RU2293734C9 - Трициклические противоопухолевые соединения, фармацевтическая композиция и способ лечения на их основе - Google Patents

Трициклические противоопухолевые соединения, фармацевтическая композиция и способ лечения на их основе Download PDF

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Publication number
RU2293734C9
RU2293734C9 RU2003108865/04A RU2003108865A RU2293734C9 RU 2293734 C9 RU2293734 C9 RU 2293734C9 RU 2003108865/04 A RU2003108865/04 A RU 2003108865/04A RU 2003108865 A RU2003108865 A RU 2003108865A RU 2293734 C9 RU2293734 C9 RU 2293734C9
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Russia
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group
compound
substituted
alkyl
mmol
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RU2003108865/04A
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English (en)
Russian (ru)
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RU2003108865A (ru
RU2293734C2 (ru
Inventor
Ф. Джордж НЬОРОГЕ (US)
Ф. Джордж НЬОРОГЕ
Банча ВИБУЛБХАН (US)
Банча ВИБУЛБХАН
Элэн Б. КУПЕР (US)
Элэн Б. КУПЕР
Тимоти ГУЗИ (US)
Тимоти ГУЗИ
Динанат Ф. РЕЙН (US)
Динанат Ф. РЕЙН
Кит П. МАЙНОР (US)
Кит П. МАЙНОР
Роунэлд Дж. ДОЛЛ (US)
Роунэлд Дж. ДОЛЛ
Вийур Мупил ГИРИЯВАЛЛАБХАН (US)
Вийур Мупил ГИРИЯВАЛЛАБХАН
Бама САНТАНАМ (US)
Бама САНТАНАМ
Патрик Э. ПИНТО (US)
Патрик Э. ПИНТО
Хью Й. ЖУ (US)
Хью Й. ЖУ
Картик М. КИРТИКАР (US)
Картик М. КИРТИКАР
Кармен С. АЛЬВАРЕЗ (US)
Кармен С. АЛЬВАРЕЗ
Джон Дж. БОЛДВИН (US)
Джон Дж. БОЛДВИН
Ге ЛИ (US)
Ге ЛИ
Чиа-Йу ХУАНГ (US)
Чиа-Йу ХУАНГ
Рэй Э. ДЖЕЙМС (US)
Рэй Э. ДЖЕЙМС
Роберт В. БИШОП (US)
Роберт В. БИШОП
Джеймс ВАНГ (US)
Джеймс ВАНГ
Ягдиш Э. ДИСЕЙ (US)
Ягдиш Э. ДИСЕЙ
Original Assignee
Шеринг Корпорейшн
Фармакопие Драг Дискавери, Инк.
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Publication of RU2003108865A publication Critical patent/RU2003108865A/ru
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Publication of RU2293734C2 publication Critical patent/RU2293734C2/ru
Publication of RU2293734C9 publication Critical patent/RU2293734C9/ru

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D221/00Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04Ortho- or peri-condensed ring systems
    • C07D221/06Ring systems of three rings
    • C07D221/16Ring systems of three rings containing carbocyclic rings other than six-membered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
RU2003108865/04A 2000-08-30 2001-08-28 Трициклические противоопухолевые соединения, фармацевтическая композиция и способ лечения на их основе RU2293734C9 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22918300P 2000-08-30 2000-08-30
US60/229,183 2000-08-30

Publications (3)

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RU2003108865A RU2003108865A (ru) 2004-11-27
RU2293734C2 RU2293734C2 (ru) 2007-02-20
RU2293734C9 true RU2293734C9 (ru) 2007-10-10

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RU2003108865/04A RU2293734C9 (ru) 2000-08-30 2001-08-28 Трициклические противоопухолевые соединения, фармацевтическая композиция и способ лечения на их основе

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US (1) US20020198216A1 (enExample)
EP (1) EP1313725B1 (enExample)
JP (1) JP2004513885A (enExample)
KR (1) KR20030034161A (enExample)
CN (1) CN100384837C (enExample)
AR (1) AR033680A1 (enExample)
AT (1) ATE359281T1 (enExample)
AU (2) AU2001288451C1 (enExample)
BR (1) BR0113675A (enExample)
CA (1) CA2420673A1 (enExample)
CO (1) CO5640109A2 (enExample)
DE (1) DE60127846T2 (enExample)
EC (1) ECSP034494A (enExample)
ES (1) ES2284686T3 (enExample)
HK (1) HK1054548B (enExample)
HU (1) HUP0302942A3 (enExample)
IL (1) IL154528A0 (enExample)
MX (1) MXPA03001849A (enExample)
NO (1) NO20030918L (enExample)
NZ (1) NZ524246A (enExample)
PE (1) PE20020486A1 (enExample)
PL (1) PL361103A1 (enExample)
RU (1) RU2293734C9 (enExample)
SK (1) SK2292003A3 (enExample)
TW (1) TWI268280B (enExample)
WO (1) WO2002018368A1 (enExample)
ZA (1) ZA200301545B (enExample)

Families Citing this family (17)

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Publication number Priority date Publication date Assignee Title
US7342016B2 (en) 2000-08-30 2008-03-11 Schering Corporation Farnesyl protein transferase inhibitors as antitumor agents
US7312237B2 (en) * 2001-03-14 2007-12-25 Bristol-Myers Squibb Co. Combination of epothilone analogs and chemotherapeutic agents for the treatment of prolilferative diseases
WO2003030908A2 (en) * 2001-10-09 2003-04-17 The University Of Cincinnati Inhibitors of the egf receptor for the treatment of thyroid cancer
AU2002352941A1 (en) * 2001-11-30 2003-06-17 Schering Corporation Use of an farsenyl protein tranferase inhibitor in combination with other antineoplastic agents for the manufacture of a medicament against cancer
CA2468996A1 (en) * 2001-12-03 2003-06-12 Schering Corporation Use of fpt inhibitors and at least two antineoplastic agents in the treatment of cancer
US20030195192A1 (en) * 2002-04-05 2003-10-16 Fortuna Haviv Nicotinamides having antiangiogenic activity
US20040014744A1 (en) * 2002-04-05 2004-01-22 Fortuna Haviv Substituted pyridines having antiangiogenic activity
EP2260846B1 (en) * 2003-03-27 2018-11-28 Lankenau Institute for Medical Research Novel methods for the treatment of cancer
JP2006526662A (ja) * 2003-06-05 2006-11-24 アシュカル,チャールズ 過増殖性細胞疾患を治療する方法
RU2431500C2 (ru) * 2003-06-09 2011-10-20 Самуэль ВАКСАЛ Способ ингибирования рецепторных тирозинкиназ с помощью внеклеточного антагониста и внутриклеточного антагониста
ES2235611B2 (es) * 2003-07-25 2006-07-16 Universidade De Santiago De Compostela Metodo cuantitativo para la deteccion de yesotoxinas en productos pesqueros basado en la activacion que producen en las fosfodiesterasas.
AU2004263493A1 (en) * 2003-08-07 2005-02-17 Schering Corporation Novel farnesyl protein transferase inhibitors as antitumor agents
US7592466B2 (en) 2003-10-09 2009-09-22 Abbott Laboratories Ureas having antiangiogenic activity
CN101124219A (zh) * 2004-12-21 2008-02-13 先灵公司 用作抗肿瘤剂的新的法呢基蛋白质转移酶抑制剂
RU2361587C1 (ru) * 2008-02-14 2009-07-20 Михаил Владимирович Кутушов Лекарственное средство для лечения онкологических заболеваний
WO2010006432A1 (en) * 2008-07-14 2010-01-21 Queen's University At Kingston Pharmaceutical compositions comprising ret inhibitors and methods for the treatment of cancer
US20220257540A1 (en) * 2019-06-28 2022-08-18 Anhui Ronghang Biotech Development Co., Ltd. Compositions and methods for treatment of hepatitis b virus infection

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5089496A (en) * 1986-10-31 1992-02-18 Schering Corporation Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies
RU2086549C1 (ru) * 1990-06-22 1997-08-10 Шеринг Корпорейшн Производные бис-бензо- или бензопиридо-циклогептапиперидина, пиперидилидена и пеперазина и фармацевтическая композиция на их основе
US5925648A (en) * 1997-07-29 1999-07-20 Schering Corporation Tricyclic N-cyanoimines useful as inhibitors of a farnesyl-protein transferase
US6071907A (en) * 1996-09-13 2000-06-06 Schering Corporation Tricyclic compounds useful as FPT inhibitors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5719148A (en) * 1993-10-15 1998-02-17 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
PE92098A1 (es) * 1996-07-31 1998-12-31 Schering Corp N-cianoiminas triciclicas utiles como inhibidores de transferasa de proteina farnesilo
CZ20011900A3 (cs) * 1998-12-18 2002-02-13 Schering Corporation Látka, způsob léčby a farmaceutický přípravek tuto látku obsahující a jeho pouľití k inhibici farnesyl protein transferázy

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5089496A (en) * 1986-10-31 1992-02-18 Schering Corporation Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies
RU2086549C1 (ru) * 1990-06-22 1997-08-10 Шеринг Корпорейшн Производные бис-бензо- или бензопиридо-циклогептапиперидина, пиперидилидена и пеперазина и фармацевтическая композиция на их основе
US6071907A (en) * 1996-09-13 2000-06-06 Schering Corporation Tricyclic compounds useful as FPT inhibitors
US5925648A (en) * 1997-07-29 1999-07-20 Schering Corporation Tricyclic N-cyanoimines useful as inhibitors of a farnesyl-protein transferase

Also Published As

Publication number Publication date
CN1471524A (zh) 2004-01-28
SK2292003A3 (en) 2003-08-05
HUP0302942A3 (en) 2007-02-28
PE20020486A1 (es) 2002-06-14
AU8845101A (en) 2002-03-13
ECSP034494A (es) 2003-04-25
AR033680A1 (es) 2004-01-07
CO5640109A2 (es) 2006-05-31
AU2001288451B2 (en) 2007-05-24
DE60127846T2 (de) 2008-03-06
HUP0302942A2 (hu) 2003-12-29
TWI268280B (en) 2006-12-11
EP1313725A1 (en) 2003-05-28
JP2004513885A (ja) 2004-05-13
EP1313725B1 (en) 2007-04-11
ATE359281T1 (de) 2007-05-15
CA2420673A1 (en) 2002-03-07
NO20030918D0 (no) 2003-02-27
HK1054548A1 (en) 2003-12-05
IL154528A0 (en) 2003-09-17
ZA200301545B (en) 2004-06-22
PL361103A1 (en) 2004-09-20
HK1054548B (en) 2007-10-18
DE60127846D1 (en) 2007-05-24
WO2002018368A1 (en) 2002-03-07
AU2001288451C1 (en) 2008-03-06
US20020198216A1 (en) 2002-12-26
MXPA03001849A (es) 2003-06-04
BR0113675A (pt) 2003-06-24
RU2293734C2 (ru) 2007-02-20
NZ524246A (en) 2004-11-26
KR20030034161A (ko) 2003-05-01
NO20030918L (no) 2003-04-29
ES2284686T3 (es) 2007-11-16
CN100384837C (zh) 2008-04-30

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Effective date: 20090829