RU2617696C2 - Способы и соединения, которые можно использовать для синтеза антагонистов рецепторов орексина-2 - Google Patents
Способы и соединения, которые можно использовать для синтеза антагонистов рецепторов орексина-2 Download PDFInfo
- Publication number
- RU2617696C2 RU2617696C2 RU2014137470A RU2014137470A RU2617696C2 RU 2617696 C2 RU2617696 C2 RU 2617696C2 RU 2014137470 A RU2014137470 A RU 2014137470A RU 2014137470 A RU2014137470 A RU 2014137470A RU 2617696 C2 RU2617696 C2 RU 2617696C2
- Authority
- RU
- Russia
- Prior art keywords
- compound
- formula
- alkyl
- group
- halogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/63—Esters of sulfonic acids
- C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/73—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
- C07C303/28—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reaction of hydroxy compounds with sulfonic acids or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/42—Separation; Purification; Stabilisation; Use of additives
- C07C303/44—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/63—Esters of sulfonic acids
- C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
- C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
- C07C309/66—Methanesulfonates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
- C07C69/12—Acetic acid esters
- C07C69/16—Acetic acid esters of dihydroxylic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/22—Preparation of oxygen-containing organic compounds containing a hydroxy group aromatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
- C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
- C07C29/147—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
- C07C33/36—Polyhydroxylic alcohols containing six-membered aromatic rings and other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/03—Preparation of carboxylic acid esters by reacting an ester group with a hydroxy group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/83—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Wood Science & Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Furan Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261600109P | 2012-02-17 | 2012-02-17 | |
| US61/600,109 | 2012-02-17 | ||
| PCT/US2013/026204 WO2013123240A1 (en) | 2012-02-17 | 2013-02-14 | Methods and compounds useful in the synthesis of orexin-2 receptor antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2014137470A RU2014137470A (ru) | 2016-04-10 |
| RU2617696C2 true RU2617696C2 (ru) | 2017-04-26 |
Family
ID=47755050
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2014137470A RU2617696C2 (ru) | 2012-02-17 | 2013-02-14 | Способы и соединения, которые можно использовать для синтеза антагонистов рецепторов орексина-2 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US9416109B2 (enExample) |
| EP (1) | EP2814798B1 (enExample) |
| JP (1) | JP6147279B2 (enExample) |
| CN (1) | CN104114524B (enExample) |
| BR (1) | BR112014019909B1 (enExample) |
| CA (1) | CA2861493C (enExample) |
| ES (1) | ES2733750T3 (enExample) |
| HU (1) | HUE043995T2 (enExample) |
| IL (1) | IL232949A (enExample) |
| MX (1) | MX352881B (enExample) |
| RU (1) | RU2617696C2 (enExample) |
| SG (1) | SG11201403216UA (enExample) |
| WO (1) | WO2013123240A1 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2823998C2 (ru) * | 2019-05-15 | 2024-07-31 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Способ и соединение, пригодные в получении антагониста рецептора орексина-2, и лемборексант, содержащий небольшое количество примесей |
| US12479819B2 (en) | 2019-05-15 | 2025-11-25 | Eisai R&D Management Co., Ltd. | Method and compound useful in preparation of orexin-2 receptor antagonist, and lemborexant having few impurities |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9440982B2 (en) | 2012-02-07 | 2016-09-13 | Eolas Therapeutics, Inc. | Substituted prolines/piperidines as orexin receptor antagonists |
| JP6346862B2 (ja) | 2012-02-07 | 2018-06-20 | エオラス セラピューティクス, インコーポレイテッド | オレキシンレセプターアンタゴニストとしての置換プロリン/ピペリジン |
| US9416109B2 (en) * | 2012-02-17 | 2016-08-16 | Eisai R&D Management Co., Ltd. | Methods and compounds useful in the synthesis of orexin-2 receptor antagonists |
| ES2731648T3 (es) | 2014-08-06 | 2019-11-18 | Eisai R&D Man Co Ltd | Método para producir un compuesto de pirimidina-1-ol y compuesto intermedio del mismo |
| TW201613902A (en) | 2014-08-13 | 2016-04-16 | Eolas Therapeutics Inc | Difluoropyrrolidines as orexin receptor modulators |
| US10894789B2 (en) | 2016-02-12 | 2021-01-19 | Astrazeneca Ab | Halo-substituted piperidines as orexin receptor modulators |
| JP7179049B2 (ja) * | 2017-08-01 | 2022-11-28 | ベルゲン ファーマシューティカル、 エルエルシー | オレキシン受容体拮抗薬の結晶形及びその製造方法並びに用途 |
| GB201807898D0 (en) * | 2018-05-15 | 2018-06-27 | Kancera Ab | New processes and products with increased chiral purity |
| SG11202101818XA (en) * | 2018-09-07 | 2021-03-30 | Sumitomo Chemical Co | Method for manufacturing cyclopropane compound |
| JP7281564B2 (ja) | 2019-06-12 | 2023-05-25 | ヌーリオン ケミカルズ インターナショナル ベスローテン フェノーツハップ | 過酸化ジアシルを生成するためのプロセス |
| JP7281563B2 (ja) | 2019-06-12 | 2023-05-25 | ヌーリオン ケミカルズ インターナショナル ベスローテン フェノーツハップ | ペルオキシエステルを生成するためのプロセス |
| US11976035B2 (en) | 2019-06-12 | 2024-05-07 | Nouryon Chemicals International B.V. | Process for the production of diacyl peroxides |
| ES2963356T3 (es) * | 2019-06-12 | 2024-03-26 | Nouryon Chemicals Int Bv | Método para aislar ácido carboxílico a partir de una corriente lateral acuosa |
| JP7335362B2 (ja) | 2019-06-12 | 2023-08-29 | ヌーリオン ケミカルズ インターナショナル ベスローテン フェノーツハップ | 過酸化ジアシルを生成するためのプロセス |
| WO2020263253A1 (en) * | 2019-06-26 | 2020-12-30 | Moline Margaret | Lemborexant for treating sleep issues |
| JP2023506025A (ja) | 2019-12-11 | 2023-02-14 | テバ チェコ インダストリーズ エス.アール.オー. | レンボレキサントの固体形態 |
| EP4076463A1 (en) | 2019-12-20 | 2022-10-26 | Eisai R&D Management Co., Ltd. | Use of lemborexant for treating insomnia |
| IL328515A (en) | 2020-01-16 | 2026-07-01 | Eisai R&D Man Co Ltd | Lamborxant drug substance and medical preparation containing it |
| ES2933074B2 (es) * | 2021-07-26 | 2023-09-29 | Moehs Iberica Sl | Procedimiento de sintesis de 2,4-dimetilpirimidin-5-ol, nuevos intermedios de dicho procedimiento y uso del producto en la sintesis de lemborexant |
| WO2023178702A1 (zh) * | 2022-03-25 | 2023-09-28 | 浙江华海药业股份有限公司 | 莱博雷生及其中间体化合物的制备方法 |
| CN118871427A (zh) * | 2022-03-25 | 2024-10-29 | 浙江华海药业股份有限公司 | 一种莱博雷生及其中间体的制备方法 |
| CN114778745B (zh) * | 2022-06-21 | 2022-09-16 | 南京威凯尔生物医药科技有限公司 | 一种高效液相色谱法检测仑布雷生中间体及其对映体杂质的方法 |
| CN121045084A (zh) * | 2024-06-01 | 2025-12-02 | 常州市第四制药厂有限公司 | 一种莱博雷生关键中间体及其合成方法 |
| CN119930526B (zh) * | 2025-04-07 | 2025-07-08 | 东北制药集团股份有限公司 | 一种莱博雷生中间体的制备方法 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008057575A2 (en) * | 2006-11-07 | 2008-05-15 | Dov Pharmaceutical, Inc. | Novel arylbicyclo[3.1.0]hexylamines and methods and compositions for their preparation and use |
| WO2008150364A1 (en) * | 2007-05-23 | 2008-12-11 | Merck & Co., Inc. | Cyclopropyl pyrrolidine orexin receptor antagonists |
| RU2009147733A (ru) * | 2007-05-23 | 2011-06-27 | Мерк Шарп Энд Домэ Корп. (Us) | Пиридилпиперидновые антагонисты рецептора орексинов |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2302994A1 (fr) * | 1975-03-06 | 1976-10-01 | Fabre Sa Pierre | Procede de preparation d'acides aryl-1, hydroxy methyl-2 cyclopropanes carboxyliques et de leurs lactones utiles comme intermediaires de synthese dans l'industrie pharmaceutique |
| US5849954A (en) * | 1996-01-18 | 1998-12-15 | Research Corporation Technologies, Inc. | Method of peptide synthesis |
| AU2003285012A1 (en) | 2002-10-24 | 2004-05-13 | Sepracor, Inc. | Compositions comprising zopiclone derivatives and methods of making and using the same |
| KR20110044304A (ko) | 2008-09-18 | 2011-04-28 | 화이자 리미티드 | 치료에 유용한 아마이드 화합물 |
| KR20110091581A (ko) | 2008-12-02 | 2011-08-11 | 글락소 그룹 리미티드 | N-{[1r,4s,6r-3-(2-피리디닐카르보닐)-3-아자비시클로[4.1.0]헵트-4-일]메틸}-2-헤테로아릴아민 유도체 및 그의 용도 |
| FR2941454B1 (fr) * | 2009-01-29 | 2011-04-01 | Pf Medicament | Proced de synthese du (1s,2r)-milnacipran |
| US8101643B2 (en) | 2009-02-27 | 2012-01-24 | Enanta Pharmaceuticals, Inc. | Benzimidazole derivatives |
| US9340752B2 (en) | 2009-03-09 | 2016-05-17 | Novozymes A/S | Enzymatic removal of steryl glycosides in fatty acid alkyl esters |
| RU2571414C2 (ru) * | 2010-09-22 | 2015-12-20 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Циклопропановые соединения |
| US9416109B2 (en) * | 2012-02-17 | 2016-08-16 | Eisai R&D Management Co., Ltd. | Methods and compounds useful in the synthesis of orexin-2 receptor antagonists |
-
2013
- 2013-02-14 US US14/379,063 patent/US9416109B2/en active Active
- 2013-02-14 EP EP13706874.8A patent/EP2814798B1/en active Active
- 2013-02-14 CN CN201380009575.3A patent/CN104114524B/zh active Active
- 2013-02-14 CA CA2861493A patent/CA2861493C/en active Active
- 2013-02-14 MX MX2014009917A patent/MX352881B/es active IP Right Grant
- 2013-02-14 JP JP2014557781A patent/JP6147279B2/ja active Active
- 2013-02-14 WO PCT/US2013/026204 patent/WO2013123240A1/en not_active Ceased
- 2013-02-14 ES ES13706874T patent/ES2733750T3/es active Active
- 2013-02-14 HU HUE13706874A patent/HUE043995T2/hu unknown
- 2013-02-14 SG SG11201403216UA patent/SG11201403216UA/en unknown
- 2013-02-14 RU RU2014137470A patent/RU2617696C2/ru active
- 2013-02-14 BR BR112014019909A patent/BR112014019909B1/pt active IP Right Grant
-
2014
- 2014-06-02 IL IL232949A patent/IL232949A/en active IP Right Grant
-
2016
- 2016-05-19 US US15/158,687 patent/US9828336B2/en active Active
-
2017
- 2017-10-24 US US15/791,814 patent/US20180044285A1/en not_active Abandoned
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008057575A2 (en) * | 2006-11-07 | 2008-05-15 | Dov Pharmaceutical, Inc. | Novel arylbicyclo[3.1.0]hexylamines and methods and compositions for their preparation and use |
| WO2008150364A1 (en) * | 2007-05-23 | 2008-12-11 | Merck & Co., Inc. | Cyclopropyl pyrrolidine orexin receptor antagonists |
| RU2009147733A (ru) * | 2007-05-23 | 2011-06-27 | Мерк Шарп Энд Домэ Корп. (Us) | Пиридилпиперидновые антагонисты рецептора орексинов |
Non-Patent Citations (1)
| Title |
|---|
| K.Yamaguchi et al, Construction of a cis-Cyclopropane via Reductive Radical Decarboxylation. Enantioselective Synthesis of cis- and trans-1-Arylpiperazyl-2-phenylceclopropanes Designed as Antidopaminergic Agents. J.Org.Chem., 2003, 68, 9255-9262. * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2823998C2 (ru) * | 2019-05-15 | 2024-07-31 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Способ и соединение, пригодные в получении антагониста рецептора орексина-2, и лемборексант, содержащий небольшое количество примесей |
| US12479819B2 (en) | 2019-05-15 | 2025-11-25 | Eisai R&D Management Co., Ltd. | Method and compound useful in preparation of orexin-2 receptor antagonist, and lemborexant having few impurities |
Also Published As
| Publication number | Publication date |
|---|---|
| US20160318858A1 (en) | 2016-11-03 |
| WO2013123240A1 (en) | 2013-08-22 |
| CN104114524B (zh) | 2016-08-17 |
| US9828336B2 (en) | 2017-11-28 |
| BR112014019909A2 (enExample) | 2017-06-20 |
| EP2814798A1 (en) | 2014-12-24 |
| MX352881B (es) | 2017-12-13 |
| IL232949A0 (en) | 2014-08-03 |
| BR112014019909B1 (pt) | 2020-01-28 |
| BR112014019909A8 (pt) | 2017-07-11 |
| SG11201403216UA (en) | 2014-12-30 |
| HUE043995T2 (hu) | 2019-09-30 |
| US9416109B2 (en) | 2016-08-16 |
| US20180044285A1 (en) | 2018-02-15 |
| EP2814798B1 (en) | 2019-04-03 |
| JP6147279B2 (ja) | 2017-06-14 |
| CN104114524A (zh) | 2014-10-22 |
| CA2861493C (en) | 2019-09-24 |
| RU2014137470A (ru) | 2016-04-10 |
| JP2015509939A (ja) | 2015-04-02 |
| ES2733750T3 (es) | 2019-12-02 |
| IL232949A (en) | 2016-08-31 |
| MX2014009917A (es) | 2014-11-13 |
| CA2861493A1 (en) | 2013-08-22 |
| US20150025237A1 (en) | 2015-01-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US9828336B2 (en) | Methods and compounds useful in the synthesis of orexin-2 receptor antagonists | |
| CN109071407A (zh) | 一种沙库必曲的中间体及其制备方法 | |
| CN109071418B (zh) | 氨基酸衍生物的前药 | |
| EP4380932B1 (en) | Process for preparing aficamten | |
| KR20230104190A (ko) | 갈렉틴-3 억제 2-히드록시시클로알칸-1-카르바모일 유도체 | |
| CN106977415A (zh) | 一种沙库必曲的中间体及其制备方法 | |
| KR20230145111A (ko) | 히드록시헤테로시클로알칸-카르바모일 유도체 | |
| EP2985286B1 (en) | Midbody of ticagrelor and preparation method therefor, and preparation method for ticagrelor | |
| JP2023078126A (ja) | 光学活性ジアザスピロ[4.5]デカン誘導体の分割 | |
| WO2021187992A1 (en) | Synthesis of capsaicin derivatives | |
| CA2819381A1 (en) | Method of making azaindazole derivatives | |
| US10556887B2 (en) | Processes for the preparation of Veliparib and intermediates thereof | |
| CN116745282A (zh) | 抑制2-羟环烷-1-氨甲酰基衍生物的半乳糖凝集素-3 | |
| JP2025528916A (ja) | Jakキナーゼ阻害剤のプロドラッグ | |
| JP2025537627A (ja) | セレン含有複素環式化合物およびその使用 | |
| EP3010885A1 (en) | Intermediates useful for the preparation of saxagliptin | |
| CN115703819A (zh) | 大环类化合物及其中间体的制备方法 | |
| CN105037210A (zh) | 一种α,β-脱氢-α-氨基酸的合成方法 | |
| HK40082110B (en) | Synthesis of capsaicin derivatives | |
| JP2013100279A (ja) | マンデル酸アミド誘導体の製造方法及びその中間体 | |
| HK1260638A1 (en) | Prodrug of amino acid derivative | |
| ITMI20120842A1 (it) | Intermedi utili per la preparazione di saxagliptina e processo per la loro preparazione |