RU2327696C2 - Производные индола, обладающие индуцирующим апоптоз эффектом (варианты), фармацевтическая композиция на их основе - Google Patents

Производные индола, обладающие индуцирующим апоптоз эффектом (варианты), фармацевтическая композиция на их основе Download PDF

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Publication number
RU2327696C2
RU2327696C2 RU2006100022/04A RU2006100022A RU2327696C2 RU 2327696 C2 RU2327696 C2 RU 2327696C2 RU 2006100022/04 A RU2006100022/04 A RU 2006100022/04A RU 2006100022 A RU2006100022 A RU 2006100022A RU 2327696 C2 RU2327696 C2 RU 2327696C2
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RU
Russia
Prior art keywords
unsubstituted
substituted
chlorobenzyl
indol
compounds
Prior art date
Application number
RU2006100022/04A
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English (en)
Russian (ru)
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RU2006100022A (ru
Inventor
Сильке БААСНЕР (DE)
Сильке БААСНЕР
Матиас ГЕРЛАХ (DE)
Матиас ГЕРЛАХ
Экхард ГЮНТЕР (DE)
Экхард ГЮНТЕР
Петер ШМИДТ (DE)
Петер ШМИДТ
Тильман ШУСТЕР (DE)
Тильман ШУСТЕР
Петер ЭМИГ (DE)
Петер Эмиг
Original Assignee
Центарис Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP03012868A external-priority patent/EP1484329A1/de
Priority claimed from EP04011598A external-priority patent/EP1595878A1/de
Application filed by Центарис Гмбх filed Critical Центарис Гмбх
Publication of RU2006100022A publication Critical patent/RU2006100022A/ru
Application granted granted Critical
Publication of RU2327696C2 publication Critical patent/RU2327696C2/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
RU2006100022/04A 2003-06-05 2004-05-25 Производные индола, обладающие индуцирующим апоптоз эффектом (варианты), фармацевтическая композиция на их основе RU2327696C2 (ru)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US47627703P 2003-06-05 2003-06-05
US60/476,277 2003-06-05
EP03012868.0 2003-06-06
EP03012868A EP1484329A1 (de) 2003-06-06 2003-06-06 Indolderivate mit Apoptose induzierender Wirkung
EP04011598A EP1595878A1 (de) 2004-05-15 2004-05-15 Indolderivate mit Apoptose induzierender Wirkung
EP04011598.2 2004-05-15

Publications (2)

Publication Number Publication Date
RU2006100022A RU2006100022A (ru) 2006-05-27
RU2327696C2 true RU2327696C2 (ru) 2008-06-27

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
RU2006100022/04A RU2327696C2 (ru) 2003-06-05 2004-05-25 Производные индола, обладающие индуцирующим апоптоз эффектом (варианты), фармацевтическая композиция на их основе

Country Status (12)

Country Link
EP (1) EP1641777A1 (pt)
JP (1) JP4878285B2 (pt)
KR (1) KR101132599B1 (pt)
CN (1) CN1816543B (pt)
AU (1) AU2004245198B2 (pt)
BR (1) BRPI0410998A (pt)
CA (1) CA2526663C (pt)
MX (1) MXPA05013121A (pt)
NZ (1) NZ543853A (pt)
RS (1) RS20050901A (pt)
RU (1) RU2327696C2 (pt)
WO (1) WO2004108702A1 (pt)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2519145C2 (ru) * 2008-10-16 2014-06-10 Эррэй Биофарма Инк. Ингибиторы митоза для интенсификации процесса апоптоза при терапии

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8217042B2 (en) 2005-11-11 2012-07-10 Zentaris Gmbh Pyridopyrazines and their use as modulators of kinases
EP1957487A1 (de) * 2005-11-11 2008-08-20 AEterna Zentaris GmbH Neue pyridopyrazine und deren verwendung als modulatoren von kinasen
EP1790342A1 (de) 2005-11-11 2007-05-30 Zentaris GmbH Pyridopyrazin-Derivate und deren Verwendung als Modulatoren der Signaltransduktionswege
CN101360422B (zh) * 2005-11-23 2013-10-23 得克萨斯大学体系董事会 致癌Ras特异性细胞毒化合物及其使用方法
SG176477A1 (en) * 2006-08-07 2011-12-29 Ironwood Pharmaceuticals Inc Indole compounds
AU2007325797B2 (en) * 2006-11-28 2014-03-13 Ziopharm Oncology, Inc. Use of indolyl-3-glyoxylic acid derivatives including indibulin, alone or in combination with further agents for treating cancer
WO2012017325A2 (en) * 2010-07-19 2012-02-09 Procaps Sa Apparatus and process for encapsulating microparticles with liquid in soft gel capsules

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19814838C2 (de) * 1998-04-02 2001-01-18 Asta Medica Ag Indolyl-3-glyoxylsäure-Derivate mit Antitumorwirkung
TWI269654B (en) * 1999-09-28 2007-01-01 Baxter Healthcare Sa N-substituted indole-3-glyoxylamide compounds having anti-tumor action
DE19962300A1 (de) * 1999-12-23 2001-06-28 Asta Medica Ag Substituierte N-Benzyl-Indol-3-yl-glyoxylsäure-Derivate mit Antitumorwirkung
IT1318641B1 (it) * 2000-07-25 2003-08-27 Novuspharma Spa Ammidi di acidi 2-(1h-indol-3-il)-2-oxo-acetici ad attivita'antitumorale.
DE10037310A1 (de) * 2000-07-28 2002-02-07 Asta Medica Ag Neue Indolderivate und deren Verwendung als Arzneimittel
JP2005504790A (ja) * 2001-09-13 2005-02-17 シンタ ファーマスーティカルズ コーポレイション 癌を治療するための３−グリオキシリルアミドインドール

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2519145C2 (ru) * 2008-10-16 2014-06-10 Эррэй Биофарма Инк. Ингибиторы митоза для интенсификации процесса апоптоза при терапии

Also Published As

Publication number Publication date
NZ543853A (en) 2009-09-25
JP4878285B2 (ja) 2012-02-15
CA2526663C (en) 2011-07-19
CA2526663A1 (en) 2004-12-16
BRPI0410998A (pt) 2006-07-04
EP1641777A1 (de) 2006-04-05
CN1816543B (zh) 2011-01-19
CN1816543A (zh) 2006-08-09
KR20060034230A (ko) 2006-04-21
WO2004108702A1 (de) 2004-12-16
RU2006100022A (ru) 2006-05-27
AU2004245198A1 (en) 2004-12-16
JP2007523850A (ja) 2007-08-23
RS20050901A (en) 2007-12-31
AU2004245198B2 (en) 2009-04-23
MXPA05013121A (es) 2006-03-17
KR101132599B1 (ko) 2012-06-21

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Effective date: 20130526