RU2586330C2 - Твердые формы ингибитора диссоциации транстиретина - Google Patents

Твердые формы ингибитора диссоциации транстиретина Download PDF

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RU2586330C2
RU2586330C2 RU2014109676/04A RU2014109676A RU2586330C2 RU 2586330 C2 RU2586330 C2 RU 2586330C2 RU 2014109676/04 A RU2014109676/04 A RU 2014109676/04A RU 2014109676 A RU2014109676 A RU 2014109676A RU 2586330 C2 RU2586330 C2 RU 2586330C2
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crystalline form
compound
peaks
solid
raman
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RU2014109676/04A
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RU2014109676A (ru
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Ричард Фредерик ЛЭБОДИНЬЕР
Майкл Генри О'НЕЙЛ
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Пфайзер Инк.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D263/57—Aryl or substituted aryl radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
    • C07H5/06—Aminosugars

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
RU2014109676/04A 2011-09-16 2012-09-12 Твердые формы ингибитора диссоциации транстиретина RU2586330C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161535551P 2011-09-16 2011-09-16
US61/535,551 2011-09-16
PCT/IB2012/054748 WO2013038351A1 (en) 2011-09-16 2012-09-12 Solid forms of a transthyretin dissociation inhibitor

Publications (2)

Publication Number Publication Date
RU2014109676A RU2014109676A (ru) 2015-10-27
RU2586330C2 true RU2586330C2 (ru) 2016-06-10

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RU2014109676/04A RU2586330C2 (ru) 2011-09-16 2012-09-12 Твердые формы ингибитора диссоциации транстиретина

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US (2) US9249112B2 (OSRAM)
EP (1) EP2755961A1 (OSRAM)
JP (2) JP5869677B2 (OSRAM)
KR (1) KR20140054231A (OSRAM)
CN (1) CN103781770B (OSRAM)
AR (1) AR088755A1 (OSRAM)
AU (1) AU2012310157B2 (OSRAM)
BR (1) BR112014005810A2 (OSRAM)
CA (1) CA2847293C (OSRAM)
IL (1) IL231472A0 (OSRAM)
MX (1) MX2014003043A (OSRAM)
RU (1) RU2586330C2 (OSRAM)
SG (1) SG2014013270A (OSRAM)
TW (2) TWI476185B (OSRAM)
WO (1) WO2013038351A1 (OSRAM)
ZA (1) ZA201401202B (OSRAM)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2810493C1 (ru) * 2019-12-20 2023-12-27 Пфайзер Айэленд Фармасьютикалс Эффективный процесс получения производных 6-карбоксибензоксазола

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EP2764866A1 (en) 2013-02-07 2014-08-13 IP Gesellschaft für Management mbH Inhibitors of nedd8-activating enzyme
KR102004059B1 (ko) * 2014-09-08 2019-07-25 화이자 인코포레이티드 6-카르복시-2-(3,5-디클로로페닐)-벤족사졸의 고체 결정형
CN107344927A (zh) * 2016-05-05 2017-11-14 苏州晶云药物科技有限公司 Tafamidis葡甲胺盐的晶型E及其制备方法和用途
GB2571950A (en) * 2018-03-13 2019-09-18 Azad Pharma Ag New polymorph and new path to synthesize tafamidis
US12268669B2 (en) 2018-12-20 2025-04-08 Pfizer Inc. Pharmaceutical compositions and methods comprising a combination of a benzoxazole transthyretin stabilizer and an additional therapeutic agent
CN113874359B (zh) * 2019-04-11 2024-07-16 Inke股份公司 用于制备1-脱氧-1-甲基氨基-d-葡萄糖醇2-(3,5-二氯苯基)-6-苯并𫫇唑羧酸盐的方法
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CA3141998A1 (en) * 2019-05-31 2020-12-03 Plex Pharmaceuticals, Inc. Pharmacological agents for treating protein aggregation diseases of the eye
WO2021019448A1 (en) * 2019-08-01 2021-02-04 Honour (R&D) Process for the preparation of transthyretin dissociation inhibitor
EP4059926A4 (en) 2019-11-15 2022-12-14 Crystal Pharmaceutical (Suzhou) Co., Ltd. CRYSTALLINE FORM OF TAFAMIDIS AND PROCESS FOR PRODUCTION AND USE THEREOF
EP4077287B1 (en) 2019-12-20 2025-11-19 Pfizer Ireland Pharmaceuticals Unlimited Company Efficient process for making 6-carboxy benzoxazole derivatives
WO2021232619A1 (zh) * 2020-05-19 2021-11-25 苏州科睿思制药有限公司 一种他发米帝司游离酸的晶型及其制备方法和用途
WO2022009221A1 (en) * 2020-07-04 2022-01-13 Nuray Chemicals Private Limited Solid state forms of 6-carboxy-2-(3, 5-dichlorophenyl)-benzoxazole of formula-i and pharmaceutically acceptable salts thereof
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WO2022084790A1 (en) * 2020-10-19 2022-04-28 Glenmark Life Sciences Limited Process for preparation of tafamidis and salts thereof
WO2022112919A1 (en) 2020-11-25 2022-06-02 Pfizer Inc. (aza)benzothiazolyl substituted pyrazole compounds
EP4083027A1 (en) 2021-04-26 2022-11-02 Química Sintética, S.A. A solid state form of tafamidis and a process for its preparation
WO2023020762A1 (en) 2021-08-16 2023-02-23 Synthon B.V. Crystalline forms of tafamidis nicotinamide adduct
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2810493C1 (ru) * 2019-12-20 2023-12-27 Пфайзер Айэленд Фармасьютикалс Эффективный процесс получения производных 6-карбоксибензоксазола

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HK1197239A1 (zh) 2015-01-09
TWI538909B (zh) 2016-06-21
JP2014526498A (ja) 2014-10-06
JP2016128444A (ja) 2016-07-14
MX2014003043A (es) 2015-02-05
JP5869677B2 (ja) 2016-02-24
CN103781770B (zh) 2016-04-13
TW201315720A (zh) 2013-04-16
KR20140054231A (ko) 2014-05-08
AU2012310157B2 (en) 2015-11-12
AR088755A1 (es) 2014-07-02
BR112014005810A2 (pt) 2017-03-28
WO2013038351A1 (en) 2013-03-21
CN103781770A (zh) 2014-05-07
CA2847293A1 (en) 2013-03-21
US20150031735A1 (en) 2015-01-29
NZ621194A (en) 2016-02-26
SG2014013270A (en) 2014-05-29
US20160185739A1 (en) 2016-06-30
AU2012310157A1 (en) 2014-04-03
RU2014109676A (ru) 2015-10-27
TWI476185B (zh) 2015-03-11
TW201516039A (zh) 2015-05-01
ZA201401202B (en) 2016-01-27
IL231472A0 (en) 2014-04-30
CA2847293C (en) 2017-03-28
US9249112B2 (en) 2016-02-02
EP2755961A1 (en) 2014-07-23

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