JP2007506803A5 - - Google Patents
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- Publication number
- JP2007506803A5 JP2007506803A5 JP2006533446A JP2006533446A JP2007506803A5 JP 2007506803 A5 JP2007506803 A5 JP 2007506803A5 JP 2006533446 A JP2006533446 A JP 2006533446A JP 2006533446 A JP2006533446 A JP 2006533446A JP 2007506803 A5 JP2007506803 A5 JP 2007506803A5
- Authority
- JP
- Japan
- Prior art keywords
- aliphatic
- aryl
- heteroaryl
- heterocyclyl
- cycloaliphatic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 *CC(C(*)=O)NC(C(*)N(C=C(*)C=C1N*)C1=O)=O Chemical compound *CC(C(*)=O)NC(C(*)N(C=C(*)C=C1N*)C1=O)=O 0.000 description 6
- WKRJMFJKARFMHN-LEQYJYOASA-N CC[C@@H](C(NC(C1)(C1C(O)=O)C(COc(c(F)c(cc1F)F)c1F)=O)=O)N(C=CC=C1NC(C)=O)C1=O Chemical compound CC[C@@H](C(NC(C1)(C1C(O)=O)C(COc(c(F)c(cc1F)F)c1F)=O)=O)N(C=CC=C1NC(C)=O)C1=O WKRJMFJKARFMHN-LEQYJYOASA-N 0.000 description 1
- ZDSDYSRLSRPBRM-LOACHALJSA-N CC[C@@H](C(NC(CC(O)=O)C(CF)=O)=O)N(C=CC=C1NC(c2ccccn2)=O)C1=O Chemical compound CC[C@@H](C(NC(CC(O)=O)C(CF)=O)=O)N(C=CC=C1NC(c2ccccn2)=O)C1=O ZDSDYSRLSRPBRM-LOACHALJSA-N 0.000 description 1
- YNIFSTZXBSNENZ-ZFWWWQNUSA-N CC[C@@H](C(N[C@@H](CC(O)=O)C(COc(c(F)c(cc1F)F)c1F)=O)=O)N(C=C(C(F)(F)F)C=C1NS(CC)(=O)=O)C1=O Chemical compound CC[C@@H](C(N[C@@H](CC(O)=O)C(COc(c(F)c(cc1F)F)c1F)=O)=O)N(C=C(C(F)(F)F)C=C1NS(CC)(=O)=O)C1=O YNIFSTZXBSNENZ-ZFWWWQNUSA-N 0.000 description 1
- GUYNFOUSOJDSPF-VIFPVBQESA-N CC[C@@H](C(O)=O)N(C=CC=C1NC(C)=O)C1=O Chemical compound CC[C@@H](C(O)=O)N(C=CC=C1NC(C)=O)C1=O GUYNFOUSOJDSPF-VIFPVBQESA-N 0.000 description 1
- SHJOOHKOKCNLCY-LBPRGKRZSA-N CC[C@@H](C(OC(C)(C)C)=O)N(C=CC=C1NC(C)=O)C1=O Chemical compound CC[C@@H](C(OC(C)(C)C)=O)N(C=CC=C1NC(C)=O)C1=O SHJOOHKOKCNLCY-LBPRGKRZSA-N 0.000 description 1
- FMEFCRPEUGLMLN-KRWDZBQOSA-N CC[C@@H](C(OC(C)(C)C)=O)N(C=CC=C1NC(OCc2ccccc2)=O)C1=O Chemical compound CC[C@@H](C(OC(C)(C)C)=O)N(C=CC=C1NC(OCc2ccccc2)=O)C1=O FMEFCRPEUGLMLN-KRWDZBQOSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47362203P | 2003-05-27 | 2003-05-27 | |
| US60/473,622 | 2003-05-27 | ||
| PCT/US2004/016706 WO2004106304A2 (en) | 2003-05-27 | 2004-05-27 | 3 - [2- (3-amino-2-oxo-2h-pyridin-1-yl) - acetylamino] - 4- oxo-pentanoic acid derivatives and their use as caspase inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007139751A Division JP2007308501A (ja) | 2003-05-27 | 2007-05-25 | カスパーゼ阻害剤およびそれらの用途 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007506803A JP2007506803A (ja) | 2007-03-22 |
| JP2007506803A5 true JP2007506803A5 (https=) | 2007-07-19 |
| JP4791365B2 JP4791365B2 (ja) | 2011-10-12 |
Family
ID=33490622
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006533446A Expired - Fee Related JP4791365B2 (ja) | 2003-05-27 | 2004-05-27 | カスパーゼ阻害剤およびそれらの用途 |
| JP2007139751A Pending JP2007308501A (ja) | 2003-05-27 | 2007-05-25 | カスパーゼ阻害剤およびそれらの用途 |
| JP2011215595A Pending JP2012036206A (ja) | 2003-05-27 | 2011-09-29 | カスパーゼ阻害剤およびそれらの用途 |
| JP2011215594A Pending JP2012021019A (ja) | 2003-05-27 | 2011-09-29 | カスパーゼ阻害剤およびそれらの用途 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007139751A Pending JP2007308501A (ja) | 2003-05-27 | 2007-05-25 | カスパーゼ阻害剤およびそれらの用途 |
| JP2011215595A Pending JP2012036206A (ja) | 2003-05-27 | 2011-09-29 | カスパーゼ阻害剤およびそれらの用途 |
| JP2011215594A Pending JP2012021019A (ja) | 2003-05-27 | 2011-09-29 | カスパーゼ阻害剤およびそれらの用途 |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US20040242494A1 (https=) |
| EP (2) | EP1631549A2 (https=) |
| JP (4) | JP4791365B2 (https=) |
| KR (2) | KR20110114735A (https=) |
| CN (2) | CN1812972B (https=) |
| AR (1) | AR044770A1 (https=) |
| AU (1) | AU2004243308B9 (https=) |
| BR (1) | BRPI0410669A (https=) |
| CA (1) | CA2526749A1 (https=) |
| IL (1) | IL172159A (https=) |
| MX (1) | MXPA05012837A (https=) |
| NO (1) | NO20056192L (https=) |
| NZ (2) | NZ575857A (https=) |
| PE (1) | PE20050159A1 (https=) |
| RU (1) | RU2372335C2 (https=) |
| TW (2) | TWI344956B (https=) |
| UY (1) | UY28333A1 (https=) |
| WO (1) | WO2004106304A2 (https=) |
| ZA (1) | ZA200509700B (https=) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20011350A1 (es) | 2000-05-19 | 2002-01-15 | Vertex Pharma | PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE) |
| PL374598A1 (en) | 2002-06-28 | 2005-10-31 | Vertex Pharmaceuticals Incorporated | Caspase inhibitors and uses thereof |
| US7612091B2 (en) | 2002-12-20 | 2009-11-03 | Vertex Pharmaceuticals Incorporated | Caspase inhibitors and uses thereof |
| PE20050159A1 (es) * | 2003-05-27 | 2005-04-19 | Vertex Pharma | Derivados de acido 3-[2-(3-amino-2-oxo-2h-piridin-1-il)-acetilamino]-4-oxo-pentanoico como inhibidores de caspasa |
| GB0327494D0 (en) * | 2003-11-26 | 2003-12-31 | Amersham Plc | Novel imaging agents |
| EP2399916B1 (en) * | 2004-03-12 | 2014-12-10 | Vertex Pharmaceuticals Incorporated | Process and intermediates for the preparation of aspartic acetal caspase ihnhibitors |
| WO2005115362A1 (en) * | 2004-05-15 | 2005-12-08 | Vertex Pharmaceuticals Incorporated | Treating seizures using ice inhibitors |
| ATE543803T1 (de) | 2004-11-24 | 2012-02-15 | Vertex Pharma | 3-ä2-(3-azylamino-2-oxo-2h-pyridin-1- yl)acetylaminoü-4-oxopentansäurederivate und deren verwendung als caspase-inhibitoren |
| US7989441B2 (en) * | 2005-06-08 | 2011-08-02 | Novartis Ag | Organic compounds |
| CN101268084A (zh) | 2005-07-28 | 2008-09-17 | 沃泰克斯药物股份有限公司 | 天冬氨酸特异性半胱氨酸蛋白酶抑制剂前体药物 |
| CA2659084C (en) | 2006-08-02 | 2011-07-12 | Lg Life Sciences Ltd. | Caspase inhibitors based on pyridazinone scaffold |
| KR20080042290A (ko) * | 2006-11-09 | 2008-05-15 | 주식회사 엘지생명과학 | 피리돈 구조를 포함하는 캐스파제 저해제 |
| WO2010120880A1 (en) * | 2009-04-14 | 2010-10-21 | Vertex Pharmaceuticals Incorporated | Treatment of liver diseases with a caspase inhibitor |
| US9956260B1 (en) | 2011-07-22 | 2018-05-01 | The J. David Gladstone Institutes | Treatment of HIV-1 infection and AIDS |
| CN104254526B (zh) * | 2012-03-31 | 2017-06-20 | 乔治亚大学研究基金公司 | 针对结核病的新的抗分枝杆菌药物 |
| EP2687511A1 (de) * | 2012-07-17 | 2014-01-22 | Zedira GmbH | Pyridinonderivate als Gewebetransglutaminaseinhibitoren |
| US9969283B2 (en) | 2013-09-10 | 2018-05-15 | General Electric Company | Battery changing system and method |
| US10143267B1 (en) | 2013-12-31 | 2018-12-04 | Dynasty Footwear, Ltd. | Shoe bottom surface having attached particles |
| JP2017515854A (ja) | 2014-05-12 | 2017-06-15 | クオナトウス ファーマシューティカルズ，インコーポレイテッド | カスパーゼ阻害剤による慢性肝疾患の合併症の治療 |
| WO2017079566A1 (en) | 2015-11-05 | 2017-05-11 | Conatus Pharmaceuticals, Inc. | Caspase inhibitors for use in the treatment of liver cancer |
| CA3010286A1 (en) | 2015-12-31 | 2017-07-06 | Conatus Pharmaceuticals Inc. | Methods of using caspase inhibitors in treatment of liver disease |
| RU2019113150A (ru) | 2016-10-05 | 2020-11-06 | Новартис Аг | Комбинация композиций, содержащих агонисты fxr, предназначенная для лечения или предупреждения фиброзирующего, цирротического заболевания или нарушения |
| JP2021525269A (ja) | 2018-05-29 | 2021-09-24 | セルシィ セラピューティクス，インコーポレーテッド | 疼痛処置のための化合物、それを含む組成物及びそれを使用する方法 |
| EP3814327A1 (en) | 2018-06-29 | 2021-05-05 | Histogen, Inc. | (s)-3-(2-(4-(benzyl)-3-oxopiperazin-1-yl)acetamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid derivatives and related compounds as caspase inhibitors for treating cardiovascular diseases |
| SG11202110561XA (en) | 2019-05-10 | 2021-10-28 | Cersci Therapeutics Inc | Manufacturing methods and polymorphs of a thiazoline anti-hyperalgesic agent |
| WO2022123062A1 (en) | 2020-12-11 | 2022-06-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Blocking caspase and/or fasl for preventing fatal outcome in covid-19 patients |
| KR102670554B1 (ko) * | 2022-01-04 | 2024-05-30 | 주식회사 이노보테라퓨틱스 | 캐스파제 저해제로서의 신규한 이소인돌리논 유도체 화합물 |
| WO2025113519A1 (zh) * | 2023-11-28 | 2025-06-05 | 成都地奥制药集团有限公司 | 内酰胺环类化合物及其用途 |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5874424A (en) | 1995-12-20 | 1999-02-23 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β converting enzyme |
| US6204261B1 (en) | 1995-12-20 | 2001-03-20 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β Converting enzyme inhibitors |
| EP0058633B1 (de) | 1981-02-03 | 1984-12-27 | Airwick AG | Komposition, enthaltend einen scheuernden Träger, für die Reinigung harter Oberflächen |
| DD232699A1 (de) | 1983-11-18 | 1986-02-05 | Adw Ddr | Verfahren zur herstellung von chinazolin-4-on-3-alkansaeuren und deren estern |
| FR2582514B1 (fr) * | 1985-05-30 | 1988-02-19 | Rhone Poulenc Sante | Medicaments a base d'amides, nouveaux amides et leur preparation |
| GB9207145D0 (en) * | 1991-04-18 | 1992-05-13 | Ici Plc | Heterocyclic amides |
| GB9216272D0 (en) | 1991-08-15 | 1992-09-09 | Ici Plc | Substituted heterocycles |
| AU3666893A (en) | 1992-02-21 | 1993-09-13 | Merck & Co., Inc. | Peptidyl derivatives as inhibitors of interleukin-1beta converting enzyme |
| US5441960A (en) | 1992-04-16 | 1995-08-15 | Zeneca Limited | 1-pyrimidinylacetamide human leukocyte elastate inhibitors |
| US5714484A (en) | 1993-12-08 | 1998-02-03 | Prototek, Inc. | α-(1,3-dicarbonylenol ether) methyl ketones as cysteine protease inhibitors |
| CN1504462A (zh) | 1994-03-31 | 2004-06-16 | ������˹ҩƷ��˾ | 作为白细胞介素抑制剂的嘧啶基衍生物 |
| US5847135A (en) * | 1994-06-17 | 1998-12-08 | Vertex Pharmaceuticals, Incorporated | Inhibitors of interleukin-1β converting enzyme |
| US6420522B1 (en) | 1995-06-05 | 2002-07-16 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β converting enzyme |
| US5716929A (en) | 1994-06-17 | 1998-02-10 | Vertex Pharmaceuticals, Inc. | Inhibitors of interleukin-1β converting enzyme |
| US5756466A (en) | 1994-06-17 | 1998-05-26 | Vertex Pharmaceuticals, Inc. | Inhibitors of interleukin-1β converting enzyme |
| US5565430A (en) | 1994-08-02 | 1996-10-15 | Sterling Winthrop Inc. | Azaaspartic acid analogs as interleukin-1β converting enzyme inhibitors |
| GB2292149A (en) | 1994-08-09 | 1996-02-14 | Ferring Res Ltd | Peptide inhibitors of pro-interleukin-1beta converting enzyme |
| EP0826671B1 (en) * | 1995-04-27 | 2004-12-29 | Mitsubishi Pharma Corporation | Heterocyclic amide compounds and medicinal use of the same |
| EP0761680A3 (en) | 1995-09-12 | 1999-05-06 | Ono Pharmaceutical Co., Ltd. | Tetrazole compounds having Interleukin-1beta converting enzyme inhibitory activity |
| US6063794A (en) * | 1996-10-11 | 2000-05-16 | Cor Therapeutics Inc. | Selective factor Xa inhibitors |
| AU738341B2 (en) * | 1996-10-11 | 2001-09-13 | Abbott Gmbh & Co. Kg | Asparate ester inhibitors of interleukin-1beta converting enzyme |
| CA2268086A1 (en) | 1996-10-11 | 1998-04-23 | Warner-Lambert Company | Sulfonamide interleukin-1.beta. converting enzyme inhibitors |
| WO1998018781A2 (en) | 1996-10-28 | 1998-05-07 | Versicor, Inc. | Fused 2,4-pyrimidinedione combinatorial libraries, their preparation and the use of fused 2,4-pyrimidinediones derivatives as antimicrobial agents |
| US6184244B1 (en) | 1996-12-16 | 2001-02-06 | Idun Pharmaceuticals, Inc. | C-terminal modified (N-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases |
| US6197750B1 (en) | 1998-07-02 | 2001-03-06 | Idun Pharmaceuticals, Inc. | C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases |
| US6242422B1 (en) | 1998-10-22 | 2001-06-05 | Idun Pharmacueticals, Inc. | (Substituted)Acyl dipeptidyl inhibitors of the ice/ced-3 family of cysteine proteases |
| US6355618B1 (en) * | 1999-04-09 | 2002-03-12 | Cytovia, Inc. | Caspase inhibitors and the use thereof |
| ATE383153T1 (de) | 1999-05-07 | 2008-01-15 | Encysive Pharmaceuticals Inc | Carbonsäurederivate die die bindung von integrinen an ihre rezeptoren hemmen |
| US6972296B2 (en) | 1999-05-07 | 2005-12-06 | Encysive Pharmaceuticals Inc. | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors |
| RU2255933C9 (ru) | 1999-05-07 | 2005-11-20 | Тексэс Байотекнолоджи Копэрейшн | ПРОИЗВОДНЫЕ ПРОПИОНОВОЙ КИСЛОТЫ (ВАРИАНТЫ), ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ И СПОСОБ СЕЛЕКТИВНОГО ИНГИБИРОВАНИЯ СВЯЗЫВАНИЯ α4β1 ИНТЕГРИНА |
| AR026748A1 (es) * | 1999-12-08 | 2003-02-26 | Vertex Pharma | Un compuesto inhibidor de caspasas, una composicion farmaceutica que lo comprende, un metodo para la sintesis del mismo y un compuesto intermediario paradicha sintesis |
| WO2001094351A1 (en) | 2000-06-07 | 2001-12-13 | Vertex Pharmaceuticals Incorporated | Caspase inhibitors and uses thereof |
| WO2003024955A2 (en) * | 2001-09-18 | 2003-03-27 | Sunesis Pharmaceuticals, Inc. | Small molecule inhibitors of caspases |
| JP2005509028A (ja) | 2001-10-09 | 2005-04-07 | バーテックス ファーマシューティカルズ インコーポレイテッド | アスパラギン酸およびグルタミン酸誘導体ならびにそのジアゾケトン中間体を合成するための方法 |
| US7410956B2 (en) | 2002-02-11 | 2008-08-12 | Vertex Pharmaceuticals Incorporated | Caspase inhibitor prodrugs |
| AU2003225088A1 (en) * | 2002-04-19 | 2003-11-03 | Vertex Pharmaceuticals Incorporated | Regulation of tnf-alpha |
| PL374598A1 (en) | 2002-06-28 | 2005-10-31 | Vertex Pharmaceuticals Incorporated | Caspase inhibitors and uses thereof |
| US7612091B2 (en) * | 2002-12-20 | 2009-11-03 | Vertex Pharmaceuticals Incorporated | Caspase inhibitors and uses thereof |
| PE20050159A1 (es) | 2003-05-27 | 2005-04-19 | Vertex Pharma | Derivados de acido 3-[2-(3-amino-2-oxo-2h-piridin-1-il)-acetilamino]-4-oxo-pentanoico como inhibidores de caspasa |
| ATE543803T1 (de) * | 2004-11-24 | 2012-02-15 | Vertex Pharma | 3-ä2-(3-azylamino-2-oxo-2h-pyridin-1- yl)acetylaminoü-4-oxopentansäurederivate und deren verwendung als caspase-inhibitoren |
| CN101268084A (zh) | 2005-07-28 | 2008-09-17 | 沃泰克斯药物股份有限公司 | 天冬氨酸特异性半胱氨酸蛋白酶抑制剂前体药物 |
-
2004
- 2004-05-26 PE PE2004000535A patent/PE20050159A1/es not_active Application Discontinuation
- 2004-05-27 AU AU2004243308A patent/AU2004243308B9/en not_active Ceased
- 2004-05-27 WO PCT/US2004/016706 patent/WO2004106304A2/en not_active Ceased
- 2004-05-27 MX MXPA05012837A patent/MXPA05012837A/es active IP Right Grant
- 2004-05-27 UY UY28333A patent/UY28333A1/es not_active Application Discontinuation
- 2004-05-27 AR ARP040101830A patent/AR044770A1/es unknown
- 2004-05-27 TW TW093115134A patent/TWI344956B/zh not_active IP Right Cessation
- 2004-05-27 ZA ZA200509700A patent/ZA200509700B/xx unknown
- 2004-05-27 RU RU2005140657/04A patent/RU2372335C2/ru not_active IP Right Cessation
- 2004-05-27 NZ NZ575857A patent/NZ575857A/en not_active IP Right Cessation
- 2004-05-27 EP EP04753524A patent/EP1631549A2/en not_active Withdrawn
- 2004-05-27 CN CN2004800181618A patent/CN1812972B/zh not_active Expired - Fee Related
- 2004-05-27 CA CA002526749A patent/CA2526749A1/en not_active Abandoned
- 2004-05-27 US US10/855,699 patent/US20040242494A1/en not_active Abandoned
- 2004-05-27 JP JP2006533446A patent/JP4791365B2/ja not_active Expired - Fee Related
- 2004-05-27 CN CN201010126183A patent/CN101775012A/zh active Pending
- 2004-05-27 KR KR1020117023325A patent/KR20110114735A/ko not_active Withdrawn
- 2004-05-27 TW TW099123666A patent/TW201038534A/zh unknown
- 2004-05-27 BR BRPI0410669-5A patent/BRPI0410669A/pt not_active IP Right Cessation
- 2004-05-27 EP EP11183025A patent/EP2412707A3/en not_active Withdrawn
- 2004-05-27 NZ NZ544156A patent/NZ544156A/en unknown
- 2004-05-27 KR KR1020057022598A patent/KR20060015626A/ko not_active Abandoned
-
2005
- 2005-11-24 IL IL172159A patent/IL172159A/en not_active IP Right Cessation
- 2005-12-27 NO NO20056192A patent/NO20056192L/no not_active Application Discontinuation
-
2007
- 2007-05-25 JP JP2007139751A patent/JP2007308501A/ja active Pending
-
2008
- 2008-06-17 US US12/140,497 patent/US7960415B2/en not_active Expired - Fee Related
-
2011
- 2011-09-29 JP JP2011215595A patent/JP2012036206A/ja active Pending
- 2011-09-29 JP JP2011215594A patent/JP2012021019A/ja active Pending
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