AU2004243308B9 - 3 - [2- (3-amino-2-oxo-2H-pyridin-1-YL) - acetylamino] - 4- oxo-pentanoic acid derivatives and their use as caspase inhibitors - Google Patents
3 - [2- (3-amino-2-oxo-2H-pyridin-1-YL) - acetylamino] - 4- oxo-pentanoic acid derivatives and their use as caspase inhibitors Download PDFInfo
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- AU2004243308B9 AU2004243308B9 AU2004243308A AU2004243308A AU2004243308B9 AU 2004243308 B9 AU2004243308 B9 AU 2004243308B9 AU 2004243308 A AU2004243308 A AU 2004243308A AU 2004243308 A AU2004243308 A AU 2004243308A AU 2004243308 B9 AU2004243308 B9 AU 2004243308B9
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US47362203P | 2003-05-27 | 2003-05-27 | |
| US60/473,622 | 2003-05-27 | ||
| PCT/US2004/016706 WO2004106304A2 (en) | 2003-05-27 | 2004-05-27 | 3 - [2- (3-amino-2-oxo-2h-pyridin-1-yl) - acetylamino] - 4- oxo-pentanoic acid derivatives and their use as caspase inhibitors |
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| AU2004243308A1 AU2004243308A1 (en) | 2004-12-09 |
| AU2004243308B2 AU2004243308B2 (en) | 2011-09-29 |
| AU2004243308B9 true AU2004243308B9 (en) | 2012-02-09 |
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| EP (2) | EP2412707A3 (https=) |
| JP (4) | JP4791365B2 (https=) |
| KR (2) | KR20110114735A (https=) |
| CN (2) | CN1812972B (https=) |
| AR (1) | AR044770A1 (https=) |
| AU (1) | AU2004243308B9 (https=) |
| BR (1) | BRPI0410669A (https=) |
| CA (1) | CA2526749A1 (https=) |
| IL (1) | IL172159A (https=) |
| MX (1) | MXPA05012837A (https=) |
| NO (1) | NO20056192L (https=) |
| NZ (2) | NZ575857A (https=) |
| PE (1) | PE20050159A1 (https=) |
| RU (1) | RU2372335C2 (https=) |
| TW (2) | TW201038534A (https=) |
| UY (1) | UY28333A1 (https=) |
| WO (1) | WO2004106304A2 (https=) |
| ZA (1) | ZA200509700B (https=) |
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| PE20011350A1 (es) | 2000-05-19 | 2002-01-15 | Vertex Pharma | PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE) |
| PE20040728A1 (es) * | 2002-06-28 | 2004-10-23 | Vertex Pharma | Inhibidores de caspasa |
| TW200500343A (en) * | 2002-12-20 | 2005-01-01 | Vertex Pharma | Caspase inhibitors and uses thereof |
| PE20050159A1 (es) * | 2003-05-27 | 2005-04-19 | Vertex Pharma | Derivados de acido 3-[2-(3-amino-2-oxo-2h-piridin-1-il)-acetilamino]-4-oxo-pentanoico como inhibidores de caspasa |
| GB0327494D0 (en) * | 2003-11-26 | 2003-12-31 | Amersham Plc | Novel imaging agents |
| SG150547A1 (en) * | 2004-03-12 | 2009-03-30 | Vertex Pharma | Processes and intermediates |
| MXPA06013256A (es) * | 2004-05-15 | 2007-02-08 | Vertex Pharma | Tratamiento de crisis convulsivas utilizando inhibidores ice. |
| ATE543803T1 (de) | 2004-11-24 | 2012-02-15 | Vertex Pharma | 3-ä2-(3-azylamino-2-oxo-2h-pyridin-1- yl)acetylaminoü-4-oxopentansäurederivate und deren verwendung als caspase-inhibitoren |
| JP2008545780A (ja) * | 2005-06-08 | 2008-12-18 | ノバルティス アクチエンゲゼルシャフト | 有機化合物 |
| KR20080038369A (ko) | 2005-07-28 | 2008-05-06 | 버텍스 파마슈티칼스 인코포레이티드 | 카스파제 억제제 프로드럭 |
| NZ574791A (en) * | 2006-08-02 | 2011-12-22 | Lg Life Sciences Ltd | Caspase inhibitors based on pyridazinone scaffold |
| KR20080042290A (ko) * | 2006-11-09 | 2008-05-15 | 주식회사 엘지생명과학 | 피리돈 구조를 포함하는 캐스파제 저해제 |
| WO2010120880A1 (en) * | 2009-04-14 | 2010-10-21 | Vertex Pharmaceuticals Incorporated | Treatment of liver diseases with a caspase inhibitor |
| US9956260B1 (en) | 2011-07-22 | 2018-05-01 | The J. David Gladstone Institutes | Treatment of HIV-1 infection and AIDS |
| CN104254526B (zh) * | 2012-03-31 | 2017-06-20 | 乔治亚大学研究基金公司 | 针对结核病的新的抗分枝杆菌药物 |
| EP2687511A1 (de) * | 2012-07-17 | 2014-01-22 | Zedira GmbH | Pyridinonderivate als Gewebetransglutaminaseinhibitoren |
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| ES2751652T3 (es) | 2014-05-12 | 2020-04-01 | Conatus Pharmaceuticals Inc | Tratamiento con inhibidor de caspasa emricasan de las complicaciones por las enfermedades hepáticas crónicas |
| WO2017079566A1 (en) | 2015-11-05 | 2017-05-11 | Conatus Pharmaceuticals, Inc. | Caspase inhibitors for use in the treatment of liver cancer |
| JP2019500397A (ja) | 2015-12-31 | 2019-01-10 | クオナトウス ファーマシューティカルズ,インコーポレイテッド | カスパーゼ阻害剤を肝疾患の治療に使用する方法 |
| RU2019113150A (ru) | 2016-10-05 | 2020-11-06 | Новартис Аг | Комбинация композиций, содержащих агонисты fxr, предназначенная для лечения или предупреждения фиброзирующего, цирротического заболевания или нарушения |
| AU2019279761A1 (en) | 2018-05-29 | 2020-12-10 | Cersci Therapeutics, Inc. | Compounds for pain treatment, compositions comprising same, and methods of using same |
| US11447497B2 (en) | 2018-06-29 | 2022-09-20 | Histogen, Inc. | (S)-3-(2-(4-(benzyl)-3-oxopiperazin-1-yl)acetamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid derivatives and related compounds as caspase inhibitors for treating cardiovascular diseases |
| EP3966200A1 (en) | 2019-05-10 | 2022-03-16 | Cersci Therapeutics, Inc. | Manufacturing methods and polymorphs of a thiazoline anti-hyperalgesic agent |
| WO2022123062A1 (en) | 2020-12-11 | 2022-06-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Blocking caspase and/or fasl for preventing fatal outcome in covid-19 patients |
| KR102670554B1 (ko) * | 2022-01-04 | 2024-05-30 | 주식회사 이노보테라퓨틱스 | 캐스파제 저해제로서의 신규한 이소인돌리논 유도체 화합물 |
| WO2025113519A1 (zh) * | 2023-11-28 | 2025-06-05 | 成都地奥制药集团有限公司 | 内酰胺环类化合物及其用途 |
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| PE20050159A1 (es) | 2003-05-27 | 2005-04-19 | Vertex Pharma | Derivados de acido 3-[2-(3-amino-2-oxo-2h-piridin-1-il)-acetilamino]-4-oxo-pentanoico como inhibidores de caspasa |
| ATE543803T1 (de) * | 2004-11-24 | 2012-02-15 | Vertex Pharma | 3-ä2-(3-azylamino-2-oxo-2h-pyridin-1- yl)acetylaminoü-4-oxopentansäurederivate und deren verwendung als caspase-inhibitoren |
| KR20080038369A (ko) | 2005-07-28 | 2008-05-06 | 버텍스 파마슈티칼스 인코포레이티드 | 카스파제 억제제 프로드럭 |
-
2004
- 2004-05-26 PE PE2004000535A patent/PE20050159A1/es not_active Application Discontinuation
- 2004-05-27 ZA ZA200509700A patent/ZA200509700B/xx unknown
- 2004-05-27 WO PCT/US2004/016706 patent/WO2004106304A2/en not_active Ceased
- 2004-05-27 CN CN2004800181618A patent/CN1812972B/zh not_active Expired - Fee Related
- 2004-05-27 CN CN201010126183A patent/CN101775012A/zh active Pending
- 2004-05-27 AR ARP040101830A patent/AR044770A1/es unknown
- 2004-05-27 BR BRPI0410669-5A patent/BRPI0410669A/pt not_active IP Right Cessation
- 2004-05-27 KR KR1020117023325A patent/KR20110114735A/ko not_active Withdrawn
- 2004-05-27 US US10/855,699 patent/US20040242494A1/en not_active Abandoned
- 2004-05-27 EP EP11183025A patent/EP2412707A3/en not_active Withdrawn
- 2004-05-27 RU RU2005140657/04A patent/RU2372335C2/ru not_active IP Right Cessation
- 2004-05-27 NZ NZ575857A patent/NZ575857A/en not_active IP Right Cessation
- 2004-05-27 JP JP2006533446A patent/JP4791365B2/ja not_active Expired - Fee Related
- 2004-05-27 AU AU2004243308A patent/AU2004243308B9/en not_active Ceased
- 2004-05-27 KR KR1020057022598A patent/KR20060015626A/ko not_active Abandoned
- 2004-05-27 UY UY28333A patent/UY28333A1/es not_active Application Discontinuation
- 2004-05-27 EP EP04753524A patent/EP1631549A2/en not_active Withdrawn
- 2004-05-27 NZ NZ544156A patent/NZ544156A/en unknown
- 2004-05-27 MX MXPA05012837A patent/MXPA05012837A/es active IP Right Grant
- 2004-05-27 TW TW099123666A patent/TW201038534A/zh unknown
- 2004-05-27 TW TW093115134A patent/TWI344956B/zh not_active IP Right Cessation
- 2004-05-27 CA CA002526749A patent/CA2526749A1/en not_active Abandoned
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2005
- 2005-11-24 IL IL172159A patent/IL172159A/en not_active IP Right Cessation
- 2005-12-27 NO NO20056192A patent/NO20056192L/no not_active Application Discontinuation
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2007
- 2007-05-25 JP JP2007139751A patent/JP2007308501A/ja active Pending
-
2008
- 2008-06-17 US US12/140,497 patent/US7960415B2/en not_active Expired - Fee Related
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2011
- 2011-09-29 JP JP2011215595A patent/JP2012036206A/ja active Pending
- 2011-09-29 JP JP2011215594A patent/JP2012021019A/ja active Pending
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