RU2441007C2 - Лиганды никотиновых ацетилхолиновых рецепторов - Google Patents

Лиганды никотиновых ацетилхолиновых рецепторов Download PDF

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Publication number
RU2441007C2
RU2441007C2 RU2008143450/04A RU2008143450A RU2441007C2 RU 2441007 C2 RU2441007 C2 RU 2441007C2 RU 2008143450/04 A RU2008143450/04 A RU 2008143450/04A RU 2008143450 A RU2008143450 A RU 2008143450A RU 2441007 C2 RU2441007 C2 RU 2441007C2
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Russia
Prior art keywords
compounds
mmol
compound
furo
azabicyclo
Prior art date
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RU2008143450/04A
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English (en)
Russian (ru)
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RU2008143450A (ru
Inventor
Гуи-Фанг ЧАНГ (US)
Гуи-Фанг ЧАНГ
Кристофер ХОЛЬМКВИСТ (US)
Кристофер ХОЛЬМКВИСТ
Эйфион ФИЛЛИПС (US)
Эйфион Филлипс
Тимоти ПАЙЗЕР (US)
Тимоти ПАЙЗЕР
Томас СИМПСОН (US)
Томас СИМПСОН
Ребекка УРБАНЕК (US)
Ребекка Урбанек
Джеймс ВУДС (US)
Джеймс ВУДС
Гуи КСИОНГ (US)
Гуи КСИОНГ
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Астразенека Аб
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Application filed by Астразенека Аб filed Critical Астразенека Аб
Publication of RU2008143450A publication Critical patent/RU2008143450A/ru
Application granted granted Critical
Publication of RU2441007C2 publication Critical patent/RU2441007C2/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)
RU2008143450/04A 2006-05-17 2007-05-16 Лиганды никотиновых ацетилхолиновых рецепторов RU2441007C2 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US74747606P 2006-05-17 2006-05-17
US60/747,476 2006-05-17
US82497506P 2006-09-08 2006-09-08
US60/824,975 2006-09-08

Publications (2)

Publication Number Publication Date
RU2008143450A RU2008143450A (ru) 2010-06-27
RU2441007C2 true RU2441007C2 (ru) 2012-01-27

Family

ID=38694158

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2008143450/04A RU2441007C2 (ru) 2006-05-17 2007-05-16 Лиганды никотиновых ацетилхолиновых рецепторов

Country Status (19)

Country Link
US (2) US7842803B2 (enExample)
EP (1) EP2019831B1 (enExample)
JP (1) JP2009537517A (enExample)
KR (1) KR20090007753A (enExample)
AR (1) AR060914A1 (enExample)
AU (1) AU2007250560B2 (enExample)
BR (1) BRPI0711941A2 (enExample)
CA (1) CA2652610A1 (enExample)
CL (1) CL2007001405A1 (enExample)
EC (1) ECSP088971A (enExample)
ES (1) ES2392997T3 (enExample)
IL (1) IL195019A0 (enExample)
MX (1) MX2008014436A (enExample)
NO (1) NO20084915L (enExample)
RU (1) RU2441007C2 (enExample)
SA (1) SA07280244B1 (enExample)
TW (1) TW200813067A (enExample)
UY (1) UY30349A1 (enExample)
WO (1) WO2007133155A1 (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0220581D0 (en) 2002-09-04 2002-10-09 Novartis Ag Organic Compound
PE20060437A1 (es) 2004-06-18 2006-06-08 Novartis Ag COMPUESTOS AZA-BICICLONONANOS COMO LIGANDOS COLINERGICOS DE nAChR
GB0415746D0 (en) 2004-07-14 2004-08-18 Novartis Ag Organic compounds
GB0521508D0 (en) 2005-10-21 2005-11-30 Novartis Ag Organic compounds
GB0525673D0 (en) 2005-12-16 2006-01-25 Novartis Ag Organic compounds
GB0525672D0 (en) 2005-12-16 2006-01-25 Novartis Ag Organic compounds
WO2009066107A1 (en) * 2007-11-21 2009-05-28 Astrazeneca Ab Use of a nicotinic receptor agonist
TWI558398B (zh) 2009-09-22 2016-11-21 諾華公司 菸鹼乙醯膽鹼受體α７活化劑之用途
BR112013018726A2 (pt) 2011-01-27 2016-10-25 Novartis Ag uso de ativadores de alfa 7 do receptor nicotínico de acetilcolina
MX2013010698A (es) 2011-03-18 2014-02-17 Novartis Ag Combinaciones de activadores del receptor de acetil-colina nicotinico alfa-7 y antagonistas del receptor de glutamato metabotropico 5 (mglur5) para usarse en la discinesia inducida por dopamina en la enfermedad de parkinson.
AU2012324458B2 (en) 2011-10-20 2016-05-19 Novartis Ag Biomarkers predictive of responsiveness to alpha 7 nicotinic acetylcholine receptor activator treatment
JP6114951B2 (ja) 2012-12-11 2017-04-19 ノバルティス アーゲー アルファ７ニコチン性アセチルコリン受容体アクチベーターによる処置に対する応答性を予測するバイオマーカー
JP2016508159A (ja) 2013-01-15 2016-03-17 ノバルティス アーゲー アルファ７ニコチン性アセチルコリン受容体アゴニストの使用
KR101879920B1 (ko) 2013-01-15 2018-07-18 노파르티스 아게 알파 7 니코틴성 아세틸콜린 수용체 작용물질의 용도
CN105263492B (zh) 2013-01-15 2018-04-10 诺华有限公司 α7烟碱型乙酰胆碱受体激动剂在治疗发作性睡病中的应用
US11209254B2 (en) * 2016-03-09 2021-12-28 Msato, Llc Pellet shaped marking round for air rifles and pistols
HU231333B1 (hu) * 2018-07-13 2023-01-28 Richter Gedeon Nyrt Spirokromán származékok

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002096912A1 (en) * 2001-06-01 2002-12-05 Astrazeneca Ab Novel ligand for nicotinic acetylcholine receptors useful in therapy
WO2003087103A1 (en) * 2002-04-18 2003-10-23 Astrazeneca Ab Thienyl compounds
WO2003087102A1 (en) * 2002-04-18 2003-10-23 Astrazeneca Ab Furyl compounds
WO2003087104A1 (en) * 2002-04-18 2003-10-23 Astrazeneca Ab Heterocyclic compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR013184A1 (es) * 1997-07-18 2000-12-13 Astrazeneca Ab Aminas heterociclicas espiroazobiciclicas, composicion farmaceutica, uso de dichas aminas para preparar medicamentos y metodo de tratamiento o profilaxis
EP1668016A1 (en) * 2003-09-25 2006-06-14 AstraZeneca AB Ligands

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002096912A1 (en) * 2001-06-01 2002-12-05 Astrazeneca Ab Novel ligand for nicotinic acetylcholine receptors useful in therapy
WO2003087103A1 (en) * 2002-04-18 2003-10-23 Astrazeneca Ab Thienyl compounds
WO2003087102A1 (en) * 2002-04-18 2003-10-23 Astrazeneca Ab Furyl compounds
WO2003087104A1 (en) * 2002-04-18 2003-10-23 Astrazeneca Ab Heterocyclic compounds

Also Published As

Publication number Publication date
ES2392997T3 (es) 2012-12-17
UY30349A1 (es) 2008-01-02
CA2652610A1 (en) 2007-11-22
SA07280244B1 (ar) 2011-06-22
WO2007133155A1 (en) 2007-11-22
EP2019831B1 (en) 2012-09-12
AU2007250560B2 (en) 2011-06-23
US20110136804A1 (en) 2011-06-09
NO20084915L (no) 2009-02-13
AU2007250560A1 (en) 2007-11-22
MX2008014436A (es) 2008-11-27
US7842803B2 (en) 2010-11-30
TW200813067A (en) 2008-03-16
EP2019831A1 (en) 2009-02-04
EP2019831A4 (en) 2010-06-09
BRPI0711941A2 (pt) 2011-12-13
JP2009537517A (ja) 2009-10-29
AR060914A1 (es) 2008-07-23
US20080139600A1 (en) 2008-06-12
CL2007001405A1 (es) 2008-01-25
KR20090007753A (ko) 2009-01-20
RU2008143450A (ru) 2010-06-27
ECSP088971A (es) 2009-01-30
IL195019A0 (en) 2009-08-03

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MM4A The patent is invalid due to non-payment of fees

Effective date: 20140517