghai Hengrui Pharmaceutical Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
CN201280011690.XA 2012-01-12 2012-12-27 多环类衍生物、其制备方法及其在医药上的应用 Active CN103429581B (zh)

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Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN201210008286.9 2012-01-12
CN2012100082869 2012-01-12
CN201210008286 2012-01-12
PCT/CN2012/087606 WO2013104257A1 (zh) 2012-01-12 2012-12-27 多环类衍生物、其制备方法及其在医药上的应用
CN201280011690.XA CN103429581B (zh) 2012-01-12 2012-12-27 多环类衍生物、其制备方法及其在医药上的应用

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CN103429581B true CN103429581B (zh) 2015-08-26

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US (1) US9139548B2 (enExample)
EP (1) EP2803664B1 (enExample)
JP (1) JP6122871B2 (enExample)
KR (1) KR102036547B1 (enExample)
CN (1) CN103429581B (enExample)
AU (1) AU2012365706B2 (enExample)
BR (1) BR112014016648B1 (enExample)
CA (1) CA2860353A1 (enExample)
MX (1) MX357780B (enExample)
RU (1) RU2621039C1 (enExample)
TW (1) TWI588136B (enExample)
UA (1) UA115975C2 (enExample)
WO (1) WO2013104257A1 (enExample)
ZA (1) ZA201404625B (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108236611A (zh) * 2016-12-27 2018-07-03 江苏恒瑞医药股份有限公司 两种化合物联合在制备治疗糖尿病药物中的用途
WO2022053013A1 (zh) * 2020-09-10 2022-03-17 上海爱博医药科技有限公司 苯并含氧杂环类化合物及其医药应用

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CN104592211B (zh) * 2013-10-31 2018-10-16 广东东阳光药业有限公司 联苯类化合物及其用途
CN104650055A (zh) * 2013-11-22 2015-05-27 山东轩竹医药科技有限公司 芳香多环羧酸衍生物
CN104788412B (zh) * 2014-01-22 2017-02-15 山东轩竹医药科技有限公司 芳香多环羧酸衍生物
WO2016022742A1 (en) 2014-08-08 2016-02-11 Merck Sharp & Dohme Corp. Antidiabetic bicyclic compounds
WO2016022446A1 (en) 2014-08-08 2016-02-11 Merck Sharp & Dohme Corp. [5,6]-fused bicyclic antidiabetic compounds
WO2016019587A1 (en) 2014-08-08 2016-02-11 Merck Sharp & Dohme Corp. [7, 6]-fused bicyclic antidiabetic compounds
US10662171B2 (en) 2014-08-08 2020-05-26 Merck Sharp & Dohme Corp. Antidiabetic bicyclic compounds
US10087395B2 (en) 2014-10-14 2018-10-02 Basf Se Use of hexadeca-8,15-dienal as aroma chemical
CN106478616B (zh) * 2015-08-27 2020-05-12 江苏恒瑞医药股份有限公司 一种gpr40激动剂的结晶形式及其制备方法
CN108236609B (zh) * 2016-12-27 2022-10-21 江苏恒瑞医药股份有限公司 一种gpr40激动剂药物组合物及其制备方法
JP7062792B2 (ja) 2018-02-13 2022-05-06 ギリアード サイエンシーズ， インコーポレイテッド Ｐｄ－１／ｐｄ－ｌ１阻害剤
EP3781556B1 (en) 2018-04-19 2025-06-18 Gilead Sciences, Inc. Pd-1/pd-l1 inhibitors
CN118221646A (zh) 2018-07-13 2024-06-21 吉利德科学公司 Pd-1/pd-l1抑制剂
KR102635333B1 (ko) 2018-10-24 2024-02-15 길리애드 사이언시즈, 인코포레이티드 Pd-1/pd-l1 억제제
JP2022552655A (ja) 2019-10-07 2022-12-19 キャリーオペ，インク． Ｇｐｒ１１９アゴニスト
PH12022552277A1 (en) 2020-02-28 2024-03-04 Kallyope Inc Gpr40 agonists
CA3178994A1 (en) 2020-05-19 2021-11-25 Iyassu Sebhat Ampk activators
JP2023531726A (ja) 2020-06-26 2023-07-25 キャリーオペ，インク． Ａｍｐｋアクチベーター

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EP1630152A1 (en) * 2003-05-30 2006-03-01 Takeda Pharmaceutical Company Limited Condensed ring compound
US20070244155A1 (en) * 2006-03-14 2007-10-18 Amgen Inc. Bicyclic carboxylic acid derivatives useful for treating metabolic disorders
CN101616913A (zh) * 2006-06-27 2009-12-30 武田药品工业株式会社 稠环化合物
WO2010123016A1 (ja) * 2009-04-22 2010-10-28 アステラス製薬株式会社 カルボン酸化合物

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JP4074616B2 (ja) * 2003-12-25 2008-04-09 武田薬品工業株式会社 ３−（４−ベンジルオキシフェニル）プロパン酸誘導体
BRPI0418148A (pt) * 2003-12-25 2007-04-17 Takeda Pharmaceutical composto, prodroga de um composto, modulador da função do receptor gpr40, agente farmacêutico, uso de um composto e métodos de modificação de uma função do receptor gpr40 em um mamìfero, de profilaxia ou tratamento de diabetes em um mamìfero e de produção de um composto
EP1726580A4 (en) * 2004-03-15 2008-02-13 Takeda Pharmaceutical AMINOPHNYLPROPANO ACID DERIVATIVE
JP2008500358A (ja) * 2004-05-25 2008-01-10 メタボレックス インコーポレーティッド Ｐｐａｒのモジュレーターとしての、二環式の置換されたトリアゾール、およびこれらの調製方法
UA107917C2 (ru) 2008-10-21 2015-03-10 Сімабей Терапьютікс, Інк. Арильный агонист рецептора gpr120 и его применение
AR074760A1 (es) 2008-12-18 2011-02-09 Metabolex Inc Agonistas del receptor gpr120 y usos de los mismos en medicamentos para el tratamiento de diabetes y el sindrome metabolico.
WO2010087430A1 (ja) 2009-01-30 2010-08-05 富山化学工業株式会社 Ｎ－アシルアントラニル酸誘導体またはその塩
WO2010143733A1 (en) 2009-06-09 2010-12-16 Takeda Pharmaceutical Company Limited Novel fused cyclic compound and use thereof
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EP1630152A1 (en) * 2003-05-30 2006-03-01 Takeda Pharmaceutical Company Limited Condensed ring compound
US20070244155A1 (en) * 2006-03-14 2007-10-18 Amgen Inc. Bicyclic carboxylic acid derivatives useful for treating metabolic disorders
CN101616913A (zh) * 2006-06-27 2009-12-30 武田药品工业株式会社 稠环化合物
WO2010123016A1 (ja) * 2009-04-22 2010-10-28 アステラス製薬株式会社 カルボン酸化合物

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108236611A (zh) * 2016-12-27 2018-07-03 江苏恒瑞医药股份有限公司 两种化合物联合在制备治疗糖尿病药物中的用途
WO2022053013A1 (zh) * 2020-09-10 2022-03-17 上海爱博医药科技有限公司 苯并含氧杂环类化合物及其医药应用

Also Published As

Publication number Publication date
BR112014016648A8 (pt) 2017-07-04
KR20140117498A (ko) 2014-10-07
MX357780B (es) 2018-07-24
CA2860353A1 (en) 2013-07-18
AU2012365706B2 (en) 2015-08-20
BR112014016648A2 (pt) 2017-06-13
KR102036547B1 (ko) 2019-10-25
US20150005282A1 (en) 2015-01-01
JP2015503595A (ja) 2015-02-02
TW201329058A (zh) 2013-07-16
WO2013104257A1 (zh) 2013-07-18
HK1188781A1 (zh) 2014-05-16
AU2012365706A1 (en) 2014-07-24
RU2621039C1 (ru) 2017-05-31
UA115975C2 (uk) 2018-01-25
EP2803664B1 (en) 2018-11-21
MX2014008125A (es) 2014-09-22
EP2803664A1 (en) 2014-11-19
TWI588136B (zh) 2017-06-21
ZA201404625B (en) 2015-11-25
BR112014016648B1 (pt) 2020-10-27
US9139548B2 (en) 2015-09-22
EP2803664A4 (en) 2015-10-28
JP6122871B2 (ja) 2017-04-26
CN103429581A (zh) 2013-12-04

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