RU2401661C9 - Индукция апоптоза в опухолевых клетках, экспрессирующих toll-подобный рецептор - Google Patents

Индукция апоптоза в опухолевых клетках, экспрессирующих toll-подобный рецептор Download PDF

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Publication number
RU2401661C9
RU2401661C9 RU2007105987/14A RU2007105987A RU2401661C9 RU 2401661 C9 RU2401661 C9 RU 2401661C9 RU 2007105987/14 A RU2007105987/14 A RU 2007105987/14A RU 2007105987 A RU2007105987 A RU 2007105987A RU 2401661 C9 RU2401661 C9 RU 2401661C9
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Russia
Prior art keywords
cells
poly
apoptosis
tlr
tlr3
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RU2007105987/14A
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English (en)
Russian (ru)
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RU2401661C2 (ru
RU2007105987A (ru
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Серж ЛЕБЕК (FR)
Серж ЛЕБЕК
Туфик РЕННО (FR)
Туфик РЕННО
Брюно САЛОН (CH)
Брюно САЛОН
Изабель КОСТ-ИНВЕРНИЦЦИ (FR)
Изабель КОСТ-ИНВЕРНИЦЦИ
Мари-Клотильд РИССОАН (FR)
Мари-Клотильд РИССОАН
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Шеринг Корпорейшн
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0331—Animal model for proliferative diseases

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
RU2007105987/14A 2004-07-20 2005-07-19 Индукция апоптоза в опухолевых клетках, экспрессирующих toll-подобный рецептор RU2401661C9 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58961604P 2004-07-20 2004-07-20
US60/589,616 2004-07-20

Publications (3)

Publication Number Publication Date
RU2007105987A RU2007105987A (ru) 2008-08-27
RU2401661C2 RU2401661C2 (ru) 2010-10-20
RU2401661C9 true RU2401661C9 (ru) 2011-01-27

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RU2007105987/14A RU2401661C9 (ru) 2004-07-20 2005-07-19 Индукция апоптоза в опухолевых клетках, экспрессирующих toll-подобный рецептор

Country Status (12)

Country Link
US (2) US20060147456A1 (enExample)
EP (1) EP1768699A1 (enExample)
JP (1) JP2008507530A (enExample)
KR (1) KR20070043795A (enExample)
CN (1) CN101018567B (enExample)
AT (1) ATE511859T1 (enExample)
AU (2) AU2005269733B2 (enExample)
CA (1) CA2574176A1 (enExample)
MX (1) MX2007000770A (enExample)
NO (1) NO20070945L (enExample)
RU (1) RU2401661C9 (enExample)
WO (1) WO2006014653A1 (enExample)

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RU2826262C2 (ru) * 2018-05-04 2024-09-09 Толлиз Лиганды tlr3, которые активируют как эпителиальные, так и миелоидные клетки

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US8957035B2 (en) 2006-05-15 2015-02-17 University Of Kentucky Research Foundation Toll like receptor (TLR) stimulation for ocular angiogenesis and macular degeneration
EP1881080A1 (en) * 2006-07-18 2008-01-23 Institut Gustave Roussy Toll like receptor 4 dysfunction and the biological applications thereof
US20080124366A1 (en) * 2006-08-06 2008-05-29 Ohlfest John R Methods and Compositions for Treating Tumors
JP5115921B2 (ja) * 2007-02-28 2013-01-09 株式会社ペルセウスプロテオミクス 腎癌の診断薬および治療薬
AU2008242540A1 (en) * 2007-04-24 2008-10-30 John Wayne Cancer Institute Functional toll-like receptors (TLR) on melanocytes and melanoma cells and uses thereof
SG185942A1 (en) * 2007-11-02 2012-12-28 Agency Science Tech & Res Methods and compounds for preventing and treating a tumour
JP2011505011A (ja) * 2007-11-28 2011-02-17 スマート チューブ，インコーポレイテッド 生体試料の採取、刺激、安定化及び分析のためのデバイス、システム及び方法
AU2009215795A1 (en) 2008-02-21 2009-08-27 University Of Kentucky Research Foundation Ultra-small RNAs as toll-like receptor-3 antagonists
CA2722589A1 (en) 2008-04-25 2009-10-29 Innate Pharma Improved tlr3 agonist compositions
WO2010020590A1 (en) * 2008-08-20 2010-02-25 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting the response to anti-cancer treatment with an agonist of tlr7 or an agonist of tlr8
GB0820698D0 (en) * 2008-11-12 2008-12-17 Ludwig Inst Cancer Res Uses of immunomodulators
WO2010068680A1 (en) 2008-12-10 2010-06-17 Mount Sinai School Of Medicine Of New York University Thelper cell type 17 lineage-specific adjuvants, compositions and methods
US20120301463A1 (en) 2009-09-30 2012-11-29 President And Fellows Of Harvard College Methods for Modulation of Autophagy Through the Modulation of Autophagy-Enhancing Gene Products
WO2011072871A1 (en) * 2009-12-18 2011-06-23 Bavarian Nordic A/S Production of ifn-lambda by conventional dendritic cells and uses thereof
KR101250419B1 (ko) * 2010-12-16 2013-04-05 강원대학교산학협력단 Ｔｌｒ 작동제를 포함하는 유방암 방사선 치료 보조제
RU2014103159A (ru) * 2011-07-22 2015-08-27 Павел КАЛИНСКИЙ Опухолесективная модуляция хемокинов
CN102652802A (zh) * 2012-04-18 2012-09-05 南京中医药大学 癌毒方在制备调控肝癌细胞TLRs／NF-κB信号转导药物中的应用
WO2014022287A1 (en) * 2012-07-29 2014-02-06 The Regents Of The University Of Colorado, A Body Corporate Antagonists of the toll-like receptor 1/2 complex
WO2015127002A1 (en) * 2014-02-19 2015-08-27 The Johns Hopkins University Compositions and methods for promoting skin regeneration and hair growth
US10434064B2 (en) 2014-06-04 2019-10-08 Exicure, Inc. Multivalent delivery of immune modulators by liposomal spherical nucleic acids for prophylactic or therapeutic applications
CN105796594A (zh) * 2016-03-28 2016-07-27 南京大学 一种组合物在制备治疗肿瘤药物中的应用及该组合物的使用方法
CN106191238B (zh) * 2016-07-08 2020-01-10 中国医学科学院基础医学研究所 Tlr3预测肿瘤转移、评估预后和选择防治方案的应用
WO2018039629A2 (en) 2016-08-25 2018-03-01 Northwestern University Micellar spherical nucleic acids from thermoresponsive, traceless templates
WO2018209270A1 (en) 2017-05-11 2018-11-15 Northwestern University Adoptive cell therapy using spherical nucleic acids (snas)
CN108295060A (zh) * 2018-04-08 2018-07-20 王长国 一种tlr7激动剂在增强cik细胞对肿瘤细胞杀伤力方面的应用
WO2020232226A1 (en) 2019-05-16 2020-11-19 The Johns Hopkins University Compositions and methods for skin rejuvenation
CN111117966A (zh) * 2020-03-02 2020-05-08 南通大学 一种利用乳酸的体外细胞培养方法
CN111579538B (zh) * 2020-04-22 2022-12-30 山东第一医科大学(山东省医学科学院) 一种利用凋亡试剂盒检测循环肿瘤细胞的方法
CA3221194A1 (en) * 2021-05-24 2022-12-01 Cha Vaccine Research Institute Co., Ltd Immuno-oncology therapeutic composition using adjuvant including lipopeptides and poly (i:c)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2826262C2 (ru) * 2018-05-04 2024-09-09 Толлиз Лиганды tlr3, которые активируют как эпителиальные, так и миелоидные клетки

Also Published As

Publication number Publication date
WO2006014653A1 (en) 2006-02-09
NO20070945L (no) 2007-02-19
CN101018567A (zh) 2007-08-15
CN101018567B (zh) 2011-07-27
RU2401661C2 (ru) 2010-10-20
KR20070043795A (ko) 2007-04-25
AU2008249173A1 (en) 2008-12-11
US20060147456A1 (en) 2006-07-06
US20090285779A1 (en) 2009-11-19
AU2005269733B2 (en) 2008-10-30
AU2005269733A1 (en) 2006-02-09
JP2008507530A (ja) 2008-03-13
RU2007105987A (ru) 2008-08-27
EP1768699A1 (en) 2007-04-04
CA2574176A1 (en) 2006-02-09
ATE511859T1 (de) 2011-06-15
MX2007000770A (es) 2007-03-26

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