KR20080038369A - 카스파제 억제제 프로드럭 - Google Patents

카스파제 억제제 프로드럭 Download PDF

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Publication number
KR20080038369A
KR20080038369A KR1020087004718A KR20087004718A KR20080038369A KR 20080038369 A KR20080038369 A KR 20080038369A KR 1020087004718 A KR1020087004718 A KR 1020087004718A KR 20087004718 A KR20087004718 A KR 20087004718A KR 20080038369 A KR20080038369 A KR 20080038369A
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South Korea
Prior art keywords
alkyl
membered
disease
formula
compound
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KR1020087004718A
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English (en)
Korean (ko)
Inventor
스티븐 듀런트
쟝-다미엥 샤리에르
존 스터들리
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버텍스 파마슈티칼스 인코포레이티드
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Publication of KR20080038369A publication Critical patent/KR20080038369A/ko
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Psychology (AREA)
  • Emergency Medicine (AREA)
  • Biotechnology (AREA)
  • Hospice & Palliative Care (AREA)
KR1020087004718A 2005-07-28 2006-07-20 카스파제 억제제 프로드럭 Ceased KR20080038369A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70337505P 2005-07-28 2005-07-28
US60/703,375 2005-07-28

Publications (1)

Publication Number Publication Date
KR20080038369A true KR20080038369A (ko) 2008-05-06

Family

ID=37709070

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020087004718A Ceased KR20080038369A (ko) 2005-07-28 2006-07-20 카스파제 억제제 프로드럭

Country Status (14)

Country Link
US (2) US7879891B2 (https=)
EP (1) EP1910379B1 (https=)
JP (1) JP2009502922A (https=)
KR (1) KR20080038369A (https=)
CN (1) CN101268084A (https=)
AT (1) ATE529430T1 (https=)
AU (1) AU2006276096A1 (https=)
CA (1) CA2616337A1 (https=)
IL (1) IL188997A0 (https=)
NO (1) NO20081050L (https=)
NZ (1) NZ566022A (https=)
RU (1) RU2427582C2 (https=)
WO (1) WO2007015931A2 (https=)
ZA (1) ZA200801172B (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025221068A1 (ko) * 2024-04-19 2025-10-23 (주)노보메디슨 심장질환의 예방 또는 치료를 위한 캐스파제 저해제

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PE20050159A1 (es) 2003-05-27 2005-04-19 Vertex Pharma Derivados de acido 3-[2-(3-amino-2-oxo-2h-piridin-1-il)-acetilamino]-4-oxo-pentanoico como inhibidores de caspasa
MXPA06013256A (es) * 2004-05-15 2007-02-08 Vertex Pharma Tratamiento de crisis convulsivas utilizando inhibidores ice.
ATE543803T1 (de) * 2004-11-24 2012-02-15 Vertex Pharma 3-ä2-(3-azylamino-2-oxo-2h-pyridin-1- yl)acetylaminoü-4-oxopentansäurederivate und deren verwendung als caspase-inhibitoren
EP1954277B1 (en) 2005-11-03 2017-01-18 Vertex Pharmaceuticals Incorporated Aminopyrimidines useful as kinase inhibitors
KR20090099886A (ko) * 2008-03-18 2009-09-23 주식회사 엘지생명과학 캐스파제 저해제의 프로드럭
WO2010017408A1 (en) 2008-08-06 2010-02-11 The Buck Institute For Age Research Caspase inhibitors and uses thereof
SG176100A1 (en) * 2009-05-22 2011-12-29 Abbott Lab Modulators of 5-ht receptors and methods of use thereof
ES2530266T3 (es) * 2009-07-31 2015-02-27 Global Alliance For Tb Drug Development Análogos de nitroimidazooxazina y sus usos
WO2011014774A1 (en) * 2009-07-31 2011-02-03 Global Alliance For Tb Drug Development Nitroimidazooxazines and their uses in anti-tubercular therapy
KR101770979B1 (ko) 2010-05-21 2017-08-24 애브비 인코포레이티드 5­ｈｔ 수용체의 조절제 및 이의 사용방법
CN101979403A (zh) * 2010-09-13 2011-02-23 沈陵陵 新型半胱氨酸天冬氨酸广谱蛋白酶抑制剂及其制备方法和用途
US9956260B1 (en) 2011-07-22 2018-05-01 The J. David Gladstone Institutes Treatment of HIV-1 infection and AIDS
US20180065990A1 (en) * 2016-09-07 2018-03-08 Dsm Ip Assets B.V. Process for the preparation of a substituted imidazothiazolone compound
JP2022529973A (ja) * 2019-04-19 2022-06-27 エルジー・ケム・リミテッド カスパーゼ阻害剤のプロドラッグ
WO2020222541A1 (ko) 2019-04-30 2020-11-05 주식회사 엘지화학 캐스파제 저해제의 프로드럭
EP3970698A4 (en) 2019-05-31 2022-08-31 LG Chem, Ltd. INJECTABLE COMPOSITION WITH PRODRUG OF CASPASE INHIBITORS AND METHOD OF MANUFACTURE THEREOF
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