RU2591518C2 - Усовершенствованный способ получения макрогранул - Google Patents

Усовершенствованный способ получения макрогранул Download PDF

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Publication number
RU2591518C2
RU2591518C2 RU2014133367/10A RU2014133367A RU2591518C2 RU 2591518 C2 RU2591518 C2 RU 2591518C2 RU 2014133367/10 A RU2014133367/10 A RU 2014133367/10A RU 2014133367 A RU2014133367 A RU 2014133367A RU 2591518 C2 RU2591518 C2 RU 2591518C2
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Russia
Prior art keywords
cells
granules
agarose
mineral oil
granule
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RU2014133367/10A
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English (en)
Russian (ru)
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RU2014133367A (ru
Inventor
Лоуренс ГЭЗДА
Мелисса ЛЭРЭМОР
Тимоти ХЭМИЛТОН
Бэрри Смит
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Де Рогозин Инститьют Инк.
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/04—Enzymes or microbial cells immobilised on or in an organic carrier entrapped within the carrier, e.g. gel or hollow fibres
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B25—HAND TOOLS; PORTABLE POWER-DRIVEN TOOLS; MANIPULATORS
    • B25J—MANIPULATORS; CHAMBERS PROVIDED WITH MANIPULATION DEVICES
    • B25J15/00—Gripping heads and other end effectors
    • B25J15/06—Gripping heads and other end effectors with vacuum or magnetic holding means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B25—HAND TOOLS; PORTABLE POWER-DRIVEN TOOLS; MANIPULATORS
    • B25J—MANIPULATORS; CHAMBERS PROVIDED WITH MANIPULATION DEVICES
    • B25J15/00—Gripping heads and other end effectors
    • B25J15/06—Gripping heads and other end effectors with vacuum or magnetic holding means
    • B25J15/0616—Gripping heads and other end effectors with vacuum or magnetic holding means with vacuum
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0012—Cell encapsulation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0693—Tumour cells; Cancer cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/70—Polysaccharides
    • C12N2533/76—Agarose, agar-agar

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  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Mechanical Engineering (AREA)
  • Robotics (AREA)
  • Developmental Biology & Embryology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Dispersion Chemistry (AREA)
  • Oncology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
RU2014133367/10A 2012-01-31 2013-01-30 Усовершенствованный способ получения макрогранул RU2591518C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261592949P 2012-01-31 2012-01-31
US61/592,949 2012-01-31
PCT/US2013/023802 WO2013116306A1 (en) 2012-01-31 2013-01-30 Improved method for manufacture of macrobeads

Publications (2)

Publication Number Publication Date
RU2014133367A RU2014133367A (ru) 2016-03-27
RU2591518C2 true RU2591518C2 (ru) 2016-07-20

Family

ID=48903127

Family Applications (1)

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RU2014133367/10A RU2591518C2 (ru) 2012-01-31 2013-01-30 Усовершенствованный способ получения макрогранул

Country Status (21)

Country Link
US (2) US9090866B2 (zh)
EP (1) EP2809782B1 (zh)
JP (1) JP5986226B2 (zh)
KR (1) KR101722824B1 (zh)
CN (1) CN103975059B (zh)
AP (1) AP2014007623A0 (zh)
AU (1) AU2013202026B2 (zh)
BR (1) BR112014015804B1 (zh)
CA (1) CA2851023C (zh)
DK (1) DK2809782T3 (zh)
ES (1) ES2647613T3 (zh)
HK (1) HK1199903A1 (zh)
HU (1) HUE034618T2 (zh)
IL (1) IL231834A (zh)
MX (1) MX350593B (zh)
NO (1) NO2904201T3 (zh)
NZ (1) NZ624195A (zh)
PL (1) PL2809782T3 (zh)
PT (1) PT2809782T (zh)
RU (1) RU2591518C2 (zh)
WO (1) WO2013116306A1 (zh)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017020141A1 (es) * 2015-08-03 2017-02-09 Vera Campos Claudio Herramienta, sistema y procedimiento automatizado de toma de muestras
US11549097B2 (en) 2016-03-01 2023-01-10 Oxford University Innovation Limited Phase transfer of a cargo laden scaffold
DE102017106867B4 (de) * 2017-03-30 2021-12-02 Hamilton Bonaduz Ag Verfahren zur Herstellung einer Portionseinheit
JP7357599B2 (ja) * 2019-12-30 2023-10-06 財團法人工業技術研究院 細胞外小胞分離法、コロイド粒子とその調製方法
TW202208062A (zh) * 2020-08-20 2022-03-01 財桂生物股份有限公司 微量管上蓋及其組裝裝置
KR102703949B1 (ko) * 2021-12-27 2024-09-06 주식회사 엠엠티 매크로 비드, 이를 포함하는 질소화합물 흡착제, 질소화합물의 제거방법, 이를 포함하는 반응기 및 이의 제조방법
KR102703950B1 (ko) * 2021-12-27 2024-09-06 주식회사 엠엠티 매크로 비드, 이를 포함하는 질소화합물 흡착제, 질소화합물의 제거방법, 이를 포함하는 반응기 및 이의 제조방법

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010015372A1 (en) * 1999-12-08 2001-08-23 E .M Co., Ltd., Apparatus for transferring micro-balls
RU2208636C2 (ru) * 1994-01-13 2003-07-20 Дзе Рогозин Институт Макрогранула с секреторными клетками, способ ее получения и способ лечения заболеваний, вызванных нарушением функционирования секреторных клеток
US20070071732A1 (en) * 2005-09-26 2007-03-29 Lawrence Gazda Secretory cell-containing macrobeads comprising seakem gold agarose, and uses thereof
US20070069408A1 (en) * 2005-09-15 2007-03-29 Millipore Corporation Method and apparatus for making porous agarose beads
US20080202631A1 (en) * 2004-02-25 2008-08-28 And How Innovovations, Llc. Leak Resistant Siphoning Device For Use in Fluid Transfer

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997036495A1 (en) * 1996-04-03 1997-10-09 The Rogosin Institute Implantable agarose-collagen beads containing cells which produce a diffusible biological product, and uses thereof
US6303151B1 (en) 1996-04-03 2001-10-16 The Rogosin Institute Cancer-cell proliferation-suppressing material produced by cancer cells restricted by entrapment
US5888497A (en) 1996-04-03 1999-03-30 The Rogosin Institute Agarose coated agarose beads containing cancer cells that produce material which suppresses cancer cell proliferation
US6224912B1 (en) 1996-04-03 2001-05-01 The Rogo Institute Cancer-cell proliferation-suppressing material produced by cancer cells restricted by entrapment
US20030012699A1 (en) * 1998-11-18 2003-01-16 Thomas Moore Simultaneous handling of magnetic beads in a two-dimensional arrangement
US6497155B1 (en) 1999-02-09 2002-12-24 Pharmacopeia, Inc. Article comprising a particle retrieval device
US6558665B1 (en) 1999-05-18 2003-05-06 Arch Development Corporation Encapsulating particles with coatings that conform to size and shape of the particles
US20050053586A1 (en) 2003-09-04 2005-03-10 Bryan Conn Entrapped stem cells and uses thereof
JP2005114576A (ja) 2003-10-08 2005-04-28 Hitachi Software Eng Co Ltd 両親媒性分子固定化ビーズ、その製造方法、及びキャピラリビーズアレイのビーズ配列方法
JP4520359B2 (ja) 2005-05-13 2010-08-04 日立ソフトウエアエンジニアリング株式会社 粒子捕捉装置、並びに粒子配列方法及び粒子配列装置
EP2195114B1 (en) 2007-09-29 2017-03-22 El Spectra, LLC Instrumented pipette tip
WO2010138687A1 (en) * 2009-05-28 2010-12-02 Corning Incorporated Synthetic microcarriers for culturing cells
USD625429S1 (en) 2009-10-01 2010-10-12 Holger Link Pipette
DE102010040681A1 (de) 2010-09-14 2012-03-15 Hamilton Bonaduz Ag Unterdruckgreifer zur Handhabung von Wirkstoff-Beads mit vorzugsweise konkaver Bead-Kontaktfläche
DE102010040687A1 (de) 2010-09-14 2012-03-15 Hamilton Bonaduz Ag Verfahren zum Herstellen von Wirkstoff-Beads
DE102010040684A1 (de) 2010-09-14 2012-03-15 Hamilton Bonaduz Ag Röhrenförmiger Unterdruckgreifer zur Handhabung von Rohlingen von Wirkstoff-Beads
DE102010040685A1 (de) 2010-09-14 2012-03-15 Hamilton Bonaduz Ag Temperiervorrichtung zur thermischen Verfestigung von Wirkstoff-Beads
DE102011050024A1 (de) 2011-04-29 2012-10-31 Hamilton Bonaduz Ag Analysevorrichtung für eine berührungslose Analyse der Ausformung eines transparenten Körpers und Verfahren zur Durchführung der berührungslosen Analyse

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2208636C2 (ru) * 1994-01-13 2003-07-20 Дзе Рогозин Институт Макрогранула с секреторными клетками, способ ее получения и способ лечения заболеваний, вызванных нарушением функционирования секреторных клеток
US20010015372A1 (en) * 1999-12-08 2001-08-23 E .M Co., Ltd., Apparatus for transferring micro-balls
US20080202631A1 (en) * 2004-02-25 2008-08-28 And How Innovovations, Llc. Leak Resistant Siphoning Device For Use in Fluid Transfer
US20070069408A1 (en) * 2005-09-15 2007-03-29 Millipore Corporation Method and apparatus for making porous agarose beads
US20070071732A1 (en) * 2005-09-26 2007-03-29 Lawrence Gazda Secretory cell-containing macrobeads comprising seakem gold agarose, and uses thereof

Also Published As

Publication number Publication date
MX2014009295A (es) 2014-09-11
BR112014015804B1 (pt) 2022-10-18
HK1199903A1 (zh) 2015-07-24
EP2809782A1 (en) 2014-12-10
RU2014133367A (ru) 2016-03-27
MX350593B (es) 2017-09-11
KR101722824B1 (ko) 2017-04-03
IL231834A0 (en) 2014-05-28
KR20140122742A (ko) 2014-10-20
HUE034618T2 (en) 2018-02-28
CN103975059A (zh) 2014-08-06
CN103975059B (zh) 2016-08-31
NO2904201T3 (zh) 2018-01-20
JP5986226B2 (ja) 2016-09-06
EP2809782B1 (en) 2017-08-23
DK2809782T3 (da) 2017-11-20
JP2015510396A (ja) 2015-04-09
EP2809782A4 (en) 2015-11-04
WO2013116306A1 (en) 2013-08-08
US20130202802A1 (en) 2013-08-08
USRE47439E1 (en) 2019-06-18
US9090866B2 (en) 2015-07-28
AU2013202026B2 (en) 2014-05-08
IL231834A (en) 2016-04-21
ES2647613T3 (es) 2017-12-22
CA2851023C (en) 2018-03-20
PL2809782T3 (pl) 2018-04-30
CA2851023A1 (en) 2013-08-08
NZ624195A (en) 2015-07-31
PT2809782T (pt) 2017-12-01
AU2013202026A1 (en) 2013-08-15
AP2014007623A0 (en) 2014-05-31
BR112014015804A2 (pt) 2021-08-31

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