RU2478630C2 - Промежуточные соединения и способы получения зеараленоновых макролидных аналогов - Google Patents

Промежуточные соединения и способы получения зеараленоновых макролидных аналогов Download PDF

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Publication number
RU2478630C2
RU2478630C2 RU2010128103/04A RU2010128103A RU2478630C2 RU 2478630 C2 RU2478630 C2 RU 2478630C2 RU 2010128103/04 A RU2010128103/04 A RU 2010128103/04A RU 2010128103 A RU2010128103 A RU 2010128103A RU 2478630 C2 RU2478630 C2 RU 2478630C2
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Russia
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group
hydrogen
formula
compound
alkyl
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RU2010128103/04A
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English (en)
Russian (ru)
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RU2010128103A (ru
Inventor
Рош БУАВЕН
Сильвио А. КАМПАНЬЯ
Хун ДУ
Фрэнсис Дж. ФАН
Томас ХОРСТМАНН
Шарль-Андре ЛЕМЕЛИН
Цзин Ли
Памела МаксГИННЕСС
Сян НЮ
Мэттью Дж. ШНАДЕРБЕК
Кевин У (куо-мин)
Сяоцзе ЧЖУ (джефф)
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ЭЙСАН Ар ЭНД Ди МЕНЕДЖМЕНТ КО., ЛТД.
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Publication of RU2010128103A publication Critical patent/RU2010128103A/ru
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/22—Radicals substituted by singly bound oxygen or sulfur atoms etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/24—Radicals substituted by singly bound oxygen or sulfur atoms esterified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/08—1,3-Dioxanes; Hydrogenated 1,3-dioxanes condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Cosmetics (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicinal Preparation (AREA)
RU2010128103/04A 2007-12-07 2008-12-08 Промежуточные соединения и способы получения зеараленоновых макролидных аналогов RU2478630C2 (ru)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US1240907P 2007-12-07 2007-12-07
US1241107P 2007-12-07 2007-12-07
US1240807P 2007-12-07 2007-12-07
US61/012,409 2007-12-07
US61/012,411 2007-12-07
US61/012,408 2007-12-07
US8004808P 2008-07-11 2008-07-11
US61/080,048 2008-07-11
PCT/US2008/013498 WO2009075818A1 (en) 2007-12-07 2008-12-08 Intermediates and methods for making zearalenone macrolide analogs

Publications (2)

Publication Number Publication Date
RU2010128103A RU2010128103A (ru) 2012-01-20
RU2478630C2 true RU2478630C2 (ru) 2013-04-10

Family

ID=40445478

Family Applications (2)

Application Number Title Priority Date Filing Date
RU2010128103/04A RU2478630C2 (ru) 2007-12-07 2008-12-08 Промежуточные соединения и способы получения зеараленоновых макролидных аналогов
RU2010128096/04A RU2497803C2 (ru) 2007-12-07 2008-12-08 Промежуточные продукты в синтезе аналогов зеараленоновых макролидов

Family Applications After (1)

Application Number Title Priority Date Filing Date
RU2010128096/04A RU2497803C2 (ru) 2007-12-07 2008-12-08 Промежуточные продукты в синтезе аналогов зеараленоновых макролидов

Country Status (10)

Country Link
US (3) US8350059B2 (enExample)
EP (2) EP2231634B1 (enExample)
JP (3) JP5492786B2 (enExample)
CN (2) CN101889005B (enExample)
BR (2) BRPI0820953B1 (enExample)
CA (2) CA2708143C (enExample)
IL (2) IL205954A (enExample)
MX (2) MX2010006091A (enExample)
RU (2) RU2478630C2 (enExample)
WO (2) WO2009075823A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ535101A (en) 2002-03-08 2007-07-27 Eisai Co Ltd Macrocyclic compounds useful as pharmaceuticals
EP2182941B1 (en) 2007-07-25 2018-02-28 Eisai R&D Management Co., Ltd. Multikinase inhibitors for use in the treatment of cancer
JP5492786B2 (ja) 2007-12-07 2014-05-14 エーザイ・アール・アンド・ディー・マネジメント株式会社 ゼラレノンマクロライドアナログを作製するための中間体および方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1375135A3 (ru) * 1982-09-13 1988-02-15 Эли Лилли Энд Компани (Фирма) Способ получени макролидных соединений
WO2003076424A1 (en) * 2002-03-08 2003-09-18 Eisai Co. Ltd. Macrocyclic compounds useful as pharmaceuticals

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9225396D0 (en) 1992-12-04 1993-01-27 Sandoz Ltd Improvements in or relating to organic compounds
US5795910A (en) 1994-10-28 1998-08-18 Cor Therapeutics, Inc. Method and compositions for inhibiting protein kinases
SK286592B6 (sk) * 1997-07-08 2009-01-07 Bristol-Myers Squibb Company Derivát epotilónu, farmaceutický prostriedok s jeho obsahom a jeho použitie
JP2004292315A (ja) 2000-12-14 2004-10-21 Chugai Pharmaceut Co Ltd Ｔａｋ１阻害剤
JP2004292314A (ja) 2000-12-14 2004-10-21 Chugai Pharmaceut Co Ltd ケラチノサイト増殖抑制剤
US7915306B2 (en) 2002-03-08 2011-03-29 Eisai Co., Ltd. Macrocyclic compounds useful as pharmaceuticals
WO2008021213A1 (en) 2006-08-11 2008-02-21 Nicolas Winssinger Macrocyclic compounds useful as inhibitors of kinases and hsp90
WO2008149244A2 (en) * 2007-06-05 2008-12-11 Nicolas Winssinger Compositions and methods comprising analogues of radicicol a
EP2182941B1 (en) 2007-07-25 2018-02-28 Eisai R&D Management Co., Ltd. Multikinase inhibitors for use in the treatment of cancer
TW200924749A (en) * 2007-07-25 2009-06-16 Eisai R & Amp D Man Co Ltd Zearalenone macrolide derivatives and uses of the same
JP5492786B2 (ja) 2007-12-07 2014-05-14 エーザイ・アール・アンド・ディー・マネジメント株式会社 ゼラレノンマクロライドアナログを作製するための中間体および方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1375135A3 (ru) * 1982-09-13 1988-02-15 Эли Лилли Энд Компани (Фирма) Способ получени макролидных соединений
WO2003076424A1 (en) * 2002-03-08 2003-09-18 Eisai Co. Ltd. Macrocyclic compounds useful as pharmaceuticals
US20060247448A1 (en) * 2002-03-08 2006-11-02 Eisai Co., Ltd. Macrocyclic compounds useful as pharmaceuticals

Also Published As

Publication number Publication date
CA2708141A1 (en) 2009-06-18
EP2231634B1 (en) 2016-05-11
RU2010128103A (ru) 2012-01-20
US20110237805A1 (en) 2011-09-29
RU2010128096A (ru) 2012-01-20
CN101889006A (zh) 2010-11-17
US20110046398A1 (en) 2011-02-24
BRPI0820953B1 (pt) 2022-04-05
CN101889006B (zh) 2013-09-04
CA2708143A1 (en) 2009-06-18
CA2708141C (en) 2016-07-05
EP2231635B1 (en) 2014-03-19
IL205983A0 (en) 2010-11-30
BRPI0820958A2 (pt) 2015-07-07
MX2010005999A (es) 2010-06-23
US8507696B2 (en) 2013-08-13
WO2009075818A1 (en) 2009-06-18
CA2708143C (en) 2016-10-11
IL205954A0 (en) 2010-11-30
JP2014141498A (ja) 2014-08-07
CN101889005A (zh) 2010-11-17
IL205983A (en) 2017-01-31
US20130211103A1 (en) 2013-08-15
JP5492786B2 (ja) 2014-05-14
WO2009075823A1 (en) 2009-06-18
CN101889005B (zh) 2015-06-03
EP2231635A1 (en) 2010-09-29
JP2011506323A (ja) 2011-03-03
MX2010006091A (es) 2010-06-25
US8350059B2 (en) 2013-01-08
EP2231634A1 (en) 2010-09-29
BRPI0820958B1 (pt) 2022-04-05
IL205954A (en) 2017-01-31
JP5496908B2 (ja) 2014-05-21
BRPI0820953A2 (pt) 2015-06-23
RU2497803C2 (ru) 2013-11-10
JP2011506324A (ja) 2011-03-03

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