RU2427582C2 - Пролекарства ингибитора каспазы - Google Patents
Пролекарства ингибитора каспазы Download PDFInfo
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- RU2427582C2 RU2427582C2 RU2008107576/04A RU2008107576A RU2427582C2 RU 2427582 C2 RU2427582 C2 RU 2427582C2 RU 2008107576/04 A RU2008107576/04 A RU 2008107576/04A RU 2008107576 A RU2008107576 A RU 2008107576A RU 2427582 C2 RU2427582 C2 RU 2427582C2
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| WO2005115362A1 (en) * | 2004-05-15 | 2005-12-08 | Vertex Pharmaceuticals Incorporated | Treating seizures using ice inhibitors |
| ATE543803T1 (de) * | 2004-11-24 | 2012-02-15 | Vertex Pharma | 3-ä2-(3-azylamino-2-oxo-2h-pyridin-1- yl)acetylaminoü-4-oxopentansäurederivate und deren verwendung als caspase-inhibitoren |
| MX2008005814A (es) | 2005-11-03 | 2008-10-15 | Vertex Pharma | Aminopirimidinas utiles como inhibidores de cinasa. |
| KR20090099886A (ko) * | 2008-03-18 | 2009-09-23 | 주식회사 엘지생명과학 | 캐스파제 저해제의 프로드럭 |
| WO2010017408A1 (en) | 2008-08-06 | 2010-02-11 | The Buck Institute For Age Research | Caspase inhibitors and uses thereof |
| RU2542103C2 (ru) * | 2009-05-22 | 2015-02-20 | Эббви Инк. | Модуляторы рецепторов 5-нт и способы их применения |
| BR112012002214B1 (pt) * | 2009-07-31 | 2022-01-25 | Global Alliance For Tb Drug Development | Análogos de nitroimidazooxazina e nitroimidazooxazol, seus usos e composição farmacêutica |
| CA2769359C (en) * | 2009-07-31 | 2017-03-07 | Global Alliance For Tb Drug Development | Nitroimidazooxazines and their uses in anti-tubercular therapy |
| WO2011146089A1 (en) * | 2010-05-21 | 2011-11-24 | Abbott Laboratories | Modulators of 5-ht receptors and methods of use thereof |
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| US9956260B1 (en) | 2011-07-22 | 2018-05-01 | The J. David Gladstone Institutes | Treatment of HIV-1 infection and AIDS |
| CN107793434B (zh) * | 2016-09-07 | 2022-05-24 | 帝斯曼知识产权资产管理有限公司 | 用于制备经取代的咪唑并噻唑酮的方法 |
| JP2022529973A (ja) * | 2019-04-19 | 2022-06-27 | エルジー・ケム・リミテッド | カスパーゼ阻害剤のプロドラッグ |
| KR102442103B1 (ko) | 2019-04-30 | 2022-09-08 | 주식회사 엘지화학 | 캐스파제 저해제의 프로드럭 |
| KR102366226B1 (ko) | 2019-05-31 | 2022-02-22 | 주식회사 엘지화학 | 캐스파제 저해제 프로드럭을 함유하는 주사용 조성물 및 이의 제조 방법 |
| JP7362184B2 (ja) | 2019-05-31 | 2023-10-17 | エルジー・ケム・リミテッド | カスパーゼ阻害剤プロドラッグの注射用組成物 |
| KR102670554B1 (ko) | 2022-01-04 | 2024-05-30 | 주식회사 이노보테라퓨틱스 | 캐스파제 저해제로서의 신규한 이소인돌리논 유도체 화합물 |
| WO2025221068A1 (ko) * | 2024-04-19 | 2025-10-23 | (주)노보메디슨 | 심장질환의 예방 또는 치료를 위한 캐스파제 저해제 |
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| EP1278737B1 (en) | 2000-04-24 | 2010-06-30 | Vertex Pharmaceuticals Incorporated | Process and intermediates for making substituted aspartic acid acetals |
| PE20011350A1 (es) * | 2000-05-19 | 2002-01-15 | Vertex Pharma | PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE) |
| KR20020025959A (ko) | 2000-05-23 | 2002-04-04 | 버텍스 파마슈티칼스 인코포레이티드 | 카스파제 억제제 및 이의 용도 |
| WO2001094351A1 (en) | 2000-06-07 | 2001-12-13 | Vertex Pharmaceuticals Incorporated | Caspase inhibitors and uses thereof |
| CA2418720A1 (en) | 2000-09-13 | 2002-03-21 | Vertex Pharmaceuticals Incorporated | Caspase inhibitors and uses thereof |
| DE60127860T2 (de) | 2000-11-21 | 2008-01-17 | Vertex Pharmaceuticals Inc., Cambridge | Imidazol- und benzimidazol- caspase inhibitoren und deren verwendung |
| US20030096737A1 (en) | 2001-04-19 | 2003-05-22 | Anita Diu-Hercend | Caspase inhibitors and uses thereof |
| WO2002094263A2 (en) | 2001-05-23 | 2002-11-28 | Vertex Pharmaceuticals Incorporated | Caspase inhibitors and uses thereof |
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2006
- 2006-07-20 CN CNA2006800345091A patent/CN101268084A/zh active Pending
- 2006-07-20 EP EP06787963A patent/EP1910379B1/en not_active Not-in-force
- 2006-07-20 CA CA002616337A patent/CA2616337A1/en not_active Abandoned
- 2006-07-20 AU AU2006276096A patent/AU2006276096A1/en not_active Abandoned
- 2006-07-20 KR KR1020087004718A patent/KR20080038369A/ko not_active Ceased
- 2006-07-20 RU RU2008107576/04A patent/RU2427582C2/ru not_active IP Right Cessation
- 2006-07-20 JP JP2008523976A patent/JP2009502922A/ja active Pending
- 2006-07-20 ZA ZA200801172A patent/ZA200801172B/xx unknown
- 2006-07-20 AT AT06787963T patent/ATE529430T1/de not_active IP Right Cessation
- 2006-07-20 WO PCT/US2006/028174 patent/WO2007015931A2/en not_active Ceased
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- 2006-07-20 US US11/489,939 patent/US7879891B2/en not_active Expired - Fee Related
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- 2008-01-24 IL IL188997A patent/IL188997A0/en not_active IP Right Cessation
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| Publication number | Priority date | Publication date | Assignee | Title |
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| SU1441748A1 (ru) * | 1987-03-04 | 1995-09-10 | Пермский государственный университет | 3-(4-бромфенил)-3а,4,6,6а-тетрагидрофуро[3,4-d]изоксазол-4-он, проявляющий противовоспалительную активность |
| SU1586154A1 (ru) * | 1988-09-15 | 2006-12-20 | Краснодарский политехнический институт | 3-(2,4-Дихлорфенил)-4-оксо-3a,4,6,6a-тетрагидрофуро-[3,4-d]изоксазол, проявляющий антигельминтную и анальгетическую активность |
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Also Published As
| Publication number | Publication date |
|---|---|
| NZ566022A (en) | 2011-04-29 |
| RU2008107576A (ru) | 2009-09-10 |
| NO20081050L (no) | 2008-04-28 |
| CA2616337A1 (en) | 2007-02-08 |
| US7879891B2 (en) | 2011-02-01 |
| CN101268084A (zh) | 2008-09-17 |
| EP1910379A2 (en) | 2008-04-16 |
| WO2007015931A2 (en) | 2007-02-08 |
| KR20080038369A (ko) | 2008-05-06 |
| IL188997A0 (en) | 2008-08-07 |
| WO2007015931A3 (en) | 2007-06-07 |
| ZA200801172B (en) | 2009-04-29 |
| AU2006276096A1 (en) | 2007-02-08 |
| US20110137037A1 (en) | 2011-06-09 |
| US20070155718A1 (en) | 2007-07-05 |
| JP2009502922A (ja) | 2009-01-29 |
| EP1910379B1 (en) | 2011-10-19 |
| US8168798B2 (en) | 2012-05-01 |
| ATE529430T1 (de) | 2011-11-15 |
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