RU2346945C2 - Производные n-гетероциклилметилбензамидов, их получение и их применение в терапии - Google Patents

Производные n-гетероциклилметилбензамидов, их получение и их применение в терапии Download PDF

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Publication number
RU2346945C2
RU2346945C2 RU2006116889/04A RU2006116889A RU2346945C2 RU 2346945 C2 RU2346945 C2 RU 2346945C2 RU 2006116889/04 A RU2006116889/04 A RU 2006116889/04A RU 2006116889 A RU2006116889 A RU 2006116889A RU 2346945 C2 RU2346945 C2 RU 2346945C2
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group
oct
azabicyclo
threo
hydrochloride
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RU2006116889/04A
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English (en)
Russian (ru)
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RU2006116889A (ru
Inventor
Жиад ДАРГАЗАНЛИ (FR)
Жиад Даргазанли
Женевьев ЭСТЕНН-БУТУ (FR)
Женевьев Эстенн-Буту
Паскаль МАГА (FR)
Паскаль Мага
Бенуа МАРАБУ (FR)
Бенуа Марабу
Пьер РОЖЕР (FR)
Пьер РОЖЕР
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Санофи-Авентис
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
RU2006116889/04A 2003-10-17 2004-10-15 Производные n-гетероциклилметилбензамидов, их получение и их применение в терапии RU2346945C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0312165 2003-10-17
FR0312165A FR2861076B1 (fr) 2003-10-17 2003-10-17 Derives de n-heterocyclymethylbenzamide, leur preparation et leur application en therapeutique

Publications (2)

Publication Number Publication Date
RU2006116889A RU2006116889A (ru) 2007-11-27
RU2346945C2 true RU2346945C2 (ru) 2009-02-20

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RU2006116889/04A RU2346945C2 (ru) 2003-10-17 2004-10-15 Производные n-гетероциклилметилбензамидов, их получение и их применение в терапии

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US (3) US7288656B2 (cg-RX-API-DMAC7.html)
EP (1) EP1680421B1 (cg-RX-API-DMAC7.html)
JP (1) JP4853918B2 (cg-RX-API-DMAC7.html)
KR (1) KR101125305B1 (cg-RX-API-DMAC7.html)
CN (2) CN1882587B (cg-RX-API-DMAC7.html)
AT (1) ATE386036T1 (cg-RX-API-DMAC7.html)
AU (1) AU2004281217B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0415489A (cg-RX-API-DMAC7.html)
CA (1) CA2542647C (cg-RX-API-DMAC7.html)
CR (1) CR8342A (cg-RX-API-DMAC7.html)
CY (1) CY1108925T1 (cg-RX-API-DMAC7.html)
DE (1) DE602004011806T2 (cg-RX-API-DMAC7.html)
DK (1) DK1680421T3 (cg-RX-API-DMAC7.html)
EC (1) ECSP066511A (cg-RX-API-DMAC7.html)
ES (1) ES2300837T3 (cg-RX-API-DMAC7.html)
FR (1) FR2861076B1 (cg-RX-API-DMAC7.html)
HR (1) HRP20080186T3 (cg-RX-API-DMAC7.html)
IL (1) IL174940A (cg-RX-API-DMAC7.html)
MA (1) MA28099A1 (cg-RX-API-DMAC7.html)
ME (1) ME00111B (cg-RX-API-DMAC7.html)
NO (1) NO335462B1 (cg-RX-API-DMAC7.html)
NZ (1) NZ547163A (cg-RX-API-DMAC7.html)
OA (1) OA13317A (cg-RX-API-DMAC7.html)
PL (1) PL1680421T3 (cg-RX-API-DMAC7.html)
PT (1) PT1680421E (cg-RX-API-DMAC7.html)
RS (2) RS20060314A (cg-RX-API-DMAC7.html)
RU (1) RU2346945C2 (cg-RX-API-DMAC7.html)
SG (1) SG147435A1 (cg-RX-API-DMAC7.html)
TN (1) TNSN06110A1 (cg-RX-API-DMAC7.html)
UA (1) UA81186C2 (cg-RX-API-DMAC7.html)
WO (1) WO2005037783A2 (cg-RX-API-DMAC7.html)
ZA (1) ZA200603861B (cg-RX-API-DMAC7.html)

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FR2861071B1 (fr) * 2003-10-17 2006-01-06 Sanofi Synthelabo Derives de n-[phenyl(alkylpiperidin-2-yl) methyl]benzamide, leur prepartation et leur application en therapeutique
FR2861074B1 (fr) * 2003-10-17 2006-04-07 Sanofi Synthelabo Derives de n-[phenyl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique
FR2861076B1 (fr) * 2003-10-17 2006-01-06 Sanofi Synthelabo Derives de n-heterocyclymethylbenzamide, leur preparation et leur application en therapeutique
JP2007530664A (ja) * 2004-03-30 2007-11-01 ペインセプター ファーマ コーポレーション ゲートイオンチャンネルを調節するための組成物及び方法
FR2906251B1 (fr) * 2006-09-22 2008-11-07 Sanofi Aventis Sa Derives de pyrrolizine, indolizine et quinolizine, leur preparation et leur application en therapeutique
US11817637B2 (en) 2006-11-18 2023-11-14 Rfmicron, Inc. Radio frequency identification (RFID) moisture tag(s) and sensors with extended sensing via capillaries
US9582981B2 (en) 2014-10-08 2017-02-28 Rfmicron, Inc. Radio frequency identification (RFID) moisture tag(s) and sensors with extended sensing via capillaries
TW200911808A (en) * 2007-07-23 2009-03-16 Astrazeneca Ab Novel compounds
MX2009014235A (es) 2007-08-22 2010-04-27 Abbott Gmbh & Co Kg 4-bencilaminoquinolonas, composiciones farmaceuticas que las contiene y su uso.
ES2397764T3 (es) 2008-04-01 2013-03-11 Abbott Gmbh & Co. Kg Tetrahidroisoquinolinas, composiciones farmacéuticas que las contienen, y su uso en terapia
BRPI0922787A2 (pt) * 2008-12-04 2017-07-11 Sanofi Sa Formas polimórficas de um derivado da azabiciclo-trifluorometil benzamida
JP2012516326A (ja) * 2009-01-28 2012-07-19 アストラゼネカ・アクチエボラーグ ２−アザ−ビシクロ［２．２．１］ヘプタン化合物及びそれらの使用
WO2010087761A1 (en) * 2009-01-28 2010-08-05 Astrazeneca Ab 2-aza-bicyclo[2.2.2]octane compounds and uses thereof
FR2941954B1 (fr) * 2009-02-10 2011-04-08 Sanofi Aventis Derives de n-°(6-aza-bicyclo°3.2.1!oct-1-yl)-aryl-methyl! benzamide, leur preparation et leur application en therapeutique
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FR2943056A1 (fr) * 2009-03-16 2010-09-17 Sanofi Aventis Derives de n-°2-aza-bicyclo°2.1.1!hex-1-yl)-aryl-methyl!- heterobenzamide, leur preparation et leur application en therapeutique
RU2011141778A (ru) * 2009-03-16 2013-04-27 Санофи Производные n-[(2-азабицикло[2.1.1]гекс-1-ил)арилметил]гетеробензамида, их получение и их применение в терапии
FR2944284A1 (fr) * 2009-04-14 2010-10-15 Sanofi Aventis Derives de n-°7-aza-bicyclo°2.2.1!hept-1-yl)-aryl-methyl! -benzamide, leur preparation et leur application en therapeutique
US8153653B2 (en) 2010-06-22 2012-04-10 Hoffmann-La Roche Inc. Amido-tropane derivatives
US8846743B2 (en) 2010-08-13 2014-09-30 Abbott Laboratories Aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy
US9045459B2 (en) * 2010-08-13 2015-06-02 AbbVie Deutschland GmbH & Co. KG Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
US9051280B2 (en) 2010-08-13 2015-06-09 AbbVie Deutschland GmbH & Co. KG Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy
US8877794B2 (en) 2010-08-13 2014-11-04 Abbott Laboratories Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
US8883839B2 (en) 2010-08-13 2014-11-11 Abbott Laboratories Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy
US9309200B2 (en) 2011-05-12 2016-04-12 AbbVie Deutschland GmbH & Co. KG Benzazepine derivatives, pharmaceutical compositions containing them, and their use in therapy
WO2013020930A1 (en) 2011-08-05 2013-02-14 Abbott Gmbh & Co. Kg Aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, pharmaceutical compositions containing them, and their use in therapy
WO2013072520A1 (en) 2011-11-18 2013-05-23 AbbVie Deutschland GmbH & Co. KG N-substituted aminobenzocycloheptene, aminotetraline, aminoindane and phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
TR201806764T4 (tr) * 2011-11-29 2018-06-21 Vivozon Inc Yeni benzamid türevi ve bunun kullanımı.
US9365512B2 (en) 2012-02-13 2016-06-14 AbbVie Deutschland GmbH & Co. KG Isoindoline derivatives, pharmaceutical compositions containing them, and their use in therapy
US9656955B2 (en) 2013-03-15 2017-05-23 Abbvie Inc. Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy
US9650334B2 (en) 2013-03-15 2017-05-16 Abbvie Inc. Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy
KR20160062164A (ko) 2013-10-17 2016-06-01 아비에 도이치란트 게엠베하 운트 콤파니 카게 아미노크로만, 아미노티오크로만 및 아미노-1,2,3,4-테트라하이드로퀴놀린 유도체, 이들을 포함하는 약제학적 조성물, 및 치료에서 이들의 용도
CA2924699A1 (en) 2013-10-17 2015-04-23 AbbVie Deutschland GmbH & Co. KG Aminotetraline and aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy
US9550754B2 (en) 2014-09-11 2017-01-24 AbbVie Deutschland GmbH & Co. KG 4,5-dihydropyrazole derivatives, pharmaceutical compositions containing them, and their use in therapy
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CA2542647A1 (fr) 2005-04-28
US7619089B2 (en) 2009-11-17
PL1680421T3 (pl) 2008-07-31
CN1882587A (zh) 2006-12-20
PT1680421E (pt) 2008-05-13
FR2861076A1 (fr) 2005-04-22
CA2542647C (fr) 2012-07-10
TNSN06110A1 (fr) 2007-11-15
CN1882587B (zh) 2012-06-27
KR20060109432A (ko) 2006-10-20
JP2007508361A (ja) 2007-04-05
ECSP066511A (es) 2006-10-10
WO2005037783A3 (fr) 2005-07-07
AU2004281217B2 (en) 2010-07-22
SG147435A1 (en) 2008-11-28
BRPI0415489A (pt) 2006-12-26
US20060264441A1 (en) 2006-11-23
ZA200603861B (en) 2007-12-27
KR101125305B1 (ko) 2012-03-27
EP1680421B1 (fr) 2008-02-13
CN101684118B (zh) 2013-04-10
US20100022548A1 (en) 2010-01-28
DE602004011806D1 (de) 2008-03-27
NZ547163A (en) 2010-01-29
UA81186C2 (en) 2007-12-10
CY1108925T1 (el) 2014-07-02
FR2861076B1 (fr) 2006-01-06
CR8342A (es) 2006-10-04
DE602004011806T2 (de) 2009-02-05
HK1098465A1 (en) 2007-07-20
HRP20080186T3 (en) 2008-05-31
IL174940A (en) 2010-11-30
OA13317A (fr) 2007-04-13
ES2300837T3 (es) 2008-06-16
ATE386036T1 (de) 2008-03-15
ME00111B (me) 2010-10-10
JP4853918B2 (ja) 2012-01-11
NO20062030L (no) 2006-07-07
MEP12208A (en) 2010-06-10
CN101684118A (zh) 2010-03-31
RU2006116889A (ru) 2007-11-27
IL174940A0 (en) 2006-08-20
US7288656B2 (en) 2007-10-30
AU2004281217A1 (en) 2005-04-28
HK1142887A1 (en) 2010-12-17
MA28099A1 (fr) 2006-08-01
NO335462B1 (no) 2014-12-15
RS51587B (sr) 2011-08-31
US20080070941A1 (en) 2008-03-20
RS20060314A (sr) 2008-08-07
WO2005037783A2 (fr) 2005-04-28
EP1680421A2 (fr) 2006-07-19
DK1680421T3 (da) 2008-06-09
US8513246B2 (en) 2013-08-20

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