RU2466742C2 - Способ инактивирования патогенов в донорской крови, плазме крови или концентратах эритроцитов в гибких контейнерах с помощью встряхивания - Google Patents
Способ инактивирования патогенов в донорской крови, плазме крови или концентратах эритроцитов в гибких контейнерах с помощью встряхивания Download PDFInfo
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- RU2466742C2 RU2466742C2 RU2008129480/14A RU2008129480A RU2466742C2 RU 2466742 C2 RU2466742 C2 RU 2466742C2 RU 2008129480/14 A RU2008129480/14 A RU 2008129480/14A RU 2008129480 A RU2008129480 A RU 2008129480A RU 2466742 C2 RU2466742 C2 RU 2466742C2
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- irradiation
- radiation
- preceding paragraphs
- bags
- blood
- Prior art date
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- 229960000907 methylthioninium chloride Drugs 0.000 claims description 6
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- -1 porphyrin compounds Chemical class 0.000 claims 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N23/00—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/16—Blood plasma; Blood serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/10—Inactivation or decontamination of a medicinal preparation prior to administration to an animal or a person
- A61K41/17—Inactivation or decontamination of a medicinal preparation prior to administration to an animal or a person by ultraviolet [UV] or infrared [IR] light, X-rays or gamma rays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/08—Radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/08—Radiation
- A61L2/10—Ultraviolet radiation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
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- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Developmental Biology & Embryology (AREA)
- Virology (AREA)
- Zoology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102005062634A DE102005062634A1 (de) | 2005-12-23 | 2005-12-23 | Verfahren zur Inaktivierung von Pathogenen in Spenderblut, Blutplasma oder Erythrozytenkonzentraten in flexiblen Behältnissen unter Bewegung |
| DE102005062634.3 | 2005-12-23 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2008129480A RU2008129480A (ru) | 2010-01-27 |
| RU2466742C2 true RU2466742C2 (ru) | 2012-11-20 |
Family
ID=38043033
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2008129480/14A RU2466742C2 (ru) | 2005-12-23 | 2006-12-21 | Способ инактивирования патогенов в донорской крови, плазме крови или концентратах эритроцитов в гибких контейнерах с помощью встряхивания |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US8164073B2 (enExample) |
| EP (2) | EP2198886B1 (enExample) |
| JP (1) | JP5232008B2 (enExample) |
| KR (1) | KR101499735B1 (enExample) |
| CN (1) | CN101340930B (enExample) |
| AT (2) | ATE457739T1 (enExample) |
| AU (1) | AU2006332291B2 (enExample) |
| CA (1) | CA2632558C (enExample) |
| DE (2) | DE102005062634A1 (enExample) |
| DK (2) | DK2198886T3 (enExample) |
| ES (2) | ES2341368T3 (enExample) |
| PL (2) | PL1962905T3 (enExample) |
| PT (2) | PT2198886E (enExample) |
| RU (1) | RU2466742C2 (enExample) |
| SI (2) | SI2198886T1 (enExample) |
| WO (1) | WO2007076832A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2808624C1 (ru) * | 2022-12-19 | 2023-11-30 | федеральное государственное автономное образовательное учреждение высшего образования Первый Московский государственный медицинский университет имени И.М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский университет) (ФГАОУ ВО Первый МГМУ им. И.М. Сеченова Минздрава России (Се | Способ обработки консервированной крови |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102005062410A1 (de) * | 2005-12-23 | 2007-08-09 | Forschungsgemeinschaft Der Drk-Blutspendedienste E.V. | Verfahren zur Bestrahlung von Thrombozytenkonzentraten in flexiblen Behältnissen mit ultraviolettem Licht |
| DE102005062634A1 (de) | 2005-12-23 | 2007-06-28 | Blutspendedienst der Landesverbände des Deutschen Roten Kreuzes Niedersachsen, Sachsen-Anhalt, Thüringen, Oldenburg und Bremen gGmbH | Verfahren zur Inaktivierung von Pathogenen in Spenderblut, Blutplasma oder Erythrozytenkonzentraten in flexiblen Behältnissen unter Bewegung |
| EP1902740A1 (en) | 2006-09-19 | 2008-03-26 | Maco Pharma S.A. | Blood bag system and process for the inactivation of pathogens in platelet concentrates by use of the blood bag system |
| EP2008669A1 (en) | 2007-06-22 | 2008-12-31 | Maco Pharma S.A. | Irradiation apparatus for inactivating pathogens and/or leukocytes in a biological fluid and process |
| EP2459248B1 (en) * | 2009-06-02 | 2019-05-22 | biolitec Unternehmensbeteiligungs II AG | A novel method for microbial depletion in human blood and blood products using antimicrobial photodynamic therapy |
| GB201006753D0 (en) | 2010-04-22 | 2010-06-09 | Biotest Ag | Process for preparing an immunolobulin composition |
| US12279610B2 (en) | 2011-03-15 | 2025-04-22 | Paragonix Technonogies, Inc. | System for hypothermic transport of samples |
| US8883409B1 (en) * | 2013-12-08 | 2014-11-11 | Hemalux LLC | Method of reducing pathogens in whole blood by illuminating with ultraviolet light under low oxygen conditions |
| CN107833751A (zh) * | 2017-10-27 | 2018-03-23 | 吉林化工学院 | 一种复合膜电极制备方法及光电性质检测方法 |
| US11964092B2 (en) | 2019-03-11 | 2024-04-23 | ABC Med Tech Corp. | Portable centrifuge and method of use |
| EP3982725A4 (en) * | 2019-06-11 | 2023-07-19 | Paragonix Technologies Inc. | ORGAN TRANSPORT CONTAINER WITH ANTIVIRAL THERAPY |
| EP4034303B1 (en) * | 2019-09-24 | 2024-03-20 | ABC Med Tech Corp. | Centrifuge device and method of use |
| US11632951B2 (en) | 2020-01-31 | 2023-04-25 | Paragonix Technologies, Inc. | Apparatus for tissue transport and preservation |
| US11116858B1 (en) | 2020-05-01 | 2021-09-14 | Uv Innovators, Llc | Ultraviolet (UV) light emission device employing visible light for target distance guidance, and related methods of use, particularly suited for decontamination |
| FR3117872A1 (fr) * | 2020-12-21 | 2022-06-24 | Maco Pharma | Procédé et système pour produire des cellules mononucléées apoptotiques |
| DE102021119408A1 (de) | 2021-07-27 | 2023-02-02 | Blutspendedienst der Landesverbände des DRK in Niedersachsen, Sachsen-Anhalt, Thüringen, Oldenburg und Bremen g.G.m.b.H. | Additivlösung für Erythrozytenkonzentrate |
| CN115350296A (zh) * | 2022-08-30 | 2022-11-18 | 南京双威生物医学科技有限公司 | 基于核黄素光化学法的血液病原体灭活处理系统 |
| US20250064674A1 (en) | 2023-08-25 | 2025-02-27 | Paragonix Technologies, Inc. | Methods and systems for cyclically inflating and deflating a lung ex-vivo |
| US12410408B2 (en) | 2024-02-02 | 2025-09-09 | Paragonix Technologies, Inc. | Method for hypothermic transport of biological samples |
| USD1087382S1 (en) | 2025-01-30 | 2025-08-05 | Paragonix Technologies, Inc. | Device for transporting a biological sample |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5300019A (en) * | 1990-12-20 | 1994-04-05 | Baxter International Inc. | Systems and methods for eradicating contaminants using photoactive materials in fluids like blood |
| RU2086272C1 (ru) * | 1988-03-29 | 1997-08-10 | Иатрос Лимитед | Устройство для стерилизации ультрафиолетовым излучением и способ стерилизации ультрафиолетовым излучением |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4469227A (en) | 1983-08-17 | 1984-09-04 | Clifford Faust | Package for cryogenically frozen liquids |
| US4586928A (en) | 1984-10-09 | 1986-05-06 | Miles Laboratories, Inc. | Pivoting frangible valve for plastic bags |
| US4952812A (en) | 1986-08-26 | 1990-08-28 | Baxter International Inc. | Irradiation of blood products |
| US4878891A (en) | 1987-06-25 | 1989-11-07 | Baylor Research Foundation | Method for eradicating infectious biological contaminants in body tissues |
| US5661126A (en) * | 1989-01-19 | 1997-08-26 | The General Hospital Corporation | Use of mullerian inhibiting substance for treating certain tumors and for modulating class I major histocompatibility antigen expression |
| US4952818A (en) * | 1989-05-17 | 1990-08-28 | International Business Machines Corporation | Transmission line driver circuits |
| JPH05131018A (ja) | 1991-11-11 | 1993-05-28 | Terumo Corp | バツグ連結体およびその製造方法 |
| US6420570B1 (en) * | 1993-06-28 | 2002-07-16 | Cerus Corporation | Psoralen compounds |
| US5625079A (en) * | 1993-06-28 | 1997-04-29 | Cerus Corporation | Synthesizing psoralen compounds useful as intermediates |
| ES2201093T3 (es) | 1993-11-10 | 2004-03-16 | Cerus Corporation | Dispositivo y procedimiento para fotoactivacion. |
| EP0840624B1 (fr) * | 1995-07-14 | 2007-07-25 | CAF - DCF cvba - scrl | Installation d'inactivation de contaminants viraux presents dans des produits sanguins |
| DE29801590U1 (de) | 1998-01-30 | 1998-04-16 | Maco Pharma Int Gmbh | Blutbeutelsystem zur Virusinaktivierung von Blut, Blutkomponenten und Plasma |
| DE19831768A1 (de) * | 1998-07-15 | 2000-02-17 | Paa Lab Gmbh | Vorrichtung zur Bestrahlung einer Flüssigkeit |
| EP1002512A3 (en) | 1998-11-19 | 2001-01-24 | Bracco International B.V. | Flexible container for the containment and delivery of fluids |
| US7445756B2 (en) | 1999-06-03 | 2008-11-04 | Fenwal, Inc. | Fluid processing sets and organizers for the same |
| US7068361B2 (en) | 1999-06-03 | 2006-06-27 | Baxter International | Apparatus, systems and methods for processing and treating a biological fluid with light |
| US7094378B1 (en) | 2000-06-15 | 2006-08-22 | Gambro, Inc. | Method and apparatus for inactivation of biological contaminants using photosensitizers |
| US6268120B1 (en) * | 1999-10-19 | 2001-07-31 | Gambro, Inc. | Isoalloxazine derivatives to neutralize biological contaminants |
| US6596230B1 (en) * | 2000-01-28 | 2003-07-22 | Baxter International Inc. | Device and method for pathogen inactivation of therapeutic fluids with sterilizing radiation |
| US6576201B1 (en) * | 2000-01-28 | 2003-06-10 | Baxter International Inc. | Device and method for pathogen inactivation of therapeutic fluids with sterilizing radiation |
| AU2001296309A1 (en) | 2000-09-27 | 2002-04-08 | Gambro, Inc | Inactivation of contaminants using photosensitizers and pulsed light |
| US20020138066A1 (en) | 2001-03-23 | 2002-09-26 | Gambro, Inc. | Multiple compartment bag with openable closure assembly |
| US20030127603A1 (en) * | 2001-05-15 | 2003-07-10 | Bernard Horowitz | Apparatus for the inactivation of pathogens in protein-containing fluids and uses thereof |
| US20030064001A1 (en) | 2001-05-17 | 2003-04-03 | Fries William M. | System for the decontamination of fluid products using light |
| US20030228564A1 (en) | 2001-05-30 | 2003-12-11 | Edrich Richard Alan | Nitric oxide in a pathogen inactivation process |
| EP1429823A1 (en) * | 2001-09-27 | 2004-06-23 | Gambro, Inc., | Radio frequency or electromagnetic information systems and methods for use in extracorporeal blood processing |
| DE10152159A1 (de) | 2001-10-25 | 2003-05-15 | Aventis Behring Gmbh | Verfahren zur proteinschonenden Reinigung von kontaminierten biologischen Flüssigkeiten |
| EP1469891B1 (en) | 2002-02-01 | 2009-04-15 | CaridianBCT Biotechnologies, LLC | Reduction of contaminants in blood and blood products using photosensitizers and peak wavelengths of light |
| MXPA04010027A (es) | 2002-04-12 | 2005-07-01 | Throwleigh Technologies L L C | Metodos y aparatos para descontaminar fluidos. |
| US7077559B2 (en) | 2002-04-26 | 2006-07-18 | Gambro, Inc. | Container or bag mixing apparatuses and/or methods |
| JP4154191B2 (ja) * | 2002-08-28 | 2008-09-24 | テルモ株式会社 | 光照射装置および光照射方法 |
| US7207964B2 (en) | 2003-03-17 | 2007-04-24 | Hemavation, Llc | Apparatus and method for down-regulating immune system mediators in blood |
| US20080177217A1 (en) * | 2004-05-14 | 2008-07-24 | Hans-Dietrich Polaschegg | Taurolidine Formulations and Delivery: Therapeutic Treatments and Antimicrobial Protection Against Bacterial Biofilm Formation |
| US8296071B2 (en) * | 2004-03-15 | 2012-10-23 | Terumo Bct Biotechnologies, Llc | Methods for uniformly treating biological samples with electromagnetic radiation |
| FR2887335B1 (fr) | 2005-06-21 | 2007-08-10 | Maco Pharma Sa | Procede pour la determination d'une contamination pathogene dans un fluide contenant des plaquettes sanguines |
| DE102005062634A1 (de) | 2005-12-23 | 2007-06-28 | Blutspendedienst der Landesverbände des Deutschen Roten Kreuzes Niedersachsen, Sachsen-Anhalt, Thüringen, Oldenburg und Bremen gGmbH | Verfahren zur Inaktivierung von Pathogenen in Spenderblut, Blutplasma oder Erythrozytenkonzentraten in flexiblen Behältnissen unter Bewegung |
| DE102005062410A1 (de) | 2005-12-23 | 2007-08-09 | Forschungsgemeinschaft Der Drk-Blutspendedienste E.V. | Verfahren zur Bestrahlung von Thrombozytenkonzentraten in flexiblen Behältnissen mit ultraviolettem Licht |
| EP1902740A1 (en) * | 2006-09-19 | 2008-03-26 | Maco Pharma S.A. | Blood bag system and process for the inactivation of pathogens in platelet concentrates by use of the blood bag system |
| EP2008669A1 (en) * | 2007-06-22 | 2008-12-31 | Maco Pharma S.A. | Irradiation apparatus for inactivating pathogens and/or leukocytes in a biological fluid and process |
-
2005
- 2005-12-23 DE DE102005062634A patent/DE102005062634A1/de not_active Withdrawn
-
2006
- 2006-12-21 AT AT06840887T patent/ATE457739T1/de active
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- 2006-12-21 US US11/643,728 patent/US8164073B2/en active Active
- 2006-12-21 PT PT10001518T patent/PT2198886E/pt unknown
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- 2006-12-21 CN CN2006800479151A patent/CN101340930B/zh active Active
- 2006-12-21 DK DK10001518.9T patent/DK2198886T3/da active
- 2006-12-21 RU RU2008129480/14A patent/RU2466742C2/ru active
- 2006-12-21 SI SI200631112T patent/SI2198886T1/sl unknown
- 2006-12-21 EP EP10001518A patent/EP2198886B1/de active Active
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- 2006-12-21 KR KR1020087017172A patent/KR101499735B1/ko active Active
- 2006-12-21 WO PCT/DE2006/002307 patent/WO2007076832A1/de not_active Ceased
- 2006-12-21 DK DK06840887.1T patent/DK1962905T3/da active
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- 2006-12-21 AU AU2006332291A patent/AU2006332291B2/en active Active
-
2012
- 2012-03-14 US US13/419,778 patent/US8525128B2/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2086272C1 (ru) * | 1988-03-29 | 1997-08-10 | Иатрос Лимитед | Устройство для стерилизации ультрафиолетовым излучением и способ стерилизации ультрафиолетовым излучением |
| US5300019A (en) * | 1990-12-20 | 1994-04-05 | Baxter International Inc. | Systems and methods for eradicating contaminants using photoactive materials in fluids like blood |
Non-Patent Citations (2)
| Title |
|---|
| MOHR H. et al. Inactivation of pathogens in platelet concentrates by using a two-step procedure // Vox Sang. 2003 Feb; 84(2): 96-104, abstract PubMed, найдено [22.09.2010] из Интернет www.pubmed.com. * |
| с.4-8, 10-12, пп.1-7, 17 формулы, фиг.9. * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2808624C1 (ru) * | 2022-12-19 | 2023-11-30 | федеральное государственное автономное образовательное учреждение высшего образования Первый Московский государственный медицинский университет имени И.М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский университет) (ФГАОУ ВО Первый МГМУ им. И.М. Сеченова Минздрава России (Се | Способ обработки консервированной крови |
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