RU2451673C2 - ПРОИЗВОДНЫЕ ПИРИДИНА И ПИРИМИДИНА В КАЧЕСТВЕ АНТАГОНИСТОВ mGluR2 - Google Patents

ПРОИЗВОДНЫЕ ПИРИДИНА И ПИРИМИДИНА В КАЧЕСТВЕ АНТАГОНИСТОВ mGluR2 Download PDF

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RU2451673C2
RU2451673C2 RU2008136732/04A RU2008136732A RU2451673C2 RU 2451673 C2 RU2451673 C2 RU 2451673C2 RU 2008136732/04 A RU2008136732/04 A RU 2008136732/04A RU 2008136732 A RU2008136732 A RU 2008136732A RU 2451673 C2 RU2451673 C2 RU 2451673C2
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Russia
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phenyl
trifluoromethyl
pyrimidin
methyl
pyridin
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RU2008136732/04A
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Russian (ru)
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RU2008136732A (ru
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МАКАРТУР Сильвия ГАТТИ (CH)
МАКАРТУР Сильвия ГАТТИ
Эрвин ГЁТШИ (CH)
Эрвин ГЁТШИ
Юрген Вихманн (DE)
Юрген ВИХМАНН
Томас Йоханнес ВОЛТЕРИНГ (DE)
Томас Йоханнес ВОЛТЕРИНГ
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Ф. Хоффманн-Ля Рош Аг
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2703460C1 (ru) * 2013-12-10 2019-10-17 ЭфЭмСи Корпорейшн Гербицидные замещенные пиримидинилоксибензольные соединения

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8012986B2 (en) 2007-04-02 2011-09-06 Hoffmann-La Roche Inc. Pyridine and pyrimidine derivatives as MGLUR2 antagonists
PL2231642T3 (pl) * 2008-01-11 2014-04-30 Novartis Ag Pirymidyny jako inhibitory kinazy
JPWO2012020820A1 (ja) * 2010-08-11 2013-10-28 大正製薬株式会社 ヘテロアリール−ピラゾール誘導体
CA2813639A1 (en) 2010-10-08 2012-04-12 Mochida Pharmaceutical Co. Ltd. Cyclic amide derivative
CN103261172B (zh) * 2010-12-21 2016-05-04 E.I.内穆尔杜邦公司 包括嘧啶化合物的电子装置
JP2014062047A (ja) * 2011-01-21 2014-04-10 Taisho Pharmaceutical Co Ltd ピラゾール誘導体
CN102336720B (zh) * 2011-03-02 2016-01-13 华中科技大学 2-氨基噻唑衍生物及制备方法和应用
CA2834465A1 (en) 2011-04-28 2012-11-01 Mochida Pharmaceutical Co., Ltd. Cyclic amide derivative
CN102351854B (zh) * 2011-07-29 2014-06-04 华中科技大学 氨基噻唑衍生物及制备方法和医药用途
EP2666775A1 (en) 2012-05-21 2013-11-27 Domain Therapeutics Substituted pyrazoloquinazolinones and pyrroloquinazolinones as allosteric modulators of group II metabotropic glutamate receptors
LT6064B (lt) 2012-10-15 2014-08-25 Vilniaus Universitetas Fluorinti benzensulfonamidai kaip karboanhidrazės inhibitoriai
SG11201503192XA (en) * 2012-10-23 2015-06-29 Hoffmann La Roche Mglu2/3 antagonists for the treatment of autistic disorders
JP6416125B2 (ja) * 2013-02-04 2018-10-31 プレクストン・セラピューティクス・ソシエテ・アノニム mGluR3の正のアロステリックモジュレーター
JP6541667B2 (ja) 2014-01-16 2019-07-10 エフ エム シー コーポレーションFmc Corporation 除草剤としてのピリミジニルオキシベンゼン誘導体
AU2015245743B2 (en) * 2014-04-09 2020-09-24 Genentech, Inc. Process for the manufacturing of medicaments
CA2943877A1 (en) * 2014-04-23 2015-10-29 F. Hoffmann-La Roche Ag Mglu2/3 antagonists for the treatment of intellectual disabilities
MX2016013981A (es) 2014-04-24 2016-11-15 Novartis Ag Derivados de amino-piridina como inhibidores de fosfatidil-inositol-3-cinasa.
EP3134397A1 (en) 2014-04-24 2017-03-01 Novartis AG Amino pyrazine derivatives as phosphatidylinositol 3-kinase inhibitors
BR112016023967A2 (pt) 2014-04-24 2017-08-15 Novartis Ag derivados de pirazina como inibidores de fosfatidilinositol 3-cinase
EP3154954B1 (en) * 2014-06-10 2022-02-09 Sanford-Burnham Medical Research Institute Metabotropic glutamate receptor negative allosteric modulators (nams) and uses thereof
EP3000814A1 (en) 2014-09-26 2016-03-30 Domain Therapeutics Substituted pyrazoloquinazolinones and pyrroloquinazolinones as allosteric modulators of group II metabotropic glutamate receptors
WO2016149324A1 (en) * 2015-03-16 2016-09-22 Vanderbilt University Negative allosteric modulators of metabotropic glutamate receptor 2
TWI828952B (zh) 2015-06-05 2024-01-11 美商艾佛艾姆希公司 作為除草劑之嘧啶氧基苯衍生物
JP2020100564A (ja) * 2017-04-03 2020-07-02 京都薬品工業株式会社 リードスルー誘導剤およびその医薬用途
TW201904947A (zh) 2017-05-02 2019-02-01 美商富曼西公司 作為除草劑的嘧啶氧基苯稠合化合物
CN110951051B (zh) * 2019-12-16 2021-04-20 大连理工大学 一类侧链含三氟甲基嘧啶的热致延迟荧光共聚物的制法及应用
CN116745467A (zh) * 2020-12-18 2023-09-12 巴斯夫欧洲公司 用于锡或锡合金电镀的包含流平剂的组合物
CN113501772A (zh) * 2021-07-28 2021-10-15 上海毕得医药科技股份有限公司 一种联苯-3-磺酰氯衍生物的合成方法
WO2023043833A1 (en) * 2021-09-14 2023-03-23 Vanderbilt University Heteroaryl-linked analogs as mglu5 negative allosteric modulators and methods of making and using the same

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2005101411A (ru) * 2002-06-20 2005-07-10 Астразенека Аб (Se) Антагонисты метаботропного глутаматного рецептора 5 (mglur5) и способ для профилактики и лечения гастро-эзофагеальной рефлюксной болезни (варианты)

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6059883B2 (ja) * 1978-05-08 1985-12-27 北興化学工業株式会社 農園芸用殺菌剤
DOP1981004033A (es) * 1980-12-23 1990-12-29 Ciba Geigy Ag Procedimiento para proteger plantas de cultivo de la accion fitotoxica de herbicidas.
ZA818852B (en) * 1980-12-23 1982-12-29 Ciba Geigy Use of phenylpyrimidines as antidotes for protecting cultivated plants against phytotoxic damage caused by herbicides
DE3319843A1 (de) * 1983-06-01 1984-12-06 Ali-Akbar Dipl.-Chem. Dr. 4300 Mülheim Pourzal Verfahren zur herstellung von pyrimidinen aus nitrilen und alkinen
EP0136976A3 (de) * 1983-08-23 1985-05-15 Ciba-Geigy Ag Verwendung von Phenylpyrimidinen als Pflanzenregulatoren
PH23565A (en) * 1986-09-05 1989-08-25 Sumitomo Chemical Co Novel pyrimidinylpyrimidine derivatives and a plant disease protectant containing them as the active ingredient
JP2517992B2 (ja) * 1986-12-03 1996-07-24 住友化学工業株式会社 ピリジルピリミジン誘導体およびそれを有効成分とする植物病害防除剤
CA1288433C (en) * 1986-12-03 1991-09-03 Tsuguhiro Katoh Pyridinylpyrimidine derivatives, method for production thereof and a fungicide containing them as the active ingredient
EP0496433B1 (en) 1987-10-22 1999-03-24 The Procter & Gamble Company Photoprotection compositions comprising chelating agents
JPH02149566A (ja) * 1988-08-10 1990-06-08 Sumitomo Chem Co Ltd 4―置換―2,6―ジフェニルピリミジン誘導体、その製造法およびそれを有効成分とする除草剤
DE3940476A1 (de) 1989-12-07 1991-06-13 Bayer Ag Pyridinylpyrimidin-derivate
JPH03169802A (ja) * 1989-11-28 1991-07-23 Sumitomo Chem Co Ltd ピリミジン誘導体を有効成分とする植物生長調節剤
US5022915A (en) * 1990-03-01 1991-06-11 Ici Americas Inc. Substituted 2,4-diarylpyrimidines and their use as herbicides
EP0491218A1 (en) 1990-12-17 1992-06-24 F. Hoffmann-La Roche Ag Benzodiazepinones
DE4117560A1 (de) * 1991-05-29 1992-12-03 Bayer Ag Verwendung von pyridinylpyrimidin-derivaten zum schutz technischer materialien
US5571897A (en) * 1991-12-05 1996-11-05 Wallac Oy Luminescent lanthanide chelates
GB9203790D0 (en) 1992-02-21 1992-04-08 Merck Sharp & Dohme Therapeutic agents
US5426185A (en) 1993-11-22 1995-06-20 Merck & Co., Inc. Antiarrhythmic benzodiazepines
US5521189A (en) * 1994-05-06 1996-05-28 The University Of Nc At Ch Methods of treating pneumocystis carinii pneumonia
IL117659A (en) * 1995-04-13 2000-12-06 Dainippon Pharmaceutical Co Substituted 2-phenyl pyrimidino amino acetamide derivative process for preparing the same and a pharmaceutical composition containing same
JPH09169741A (ja) * 1995-10-17 1997-06-30 Hokko Chem Ind Co Ltd ピリミジルピリミジン誘導体及び農園芸用殺菌剤
DE19712351A1 (de) * 1996-04-09 1997-10-30 Hoechst Ag [1,2,5]-Thiadiazolderivate und deren Verwendung als Komponenten von Flüssigkristallmischungen
AU5624799A (en) 1998-09-01 2000-03-21 Innogenetics N.V. Benzodiazepines and benzothiazepines derivatives and hbsag peptides binding to annexins, their compositions and use
EP2062583B1 (en) 1999-04-30 2012-12-26 The Regents of the University of Michigan Therapeutic applications of pro-apoptotic benzodiazepines
WO2001000611A1 (en) 1999-06-28 2001-01-04 Janssen Pharmaceutica N.V. Respiratory syncytial virus replication inhibitors
US6660753B2 (en) * 1999-08-19 2003-12-09 Nps Pharmaceuticals, Inc. Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
BR0107532A (pt) 2000-04-03 2004-11-03 Bristol Myers Squibb Pharma Co Composto, uso do composto, método para o tratamento de disfunções neurológicas associadas com a produção de b-amilóide, método de inibição da atividade de y-secretase e composição farmacêutica
GB0012671D0 (en) 2000-05-24 2000-07-19 Merck Sharp & Dohme Therapeutic agents
CA2379445C (en) 2000-06-01 2007-08-21 Bristol-Myers Squibb Pharma Company Lactams substituted by cyclic succinates as inhibitors of a.beta. protein production
DE60204509T2 (de) * 2001-04-20 2006-03-16 Ciba Speciality Chemicals Holding Inc. 4-Amino-2-(2-pyridinyl)pyrimidine als mikrobizide Wirksubstanzen
GB2376886A (en) * 2001-06-27 2002-12-31 Johnson & Johnson Medical Ltd Treatment and prevention of lipodermatosclerosis
WO2003027101A1 (en) * 2001-09-26 2003-04-03 Bayer Pharmaceuticals Corporation Substituted 3-pyridyl pyrroles and 3-pyridyl pyrazoles as c17,20 lyase inhibitors
DE60334781D1 (de) * 2002-03-12 2010-12-16 Merck Sharp & Dohme Di-aryl-substituierte tetrazol-modulatoren des metabotropen glutamat-rezeptors-5
WO2004039914A1 (ja) * 2002-11-01 2004-05-13 Takasago International Corporation 発光素子
EP1577300A1 (en) * 2002-11-01 2005-09-21 Takasago International Corporation Platinum complexes
US20040096693A1 (en) * 2002-11-18 2004-05-20 Chung Shan Institute Of Science & Technology Compound of ruthenium complex and electroluminescence device using the same
GB0323137D0 (en) * 2003-10-03 2003-11-05 Chang Lisa C W 2,4,6- Trisubstituted pyrimidines and their different uses
GB0325956D0 (en) * 2003-11-06 2003-12-10 Addex Pharmaceuticals Sa Novel compounds
US20070269420A1 (en) * 2003-11-24 2007-11-22 Chunduru Srinivas K Compounds, Compositions and Methods for Treatment and Prophylaxis of Hepatitis C Viral Infections and Associated Diseases
JP4409261B2 (ja) * 2003-11-26 2010-02-03 株式会社豊田中央研究所 金属錯体色素、光電極及び色素増感型太陽電池
TW200538180A (en) * 2004-02-20 2005-12-01 Astrazeneca Ab New compounds

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2005101411A (ru) * 2002-06-20 2005-07-10 Астразенека Аб (Se) Антагонисты метаботропного глутаматного рецептора 5 (mglur5) и способ для профилактики и лечения гастро-эзофагеальной рефлюксной болезни (варианты)

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
FRITZ KROHNKE. The Specific synthesis of pyridines and Oligopyridines. SYNTHESIS, 1976, №1, s.1-24. ERNEST WENKERT et al. Replacement or Metnyitnio Functions on Aromatic Hetericycles by hydrogen. Alkyl and Aryl Groups via Nickel "Induced Grignard Reactions, J.Org.Chem. 1985, 50, 1125-1126. T.ROSS KELLY et al. A Now Pyridine Synthesis, J.Am.Chem.Soc., 1985, 107-4998-4999. KAZUMASA FUNABIKI et al. Efficient and convenient entry to beta-hydroxy-beta-trifluoromethyl-beta-substituted-ketones and 2,6-disubstituted 4-trifluoromethylpyridines based on reaction of trifluoromethyl ketones with enamines or imines, J.Chem.Soc., Perkin Trans. 1, 2001,2578-2582. MARK C.BAGLEY et al. Hignly Efficient Synthesis of Pyrimidines under Microwave-assisted Conditions, Synlett, 2003, No.2, 259-261, Print 31.01.2003. ALAN C.SPIVEY et al. Traceless solid phase synthesis of 2-substituted pyrimidines using an "of-the-shelf" chlorogermanefunctionalised resin, Organic & Biomolecular Chemistry, 2003, 1, 1638-1640. *

Cited By (1)

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RU2703460C1 (ru) * 2013-12-10 2019-10-17 ЭфЭмСи Корпорейшн Гербицидные замещенные пиримидинилоксибензольные соединения

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