RU2508099C2 - Способы сохранения функции почек с использованием ингибиторов ксантин оксидоредуктазы - Google Patents
Способы сохранения функции почек с использованием ингибиторов ксантин оксидоредуктазы Download PDFInfo
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- RU2508099C2 RU2508099C2 RU2009122505/15A RU2009122505A RU2508099C2 RU 2508099 C2 RU2508099 C2 RU 2508099C2 RU 2009122505/15 A RU2009122505/15 A RU 2009122505/15A RU 2009122505 A RU2009122505 A RU 2009122505A RU 2508099 C2 RU2508099 C2 RU 2508099C2
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A61P13/04—Drugs for disorders of the urinary system for urolithiasis
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- Thiazole And Isothizaole Compounds (AREA)
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| CA2607953A1 (en) * | 2005-05-09 | 2006-11-16 | Tap Pharmaceutical Products, Inc. | Methods for treating nephrolithiasis |
| EP1940397A4 (en) * | 2005-08-03 | 2010-01-20 | Takeda Pharmaceuticals North A | METHOD FOR TREATING HYPERTONIA |
| US20090124623A1 (en) * | 2006-11-13 | 2009-05-14 | Christopher Lademacher | Methods for preserving and/or increasing renal function using xanthine oxidoreductase inhibitors |
| CN101646440A (zh) * | 2007-01-19 | 2010-02-10 | 武田制药北美公司 | 使用黄嘌呤氧化还原酶抑制剂和抗炎剂预防痛风突发或减少痛风突发次数的方法 |
| US20100311756A1 (en) * | 2009-01-22 | 2010-12-09 | Takeda Pharmaceuticals North America, Inc. | Methods for delaying the progression of at least one of cardiac hypertrophy, cardiac remodeling or left ventricular function or the onset of heart failure in subjects in need of treatment thereof |
| IT1400310B1 (it) | 2010-05-10 | 2013-05-24 | Menarini Int Operations Lu Sa | Associazione di inibitori della xantina ossidasi e statine e loro uso. |
| IT1400609B1 (it) | 2010-05-10 | 2013-06-14 | Menarini Int Operations Lu Sa | Associazione di inibitori della xantina ossidasi e metformina e loro uso. |
| IT1400309B1 (it) | 2010-05-10 | 2013-05-24 | Menarini Int Operations Lu Sa | Associazione di inibitori della xantina ossidasi e calcio antagonisti e loro uso. |
| IT1400311B1 (it) | 2010-05-10 | 2013-05-24 | Menarini Int Operations Lu Sa | Associazione di inibitori della xantina ossidasi e antagonisti del recettore dell'angiotensina ii e loro uso. |
| PE20170306A1 (es) * | 2010-06-16 | 2017-05-06 | Takeda Pharmaceuticals Usa Inc | Nuevas formas de dosificacion de liberacion modificada de un inhibidor de la xantina oxidorreductasa o de inhibidores de xantina oxidasa |
| WO2011162390A1 (ja) * | 2010-06-25 | 2011-12-29 | 帝人ファーマ株式会社 | 徐放性高血圧および腎機能障害治療剤 |
| CN102372679A (zh) * | 2010-08-27 | 2012-03-14 | 北京润德康医药技术有限公司 | 一种非布司他水溶性衍生物及其制备方法 |
| AU2011299153B2 (en) | 2010-09-10 | 2014-10-30 | Takeda Pharmaceuticals U.S.A., Inc. | Methods for concomitant treatment of theophylline and febuxostat |
| WO2012060308A1 (ja) * | 2010-11-01 | 2012-05-10 | 株式会社 三和化学研究所 | 腎機能障害の予防又は治療に用いる医薬 |
| CN102757403B (zh) * | 2011-04-27 | 2015-04-29 | 浙江九洲药业股份有限公司 | 一种非布索坦衍生物及其制备方法 |
| TW201328692A (zh) * | 2011-10-11 | 2013-07-16 | Univ Osaka | 脫髓鞘疾病之治療劑及預防劑 |
| RU2014134845A (ru) | 2012-01-27 | 2016-03-20 | Тейдзин Фарма Лимитед | Терапевтическое средство против диабета |
| WO2014065275A1 (ja) * | 2012-10-23 | 2014-05-01 | 国立大学法人福井大学 | 腫瘍融解症候群の治療薬及び予防薬 |
| CN103265636B (zh) * | 2013-05-23 | 2015-09-16 | 中国药科大学 | 一种具有降血糖作用的新型肽 |
| CN104548066A (zh) * | 2015-01-19 | 2015-04-29 | 中国药科大学 | 一种具有降血糖作用的新型肽的新用途 |
| CN105294584A (zh) * | 2015-11-30 | 2016-02-03 | 中国医科大学 | 1-取代苯基-1h-1,2,3-三唑类化合物、制备方法及其用途 |
| EP3417858B8 (en) | 2016-02-19 | 2020-12-30 | National University Corporation Tottori University | Therapeutic or prophylactic drug for dementia |
| CN106279024B (zh) * | 2016-07-19 | 2018-09-14 | 华南理工大学 | 一种黄嘌呤氧化还原酶抑制剂及其制备方法与应用 |
| KR20230119303A (ko) * | 2022-02-07 | 2023-08-16 | (주)인드림헬스케어 | 높은 혈중 요산 농도를 갖는 대상체의 만성 신장 질환의 예방 또는 치료를 위한 알로푸리놀, 페북소스타트 또는 이들의 약학적으로 허용 가능한 염을 포함하는 약제학적 조성물 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5268386A (en) * | 1989-08-03 | 1993-12-07 | Shionogi & Co., Ltd. | Certain 3,4-dihydro 4-oxospiro [2H-1 benzopyrans] useful for treating hyperuricemia |
| RU2257895C2 (ru) * | 2001-02-02 | 2005-08-10 | Домпе С.П.А. | Применение (r)-ибупрофенметансульфонамида и его солей для лечения и предотвращения реакций отторжения трансплантируемых органов |
| US20060252808A1 (en) * | 2005-05-09 | 2006-11-09 | Nancy Joseph-Ridge | Methods for treating nephrolithiasis |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3079303A (en) * | 1958-12-11 | 1963-02-26 | Smith Kline French Lab | Basic tablet granulation and process of using same |
| US4058614A (en) * | 1973-12-04 | 1977-11-15 | Merck & Co., Inc. | Substituted imidazole compounds and therapeutic compositions therewith |
| US4296122A (en) * | 1975-07-09 | 1981-10-20 | Merck & Co., Inc. | 2,3-Dihydro-6,7-disubstituted-5-(acyl)benzofuran-2-carboxylic acids |
| DE2727802A1 (de) * | 1977-06-21 | 1979-04-19 | Hoechst Ag | Sulfamoyl-arylketone und verfahren zu ihrer herstellung |
| US4510322A (en) * | 1981-07-13 | 1985-04-09 | Merck & Co., Inc. | Indacrinone having enhanced uricosuric |
| US4632930A (en) * | 1984-11-30 | 1986-12-30 | E. I. Du Pont De Nemours And Company | Antihypertensive alkyl-arylimidazole, thiazole and oxazole derivatives |
| US5047246A (en) * | 1988-09-09 | 1991-09-10 | Bristol-Myers Company | Direct compression cyclophosphamide tablet |
| ES2092580T3 (es) * | 1990-11-30 | 1996-12-01 | Teijin Ltd | Derivado de 2-ariltiazol y composicion farmaceutica que contiene el mismo. |
| US5358961A (en) * | 1991-11-30 | 1994-10-25 | Jin Ro Limited | Pyrrolidine derivatives |
| SE9301830D0 (sv) * | 1993-05-28 | 1993-05-28 | Ab Astra | New compounds |
| US6037344A (en) * | 1994-08-17 | 2000-03-14 | Virginia Tech Intellectual Properties, Inc. | Compositions and methods for controlling pest insects |
| US5514681A (en) * | 1994-08-17 | 1996-05-07 | Virginia Tech Intellectual Properties, Inc. | Compositions and methods for controlling pest insects |
| US5770601A (en) * | 1994-08-17 | 1998-06-23 | Virginia Tech Intellectual Properties, Inc. | Compositions and methods for controlling pest insects |
| AUPM835394A0 (en) * | 1994-09-23 | 1994-10-13 | King, Michael G. Dr. | Method for controlling or eliminating the need to smoke tobacco, and for treating ailments which may lead to the said need |
| DE69632854T2 (de) * | 1995-04-07 | 2005-07-14 | Teijin Ltd. | Schutzmittel für Organe und Gewebe |
| ID21775A (id) * | 1996-10-25 | 1999-07-22 | Yoshitomi Pharmaceutical | Senyawa-senyawa 1-fenilpirazol dan penggunaan farmasinya |
| US5965625A (en) * | 1997-03-21 | 1999-10-12 | King; Michael Glenn | Compositions and methods for the control of smoking |
| AU1520699A (en) * | 1997-11-07 | 1999-05-31 | Johns Hopkins University, The | Methods for treatment of disorders of cardiac contractility |
| CA2566652C (en) * | 1998-06-19 | 2008-10-21 | Teijin Limited | Polymorphic modifications of 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazole-carboxylic acid and processes for the preparation thereof |
| US6281222B1 (en) * | 1999-08-19 | 2001-08-28 | Inotek Corporation | Compositions and method for treatment of acetaminophen intoxication |
| EP1317258B1 (en) * | 2000-06-28 | 2009-02-11 | Merck & Co., Inc. | Use of allopurinol for the treatment of hypertension |
| WO2002085381A1 (en) * | 2001-04-18 | 2002-10-31 | Genzyme Corporation | Method for treating gout and binding uric acid |
| WO2002085380A1 (en) * | 2001-04-18 | 2002-10-31 | Geltex Pharmaceuticals, Inc. | Method for treating gout and reducing serum uric acid |
| CA2462132C (en) * | 2002-01-28 | 2010-08-10 | Fuji Yakuhin Co., Ltd. | 1,2,4-triazole compounds |
| WO2003082279A1 (en) * | 2002-03-28 | 2003-10-09 | Teijin Limited | Solid preparation containing single crystal form |
| US20060040945A1 (en) * | 2002-05-17 | 2006-02-23 | Merckle Gmbh | Annellated pyrrole compounds as proton pump inhibitors for treating ulcer |
| US7078423B2 (en) * | 2002-07-18 | 2006-07-18 | Inotek Pharmaceuticals Corporation | 5-Aryltetrazole compounds, compositions thereof, and uses therefor |
| US20040122067A1 (en) * | 2002-12-20 | 2004-06-24 | Lin Zhao | Treatment of chronic heart failure |
| US20040121004A1 (en) * | 2002-12-20 | 2004-06-24 | Rajneesh Taneja | Dosage forms containing a PPI, NSAID, and buffer |
| US20040131676A1 (en) * | 2002-12-20 | 2004-07-08 | Rajneesh Taneja | Dosage forms containing a PPI, NSAID, and buffer |
| WO2005018635A2 (en) * | 2003-08-07 | 2005-03-03 | Cardiome Pharma Corp. | Ion channel modulating activity i |
| WO2006028342A1 (en) * | 2004-09-06 | 2006-03-16 | Biosynergen, Inc. | A novel xanthine oxidase inhibitor and a pharmaceutical composition containing the same |
| WO2006055412A1 (en) * | 2004-11-19 | 2006-05-26 | Shiva Biomedical, Llc | Methods of treating erythropoietin-resistance |
| EP1940397A4 (en) * | 2005-08-03 | 2010-01-20 | Takeda Pharmaceuticals North A | METHOD FOR TREATING HYPERTONIA |
| US20090124623A1 (en) * | 2006-11-13 | 2009-05-14 | Christopher Lademacher | Methods for preserving and/or increasing renal function using xanthine oxidoreductase inhibitors |
| CN101646440A (zh) * | 2007-01-19 | 2010-02-10 | 武田制药北美公司 | 使用黄嘌呤氧化还原酶抑制剂和抗炎剂预防痛风突发或减少痛风突发次数的方法 |
| US20100311756A1 (en) * | 2009-01-22 | 2010-12-09 | Takeda Pharmaceuticals North America, Inc. | Methods for delaying the progression of at least one of cardiac hypertrophy, cardiac remodeling or left ventricular function or the onset of heart failure in subjects in need of treatment thereof |
| AU2011299153B2 (en) * | 2010-09-10 | 2014-10-30 | Takeda Pharmaceuticals U.S.A., Inc. | Methods for concomitant treatment of theophylline and febuxostat |
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2013
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2016
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5268386A (en) * | 1989-08-03 | 1993-12-07 | Shionogi & Co., Ltd. | Certain 3,4-dihydro 4-oxospiro [2H-1 benzopyrans] useful for treating hyperuricemia |
| RU2257895C2 (ru) * | 2001-02-02 | 2005-08-10 | Домпе С.П.А. | Применение (r)-ибупрофенметансульфонамида и его солей для лечения и предотвращения реакций отторжения трансплантируемых органов |
| US20060252808A1 (en) * | 2005-05-09 | 2006-11-09 | Nancy Joseph-Ridge | Methods for treating nephrolithiasis |
Non-Patent Citations (3)
| Title |
|---|
| FUKUNARI A. et al. Y-700 [1,3-cyano-4-(2,2-dimethylpropoxy)phenyl]-1H-pyrazole-4-carboxylic acid: a potent xanthine oxidoreductase ingibitor with hepatic excrection // The Journal of Pharmacology and Experimental Therapeuticus, 2004, vol. 311, №2, pp.519-528. * |
| ЕРОХИН А.П. и др. Крипторхизм. - М., 1995, с.209. * |
| ЕРОХИН А.П. и др. Крипторхизм. - М., 1995, с.209. FUKUNARI A. et al. Y-700 [1,3-cyano-4-(2,2-dimethylpropoxy)phenyl]-1H-pyrazole-4-carboxylic acid: a potent xanthine oxidoreductase ingibitor with hepatic excrection // The Journal of Pharmacology and Experimental Therapeuticus, 2004, vol. 311, No.2, pp.519-528. * |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2016188231A (ja) | 2016-11-04 |
| EP2101761A1 (en) | 2009-09-23 |
| KR20160031040A (ko) | 2016-03-21 |
| RU2009122505A (ru) | 2010-12-20 |
| KR20090103879A (ko) | 2009-10-01 |
| BRPI0718611A2 (pt) | 2014-02-25 |
| AU2007323919A1 (en) | 2008-05-29 |
| EP2101761A4 (en) | 2010-01-27 |
| CN101677999A (zh) | 2010-03-24 |
| CA2669935A1 (en) | 2008-05-29 |
| WO2008064015A1 (en) | 2008-05-29 |
| JP2014012726A (ja) | 2014-01-23 |
| JP2010509372A (ja) | 2010-03-25 |
| KR20150024919A (ko) | 2015-03-09 |
| JP6233899B2 (ja) | 2017-11-22 |
| MX2009004984A (es) | 2009-09-23 |
| US20080269226A1 (en) | 2008-10-30 |
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