RU2593790C2 - Разлагаемый удаляемый имплантат для непрерывного высвобождения активного соединения - Google Patents

Разлагаемый удаляемый имплантат для непрерывного высвобождения активного соединения Download PDF

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Publication number
RU2593790C2
RU2593790C2 RU2012131282/15A RU2012131282A RU2593790C2 RU 2593790 C2 RU2593790 C2 RU 2593790C2 RU 2012131282/15 A RU2012131282/15 A RU 2012131282/15A RU 2012131282 A RU2012131282 A RU 2012131282A RU 2593790 C2 RU2593790 C2 RU 2593790C2
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Russia
Prior art keywords
microparticles
tube
polymer
implant according
implant
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RU2012131282/15A
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Russian (ru)
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RU2012131282A (ru
Inventor
Дебора М. ШАХТЕР
Ливен Элвире Колетт Барт
Гюнтер Краус
Цян Чжан
Иксу ЧУНЬ
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Янссен Сайенсиз Айрлэнд Юси
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0092—Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/146—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/148—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Dispersion Chemistry (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
RU2012131282/15A 2009-12-21 2010-12-20 Разлагаемый удаляемый имплантат для непрерывного высвобождения активного соединения RU2593790C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28837309P 2009-12-21 2009-12-21
US61/288,373 2009-12-21
PCT/EP2010/070246 WO2011080141A2 (en) 2009-12-21 2010-12-20 Degradable removable implant for the sustained release of an active compound

Publications (2)

Publication Number Publication Date
RU2012131282A RU2012131282A (ru) 2014-01-27
RU2593790C2 true RU2593790C2 (ru) 2016-08-10

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RU2012131282/15A RU2593790C2 (ru) 2009-12-21 2010-12-20 Разлагаемый удаляемый имплантат для непрерывного высвобождения активного соединения

Country Status (18)

Country Link
US (3) US8784858B2 (cg-RX-API-DMAC7.html)
EP (1) EP2515877B1 (cg-RX-API-DMAC7.html)
JP (1) JP5950825B2 (cg-RX-API-DMAC7.html)
KR (1) KR101798430B1 (cg-RX-API-DMAC7.html)
CN (1) CN102740837B (cg-RX-API-DMAC7.html)
AU (1) AU2010338425B2 (cg-RX-API-DMAC7.html)
BR (1) BR112012015114B1 (cg-RX-API-DMAC7.html)
CA (1) CA2784530C (cg-RX-API-DMAC7.html)
ES (1) ES2600878T3 (cg-RX-API-DMAC7.html)
IL (1) IL219685B (cg-RX-API-DMAC7.html)
MX (1) MX2012007210A (cg-RX-API-DMAC7.html)
MY (1) MY163383A (cg-RX-API-DMAC7.html)
NZ (1) NZ600156A (cg-RX-API-DMAC7.html)
RU (1) RU2593790C2 (cg-RX-API-DMAC7.html)
SG (1) SG181759A1 (cg-RX-API-DMAC7.html)
UA (1) UA112155C2 (cg-RX-API-DMAC7.html)
WO (1) WO2011080141A2 (cg-RX-API-DMAC7.html)
ZA (1) ZA201204583B (cg-RX-API-DMAC7.html)

Cited By (3)

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Publication number Priority date Publication date Assignee Title
US11684700B2 (en) 2014-08-15 2023-06-27 The Johns Hopkins University Composite material for tissue restoration
US11771807B2 (en) 2018-05-09 2023-10-03 The Johns Hopkins University Nanofiber-hydrogel composites for cell and tissue delivery
US12036339B2 (en) 2018-05-09 2024-07-16 The Johns Hopkins University Nanofiber-hydrogel composites for enhanced soft tissue replacement and regeneration

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WO2014205252A2 (en) * 2013-06-20 2014-12-24 Mercy Medical Research Institute Extended release drug-delivery contact lenses and methods of making
WO2016149561A1 (en) * 2015-03-17 2016-09-22 Oak Crest Institute Of Science Subdermal implants for the sustained delivery of water-soluble drugs
US11779435B2 (en) 2015-08-26 2023-10-10 Flexscrewdriver I.K.E. Dental screwdriver
CN106702597B (zh) * 2016-12-20 2019-06-18 华南理工大学 一种核-壳结构纳米纤维膜及其制备方法和应用
BR112020000506A2 (pt) * 2017-07-11 2020-07-14 Sustained Nano Systems Llc formulações farmacêuticas hipercomprimidas
CN112423739A (zh) * 2018-05-16 2021-02-26 斯贝洛克斯公司 过敏性鼻炎药物输送植入物
KR20210060631A (ko) * 2018-10-16 2021-05-26 리써치 트라이앵글 인스티튜트 피하 생분해성 저장소 디바이스
CN115697304A (zh) * 2020-04-07 2023-02-03 三角研究所 用于能够生物降解的皮下储存器装置的多药配制物
WO2021229111A1 (es) * 2020-05-12 2021-11-18 Laboratorios Farmacéuticos Rovi, S.A. Procedimiento para la purificación de partículas poliméricas termoplásticas biodegradables para uso médico y/o farmacéutico

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WO2007082922A2 (en) * 2006-01-20 2007-07-26 Tibotec Pharmaceuticals Ltd. Long term treatment of hiv- infection with tcm278

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US20040115268A1 (en) * 2000-04-26 2004-06-17 Control Delivery Systems, Inc. Systemic delivery of antiviral agents
WO2007082922A2 (en) * 2006-01-20 2007-07-26 Tibotec Pharmaceuticals Ltd. Long term treatment of hiv- infection with tcm278

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11684700B2 (en) 2014-08-15 2023-06-27 The Johns Hopkins University Composite material for tissue restoration
US11707553B2 (en) 2014-08-15 2023-07-25 The Johns Hopkins University Composite material for tissue restoration
US11771807B2 (en) 2018-05-09 2023-10-03 The Johns Hopkins University Nanofiber-hydrogel composites for cell and tissue delivery
US12036339B2 (en) 2018-05-09 2024-07-16 The Johns Hopkins University Nanofiber-hydrogel composites for enhanced soft tissue replacement and regeneration
US12161781B2 (en) 2018-05-09 2024-12-10 The Johns Hopkins University Nanofiber-hydrogel composites for cell and tissue delivery

Also Published As

Publication number Publication date
NZ600156A (en) 2015-01-30
UA112155C2 (uk) 2016-08-10
BR112012015114A2 (pt) 2020-09-01
US20140296799A1 (en) 2014-10-02
IL219685A0 (en) 2012-07-31
US20120277690A1 (en) 2012-11-01
KR101798430B1 (ko) 2017-11-16
JP5950825B2 (ja) 2016-07-13
JP2013514971A (ja) 2013-05-02
SG181759A1 (en) 2012-07-30
AU2010338425A1 (en) 2012-06-07
BR112012015114B1 (pt) 2023-01-10
KR20120101084A (ko) 2012-09-12
WO2011080141A3 (en) 2012-03-08
US8784858B2 (en) 2014-07-22
US20200330654A1 (en) 2020-10-22
ES2600878T3 (es) 2017-02-13
US10744235B2 (en) 2020-08-18
CN102740837B (zh) 2017-06-06
CA2784530A1 (en) 2011-07-07
ZA201204583B (en) 2022-03-30
EP2515877B1 (en) 2016-08-10
WO2011080141A2 (en) 2011-07-07
EP2515877A2 (en) 2012-10-31
AU2010338425B2 (en) 2015-07-23
CN102740837A (zh) 2012-10-17
US11395867B2 (en) 2022-07-26
CA2784530C (en) 2018-05-22
MY163383A (en) 2017-09-15
MX2012007210A (es) 2012-07-23
RU2012131282A (ru) 2014-01-27
IL219685B (en) 2019-03-31

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