CA2632558C - Method for the inactivation of pathogens in donor blood, blood plasma or erythrocyte concentrations in flexible containers using agitation - Google Patents

Method for the inactivation of pathogens in donor blood, blood plasma or erythrocyte concentrations in flexible containers using agitation Download PDF

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Publication number
CA2632558C
CA2632558C CA2632558A CA2632558A CA2632558C CA 2632558 C CA2632558 C CA 2632558C CA 2632558 A CA2632558 A CA 2632558A CA 2632558 A CA2632558 A CA 2632558A CA 2632558 C CA2632558 C CA 2632558C
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Canada
Prior art keywords
irradiation
bags
preparations
less
blood
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2632558A
Other languages
English (en)
French (fr)
Other versions
CA2632558A1 (en
Inventor
Harald Mohr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Blutspendedienst der Landsverbande des Deutschen Roten Kreuses
Original Assignee
Blutspendedienst der Landsverbande des Deutschen Roten Kreuses
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
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Application filed by Blutspendedienst der Landsverbande des Deutschen Roten Kreuses filed Critical Blutspendedienst der Landsverbande des Deutschen Roten Kreuses
Publication of CA2632558A1 publication Critical patent/CA2632558A1/en
Application granted granted Critical
Publication of CA2632558C publication Critical patent/CA2632558C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N23/00—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/16—Blood plasma; Blood serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/10—Inactivation or decontamination of a medicinal preparation prior to administration to an animal or a person
    • A61K41/17—Inactivation or decontamination of a medicinal preparation prior to administration to an animal or a person by ultraviolet [UV] or infrared [IR] light, X-rays or gamma rays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/02—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using physical processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/02—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using physical processes
    • A61L2/08—Radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/02—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using physical processes
    • A61L2/08—Radiation
    • A61L2/10—Ultraviolet [UV] radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2103/00—Materials or objects being the target of disinfection or sterilisation
    • A61L2103/05—Living organisms or biological materials

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
CA2632558A 2005-12-23 2006-12-21 Method for the inactivation of pathogens in donor blood, blood plasma or erythrocyte concentrations in flexible containers using agitation Active CA2632558C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102005062634A DE102005062634A1 (de) 2005-12-23 2005-12-23 Verfahren zur Inaktivierung von Pathogenen in Spenderblut, Blutplasma oder Erythrozytenkonzentraten in flexiblen Behältnissen unter Bewegung
DE102005062634.3 2005-12-23
PCT/DE2006/002307 WO2007076832A1 (de) 2005-12-23 2006-12-21 Verfahren zur inaktivierung von pathogenen in spenderblut, blutplasma oder erythrozytenkonzentraten in flexiblen behältnissen unter bewegung

Publications (2)

Publication Number Publication Date
CA2632558A1 CA2632558A1 (en) 2007-07-12
CA2632558C true CA2632558C (en) 2013-06-11

Family

ID=38043033

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2632558A Active CA2632558C (en) 2005-12-23 2006-12-21 Method for the inactivation of pathogens in donor blood, blood plasma or erythrocyte concentrations in flexible containers using agitation

Country Status (16)

Country Link
US (2) US8164073B2 (enExample)
EP (2) EP1962905B1 (enExample)
JP (1) JP5232008B2 (enExample)
KR (1) KR101499735B1 (enExample)
CN (1) CN101340930B (enExample)
AT (2) ATE457739T1 (enExample)
AU (1) AU2006332291B2 (enExample)
CA (1) CA2632558C (enExample)
DE (2) DE102005062634A1 (enExample)
DK (2) DK2198886T3 (enExample)
ES (2) ES2341368T3 (enExample)
PL (2) PL1962905T3 (enExample)
PT (2) PT2198886E (enExample)
RU (1) RU2466742C2 (enExample)
SI (2) SI1962905T1 (enExample)
WO (1) WO2007076832A1 (enExample)

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DE102005062634A1 (de) 2005-12-23 2007-06-28 Blutspendedienst der Landesverbände des Deutschen Roten Kreuzes Niedersachsen, Sachsen-Anhalt, Thüringen, Oldenburg und Bremen gGmbH Verfahren zur Inaktivierung von Pathogenen in Spenderblut, Blutplasma oder Erythrozytenkonzentraten in flexiblen Behältnissen unter Bewegung
DE102005062410A1 (de) 2005-12-23 2007-08-09 Forschungsgemeinschaft Der Drk-Blutspendedienste E.V. Verfahren zur Bestrahlung von Thrombozytenkonzentraten in flexiblen Behältnissen mit ultraviolettem Licht
EP1902740A1 (en) 2006-09-19 2008-03-26 Maco Pharma S.A. Blood bag system and process for the inactivation of pathogens in platelet concentrates by use of the blood bag system
EP2008669A1 (en) 2007-06-22 2008-12-31 Maco Pharma S.A. Irradiation apparatus for inactivating pathogens and/or leukocytes in a biological fluid and process
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US8883409B1 (en) * 2013-12-08 2014-11-11 Hemalux LLC Method of reducing pathogens in whole blood by illuminating with ultraviolet light under low oxygen conditions
US20210400952A1 (en) 2017-06-07 2021-12-30 Paragonix Technologies, Inc. Apparatus for tissue transport and preservation
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US11964092B2 (en) 2019-03-11 2024-04-23 ABC Med Tech Corp. Portable centrifuge and method of use
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FR3117872A1 (fr) * 2020-12-21 2022-06-24 Maco Pharma Procédé et système pour produire des cellules mononucléées apoptotiques
JP7776724B2 (ja) 2021-04-27 2025-11-27 日亜化学工業株式会社 カルシウムチャネル及び／又はカルシウムポンプの発現を誘導する方法及び培養装置
DE102021119408A1 (de) 2021-07-27 2023-02-02 Blutspendedienst der Landesverbände des DRK in Niedersachsen, Sachsen-Anhalt, Thüringen, Oldenburg und Bremen g.G.m.b.H. Additivlösung für Erythrozytenkonzentrate
CN115350296A (zh) * 2022-08-30 2022-11-18 南京双威生物医学科技有限公司 基于核黄素光化学法的血液病原体灭活处理系统
EP4583707A1 (en) 2022-09-08 2025-07-16 Paragonix Technologies, Inc. Hypothermic tissue storage
US12357533B2 (en) 2023-08-25 2025-07-15 Paragonix Technologies, Inc. Systems and methods for maintaining organ pressure
US12410408B2 (en) 2024-02-02 2025-09-09 Paragonix Technologies, Inc. Method for hypothermic transport of biological samples
US20250311718A1 (en) 2024-04-09 2025-10-09 Paragonix Technologies, Inc. Systems and methods for preservation of an organ
USD1087382S1 (en) 2025-01-30 2025-08-05 Paragonix Technologies, Inc. Device for transporting a biological sample

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DE102005062410A1 (de) 2005-12-23 2007-08-09 Forschungsgemeinschaft Der Drk-Blutspendedienste E.V. Verfahren zur Bestrahlung von Thrombozytenkonzentraten in flexiblen Behältnissen mit ultraviolettem Licht
EP1902740A1 (en) 2006-09-19 2008-03-26 Maco Pharma S.A. Blood bag system and process for the inactivation of pathogens in platelet concentrates by use of the blood bag system
EP2008669A1 (en) 2007-06-22 2008-12-31 Maco Pharma S.A. Irradiation apparatus for inactivating pathogens and/or leukocytes in a biological fluid and process

Also Published As

Publication number Publication date
PL1962905T3 (pl) 2010-08-31
US20120228517A1 (en) 2012-09-13
ATE514432T1 (de) 2011-07-15
EP1962905B1 (de) 2010-02-17
EP1962905A1 (de) 2008-09-03
KR20080081038A (ko) 2008-09-05
PT1962905E (pt) 2010-05-14
AU2006332291A1 (en) 2007-07-12
DE102005062634A9 (de) 2007-10-11
PL2198886T3 (pl) 2012-01-31
ES2369059T3 (es) 2011-11-24
EP2198886B1 (de) 2011-06-29
HK1144249A1 (en) 2011-02-11
SI2198886T1 (sl) 2011-11-30
CA2632558A1 (en) 2007-07-12
DK1962905T3 (da) 2010-06-07
KR101499735B1 (ko) 2015-03-06
US8164073B2 (en) 2012-04-24
PT2198886E (pt) 2011-09-28
RU2008129480A (ru) 2010-01-27
HK1121407A1 (en) 2009-04-24
CN101340930B (zh) 2012-09-05
ES2341368T3 (es) 2010-06-18
DK2198886T3 (da) 2011-10-10
DE102005062634A1 (de) 2007-06-28
RU2466742C2 (ru) 2012-11-20
ATE457739T1 (de) 2010-03-15
SI1962905T1 (sl) 2010-06-30
EP2198886A1 (de) 2010-06-23
US8525128B2 (en) 2013-09-03
JP5232008B2 (ja) 2013-07-10
HK1121406A1 (zh) 2009-04-24
AU2006332291B2 (en) 2012-02-23
WO2007076832A1 (de) 2007-07-12
CN101340930A (zh) 2009-01-07
JP2009520703A (ja) 2009-05-28
US20070164233A1 (en) 2007-07-19
DE502006006204D1 (de) 2010-04-01

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