RS20050901A - Indole derivatives with apoptosis- inducing effect - Google Patents

Indole derivatives with apoptosis- inducing effect

Info

Publication number
RS20050901A
RS20050901A YUP-2005/0901A YUP20050901A RS20050901A RS 20050901 A RS20050901 A RS 20050901A YU P20050901 A YUP20050901 A YU P20050901A RS 20050901 A RS20050901 A RS 20050901A
Authority
RS
Serbia
Prior art keywords
indole derivatives
apoptosis
inducing effect
medicaments
inducing
Prior art date
Application number
YUP-2005/0901A
Other languages
Serbian (sr)
Inventor
Matthias Gerlach
Tilmann Schuster
Peter Emig
Peter Schmidt
Silke Bassner
Eckhard Gunther
Original Assignee
Zentaris Gmbh.,
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP03012868A external-priority patent/EP1484329A1/en
Priority claimed from EP04011598A external-priority patent/EP1595878A1/en
Application filed by Zentaris Gmbh., filed Critical Zentaris Gmbh.,
Publication of RS20050901A publication Critical patent/RS20050901A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Abstract

The invention relates to indole derivatives used as medicaments for the treatment of tumoral diseases, particularly in case of resistance of medicaments against other active ingredients and metastasing carcinoma.
YUP-2005/0901A 2003-06-05 2004-05-25 Indole derivatives with apoptosis- inducing effect RS20050901A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US47627703P 2003-06-05 2003-06-05
EP03012868A EP1484329A1 (en) 2003-06-06 2003-06-06 Indole derivatives with apoptosis inducing activity
EP04011598A EP1595878A1 (en) 2004-05-15 2004-05-15 Indole derivatives with apoptosis inducing activity
PCT/EP2004/005593 WO2004108702A1 (en) 2003-06-05 2004-05-25 Indole derivatives with apoptosis-inducing effect

Publications (1)

Publication Number Publication Date
RS20050901A true RS20050901A (en) 2007-12-31

Family

ID=43661564

Family Applications (1)

Application Number Title Priority Date Filing Date
YUP-2005/0901A RS20050901A (en) 2003-06-05 2004-05-25 Indole derivatives with apoptosis- inducing effect

Country Status (12)

Country Link
EP (1) EP1641777A1 (en)
JP (1) JP4878285B2 (en)
KR (1) KR101132599B1 (en)
CN (1) CN1816543B (en)
AU (1) AU2004245198B2 (en)
BR (1) BRPI0410998A (en)
CA (1) CA2526663C (en)
MX (1) MXPA05013121A (en)
NZ (1) NZ543853A (en)
RS (1) RS20050901A (en)
RU (1) RU2327696C2 (en)
WO (1) WO2004108702A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8217042B2 (en) 2005-11-11 2012-07-10 Zentaris Gmbh Pyridopyrazines and their use as modulators of kinases
WO2007054556A1 (en) * 2005-11-11 2007-05-18 Æterna Zentaris Gmbh Novel pyridopyrazines and their use as modulators of kinases
EP1790342A1 (en) 2005-11-11 2007-05-30 Zentaris GmbH Pyridopyrazine derivatives and their use as signal transduction modulators
AU2006318212C1 (en) * 2005-11-23 2012-08-30 The Board Of Regents Of The University Of Texas System Oncogenic ras-specific cytotoxic compound and methods of use thereof
WO2008019357A2 (en) * 2006-08-07 2008-02-14 Ironwood Pharmaceuticals, Inc. Indole compounds
WO2008066807A1 (en) * 2006-11-28 2008-06-05 Ziopharm Oncology, Inc. Use of indolyl-3-glyoxylic acid derivatives including indibulin, alone or in combination with further agents for treating cancer
JP5749170B2 (en) * 2008-10-16 2015-07-15 アレイ バイオファーマ、インコーポレイテッド Inhibitors of mitosis to increase apoptosis in therapy
WO2012017325A2 (en) * 2010-07-19 2012-02-09 Procaps Sa Apparatus and process for encapsulating microparticles with liquid in soft gel capsules

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19814838C2 (en) * 1998-04-02 2001-01-18 Asta Medica Ag Indolyl-3-glyoxylic acid derivatives with anti-tumor effects
TWI269654B (en) * 1999-09-28 2007-01-01 Baxter Healthcare Sa N-substituted indole-3-glyoxylamide compounds having anti-tumor action
DE19962300A1 (en) * 1999-12-23 2001-06-28 Asta Medica Ag New N-benzylindolyl glyoxylic acid derivatives are useful as antitumor agents
IT1318641B1 (en) * 2000-07-25 2003-08-27 Novuspharma Spa AMID ACIDS 2- (1H-INDOL-3-IL) -2-OXO-ACETICS WITH ANTI-TUMOR ACTIVITY.
DE10037310A1 (en) * 2000-07-28 2002-02-07 Asta Medica Ag New indole derivatives and their use as medicines
CA2460347A1 (en) * 2001-09-13 2003-03-20 Synta Pharmaceuticals Corp. 3-glyoxlylamideindoles for treating cancer

Also Published As

Publication number Publication date
AU2004245198A1 (en) 2004-12-16
RU2006100022A (en) 2006-05-27
CA2526663C (en) 2011-07-19
NZ543853A (en) 2009-09-25
CA2526663A1 (en) 2004-12-16
KR20060034230A (en) 2006-04-21
AU2004245198B2 (en) 2009-04-23
KR101132599B1 (en) 2012-06-21
JP2007523850A (en) 2007-08-23
WO2004108702A1 (en) 2004-12-16
CN1816543B (en) 2011-01-19
EP1641777A1 (en) 2006-04-05
MXPA05013121A (en) 2006-03-17
CN1816543A (en) 2006-08-09
JP4878285B2 (en) 2012-02-15
RU2327696C2 (en) 2008-06-27
BRPI0410998A (en) 2006-07-04

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