AU2006276096A1 - Caspase inhibitor prodrugs - Google Patents
Caspase inhibitor prodrugs Download PDFInfo
- Publication number
- AU2006276096A1 AU2006276096A1 AU2006276096A AU2006276096A AU2006276096A1 AU 2006276096 A1 AU2006276096 A1 AU 2006276096A1 AU 2006276096 A AU2006276096 A AU 2006276096A AU 2006276096 A AU2006276096 A AU 2006276096A AU 2006276096 A1 AU2006276096 A1 AU 2006276096A1
- Authority
- AU
- Australia
- Prior art keywords
- alkyl
- disease
- membered
- ring
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 229940002612 prodrug Drugs 0.000 title abstract description 18
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- 108010076667 Caspases Proteins 0.000 claims abstract description 23
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- 230000008569 process Effects 0.000 claims abstract description 8
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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| MXPA06013256A (es) * | 2004-05-15 | 2007-02-08 | Vertex Pharma | Tratamiento de crisis convulsivas utilizando inhibidores ice. |
| ATE543803T1 (de) * | 2004-11-24 | 2012-02-15 | Vertex Pharma | 3-ä2-(3-azylamino-2-oxo-2h-pyridin-1- yl)acetylaminoü-4-oxopentansäurederivate und deren verwendung als caspase-inhibitoren |
| EP1954277B1 (en) | 2005-11-03 | 2017-01-18 | Vertex Pharmaceuticals Incorporated | Aminopyrimidines useful as kinase inhibitors |
| KR20090099886A (ko) * | 2008-03-18 | 2009-09-23 | 주식회사 엘지생명과학 | 캐스파제 저해제의 프로드럭 |
| WO2010017408A1 (en) | 2008-08-06 | 2010-02-11 | The Buck Institute For Age Research | Caspase inhibitors and uses thereof |
| SG176100A1 (en) * | 2009-05-22 | 2011-12-29 | Abbott Lab | Modulators of 5-ht receptors and methods of use thereof |
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| CN101979403A (zh) * | 2010-09-13 | 2011-02-23 | 沈陵陵 | 新型半胱氨酸天冬氨酸广谱蛋白酶抑制剂及其制备方法和用途 |
| US9956260B1 (en) | 2011-07-22 | 2018-05-01 | The J. David Gladstone Institutes | Treatment of HIV-1 infection and AIDS |
| US20180065990A1 (en) * | 2016-09-07 | 2018-03-08 | Dsm Ip Assets B.V. | Process for the preparation of a substituted imidazothiazolone compound |
| JP2022529973A (ja) * | 2019-04-19 | 2022-06-27 | エルジー・ケム・リミテッド | カスパーゼ阻害剤のプロドラッグ |
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| EP3970698A4 (en) | 2019-05-31 | 2022-08-31 | LG Chem, Ltd. | INJECTABLE COMPOSITION WITH PRODRUG OF CASPASE INHIBITORS AND METHOD OF MANUFACTURE THEREOF |
| EP3970699A4 (en) | 2019-05-31 | 2022-08-10 | LG Chem, Ltd. | COMPOSITION FOR CASPASE INHIBITOR PRODRUG INJECTION |
| KR102670554B1 (ko) | 2022-01-04 | 2024-05-30 | 주식회사 이노보테라퓨틱스 | 캐스파제 저해제로서의 신규한 이소인돌리논 유도체 화합물 |
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| SU1441748A1 (ru) * | 1987-03-04 | 1995-09-10 | Пермский государственный университет | 3-(4-бромфенил)-3а,4,6,6а-тетрагидрофуро[3,4-d]изоксазол-4-он, проявляющий противовоспалительную активность |
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| JP2002509153A (ja) | 1998-01-20 | 2002-03-26 | ワーナー−ランバート・カンパニー | インターロイキン−１β変換酵素（ＩＣＥ）のインビボ阻害剤としてのＮ−［２−（５−ベンジルオキシカルボニル−アミノ−６−オキソ−２−（４−フルオロフェニル）−１，６−ジヒドロ−１−ピリミジニル）アセトキシル］−Ｌ−アスパラギン酸アルデヒド |
| DE69925581T2 (de) * | 1998-03-09 | 2006-04-27 | Vertex Pharmaceuticals Inc., Cambridge | 1,2-diazepanderivate als inhibitoren des interleukin-1beta umwandelnden enzyms |
| DK1064298T3 (da) * | 1998-03-19 | 2009-01-19 | Vertex Pharma | Inhibitorer af caspaser |
| US6197750B1 (en) * | 1998-07-02 | 2001-03-06 | Idun Pharmaceuticals, Inc. | C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases |
| US6242422B1 (en) * | 1998-10-22 | 2001-06-05 | Idun Pharmacueticals, Inc. | (Substituted)Acyl dipeptidyl inhibitors of the ice/ced-3 family of cysteine proteases |
| ES2274795T3 (es) | 1999-07-19 | 2007-06-01 | Merck Frosst Canada Ltd. | Pirazinonas, composiciones que contienen tales compuestos. |
| EP1163208B1 (en) * | 1999-08-06 | 2004-05-12 | Vertex Pharmaceuticals Incorporated | Caspase inhibitors and uses thereof |
| AR026748A1 (es) * | 1999-12-08 | 2003-02-26 | Vertex Pharma | Un compuesto inhibidor de caspasas, una composicion farmaceutica que lo comprende, un metodo para la sintesis del mismo y un compuesto intermediario paradicha sintesis |
| PE20011267A1 (es) * | 2000-03-29 | 2001-12-15 | Vertex Pharma | Carbamato como inhibidores de caspasa |
| CA2402128A1 (en) * | 2000-04-24 | 2001-11-01 | Vertex Pharmaceuticals Incorporated | Process and intermediates for making substituted aspartic acid acetals |
| PE20011350A1 (es) * | 2000-05-19 | 2002-01-15 | Vertex Pharma | PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE) |
| TR200200767T1 (tr) * | 2000-05-23 | 2002-09-23 | Vertex Pharmaceuticals Incorporated | Kaspaz engelleyiciler ve kullanımları |
| EP1289993B9 (en) * | 2000-06-07 | 2008-08-20 | Vertex Pharmaceuticals Incorporated | Caspase inhibitors and uses thereof |
| WO2002022611A2 (en) * | 2000-09-13 | 2002-03-21 | Vertex Pharmaceuticals Incorporated | Caspase inhibitors and uses thereof |
| AU2002232541A1 (en) * | 2000-11-21 | 2002-06-03 | Vertex Pharmaceuticals Incorporated | Imidazole and benzimidazole caspase inhibitors and uses thereof |
| US20030096737A1 (en) | 2001-04-19 | 2003-05-22 | Anita Diu-Hercend | Caspase inhibitors and uses thereof |
| JP4428926B2 (ja) * | 2001-05-23 | 2010-03-10 | バーテックス ファーマシューティカルズ インコーポレイテッド | カスパーゼインヒビターおよびそれらの使用 |
| PE20040728A1 (es) * | 2002-06-28 | 2004-10-23 | Vertex Pharma | Inhibidores de caspasa |
| PE20050159A1 (es) * | 2003-05-27 | 2005-04-19 | Vertex Pharma | Derivados de acido 3-[2-(3-amino-2-oxo-2h-piridin-1-il)-acetilamino]-4-oxo-pentanoico como inhibidores de caspasa |
-
2006
- 2006-07-20 KR KR1020087004718A patent/KR20080038369A/ko not_active Ceased
- 2006-07-20 CN CNA2006800345091A patent/CN101268084A/zh active Pending
- 2006-07-20 ZA ZA200801172A patent/ZA200801172B/xx unknown
- 2006-07-20 NZ NZ566022A patent/NZ566022A/en not_active IP Right Cessation
- 2006-07-20 WO PCT/US2006/028174 patent/WO2007015931A2/en not_active Ceased
- 2006-07-20 US US11/489,939 patent/US7879891B2/en not_active Expired - Fee Related
- 2006-07-20 RU RU2008107576/04A patent/RU2427582C2/ru not_active IP Right Cessation
- 2006-07-20 EP EP06787963A patent/EP1910379B1/en not_active Not-in-force
- 2006-07-20 AU AU2006276096A patent/AU2006276096A1/en not_active Abandoned
- 2006-07-20 AT AT06787963T patent/ATE529430T1/de not_active IP Right Cessation
- 2006-07-20 JP JP2008523976A patent/JP2009502922A/ja active Pending
- 2006-07-20 CA CA002616337A patent/CA2616337A1/en not_active Abandoned
-
2008
- 2008-01-24 IL IL188997A patent/IL188997A0/en not_active IP Right Cessation
- 2008-02-28 NO NO20081050A patent/NO20081050L/no not_active Application Discontinuation
-
2010
- 2010-12-17 US US12/971,649 patent/US8168798B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| KR20080038369A (ko) | 2008-05-06 |
| WO2007015931A3 (en) | 2007-06-07 |
| EP1910379A2 (en) | 2008-04-16 |
| US8168798B2 (en) | 2012-05-01 |
| CA2616337A1 (en) | 2007-02-08 |
| EP1910379B1 (en) | 2011-10-19 |
| US20110137037A1 (en) | 2011-06-09 |
| ATE529430T1 (de) | 2011-11-15 |
| US7879891B2 (en) | 2011-02-01 |
| US20070155718A1 (en) | 2007-07-05 |
| IL188997A0 (en) | 2008-08-07 |
| NZ566022A (en) | 2011-04-29 |
| CN101268084A (zh) | 2008-09-17 |
| NO20081050L (no) | 2008-04-28 |
| RU2427582C2 (ru) | 2011-08-27 |
| RU2008107576A (ru) | 2009-09-10 |
| ZA200801172B (en) | 2009-04-29 |
| WO2007015931A2 (en) | 2007-02-08 |
| JP2009502922A (ja) | 2009-01-29 |
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| MK5 | Application lapsed section 142(2)(e) - patent request and compl. specification not accepted |