JP5496908B2 - ゼラレノンマクロライドアナログを作製するための中間体および方法 - Google Patents

ゼラレノンマクロライドアナログを作製するための中間体および方法 Download PDF

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Publication number
JP5496908B2
JP5496908B2 JP2010536949A JP2010536949A JP5496908B2 JP 5496908 B2 JP5496908 B2 JP 5496908B2 JP 2010536949 A JP2010536949 A JP 2010536949A JP 2010536949 A JP2010536949 A JP 2010536949A JP 5496908 B2 JP5496908 B2 JP 5496908B2
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Japan
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group
hydrogen
formula
compound
alkyl
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Japanese (ja)
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JP2011506323A5 (enExample
JP2011506323A (ja
Inventor
ローシュ ボワビン，
シルビオ エー． カンパーニャ，
ホン デュ，
フランシス ジー． ファン，
トーマス ホーストマン，
チャールズ−アンドレ レメリン，
チン リー，
パメラ マクギネス，
シャン ニウ，
マシュー ジェイ． シュネーダーベック，
ケビン（クオ−ミン） ウー，
シャオチー（ジェフ） チュー，
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Eisai R&D Management Co Ltd
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Eisai R&D Management Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/22—Radicals substituted by singly bound oxygen or sulfur atoms etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/24—Radicals substituted by singly bound oxygen or sulfur atoms esterified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/08—1,3-Dioxanes; Hydrogenated 1,3-dioxanes condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Cosmetics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2010536949A 2007-12-07 2008-12-08 ゼラレノンマクロライドアナログを作製するための中間体および方法 Active JP5496908B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US1241107P 2007-12-07 2007-12-07
US1240807P 2007-12-07 2007-12-07
US1240907P 2007-12-07 2007-12-07
US61/012,411 2007-12-07
US61/012,408 2007-12-07
US61/012,409 2007-12-07
US8004808P 2008-07-11 2008-07-11
US61/080,048 2008-07-11
PCT/US2008/013498 WO2009075818A1 (en) 2007-12-07 2008-12-08 Intermediates and methods for making zearalenone macrolide analogs

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014042331A Division JP2014141498A (ja) 2007-12-07 2014-03-05 ゼラレノンマクロライドアナログを作製するための中間体および方法

Publications (3)

Publication Number Publication Date
JP2011506323A JP2011506323A (ja) 2011-03-03
JP2011506323A5 JP2011506323A5 (enExample) 2012-02-02
JP5496908B2 true JP5496908B2 (ja) 2014-05-21

Family

ID=40445478

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2010536949A Active JP5496908B2 (ja) 2007-12-07 2008-12-08 ゼラレノンマクロライドアナログを作製するための中間体および方法
JP2010536950A Active JP5492786B2 (ja) 2007-12-07 2008-12-08 ゼラレノンマクロライドアナログを作製するための中間体および方法
JP2014042331A Withdrawn JP2014141498A (ja) 2007-12-07 2014-03-05 ゼラレノンマクロライドアナログを作製するための中間体および方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2010536950A Active JP5492786B2 (ja) 2007-12-07 2008-12-08 ゼラレノンマクロライドアナログを作製するための中間体および方法
JP2014042331A Withdrawn JP2014141498A (ja) 2007-12-07 2014-03-05 ゼラレノンマクロライドアナログを作製するための中間体および方法

Country Status (10)

Country Link
US (3) US8350059B2 (enExample)
EP (2) EP2231635B1 (enExample)
JP (3) JP5496908B2 (enExample)
CN (2) CN101889006B (enExample)
BR (2) BRPI0820953B1 (enExample)
CA (2) CA2708141C (enExample)
IL (2) IL205954A (enExample)
MX (2) MX2010006091A (enExample)
RU (2) RU2478630C2 (enExample)
WO (2) WO2009075818A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003076424A1 (en) 2002-03-08 2003-09-18 Eisai Co. Ltd. Macrocyclic compounds useful as pharmaceuticals
ES2670423T3 (es) 2007-07-25 2018-05-30 Eisai R&D Management Co., Ltd. Inhibidores de multicinasas para uso en el tratamiento de cáncer
RU2478630C2 (ru) * 2007-12-07 2013-04-10 ЭЙСАН Ар ЭНД Ди МЕНЕДЖМЕНТ КО., ЛТД. Промежуточные соединения и способы получения зеараленоновых макролидных аналогов

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU561147B2 (en) * 1982-09-13 1987-04-30 Eli Lilly And Company 20-amino macrolide antibiotics
GB9225396D0 (en) 1992-12-04 1993-01-27 Sandoz Ltd Improvements in or relating to organic compounds
US5795910A (en) 1994-10-28 1998-08-18 Cor Therapeutics, Inc. Method and compositions for inhibiting protein kinases
SK286592B6 (sk) * 1997-07-08 2009-01-07 Bristol-Myers Squibb Company Derivát epotilónu, farmaceutický prostriedok s jeho obsahom a jeho použitie
JP2004292314A (ja) 2000-12-14 2004-10-21 Chugai Pharmaceut Co Ltd ケラチノサイト増殖抑制剤
JP2004292315A (ja) 2000-12-14 2004-10-21 Chugai Pharmaceut Co Ltd Ｔａｋ１阻害剤
US7915306B2 (en) * 2002-03-08 2011-03-29 Eisai Co., Ltd. Macrocyclic compounds useful as pharmaceuticals
WO2003076424A1 (en) 2002-03-08 2003-09-18 Eisai Co. Ltd. Macrocyclic compounds useful as pharmaceuticals
CA2696021C (en) 2006-08-11 2015-09-29 Nicolas Winssinger Macrocyclic compounds useful as inhibitors of kinases and hsp90
WO2008149244A2 (en) * 2007-06-05 2008-12-11 Nicolas Winssinger Compositions and methods comprising analogues of radicicol a
ES2670423T3 (es) 2007-07-25 2018-05-30 Eisai R&D Management Co., Ltd. Inhibidores de multicinasas para uso en el tratamiento de cáncer
TW200924749A (en) * 2007-07-25 2009-06-16 Eisai R & Amp D Man Co Ltd Zearalenone macrolide derivatives and uses of the same
RU2478630C2 (ru) * 2007-12-07 2013-04-10 ЭЙСАН Ар ЭНД Ди МЕНЕДЖМЕНТ КО., ЛТД. Промежуточные соединения и способы получения зеараленоновых макролидных аналогов

Also Published As

Publication number Publication date
EP2231635B1 (en) 2014-03-19
RU2497803C2 (ru) 2013-11-10
US20110046398A1 (en) 2011-02-24
IL205983A (en) 2017-01-31
BRPI0820953A2 (pt) 2015-06-23
US8507696B2 (en) 2013-08-13
EP2231635A1 (en) 2010-09-29
BRPI0820958B1 (pt) 2022-04-05
JP5492786B2 (ja) 2014-05-14
MX2010005999A (es) 2010-06-23
US20110237805A1 (en) 2011-09-29
US20130211103A1 (en) 2013-08-15
CA2708141C (en) 2016-07-05
US8350059B2 (en) 2013-01-08
BRPI0820958A2 (pt) 2015-07-07
CA2708143C (en) 2016-10-11
CA2708141A1 (en) 2009-06-18
CA2708143A1 (en) 2009-06-18
BRPI0820953B1 (pt) 2022-04-05
RU2010128096A (ru) 2012-01-20
CN101889005B (zh) 2015-06-03
WO2009075818A1 (en) 2009-06-18
JP2011506324A (ja) 2011-03-03
RU2478630C2 (ru) 2013-04-10
RU2010128103A (ru) 2012-01-20
EP2231634A1 (en) 2010-09-29
IL205983A0 (en) 2010-11-30
CN101889006B (zh) 2013-09-04
CN101889005A (zh) 2010-11-17
IL205954A (en) 2017-01-31
MX2010006091A (es) 2010-06-25
IL205954A0 (en) 2010-11-30
WO2009075823A1 (en) 2009-06-18
JP2014141498A (ja) 2014-08-07
CN101889006A (zh) 2010-11-17
JP2011506323A (ja) 2011-03-03
EP2231634B1 (en) 2016-05-11

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