JP2008507530A - Ｔｏｌｌ様受容体を発現する腫瘍細胞におけるアポトーシスの誘導 - Google Patents

Ｔｏｌｌ様受容体を発現する腫瘍細胞におけるアポトーシスの誘導 Download PDF

Info

Publication number
JP2008507530A
JP2008507530A JP2007522657A JP2007522657A JP2008507530A JP 2008507530 A JP2008507530 A JP 2008507530A JP 2007522657 A JP2007522657 A JP 2007522657A JP 2007522657 A JP2007522657 A JP 2007522657A JP 2008507530 A JP2008507530 A JP 2008507530A
Authority
JP
Japan
Prior art keywords
cells
tlr3
cancer
cell
poly
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2007522657A
Other languages
English (en)
Japanese (ja)
Other versions
JP2008507530A5 (enExample
Inventor
セルジュ ルベーク，
トゥフィク レノ，
ブルーノ サルーン，
イザベル コステ−インヴァーニジ，
マリー−クロチルド リゾアン，
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of JP2008507530A publication Critical patent/JP2008507530A/ja
Publication of JP2008507530A5 publication Critical patent/JP2008507530A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0331—Animal model for proliferative diseases

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2007522657A 2004-07-20 2005-07-19 Ｔｏｌｌ様受容体を発現する腫瘍細胞におけるアポトーシスの誘導 Pending JP2008507530A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58961604P 2004-07-20 2004-07-20
PCT/US2005/025602 WO2006014653A1 (en) 2004-07-20 2005-07-19 Induction of apoptosis in toll-like receptor expressing tumor cells

Publications (2)

Publication Number Publication Date
JP2008507530A true JP2008507530A (ja) 2008-03-13
JP2008507530A5 JP2008507530A5 (enExample) 2008-08-07

Family

ID=35229744

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007522657A Pending JP2008507530A (ja) 2004-07-20 2005-07-19 Ｔｏｌｌ様受容体を発現する腫瘍細胞におけるアポトーシスの誘導

Country Status (12)

Country Link
US (2) US20060147456A1 (enExample)
EP (1) EP1768699A1 (enExample)
JP (1) JP2008507530A (enExample)
KR (1) KR20070043795A (enExample)
CN (1) CN101018567B (enExample)
AT (1) ATE511859T1 (enExample)
AU (2) AU2005269733B2 (enExample)
CA (1) CA2574176A1 (enExample)
MX (1) MX2007000770A (enExample)
NO (1) NO20070945L (enExample)
RU (1) RU2401661C9 (enExample)
WO (1) WO2006014653A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016121157A (ja) * 2009-12-18 2016-07-07 バヴァリアン・ノルディック・アクティーゼルスカブ 従来型樹状細胞によるｉｆｎ‐ラムダの産生及びその使用

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2258712A3 (en) * 2002-03-15 2011-05-04 Multicell Immunotherapeutics, Inc. Compositions and Methods to Initiate or Enhance Antibody and Major-histocompatibility Class I or Class II-restricted T Cell Responses by Using Immunomodulatory, Non-coding RNA Motifs
AU2004225480A1 (en) * 2003-03-26 2004-10-14 Multicell Immunotherapeutics, Inc. Selected RNA motifs to include cell death and/or apoptosis
WO2006054129A1 (en) * 2004-11-19 2006-05-26 Institut Gustave Roussy Improved treatment of cancer by double-stranded rna
US20120189643A1 (en) * 2004-11-30 2012-07-26 Carton Jill M Toll Like Receptor 3 Antagonists, Methods and Uses
EP2522352B1 (en) 2006-03-02 2017-01-11 Agency for Science, Technology and Research Methods for stem cells modulation
US8957035B2 (en) 2006-05-15 2015-02-17 University Of Kentucky Research Foundation Toll like receptor (TLR) stimulation for ocular angiogenesis and macular degeneration
EP1881080A1 (en) * 2006-07-18 2008-01-23 Institut Gustave Roussy Toll like receptor 4 dysfunction and the biological applications thereof
US20080124366A1 (en) * 2006-08-06 2008-05-29 Ohlfest John R Methods and Compositions for Treating Tumors
JP5115921B2 (ja) * 2007-02-28 2013-01-09 株式会社ペルセウスプロテオミクス 腎癌の診断薬および治療薬
AU2008242540A1 (en) * 2007-04-24 2008-10-30 John Wayne Cancer Institute Functional toll-like receptors (TLR) on melanocytes and melanoma cells and uses thereof
SG185942A1 (en) * 2007-11-02 2012-12-28 Agency Science Tech & Res Methods and compounds for preventing and treating a tumour
JP2011505011A (ja) * 2007-11-28 2011-02-17 スマート チューブ，インコーポレイテッド 生体試料の採取、刺激、安定化及び分析のためのデバイス、システム及び方法
AU2009215795A1 (en) 2008-02-21 2009-08-27 University Of Kentucky Research Foundation Ultra-small RNAs as toll-like receptor-3 antagonists
CA2722589A1 (en) 2008-04-25 2009-10-29 Innate Pharma Improved tlr3 agonist compositions
WO2010020590A1 (en) * 2008-08-20 2010-02-25 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting the response to anti-cancer treatment with an agonist of tlr7 or an agonist of tlr8
GB0820698D0 (en) * 2008-11-12 2008-12-17 Ludwig Inst Cancer Res Uses of immunomodulators
WO2010068680A1 (en) 2008-12-10 2010-06-17 Mount Sinai School Of Medicine Of New York University Thelper cell type 17 lineage-specific adjuvants, compositions and methods
US20120301463A1 (en) 2009-09-30 2012-11-29 President And Fellows Of Harvard College Methods for Modulation of Autophagy Through the Modulation of Autophagy-Enhancing Gene Products
KR101250419B1 (ko) * 2010-12-16 2013-04-05 강원대학교산학협력단 Ｔｌｒ 작동제를 포함하는 유방암 방사선 치료 보조제
RU2014103159A (ru) * 2011-07-22 2015-08-27 Павел КАЛИНСКИЙ Опухолесективная модуляция хемокинов
CN102652802A (zh) * 2012-04-18 2012-09-05 南京中医药大学 癌毒方在制备调控肝癌细胞TLRs／NF-κB信号转导药物中的应用
WO2014022287A1 (en) * 2012-07-29 2014-02-06 The Regents Of The University Of Colorado, A Body Corporate Antagonists of the toll-like receptor 1/2 complex
WO2015127002A1 (en) * 2014-02-19 2015-08-27 The Johns Hopkins University Compositions and methods for promoting skin regeneration and hair growth
US10434064B2 (en) 2014-06-04 2019-10-08 Exicure, Inc. Multivalent delivery of immune modulators by liposomal spherical nucleic acids for prophylactic or therapeutic applications
CN105796594A (zh) * 2016-03-28 2016-07-27 南京大学 一种组合物在制备治疗肿瘤药物中的应用及该组合物的使用方法
CN106191238B (zh) * 2016-07-08 2020-01-10 中国医学科学院基础医学研究所 Tlr3预测肿瘤转移、评估预后和选择防治方案的应用
WO2018039629A2 (en) 2016-08-25 2018-03-01 Northwestern University Micellar spherical nucleic acids from thermoresponsive, traceless templates
WO2018209270A1 (en) 2017-05-11 2018-11-15 Northwestern University Adoptive cell therapy using spherical nucleic acids (snas)
CN108295060A (zh) * 2018-04-08 2018-07-20 王长国 一种tlr7激动剂在增强cik细胞对肿瘤细胞杀伤力方面的应用
WO2020232226A1 (en) 2019-05-16 2020-11-19 The Johns Hopkins University Compositions and methods for skin rejuvenation
CN111117966A (zh) * 2020-03-02 2020-05-08 南通大学 一种利用乳酸的体外细胞培养方法
CN111579538B (zh) * 2020-04-22 2022-12-30 山东第一医科大学(山东省医学科学院) 一种利用凋亡试剂盒检测循环肿瘤细胞的方法
CA3221194A1 (en) * 2021-05-24 2022-12-01 Cha Vaccine Research Institute Co., Ltd Immuno-oncology therapeutic composition using adjuvant including lipopeptides and poly (i:c)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003035695A2 (en) * 2001-07-26 2003-05-01 Tanox, Inc. Agents that activate or inhibit toll-like receptor 9
WO2003045431A2 (en) * 2001-11-27 2003-06-05 Schering Corporation Methods for treating cancer using a combination of a tumor-derived dendritic cell inhibitory factor antagonist and a toll-like receptor agonist
WO2003099195A2 (en) * 2002-05-28 2003-12-04 Eisai Co., Ltd. Immunomodulatory compounds and methods of use thereof
WO2004047612A2 (en) * 2002-11-22 2004-06-10 Nuvelo, Inc. Methods of therapy and diagnosis
WO2004050868A1 (ja) * 2002-11-29 2004-06-17 Japan Science And Technology Agency 哺乳動物のＴｏｌｌ様受容体３に結合する新規アダプタータンパク質およびその遺伝子

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3040121B2 (ja) * 1988-01-12 2000-05-08 ジェネンテク，インコーポレイテッド 増殖因子レセプターの機能を阻害することにより腫瘍細胞を処置する方法
CN1040504A (zh) * 1988-06-22 1990-03-21 Hem研究公司 用双链核糖核酸调节淋巴激活素抗性细胞状态
RU2136278C1 (ru) * 1998-04-07 1999-09-10 Государственный научный центр вирусологии и биотехнологии "Вектор" Противоопухолевое средство

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003035695A2 (en) * 2001-07-26 2003-05-01 Tanox, Inc. Agents that activate or inhibit toll-like receptor 9
WO2003045431A2 (en) * 2001-11-27 2003-06-05 Schering Corporation Methods for treating cancer using a combination of a tumor-derived dendritic cell inhibitory factor antagonist and a toll-like receptor agonist
WO2003099195A2 (en) * 2002-05-28 2003-12-04 Eisai Co., Ltd. Immunomodulatory compounds and methods of use thereof
WO2004047612A2 (en) * 2002-11-22 2004-06-10 Nuvelo, Inc. Methods of therapy and diagnosis
WO2004050868A1 (ja) * 2002-11-29 2004-06-17 Japan Science And Technology Agency 哺乳動物のＴｏｌｌ様受容体３に結合する新規アダプタータンパク質およびその遺伝子

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016121157A (ja) * 2009-12-18 2016-07-07 バヴァリアン・ノルディック・アクティーゼルスカブ 従来型樹状細胞によるｉｆｎ‐ラムダの産生及びその使用

Also Published As

Publication number Publication date
WO2006014653A1 (en) 2006-02-09
NO20070945L (no) 2007-02-19
CN101018567A (zh) 2007-08-15
CN101018567B (zh) 2011-07-27
RU2401661C2 (ru) 2010-10-20
KR20070043795A (ko) 2007-04-25
AU2008249173A1 (en) 2008-12-11
US20060147456A1 (en) 2006-07-06
US20090285779A1 (en) 2009-11-19
AU2005269733B2 (en) 2008-10-30
AU2005269733A1 (en) 2006-02-09
RU2007105987A (ru) 2008-08-27
EP1768699A1 (en) 2007-04-04
CA2574176A1 (en) 2006-02-09
ATE511859T1 (de) 2011-06-15
MX2007000770A (es) 2007-03-26
RU2401661C9 (ru) 2011-01-27

Similar Documents

Publication Publication Date Title
RU2401661C2 (ru) Индукция апоптоза в опухолевых клетках, экспрессирующих toll-подобный рецептор
US11274160B2 (en) Antibodies having specificity to Nectin-4 and uses thereof
CN111201038A (zh) Psgl-1拮抗剂及其用途
ES2902835T3 (es) Composiciones celulares mejoradas y métodos para la terapia contra el cáncer
ES2978486T3 (es) Métodos para promover la respuesta de linfocitos T
US11986538B2 (en) Immunoswitch nanoparticles for reprogrammed T cell responses
Luo et al. Activation of Toll-like receptor 3 induces apoptosis of oral squamous carcinoma cells in vitro and in vivo
BR112018015448A2 (en) antibody-drug conjugate, pharmaceutical composition, methods for releasing an active agent, treating a disease, inhibiting tumor progression and inhibiting, decreasing or eliminating the metastatic capacity of a tumor, and, kit.
TW201919706A (zh) 包含ｉｌ－３３拮抗劑的子宮內膜異位症治療劑
US11081235B2 (en) Extracellular matrix metalloproteinase inducer (EMMPRIN) peptides and binding antibodies
TW202035462A (zh) 使用抗ssea-4抗體結合醫療性腫瘤藥劑的組合醫療
US20230040928A1 (en) Antibodies having specificity to her4 and uses thereof
US20210220337A1 (en) Methods of modulating antigenicity to enhance recognition by t-cells
JP5665739B2 (ja) 炎症性疾患を治療するためのｃｄ９５インヒビターの使用
US20240382592A1 (en) Methods for the treatment of anaplastic large cell lymphoma
US9868792B2 (en) Methods of enhancing anti-tumor immunity by administering antibodies to the CCRL2 chemerin receptor
Parihar Characterization of the natural killer cell cytokine response to antibody-coated tumor cells
US20200181279A1 (en) Method for treating cancer using cd14 antagonists
HK1244816A1 (en) Blocking monoclonal antibodies to agr2 and its receptor c4.4a

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20080618

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20080618

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20110315

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20110614

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20110621

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20110714

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20110722

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20110812

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20110819

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20111109