RU2538688C2 - Биоразлагаемый каркас для регенерации мягких тканей и его применение - Google Patents
Биоразлагаемый каркас для регенерации мягких тканей и его применение Download PDFInfo
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- RU2538688C2 RU2538688C2 RU2012103838/15A RU2012103838A RU2538688C2 RU 2538688 C2 RU2538688 C2 RU 2538688C2 RU 2012103838/15 A RU2012103838/15 A RU 2012103838/15A RU 2012103838 A RU2012103838 A RU 2012103838A RU 2538688 C2 RU2538688 C2 RU 2538688C2
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- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
- A61L2300/414—Growth factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/43—Hormones, e.g. dexamethasone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/602—Type of release, e.g. controlled, sustained, slow
- A61L2300/604—Biodegradation
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Transplantation (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
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- Biomedical Technology (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
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- Inorganic Chemistry (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Botany (AREA)
- Polymers & Plastics (AREA)
- Dispersion Chemistry (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
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| DKPA200970054 | 2009-07-06 | ||
| DKPA200970054 | 2009-07-06 | ||
| PCT/DK2010/050176 WO2011003422A1 (en) | 2009-07-06 | 2010-07-06 | Biodegradable scaffold for soft tissue regeneration and use thereof |
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| RU2538688C2 true RU2538688C2 (ru) | 2015-01-10 |
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| EP (1) | EP2451490A1 (enExample) |
| CN (1) | CN102470189A (enExample) |
| BR (1) | BR112012000114A2 (enExample) |
| IN (1) | IN2012DN00368A (enExample) |
| RU (1) | RU2538688C2 (enExample) |
| WO (1) | WO2011003422A1 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2761018C1 (ru) * | 2018-05-24 | 2021-12-02 | Декслево Инк. | Композиция для восстановления ткани и способ ее изготовления |
| RU2800928C2 (ru) * | 2019-06-20 | 2023-08-01 | Датум Дентал Лтд. | Имплантат, содержащий коллагеновую мембрану |
Families Citing this family (107)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6902932B2 (en) | 2001-11-16 | 2005-06-07 | Tissue Regeneration, Inc. | Helically organized silk fibroin fiber bundles for matrices in tissue engineering |
| US7959666B2 (en) * | 2003-12-23 | 2011-06-14 | Sadra Medical, Inc. | Methods and apparatus for endovascularly replacing a heart valve |
| US20050137687A1 (en) | 2003-12-23 | 2005-06-23 | Sadra Medical | Heart valve anchor and method |
| DE102005003632A1 (de) | 2005-01-20 | 2006-08-17 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Katheter für die transvaskuläre Implantation von Herzklappenprothesen |
| US7896915B2 (en) | 2007-04-13 | 2011-03-01 | Jenavalve Technology, Inc. | Medical device for treating a heart valve insufficiency |
| BR112012021347A2 (pt) | 2008-02-26 | 2019-09-24 | Jenavalve Tecnology Inc | stent para posicionamento e ancoragem de uma prótese valvular em um local de implantação no coração de um paciente |
| US9044318B2 (en) | 2008-02-26 | 2015-06-02 | Jenavalve Technology Gmbh | Stent for the positioning and anchoring of a valvular prosthesis |
| RU2015108720A (ru) | 2008-12-15 | 2015-08-10 | Аллерган, Инк. | Вязаная хирургическая имплантируемая сетка |
| US9308070B2 (en) * | 2008-12-15 | 2016-04-12 | Allergan, Inc. | Pliable silk medical device |
| US9204953B2 (en) | 2008-12-15 | 2015-12-08 | Allergan, Inc. | Biocompatible surgical scaffold with varying stretch |
| US9326840B2 (en) | 2008-12-15 | 2016-05-03 | Allergan, Inc. | Prosthetic device and method of manufacturing the same |
| US9204954B2 (en) | 2008-12-15 | 2015-12-08 | Allergan, Inc. | Knitted scaffold with diagonal yarn |
| US9277999B2 (en) | 2009-02-27 | 2016-03-08 | University of Pittsburgh—of the Commonwealth System of Higher Education | Joint bioscaffolds |
| EP2519161B1 (en) | 2009-12-30 | 2020-04-29 | Vivasure Medical Limited | Closure system |
| US10856978B2 (en) | 2010-05-20 | 2020-12-08 | Jenavalve Technology, Inc. | Catheter system |
| CN103002833B (zh) | 2010-05-25 | 2016-05-11 | 耶拿阀门科技公司 | 人工心脏瓣及包括人工心脏瓣和支架的经导管输送的内假体 |
| MY168863A (en) | 2010-06-17 | 2018-12-04 | Univ Washington | Biomedical patches with aligned fibers |
| WO2012014205A1 (en) | 2010-07-27 | 2012-02-02 | Technion Research & Development Foundation Ltd. | Isolated mesenchymal progenitor cells and extracellular matrix produced thereby |
| SG187761A1 (en) * | 2010-08-12 | 2013-03-28 | Univ Nanyang Tech | A glaucoma valve, a casing for containing a glaucoma valve, and a glaucoma drainage device comprising the valve and/or the casing |
| ITMI20110386A1 (it) * | 2011-03-11 | 2012-09-12 | Antonio Sambusseti | Cuffia riassorbibile per l'ampliamento vescicale in pazienti con bassa compliance |
| US10350431B2 (en) * | 2011-04-28 | 2019-07-16 | Gt Medical Technologies, Inc. | Customizable radioactive carriers and loading system |
| US20130030452A1 (en) * | 2011-07-27 | 2013-01-31 | Health Corporation - Rambam | Devices for surgical applications |
| US9351820B2 (en) * | 2011-08-25 | 2016-05-31 | University Of Zurich | Device for repair surgery of cylindrical organs, particularly ruptured tendons |
| CA3210893A1 (en) | 2012-01-13 | 2013-07-18 | The General Hospital Corporation | Isolated human lung progenitor cells and uses thereof |
| US9820837B2 (en) | 2012-04-10 | 2017-11-21 | Ethicon, Inc. | Single plane tissue repair patch |
| US9820839B2 (en) | 2012-04-10 | 2017-11-21 | Ethicon, Inc. | Single plane tissue repair patch having a locating structure |
| US9820838B2 (en) | 2012-04-10 | 2017-11-21 | Ethicon, Inc. | Single plane tissue repair patch |
| CN102631708B (zh) * | 2012-05-17 | 2014-01-15 | 重庆市畜牧科学院 | 盆底补片复合生物材料的制备方法及其产品 |
| US20130317540A1 (en) * | 2012-05-22 | 2013-11-28 | Krasimira Hristov | Universal bioabsorbable nasal implant kit |
| US10130346B2 (en) * | 2012-07-24 | 2018-11-20 | Omrix Biopharmaceuticals Ltd. | Device and method for the application of a curable fluid composition to a bodily organ |
| EP2878314B1 (en) * | 2012-07-27 | 2017-11-29 | Association For The Advancement Of Tissue Engineering And Cell Based Technologies & Therapies (A4TEC) | Polymeric mesh with selective permeability, for the repair and regeneration of tissues |
| KR102044501B1 (ko) | 2012-09-21 | 2019-11-13 | 워싱톤 유니버시티 | 다수의 섬유를 포함하는 구조물을 생성하기 위한 시스템과 방법 및 그 구조물 |
| CN102920530A (zh) * | 2012-11-09 | 2013-02-13 | 无锡中科光远生物材料有限公司 | 防粘连可吸收疝气补片 |
| WO2014075388A1 (zh) * | 2012-11-14 | 2014-05-22 | 广州迈普再生医学科技有限公司 | 组织修复用纤维膜及其制品和制备方法 |
| CN105120802B (zh) | 2013-02-12 | 2018-01-12 | 奥斯设计公司 | 镶嵌型植入物、试剂盒和用于矫正骨缺损的方法 |
| US9220597B2 (en) | 2013-02-12 | 2015-12-29 | Ossdsign Ab | Mosaic implants, kits and methods for correcting bone defects |
| US9492683B2 (en) | 2013-03-15 | 2016-11-15 | Gammatile Llc | Dosimetrically customizable brachytherapy carriers and methods thereof in the treatment of tumors |
| ES2703785T3 (es) * | 2013-04-08 | 2019-03-12 | Regentys Corp | Método y composición para tratar una enfermedad inflamatoria intestinal sin colectomía |
| CN105377154B (zh) * | 2013-07-09 | 2020-05-01 | Ams研究有限责任公司 | 包含细胞外基质材料的生物可降解产品和用于治疗盆底疾病的方法 |
| US11306326B2 (en) | 2013-08-23 | 2022-04-19 | Rutgers, The State University Of New Jersey | Biologically active synthetic nanoparticle constructs and methods of use thereof |
| US9867694B2 (en) | 2013-08-30 | 2018-01-16 | Jenavalve Technology Inc. | Radially collapsible frame for a prosthetic valve and method for manufacturing such a frame |
| US20150104494A1 (en) * | 2013-10-11 | 2015-04-16 | Ohio State Innovation Foundation | Methods for repair of ear canal tissue defects |
| US10130457B2 (en) | 2014-03-05 | 2018-11-20 | Tela Bio, Inc. | Surgical attachment device |
| US10588732B2 (en) | 2014-03-07 | 2020-03-17 | IconLab USA, Inc. | Multipurpose implant with modeled surface structure for soft tissue reconstruction |
| RU2699811C1 (ru) | 2014-03-07 | 2019-09-11 | Айконлаб Инк. | Многоцелевой имплантат с заданной структурой поверхности для реконструкции мягких тканей |
| CN111265719B (zh) | 2014-03-21 | 2023-01-10 | 匹兹堡大学-联邦高等教育体系 | 最终消毒的来自细胞外基质的水凝胶的制备方法 |
| GB2526542A (en) * | 2014-05-26 | 2015-12-02 | David Anthony Waghorn | Stem cell implanter and absorbable stem cell implant |
| TWI549702B (zh) * | 2014-07-22 | 2016-09-21 | 國立臺灣大學 | 由生物可分解之沾黏材料構成之醫療品 |
| AU2015302923B2 (en) | 2014-08-14 | 2020-05-14 | Ossdsign Ab | Bone implants for correcting bone defects |
| JPWO2016068292A1 (ja) * | 2014-10-31 | 2017-08-17 | 富士フイルム株式会社 | 管状構造物、管状構造物を製造するための装置、及び管状構造物の製造方法 |
| EP3232939B1 (en) * | 2014-12-15 | 2020-09-23 | Vivasure Medical Limited | Implantable sealable member with mesh layer |
| US10433826B2 (en) | 2014-12-15 | 2019-10-08 | Vivasure Medical Limited | Closure apparatus with flexible sealable member and flexible support member |
| CN104524633B (zh) * | 2014-12-29 | 2018-05-11 | 东莞颠覆产品设计有限公司 | 一种基于肌肉的神经支架及其制备方法 |
| MA41413A (fr) * | 2015-01-30 | 2017-12-05 | Antonio Sambusseti | Greffon résorbable et biocompatible en pga à implanter consécutivement à l'excision de la plaque ipp |
| US9821174B1 (en) | 2015-02-06 | 2017-11-21 | Gammatile Llc | Radioactive implant planning system and placement guide system |
| CN104706442B (zh) * | 2015-03-16 | 2017-08-01 | 克力木·阿不都热依木 | 食管裂孔疝专用补片 |
| JP6829692B2 (ja) | 2015-03-20 | 2021-02-10 | イェーナヴァルヴ テクノロジー インコーポレイテッド | 心臓弁プロテーゼ送出システム及び導入体シースにより心臓弁プロテーゼを送出するための方法 |
| ES2621191B1 (es) * | 2015-03-25 | 2018-10-10 | Fundación Centro De Cirugía De Mínima Invasión Jesús Usón | Soporte quirúrgico con actividad biológica inmunomoduladora |
| CN106039405A (zh) * | 2015-04-08 | 2016-10-26 | 上海宏创医疗科技有限公司 | 一种细胞外基质复合生物补片的制备方法 |
| US10709555B2 (en) | 2015-05-01 | 2020-07-14 | Jenavalve Technology, Inc. | Device and method with reduced pacemaker rate in heart valve replacement |
| EP3294211A1 (en) * | 2015-05-15 | 2018-03-21 | Lifecell Corporation | Tissue matrices for plastic surgery |
| CN104963097A (zh) * | 2015-06-17 | 2015-10-07 | 广州迈普再生医学科技有限公司 | 一种增强电纺纤维膜及其制备方法 |
| CN104984396B (zh) * | 2015-06-29 | 2018-03-16 | 重庆市畜牧科学院 | 有机‑无机核鞘结构复合生物材料的制备方法及产品 |
| WO2017004136A1 (en) | 2015-06-30 | 2017-01-05 | Tela Bio, Inc. | Corner-lock stitch patterns |
| FR3039057B1 (fr) * | 2015-07-20 | 2017-08-11 | Edouard Pelissier | Protheses de reparation de hernies |
| EP3324882B1 (en) | 2015-07-21 | 2023-10-25 | Tela Bio, Inc. | Compliance control stitching in substrate materials |
| CN114949368B (zh) * | 2015-08-17 | 2024-09-20 | 约翰·霍普金斯大学 | 用于组织修复的纤维-水凝胶复合材料外科网片 |
| WO2017050837A1 (en) | 2015-09-23 | 2017-03-30 | Novus Scientific Ab | Three-dimensional medical implant for regeneration of soft tissue |
| CN108430512B (zh) * | 2015-09-30 | 2022-03-22 | 杜雷安教育基金会行政处 | 用于支持身体组织再生的装置以及其制造和使用方法 |
| EP3380046B1 (en) | 2015-11-24 | 2021-07-14 | OssDsign AB | Bone implants and methods for correcting bone defects |
| WO2017102941A1 (en) | 2015-12-15 | 2017-06-22 | Vivasure Medical Limited | Arteriotomy closure apparatus with slotted shoe for advantageous pressure distribution |
| CN105616040A (zh) * | 2016-03-18 | 2016-06-01 | 广州市健齿生物科技有限公司 | 一种多孔人工颞下颌关节结构及制造方法 |
| EP3448308B1 (en) | 2016-04-26 | 2024-08-14 | Tela Bio, Inc. | Hernia repair grafts having anti-adhesion barriers |
| CN109414524A (zh) * | 2016-05-12 | 2019-03-01 | 阿塞拉外科有限公司 | 组织替代材料和组织修复方法 |
| US10632228B2 (en) * | 2016-05-12 | 2020-04-28 | Acera Surgical, Inc. | Tissue substitute materials and methods for tissue repair |
| CN109475419B (zh) | 2016-05-13 | 2021-11-09 | 耶拿阀门科技股份有限公司 | 用于通过引导鞘和装载系统来递送心脏瓣膜假体的心脏瓣膜假体递送系统和方法 |
| US10888710B1 (en) | 2016-11-29 | 2021-01-12 | Gt Medical Technologies, Inc. | Transparent loading apparatus |
| WO2018138658A1 (en) | 2017-01-27 | 2018-08-02 | Jenavalve Technology, Inc. | Heart valve mimicry |
| US11426266B2 (en) * | 2017-03-29 | 2022-08-30 | Novus Scientific Ab | Medical implant |
| GB201708233D0 (en) * | 2017-05-23 | 2017-07-05 | Orthox Ltd | Implantable tissue repair devices and methods for manufacturing the same |
| ES2695629B2 (es) * | 2017-07-03 | 2022-05-10 | Viscofan Sa | Parche para la regeneración de tejidos biológicos |
| US11590262B2 (en) | 2018-03-09 | 2023-02-28 | Tela Bio, Inc. | Surgical repair graft |
| IT201800007499A1 (it) * | 2018-07-25 | 2020-01-25 | Angiologica Bm Srl | Protesi parietale di supporto, in particolare per prolassi pelvici |
| CA3115057A1 (en) * | 2018-10-03 | 2020-04-09 | Establishment Labs S.A. | Scaffolding for implantable medical devices and methods of use thereof |
| US11701232B2 (en) * | 2019-01-15 | 2023-07-18 | University Of Maryland, College Park | Acellular bioactive scaffold device and methods of fabrication and treatment relating thereto |
| US10981018B2 (en) | 2019-02-14 | 2021-04-20 | Gt Medical Technologies, Inc. | Radioactive seed loading apparatus |
| US11446130B2 (en) | 2019-03-08 | 2022-09-20 | Tela Bio, Inc. | Textured medical textiles |
| US11298220B2 (en) | 2019-05-03 | 2022-04-12 | Lifecell Corporation | Breast treatment device |
| CN110559481A (zh) * | 2019-11-04 | 2019-12-13 | 深港产学研基地 | 用于妇科骨盆底肌肉力学修复的外科植入材料 |
| WO2021119460A1 (en) * | 2019-12-13 | 2021-06-17 | W. L. Gore & Associates, Inc. | Reinforced biopolymers |
| TWI762291B (zh) * | 2020-04-30 | 2022-04-21 | 財團法人工業技術研究院 | 組織修復裝置及其之使用方法 |
| CN113576712A (zh) | 2020-04-30 | 2021-11-02 | 财团法人工业技术研究院 | 组织修复装置及其的使用方法 |
| US11957815B2 (en) | 2020-07-17 | 2024-04-16 | Datt Life Sciences Private Limited | Ready to use biodegradable and biocompatible cell-based nerve conduit for nerve injury and a method of preparation thereof |
| US11826955B2 (en) | 2020-07-24 | 2023-11-28 | City University Of Hong Kong | Magnetically-drivable microrobot |
| JP7692557B2 (ja) * | 2021-01-07 | 2025-06-16 | グンゼ株式会社 | 内視鏡用生体吸収性シート及びその製造方法 |
| CN113017905B (zh) * | 2021-05-24 | 2021-08-27 | 广州新诚生物科技有限公司 | 一种植入物 |
| IT202100017285A1 (it) | 2021-06-30 | 2022-12-30 | Evolving Healthcare S R L | Scaffold per la riparazione di difetti erniari |
| CA3227438A1 (en) | 2021-07-29 | 2023-02-02 | Acera Surgical, Inc. | Combined macro and micro-porous hybrid-scale fiber matrix |
| CA3227437A1 (en) | 2021-07-29 | 2023-02-02 | Acera Surgical, Inc. | Particle-form hybrid-scale fiber matrix |
| US12167853B2 (en) | 2021-09-07 | 2024-12-17 | Acera Surgical, Inc. | Non-woven graft materials for nerve repair and regeneration |
| CN114176698B (zh) * | 2021-12-20 | 2024-04-26 | 神遁医疗科技(上海)有限公司 | 一种栓塞物 |
| US12053644B2 (en) | 2021-12-30 | 2024-08-06 | Gt Medical Technologies, Inc. | Radiation shielding apparatus for implantable radioactive seeds |
| JP2023114677A (ja) * | 2022-02-07 | 2023-08-18 | 国立大学法人北海道大学 | 内視鏡治療用キット及び生体吸収性シート |
| EP4356922A1 (en) * | 2022-10-19 | 2024-04-24 | Servicio Andaluz de Salud | Treatment of pelvic organ prolapse |
| JP2025538294A (ja) | 2022-11-09 | 2025-11-27 | イエナバルブ テクノロジー インク | 拡張可能なインプラントの順次展開のためのカテーテルシステム |
| CN115886691B (zh) * | 2022-12-30 | 2025-06-27 | 上海安翰医疗技术有限公司 | 一种牵引管和内窥镜装置 |
| US20240374367A1 (en) * | 2023-05-10 | 2024-11-14 | Tela Bio, Inc. | Nonuniform embroidered soft tissue implant structure |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2215542C2 (ru) * | 1998-02-23 | 2003-11-10 | Массачусетс Инститьют Оф Текнолоджи | Биоразлагающиеся полимеры, способные к восстановлению формы |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6495152B2 (en) | 2000-08-18 | 2002-12-17 | Tepha, Inc. | Sulfur containing polyhydroxyalkanoate compositions and method of production |
| DE10046119A1 (de) | 2000-09-15 | 2002-03-28 | Inst Textil & Faserforschung | Medizintechnisches bioresorbierbares Implantat, Verfahren zur Herstellung und Verwendung |
| CA2777791A1 (en) | 2000-09-18 | 2002-03-21 | Organogenesis Inc. | Methods for treating a patient using a bioengineered flat sheet graft prostheses |
| US6599323B2 (en) | 2000-12-21 | 2003-07-29 | Ethicon, Inc. | Reinforced tissue implants and methods of manufacture and use |
| US8197837B2 (en) * | 2003-03-07 | 2012-06-12 | Depuy Mitek, Inc. | Method of preparation of bioabsorbable porous reinforced tissue implants and implants thereof |
| US7368124B2 (en) | 2003-03-07 | 2008-05-06 | Depuy Mitek, Inc. | Method of preparation of bioabsorbable porous reinforced tissue implants and implants thereof |
| US11395865B2 (en) * | 2004-02-09 | 2022-07-26 | DePuy Synthes Products, Inc. | Scaffolds with viable tissue |
| EP1776065B1 (en) | 2004-08-13 | 2012-02-15 | Mast Biosurgery AG | Surgical prosthesis having biodegradable and nonbiodegradable regions |
| WO2006044881A2 (en) | 2004-10-20 | 2006-04-27 | Ethicon, Inc. | A reinforced absorbable multilayered fabric for use in medical devices and method of manufacture |
| EP1674048B1 (en) | 2004-12-23 | 2009-10-21 | Novus Scientific Pte. Ltd. | Mesh implant for use in reconstruction of soft tissue defects |
| US8709023B2 (en) | 2007-07-17 | 2014-04-29 | Poly-Med, Inc. | Absorbable / biodegradable composite yarn constructs and applications thereof |
| DE602007004955D1 (de) | 2006-03-09 | 2010-04-08 | Coloplast As | Abbaubare copolymere mit einem hydrophilen block mit verbesserter biokompatibilität für die weichgeweberegeneration |
| CN101460670A (zh) | 2006-04-10 | 2009-06-17 | 伊西康公司 | 用在医疗器具中的增强的可吸收多层织物及制造方法 |
| US20080082177A1 (en) | 2006-09-29 | 2008-04-03 | Chunlin Yang | Device for tissue reinforcement having microporous and macroporous structures |
| EP2111183B1 (en) | 2007-01-02 | 2015-11-18 | Boston Scientific Scimed, Inc. | Reinforced mesh for retropubic implants |
| WO2008107483A2 (en) * | 2007-03-07 | 2008-09-12 | Coloplast A/S | Mesh comprising ecm |
| BRPI0813352A2 (pt) * | 2007-06-15 | 2014-12-30 | Ethicon Inc | Composições de fragmento de tecido para o tratamento de incontinência |
-
2010
- 2010-07-06 WO PCT/DK2010/050176 patent/WO2011003422A1/en not_active Ceased
- 2010-07-06 CN CN2010800303911A patent/CN102470189A/zh active Pending
- 2010-07-06 BR BR112012000114A patent/BR112012000114A2/pt not_active Application Discontinuation
- 2010-07-06 EP EP10730698A patent/EP2451490A1/en not_active Withdrawn
- 2010-07-06 IN IN368DEN2012 patent/IN2012DN00368A/en unknown
- 2010-07-06 US US13/382,359 patent/US20120165957A1/en not_active Abandoned
- 2010-07-06 RU RU2012103838/15A patent/RU2538688C2/ru not_active IP Right Cessation
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2215542C2 (ru) * | 1998-02-23 | 2003-11-10 | Массачусетс Инститьют Оф Текнолоджи | Биоразлагающиеся полимеры, способные к восстановлению формы |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2761018C1 (ru) * | 2018-05-24 | 2021-12-02 | Декслево Инк. | Композиция для восстановления ткани и способ ее изготовления |
| RU2805364C2 (ru) * | 2019-03-04 | 2023-10-16 | Ганс Ульрих БЕР | Биоразлагаемый сетчатый имплантат для восстановления мягких тканей, в частности герниопластики |
| RU2800928C2 (ru) * | 2019-06-20 | 2023-08-01 | Датум Дентал Лтд. | Имплантат, содержащий коллагеновую мембрану |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2011003422A1 (en) | 2011-01-13 |
| BR112012000114A2 (pt) | 2016-11-01 |
| US20120165957A1 (en) | 2012-06-28 |
| RU2012103838A (ru) | 2013-08-20 |
| IN2012DN00368A (enExample) | 2015-08-21 |
| CN102470189A (zh) | 2012-05-23 |
| EP2451490A1 (en) | 2012-05-16 |
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| Date | Code | Title | Description |
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| MM4A | The patent is invalid due to non-payment of fees |
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