JP2007506803A5 - - Google Patents
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- Publication number
- JP2007506803A5 JP2007506803A5 JP2006533446A JP2006533446A JP2007506803A5 JP 2007506803 A5 JP2007506803 A5 JP 2007506803A5 JP 2006533446 A JP2006533446 A JP 2006533446A JP 2006533446 A JP2006533446 A JP 2006533446A JP 2007506803 A5 JP2007506803 A5 JP 2007506803A5
- Authority
- JP
- Japan
- Prior art keywords
- aliphatic
- aryl
- heteroaryl
- heterocyclyl
- cycloaliphatic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 *CC(C(*)=O)NC(C(*)N(C=C(*)C=C1N*)C1=O)=O Chemical compound *CC(C(*)=O)NC(C(*)N(C=C(*)C=C1N*)C1=O)=O 0.000 description 6
- WKRJMFJKARFMHN-LEQYJYOASA-N CC[C@@H](C(NC(C1)(C1C(O)=O)C(COc(c(F)c(cc1F)F)c1F)=O)=O)N(C=CC=C1NC(C)=O)C1=O Chemical compound CC[C@@H](C(NC(C1)(C1C(O)=O)C(COc(c(F)c(cc1F)F)c1F)=O)=O)N(C=CC=C1NC(C)=O)C1=O WKRJMFJKARFMHN-LEQYJYOASA-N 0.000 description 1
- ZDSDYSRLSRPBRM-LOACHALJSA-N CC[C@@H](C(NC(CC(O)=O)C(CF)=O)=O)N(C=CC=C1NC(c2ccccn2)=O)C1=O Chemical compound CC[C@@H](C(NC(CC(O)=O)C(CF)=O)=O)N(C=CC=C1NC(c2ccccn2)=O)C1=O ZDSDYSRLSRPBRM-LOACHALJSA-N 0.000 description 1
- YNIFSTZXBSNENZ-ZFWWWQNUSA-N CC[C@@H](C(N[C@@H](CC(O)=O)C(COc(c(F)c(cc1F)F)c1F)=O)=O)N(C=C(C(F)(F)F)C=C1NS(CC)(=O)=O)C1=O Chemical compound CC[C@@H](C(N[C@@H](CC(O)=O)C(COc(c(F)c(cc1F)F)c1F)=O)=O)N(C=C(C(F)(F)F)C=C1NS(CC)(=O)=O)C1=O YNIFSTZXBSNENZ-ZFWWWQNUSA-N 0.000 description 1
- GUYNFOUSOJDSPF-VIFPVBQESA-N CC[C@@H](C(O)=O)N(C=CC=C1NC(C)=O)C1=O Chemical compound CC[C@@H](C(O)=O)N(C=CC=C1NC(C)=O)C1=O GUYNFOUSOJDSPF-VIFPVBQESA-N 0.000 description 1
- SHJOOHKOKCNLCY-LBPRGKRZSA-N CC[C@@H](C(OC(C)(C)C)=O)N(C=CC=C1NC(C)=O)C1=O Chemical compound CC[C@@H](C(OC(C)(C)C)=O)N(C=CC=C1NC(C)=O)C1=O SHJOOHKOKCNLCY-LBPRGKRZSA-N 0.000 description 1
- FMEFCRPEUGLMLN-KRWDZBQOSA-N CC[C@@H](C(OC(C)(C)C)=O)N(C=CC=C1NC(OCc2ccccc2)=O)C1=O Chemical compound CC[C@@H](C(OC(C)(C)C)=O)N(C=CC=C1NC(OCc2ccccc2)=O)C1=O FMEFCRPEUGLMLN-KRWDZBQOSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47362203P | 2003-05-27 | 2003-05-27 | |
| US60/473,622 | 2003-05-27 | ||
| PCT/US2004/016706 WO2004106304A2 (en) | 2003-05-27 | 2004-05-27 | 3 - [2- (3-amino-2-oxo-2h-pyridin-1-yl) - acetylamino] - 4- oxo-pentanoic acid derivatives and their use as caspase inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007139751A Division JP2007308501A (ja) | 2003-05-27 | 2007-05-25 | カスパーゼ阻害剤およびそれらの用途 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007506803A JP2007506803A (ja) | 2007-03-22 |
| JP2007506803A5 true JP2007506803A5 (https=) | 2007-07-19 |
| JP4791365B2 JP4791365B2 (ja) | 2011-10-12 |
Family
ID=33490622
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006533446A Expired - Fee Related JP4791365B2 (ja) | 2003-05-27 | 2004-05-27 | カスパーゼ阻害剤およびそれらの用途 |
| JP2007139751A Pending JP2007308501A (ja) | 2003-05-27 | 2007-05-25 | カスパーゼ阻害剤およびそれらの用途 |
| JP2011215595A Pending JP2012036206A (ja) | 2003-05-27 | 2011-09-29 | カスパーゼ阻害剤およびそれらの用途 |
| JP2011215594A Pending JP2012021019A (ja) | 2003-05-27 | 2011-09-29 | カスパーゼ阻害剤およびそれらの用途 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007139751A Pending JP2007308501A (ja) | 2003-05-27 | 2007-05-25 | カスパーゼ阻害剤およびそれらの用途 |
| JP2011215595A Pending JP2012036206A (ja) | 2003-05-27 | 2011-09-29 | カスパーゼ阻害剤およびそれらの用途 |
| JP2011215594A Pending JP2012021019A (ja) | 2003-05-27 | 2011-09-29 | カスパーゼ阻害剤およびそれらの用途 |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US20040242494A1 (https=) |
| EP (2) | EP2412707A3 (https=) |
| JP (4) | JP4791365B2 (https=) |
| KR (2) | KR20110114735A (https=) |
| CN (2) | CN1812972B (https=) |
| AR (1) | AR044770A1 (https=) |
| AU (1) | AU2004243308B9 (https=) |
| BR (1) | BRPI0410669A (https=) |
| CA (1) | CA2526749A1 (https=) |
| IL (1) | IL172159A (https=) |
| MX (1) | MXPA05012837A (https=) |
| NO (1) | NO20056192L (https=) |
| NZ (2) | NZ575857A (https=) |
| PE (1) | PE20050159A1 (https=) |
| RU (1) | RU2372335C2 (https=) |
| TW (2) | TW201038534A (https=) |
| UY (1) | UY28333A1 (https=) |
| WO (1) | WO2004106304A2 (https=) |
| ZA (1) | ZA200509700B (https=) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20011350A1 (es) | 2000-05-19 | 2002-01-15 | Vertex Pharma | PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE) |
| PE20040728A1 (es) * | 2002-06-28 | 2004-10-23 | Vertex Pharma | Inhibidores de caspasa |
| TW200500343A (en) * | 2002-12-20 | 2005-01-01 | Vertex Pharma | Caspase inhibitors and uses thereof |
| PE20050159A1 (es) * | 2003-05-27 | 2005-04-19 | Vertex Pharma | Derivados de acido 3-[2-(3-amino-2-oxo-2h-piridin-1-il)-acetilamino]-4-oxo-pentanoico como inhibidores de caspasa |
| GB0327494D0 (en) * | 2003-11-26 | 2003-12-31 | Amersham Plc | Novel imaging agents |
| SG150547A1 (en) * | 2004-03-12 | 2009-03-30 | Vertex Pharma | Processes and intermediates |
| MXPA06013256A (es) * | 2004-05-15 | 2007-02-08 | Vertex Pharma | Tratamiento de crisis convulsivas utilizando inhibidores ice. |
| ATE543803T1 (de) | 2004-11-24 | 2012-02-15 | Vertex Pharma | 3-ä2-(3-azylamino-2-oxo-2h-pyridin-1- yl)acetylaminoü-4-oxopentansäurederivate und deren verwendung als caspase-inhibitoren |
| JP2008545780A (ja) * | 2005-06-08 | 2008-12-18 | ノバルティス アクチエンゲゼルシャフト | 有機化合物 |
| KR20080038369A (ko) | 2005-07-28 | 2008-05-06 | 버텍스 파마슈티칼스 인코포레이티드 | 카스파제 억제제 프로드럭 |
| NZ574791A (en) * | 2006-08-02 | 2011-12-22 | Lg Life Sciences Ltd | Caspase inhibitors based on pyridazinone scaffold |
| KR20080042290A (ko) * | 2006-11-09 | 2008-05-15 | 주식회사 엘지생명과학 | 피리돈 구조를 포함하는 캐스파제 저해제 |
| WO2010120880A1 (en) * | 2009-04-14 | 2010-10-21 | Vertex Pharmaceuticals Incorporated | Treatment of liver diseases with a caspase inhibitor |
| US9956260B1 (en) | 2011-07-22 | 2018-05-01 | The J. David Gladstone Institutes | Treatment of HIV-1 infection and AIDS |
| CN104254526B (zh) * | 2012-03-31 | 2017-06-20 | 乔治亚大学研究基金公司 | 针对结核病的新的抗分枝杆菌药物 |
| EP2687511A1 (de) * | 2012-07-17 | 2014-01-22 | Zedira GmbH | Pyridinonderivate als Gewebetransglutaminaseinhibitoren |
| US9969283B2 (en) | 2013-09-10 | 2018-05-15 | General Electric Company | Battery changing system and method |
| US10143267B1 (en) | 2013-12-31 | 2018-12-04 | Dynasty Footwear, Ltd. | Shoe bottom surface having attached particles |
| ES2751652T3 (es) | 2014-05-12 | 2020-04-01 | Conatus Pharmaceuticals Inc | Tratamiento con inhibidor de caspasa emricasan de las complicaciones por las enfermedades hepáticas crónicas |
| WO2017079566A1 (en) | 2015-11-05 | 2017-05-11 | Conatus Pharmaceuticals, Inc. | Caspase inhibitors for use in the treatment of liver cancer |
| JP2019500397A (ja) | 2015-12-31 | 2019-01-10 | クオナトウス ファーマシューティカルズ，インコーポレイテッド | カスパーゼ阻害剤を肝疾患の治療に使用する方法 |
| RU2019113150A (ru) | 2016-10-05 | 2020-11-06 | Новартис Аг | Комбинация композиций, содержащих агонисты fxr, предназначенная для лечения или предупреждения фиброзирующего, цирротического заболевания или нарушения |
| AU2019279761A1 (en) | 2018-05-29 | 2020-12-10 | Cersci Therapeutics, Inc. | Compounds for pain treatment, compositions comprising same, and methods of using same |
| US11447497B2 (en) | 2018-06-29 | 2022-09-20 | Histogen, Inc. | (S)-3-(2-(4-(benzyl)-3-oxopiperazin-1-yl)acetamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid derivatives and related compounds as caspase inhibitors for treating cardiovascular diseases |
| EP3966200A1 (en) | 2019-05-10 | 2022-03-16 | Cersci Therapeutics, Inc. | Manufacturing methods and polymorphs of a thiazoline anti-hyperalgesic agent |
| WO2022123062A1 (en) | 2020-12-11 | 2022-06-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Blocking caspase and/or fasl for preventing fatal outcome in covid-19 patients |
| KR102670554B1 (ko) * | 2022-01-04 | 2024-05-30 | 주식회사 이노보테라퓨틱스 | 캐스파제 저해제로서의 신규한 이소인돌리논 유도체 화합물 |
| WO2025113519A1 (zh) * | 2023-11-28 | 2025-06-05 | 成都地奥制药集团有限公司 | 内酰胺环类化合物及其用途 |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5874424A (en) | 1995-12-20 | 1999-02-23 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β converting enzyme |
| US6204261B1 (en) | 1995-12-20 | 2001-03-20 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β Converting enzyme inhibitors |
| DE3261645D1 (en) | 1981-02-03 | 1985-02-07 | Airwick Ag | Composition containing an abrasive substrate for the cleaning of hard surfaces |
| DD232699A1 (de) | 1983-11-18 | 1986-02-05 | Adw Ddr | Verfahren zur herstellung von chinazolin-4-on-3-alkansaeuren und deren estern |
| FR2582514B1 (fr) * | 1985-05-30 | 1988-02-19 | Rhone Poulenc Sante | Medicaments a base d'amides, nouveaux amides et leur preparation |
| GB9207145D0 (en) * | 1991-04-18 | 1992-05-13 | Ici Plc | Heterocyclic amides |
| GB9216272D0 (en) | 1991-08-15 | 1992-09-09 | Ici Plc | Substituted heterocycles |
| EP0627926B1 (en) | 1992-02-21 | 1998-08-05 | Merck & Co., Inc. (a New Jersey corp.) | PEPTIDYL DERIVATIVES AS INHIBITORS OF INTERLEUKIN-1$g(b) CONVERTING ENZYME |
| US5441960A (en) | 1992-04-16 | 1995-08-15 | Zeneca Limited | 1-pyrimidinylacetamide human leukocyte elastate inhibitors |
| US5714484A (en) | 1993-12-08 | 1998-02-03 | Prototek, Inc. | α-(1,3-dicarbonylenol ether) methyl ketones as cysteine protease inhibitors |
| CN1118458C (zh) | 1994-03-31 | 2003-08-20 | 弗特克斯药品有限公司 | 作为白细胞介素抑制剂的嘧啶基衍生物 |
| US5847135A (en) * | 1994-06-17 | 1998-12-08 | Vertex Pharmaceuticals, Incorporated | Inhibitors of interleukin-1β converting enzyme |
| US5716929A (en) | 1994-06-17 | 1998-02-10 | Vertex Pharmaceuticals, Inc. | Inhibitors of interleukin-1β converting enzyme |
| US5756466A (en) * | 1994-06-17 | 1998-05-26 | Vertex Pharmaceuticals, Inc. | Inhibitors of interleukin-1β converting enzyme |
| US6420522B1 (en) | 1995-06-05 | 2002-07-16 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β converting enzyme |
| US5565430A (en) | 1994-08-02 | 1996-10-15 | Sterling Winthrop Inc. | Azaaspartic acid analogs as interleukin-1β converting enzyme inhibitors |
| GB2292149A (en) | 1994-08-09 | 1996-02-14 | Ferring Res Ltd | Peptide inhibitors of pro-interleukin-1beta converting enzyme |
| US5948785A (en) * | 1995-04-27 | 1999-09-07 | The Green Cross Corporation | Heterocyclic amide compounds and pharmaceutical use of the same |
| EP0761680A3 (en) | 1995-09-12 | 1999-05-06 | Ono Pharmaceutical Co., Ltd. | Tetrazole compounds having Interleukin-1beta converting enzyme inhibitory activity |
| NZ334906A (en) | 1996-10-11 | 2000-09-29 | Basf Ag | A sulphonamido pentanoic acid derivative useful as an interleukin-1-beta converting enzyme inhibitor |
| US6063794A (en) * | 1996-10-11 | 2000-05-16 | Cor Therapeutics Inc. | Selective factor Xa inhibitors |
| WO1998016502A1 (en) * | 1996-10-11 | 1998-04-23 | Warner-Lambert Company | ASPARTATE ESTER INHIBITORS OF INTERLEUKIN-1β CONVERTING ENZYME |
| WO1998018781A2 (en) | 1996-10-28 | 1998-05-07 | Versicor, Inc. | Fused 2,4-pyrimidinedione combinatorial libraries, their preparation and the use of fused 2,4-pyrimidinediones derivatives as antimicrobial agents |
| US6184244B1 (en) | 1996-12-16 | 2001-02-06 | Idun Pharmaceuticals, Inc. | C-terminal modified (N-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases |
| US6197750B1 (en) | 1998-07-02 | 2001-03-06 | Idun Pharmaceuticals, Inc. | C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases |
| US6242422B1 (en) * | 1998-10-22 | 2001-06-05 | Idun Pharmacueticals, Inc. | (Substituted)Acyl dipeptidyl inhibitors of the ice/ced-3 family of cysteine proteases |
| CN1176941C (zh) * | 1999-04-09 | 2004-11-24 | 西托维亚公司 | Caspase抑制剂及其应用 |
| US6972296B2 (en) | 1999-05-07 | 2005-12-06 | Encysive Pharmaceuticals Inc. | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors |
| BR0010349B1 (pt) | 1999-05-07 | 2011-10-04 | derivados de ácido propanóico que inibem a ligação de integrinas aos seus receptores. | |
| DK1176956T3 (da) | 1999-05-07 | 2008-05-26 | Encysive Pharmaceuticals Inc | Carboxylsyrederivater, som inhiberer bindingen af integriner til deres receptorer |
| AR026748A1 (es) * | 1999-12-08 | 2003-02-26 | Vertex Pharma | Un compuesto inhibidor de caspasas, una composicion farmaceutica que lo comprende, un metodo para la sintesis del mismo y un compuesto intermediario paradicha sintesis |
| EP1289993B9 (en) | 2000-06-07 | 2008-08-20 | Vertex Pharmaceuticals Incorporated | Caspase inhibitors and uses thereof |
| US6878743B2 (en) * | 2001-09-18 | 2005-04-12 | Sunesis Pharmaceuticals, Inc. | Small molecule inhibitors of caspases |
| AU2002348533A1 (en) | 2001-10-09 | 2003-05-26 | Vertex Pharmaceuticals Incorporated | Process for synthesizing aspartic and glutamic acid derivatives and diazoketone intermediates thereof |
| US7410956B2 (en) | 2002-02-11 | 2008-08-12 | Vertex Pharmaceuticals Incorporated | Caspase inhibitor prodrugs |
| US7960398B2 (en) * | 2002-04-19 | 2011-06-14 | Vertex Pharmaceuticals Incorporated | Regulation of TNF-alpha |
| PE20040728A1 (es) * | 2002-06-28 | 2004-10-23 | Vertex Pharma | Inhibidores de caspasa |
| TW200500343A (en) | 2002-12-20 | 2005-01-01 | Vertex Pharma | Caspase inhibitors and uses thereof |
| PE20050159A1 (es) | 2003-05-27 | 2005-04-19 | Vertex Pharma | Derivados de acido 3-[2-(3-amino-2-oxo-2h-piridin-1-il)-acetilamino]-4-oxo-pentanoico como inhibidores de caspasa |
| ATE543803T1 (de) * | 2004-11-24 | 2012-02-15 | Vertex Pharma | 3-ä2-(3-azylamino-2-oxo-2h-pyridin-1- yl)acetylaminoü-4-oxopentansäurederivate und deren verwendung als caspase-inhibitoren |
| KR20080038369A (ko) | 2005-07-28 | 2008-05-06 | 버텍스 파마슈티칼스 인코포레이티드 | 카스파제 억제제 프로드럭 |
-
2004
- 2004-05-26 PE PE2004000535A patent/PE20050159A1/es not_active Application Discontinuation
- 2004-05-27 ZA ZA200509700A patent/ZA200509700B/xx unknown
- 2004-05-27 WO PCT/US2004/016706 patent/WO2004106304A2/en not_active Ceased
- 2004-05-27 CN CN2004800181618A patent/CN1812972B/zh not_active Expired - Fee Related
- 2004-05-27 CN CN201010126183A patent/CN101775012A/zh active Pending
- 2004-05-27 AR ARP040101830A patent/AR044770A1/es unknown
- 2004-05-27 BR BRPI0410669-5A patent/BRPI0410669A/pt not_active IP Right Cessation
- 2004-05-27 KR KR1020117023325A patent/KR20110114735A/ko not_active Withdrawn
- 2004-05-27 US US10/855,699 patent/US20040242494A1/en not_active Abandoned
- 2004-05-27 EP EP11183025A patent/EP2412707A3/en not_active Withdrawn
- 2004-05-27 RU RU2005140657/04A patent/RU2372335C2/ru not_active IP Right Cessation
- 2004-05-27 NZ NZ575857A patent/NZ575857A/en not_active IP Right Cessation
- 2004-05-27 JP JP2006533446A patent/JP4791365B2/ja not_active Expired - Fee Related
- 2004-05-27 AU AU2004243308A patent/AU2004243308B9/en not_active Ceased
- 2004-05-27 KR KR1020057022598A patent/KR20060015626A/ko not_active Abandoned
- 2004-05-27 UY UY28333A patent/UY28333A1/es not_active Application Discontinuation
- 2004-05-27 EP EP04753524A patent/EP1631549A2/en not_active Withdrawn
- 2004-05-27 NZ NZ544156A patent/NZ544156A/en unknown
- 2004-05-27 MX MXPA05012837A patent/MXPA05012837A/es active IP Right Grant
- 2004-05-27 TW TW099123666A patent/TW201038534A/zh unknown
- 2004-05-27 TW TW093115134A patent/TWI344956B/zh not_active IP Right Cessation
- 2004-05-27 CA CA002526749A patent/CA2526749A1/en not_active Abandoned
-
2005
- 2005-11-24 IL IL172159A patent/IL172159A/en not_active IP Right Cessation
- 2005-12-27 NO NO20056192A patent/NO20056192L/no not_active Application Discontinuation
-
2007
- 2007-05-25 JP JP2007139751A patent/JP2007308501A/ja active Pending
-
2008
- 2008-06-17 US US12/140,497 patent/US7960415B2/en not_active Expired - Fee Related
-
2011
- 2011-09-29 JP JP2011215595A patent/JP2012036206A/ja active Pending
- 2011-09-29 JP JP2011215594A patent/JP2012021019A/ja active Pending
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