JP2009502922A - カスパーゼ阻害剤プロドラッグ - Google Patents

カスパーゼ阻害剤プロドラッグ Download PDF

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Publication number
JP2009502922A
JP2009502922A JP2008523976A JP2008523976A JP2009502922A JP 2009502922 A JP2009502922 A JP 2009502922A JP 2008523976 A JP2008523976 A JP 2008523976A JP 2008523976 A JP2008523976 A JP 2008523976A JP 2009502922 A JP2009502922 A JP 2009502922A
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Japan
Prior art keywords
alkyl
membered
aryl
disease
ring
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JP2008523976A
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Japanese (ja)
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JP2009502922A5 (https=
Inventor
スティーブン デュラント，
ジャン−ダミアン シャリエ，
ジョン スタッドリー，
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Vertex Pharmaceuticals Inc
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Vertex Pharmaceuticals Inc
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Application filed by Vertex Pharmaceuticals Inc filed Critical Vertex Pharmaceuticals Inc
Publication of JP2009502922A publication Critical patent/JP2009502922A/ja
Publication of JP2009502922A5 publication Critical patent/JP2009502922A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
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    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Psychology (AREA)
  • Cardiology (AREA)
  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Hospice & Palliative Care (AREA)
JP2008523976A 2005-07-28 2006-07-20 カスパーゼ阻害剤プロドラッグ Pending JP2009502922A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70337505P 2005-07-28 2005-07-28
PCT/US2006/028174 WO2007015931A2 (en) 2005-07-28 2006-07-20 Caspase inhibitor prodrugs

Publications (2)

Publication Number Publication Date
JP2009502922A true JP2009502922A (ja) 2009-01-29
JP2009502922A5 JP2009502922A5 (https=) 2009-09-03

Family

ID=37709070

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008523976A Pending JP2009502922A (ja) 2005-07-28 2006-07-20 カスパーゼ阻害剤プロドラッグ

Country Status (14)

Country Link
US (2) US7879891B2 (https=)
EP (1) EP1910379B1 (https=)
JP (1) JP2009502922A (https=)
KR (1) KR20080038369A (https=)
CN (1) CN101268084A (https=)
AT (1) ATE529430T1 (https=)
AU (1) AU2006276096A1 (https=)
CA (1) CA2616337A1 (https=)
IL (1) IL188997A0 (https=)
NO (1) NO20081050L (https=)
NZ (1) NZ566022A (https=)
RU (1) RU2427582C2 (https=)
WO (1) WO2007015931A2 (https=)
ZA (1) ZA200801172B (https=)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20050159A1 (es) 2003-05-27 2005-04-19 Vertex Pharma Derivados de acido 3-[2-(3-amino-2-oxo-2h-piridin-1-il)-acetilamino]-4-oxo-pentanoico como inhibidores de caspasa
WO2005115362A1 (en) * 2004-05-15 2005-12-08 Vertex Pharmaceuticals Incorporated Treating seizures using ice inhibitors
ATE543803T1 (de) * 2004-11-24 2012-02-15 Vertex Pharma 3-ä2-(3-azylamino-2-oxo-2h-pyridin-1- yl)acetylaminoü-4-oxopentansäurederivate und deren verwendung als caspase-inhibitoren
MX2008005814A (es) 2005-11-03 2008-10-15 Vertex Pharma Aminopirimidinas utiles como inhibidores de cinasa.
KR20090099886A (ko) * 2008-03-18 2009-09-23 주식회사 엘지생명과학 캐스파제 저해제의 프로드럭
WO2010017408A1 (en) 2008-08-06 2010-02-11 The Buck Institute For Age Research Caspase inhibitors and uses thereof
RU2542103C2 (ru) * 2009-05-22 2015-02-20 Эббви Инк. Модуляторы рецепторов 5-нт и способы их применения
BR112012002214B1 (pt) * 2009-07-31 2022-01-25 Global Alliance For Tb Drug Development Análogos de nitroimidazooxazina e nitroimidazooxazol, seus usos e composição farmacêutica
CA2769359C (en) * 2009-07-31 2017-03-07 Global Alliance For Tb Drug Development Nitroimidazooxazines and their uses in anti-tubercular therapy
WO2011146089A1 (en) * 2010-05-21 2011-11-24 Abbott Laboratories Modulators of 5-ht receptors and methods of use thereof
CN101979403A (zh) * 2010-09-13 2011-02-23 沈陵陵 新型半胱氨酸天冬氨酸广谱蛋白酶抑制剂及其制备方法和用途
US9956260B1 (en) 2011-07-22 2018-05-01 The J. David Gladstone Institutes Treatment of HIV-1 infection and AIDS
CN107793434B (zh) * 2016-09-07 2022-05-24 帝斯曼知识产权资产管理有限公司 用于制备经取代的咪唑并噻唑酮的方法
JP2022529973A (ja) * 2019-04-19 2022-06-27 エルジー・ケム・リミテッド カスパーゼ阻害剤のプロドラッグ
KR102442103B1 (ko) 2019-04-30 2022-09-08 주식회사 엘지화학 캐스파제 저해제의 프로드럭
KR102366226B1 (ko) 2019-05-31 2022-02-22 주식회사 엘지화학 캐스파제 저해제 프로드럭을 함유하는 주사용 조성물 및 이의 제조 방법
JP7362184B2 (ja) 2019-05-31 2023-10-17 エルジー・ケム・リミテッド カスパーゼ阻害剤プロドラッグの注射用組成物
KR102670554B1 (ko) 2022-01-04 2024-05-30 주식회사 이노보테라퓨틱스 캐스파제 저해제로서의 신규한 이소인돌리논 유도체 화합물
WO2025221068A1 (ko) * 2024-04-19 2025-10-23 (주)노보메디슨 심장질환의 예방 또는 치료를 위한 캐스파제 저해제

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US7879891B2 (en) 2011-02-01
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WO2007015931A2 (en) 2007-02-08
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US20110137037A1 (en) 2011-06-09
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US8168798B2 (en) 2012-05-01
ATE529430T1 (de) 2011-11-15

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