RU2406503C2 - Дигидроптеридиноны, предназначенные для лечения раковых заболеваний - Google Patents
Дигидроптеридиноны, предназначенные для лечения раковых заболеваний Download PDFInfo
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- RU2406503C2 RU2406503C2 RU2007109109/15A RU2007109109A RU2406503C2 RU 2406503 C2 RU2406503 C2 RU 2406503C2 RU 2007109109/15 A RU2007109109/15 A RU 2007109109/15A RU 2007109109 A RU2007109109 A RU 2007109109A RU 2406503 C2 RU2406503 C2 RU 2406503C2
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- 0 CN(C(C(*)(*)N1*)=O)c2c1nc(Nc(cc1)c(*)cc1C(NN)=O)nc2 Chemical compound CN(C(C(*)(*)N1*)=O)c2c1nc(Nc(cc1)c(*)cc1C(NN)=O)nc2 0.000 description 2
- GNOUFBFWWBCKIT-UHFFFAOYSA-N CC(C)(C)CN1CCCC1 Chemical compound CC(C)(C)CN1CCCC1 GNOUFBFWWBCKIT-UHFFFAOYSA-N 0.000 description 1
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Abstract
Изобретение относится к области фармакологии и медицины и касается применения соединений общей формулы (1) для лечения заболеваний, характеризующихся аномальной пролиферацией клеток в организме человека или млекопитающего, не являющегося человеком, путем ингибирования polo-подобных киназ, как регуляторов митоза. Изобретение предоставляет высокоактивные противоопухолевые средства. 7 з.п. ф-лы, 2 табл.
Description
Claims (7)
1. Применение соединения формулы (I)
в котором соединение выбрано из группы соединений, приведенных в представленной ниже таблице
Пример R1 R2 Конфигурация R1 или R2 R3 R4 Ln-R5 m
27 Н R
44 Н R Н
46 Н R
55 Н R
58 Н R
102 Н R
103 Н R
105 Н R
110 Н R
115 Н R
133 Н R
134 Н R
234 Н R
240 Н R
где обозначения X1, X2, Х3, Х4 и Х5, использованные в таблице, в каждом случае обозначают связывание в положении в общей формуле, приведенной в таблице, а не соответствующие группы R1, R2, R3, R4 и L-R5, необязательно в форме его рацематов и необязательно в форме его фармакологически приемлемых солей присоединения с кислотами, сольватов или гидратов, для приготовления фармацевтической композиции, предназначенной для лечения заболеваний, характеризующихся аномальной пролиферацией клеток в организме человека или млекопитающего, не являющегося человеком, путем ингибирования polo-подобных киназ, как регуляторов митоза.
в котором соединение выбрано из группы соединений, приведенных в представленной ниже таблице
где обозначения X1, X2, Х3, Х4 и Х5, использованные в таблице, в каждом случае обозначают связывание в положении в общей формуле, приведенной в таблице, а не соответствующие группы R1, R2, R3, R4 и L-R5, необязательно в форме его рацематов и необязательно в форме его фармакологически приемлемых солей присоединения с кислотами, сольватов или гидратов, для приготовления фармацевтической композиции, предназначенной для лечения заболеваний, характеризующихся аномальной пролиферацией клеток в организме человека или млекопитающего, не являющегося человеком, путем ингибирования polo-подобных киназ, как регуляторов митоза.
2. Применение по п.1, в котором polo-подобной киназой является ППК-1.
3. Применение по п.1 или 2, характеризующееся тем, что заболевание характеризуется неприемлемой пролиферацией, миграцией, апоптозом или ангиогенезом клеток.
4. Применение по любому из пп.1-3, характеризующееся тем, что заболеванием является рак, выбранный из группы, включающей карциномы, саркомы, меланомы, миелому, опухоли кроветворной системы, лимфомы и раковые заболевания детей.
5. Применение по п.4, характеризующееся тем, что раком является лейкоз.
6. Применение по любому из пп.1-5, характеризующееся тем, что заболеванием является рак, выбранный из группы, включающей смешанные опухоли, недифференцированные опухоли и их метастазы.
7. Применение по любому из пп.1-6, в котором активный ингредиент вводят перорально, энтерально, чрескожно, внутривенно, внутрибрюшинно или путем инъекции.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04019359.1 | 2004-08-14 | ||
EP04019359 | 2004-08-14 |
Publications (2)
Publication Number | Publication Date |
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RU2007109109A RU2007109109A (ru) | 2008-09-20 |
RU2406503C2 true RU2406503C2 (ru) | 2010-12-20 |
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Application Number | Title | Priority Date | Filing Date |
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RU2007109109/15A RU2406503C2 (ru) | 2004-08-14 | 2005-08-09 | Дигидроптеридиноны, предназначенные для лечения раковых заболеваний |
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US (2) | US20060074088A1 (ru) |
EP (3) | EP3560499B1 (ru) |
JP (2) | JP2008509949A (ru) |
KR (2) | KR101283378B1 (ru) |
CN (2) | CN104055778A (ru) |
AR (1) | AR050694A1 (ru) |
AU (1) | AU2005274387B2 (ru) |
BR (1) | BRPI0513977A (ru) |
CA (1) | CA2575787C (ru) |
ES (2) | ES2975234T3 (ru) |
IL (2) | IL181304A (ru) |
MX (2) | MX2007001851A (ru) |
NZ (1) | NZ553722A (ru) |
RU (1) | RU2406503C2 (ru) |
TW (1) | TWI360420B (ru) |
WO (1) | WO2006018185A2 (ru) |
ZA (1) | ZA200700281B (ru) |
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