JP2001500493A - 心臓線維芽細胞の増殖および心線維症を抑制する方法 - Google Patents
心臓線維芽細胞の増殖および心線維症を抑制する方法Info
- Publication number
- JP2001500493A JP2001500493A JP10512598A JP51259898A JP2001500493A JP 2001500493 A JP2001500493 A JP 2001500493A JP 10512598 A JP10512598 A JP 10512598A JP 51259898 A JP51259898 A JP 51259898A JP 2001500493 A JP2001500493 A JP 2001500493A
- Authority
- JP
- Japan
- Prior art keywords
- cardiac
- fibroblasts
- vesnarinone
- cells
- carbostyril
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.心臓の線維芽細胞を、下記の一般式(1)で示されるカルボスチリル誘導体: [式中、Rは、フェニル環に置換基として低級アルコキシ基を有していてもよい ベンゾイル基であり、カルボスチリル骨格の3位および4位の炭素-炭素結合は 単結合または二重結合である。]、またはその薬学的に許容される塩の有効量と 接触させることを包含する、心臓線維芽細胞の増殖抑制方法。 2.上記カルボスチリルが、3,4-ジヒドロ-6-[4-(3,4-ジ メトキシベンゾイル)-1-ピペラジニル]-2(1H)-キノリン、またはその薬学的に許 容されるその塩である請求項1に記載の方法。 3.心線維症の抑制治療を必要とする被験者に下記一般式(1)で示されるカルボ スチリル誘導体: [式中、Rは、フェニル環に置換基として低級アルコキシ基を有していてもよい ベンゾイル基であり、カルボスチリル骨格の3位および4位の炭素-炭素結合は 単結合または二重結合である。]、またはその薬学的に許容される塩の薬学的有 効量を投与することを包含する該被験者の心線維症の抑制方法。 4.上記カルボスチリルが、3,4-ジヒドロ-6-[4-(3,4-ジメトキシベンゾイル)-1- ピペラジニル]-2(1H)-キノリン、またはその薬学的に許容される塩である請求項 3に記載の方法。 5.上記被験者の心線維症が、大動脈弁逆流および僧帽弁逆流から成る群から選 択される心疾患に帰因するものである、請求項3に記載の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/708,581 | 1996-09-05 | ||
US08/708,581 US5684007A (en) | 1996-09-05 | 1996-09-05 | Methods for inhibiting cardiac fibroblast growth and cardiac fibrosis |
PCT/US1996/014386 WO1998009628A1 (en) | 1996-09-05 | 1996-10-16 | Methods for inhibiting cardiac fibroblast growth and cardiac fibrosis |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2001500493A true JP2001500493A (ja) | 2001-01-16 |
JP2001500493A5 JP2001500493A5 (ja) | 2004-10-28 |
JP4096122B2 JP4096122B2 (ja) | 2008-06-04 |
Family
ID=24846377
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP51259898A Expired - Fee Related JP4096122B2 (ja) | 1996-09-05 | 1996-10-16 | 心臓線維芽細胞の増殖および心線維症を抑制する方法 |
Country Status (4)
Country | Link |
---|---|
US (1) | US5684007A (ja) |
JP (1) | JP4096122B2 (ja) |
AU (1) | AU7359496A (ja) |
WO (1) | WO1998009628A1 (ja) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6898532B1 (en) | 1995-06-07 | 2005-05-24 | Biomerieux, Inc. | Method and apparatus for predicting the presence of haemostatic dysfunction in a patient sample |
US6429017B1 (en) | 1999-02-04 | 2002-08-06 | Biomerieux | Method for predicting the presence of haemostatic dysfunction in a patient sample |
US6321164B1 (en) | 1995-06-07 | 2001-11-20 | Akzo Nobel N.V. | Method and apparatus for predicting the presence of an abnormal level of one or more proteins in the clotting cascade |
US6502040B2 (en) | 1997-12-31 | 2002-12-31 | Biomerieux, Inc. | Method for presenting thrombosis and hemostasis assay data |
US6211217B1 (en) | 1999-03-16 | 2001-04-03 | Novartis Ag | Method for reducing pericardial fibrosis and adhesion formation |
US7179612B2 (en) | 2000-06-09 | 2007-02-20 | Biomerieux, Inc. | Method for detecting a lipoprotein-acute phase protein complex and predicting an increased risk of system failure or mortality |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5777676A (en) * | 1980-10-31 | 1982-05-15 | Otsuka Pharmaceut Co Ltd | Carbostyril derivative |
US5543412A (en) * | 1991-07-03 | 1996-08-06 | Otsuka Pharmaceutical Co., Ltd. | Hepatitis treatment with carbostyril compounds |
US5504093A (en) * | 1994-08-01 | 1996-04-02 | Otsuka Pharmaceutical Co., Ltd. | Method for inhibiting nucleoside and nucleobase transport in mammalian cells, and method for inhibition of DNA virus replication |
-
1996
- 1996-09-05 US US08/708,581 patent/US5684007A/en not_active Expired - Lifetime
- 1996-10-16 JP JP51259898A patent/JP4096122B2/ja not_active Expired - Fee Related
- 1996-10-16 AU AU73594/96A patent/AU7359496A/en not_active Abandoned
- 1996-10-16 WO PCT/US1996/014386 patent/WO1998009628A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
US5684007A (en) | 1997-11-04 |
AU7359496A (en) | 1998-03-26 |
JP4096122B2 (ja) | 2008-06-04 |
WO1998009628A1 (en) | 1998-03-12 |
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