RU2243226C2 - Новые производные бензимидазола и содержащие эти соединения фармацевтические композиции - Google Patents
Новые производные бензимидазола и содержащие эти соединения фармацевтические композицииInfo
- Publication number
- RU2243226C2 RU2243226C2 RU2001131104/04A RU2001131104A RU2243226C2 RU 2243226 C2 RU2243226 C2 RU 2243226C2 RU 2001131104/04 A RU2001131104/04 A RU 2001131104/04A RU 2001131104 A RU2001131104 A RU 2001131104A RU 2243226 C2 RU2243226 C2 RU 2243226C2
- Authority
- RU
- Russia
- Prior art keywords
- piperazinyl
- alkyl
- benzimidazole
- phenyl
- carboxylate
- Prior art date
Links
- 0 *c1cc(*(C*2)c3c2cc(C(O)O*)cc3)ccc1 Chemical compound *c1cc(*(C*2)c3c2cc(C(O)O*)cc3)ccc1 0.000 description 5
- OQHWKAMJEGNJPD-UHFFFAOYSA-N CC(C(C=CC12)=CC1N=CN2c1cccc(N2CCNCC2)c1)=O Chemical compound CC(C(C=CC12)=CC1N=CN2c1cccc(N2CCNCC2)c1)=O OQHWKAMJEGNJPD-UHFFFAOYSA-N 0.000 description 1
- SBRHZGGBIBUPBC-UHFFFAOYSA-N CCN(CC1)CC=C1c1cccc(Nc(c(N)c2)ccc2C(OCOC)=O)c1 Chemical compound CCN(CC1)CC=C1c1cccc(Nc(c(N)c2)ccc2C(OCOC)=O)c1 SBRHZGGBIBUPBC-UHFFFAOYSA-N 0.000 description 1
- DOFNEDSQQBBBFQ-UHFFFAOYSA-N CCN(CC1)CC=C1c1cccc(Nc(ccc(C(OCOC)=O)c2)c2[N+]([O-])=O)c1 Chemical compound CCN(CC1)CC=C1c1cccc(Nc(ccc(C(OCOC)=O)c2)c2[N+]([O-])=O)c1 DOFNEDSQQBBBFQ-UHFFFAOYSA-N 0.000 description 1
- SWUAUESANMWSRU-UHFFFAOYSA-N CCOC(CN(CC1)CCN1C(CC(C1)C2CCCCC2)CC1[n]1c(ccc(-c2c[o]cc2)c2)c2nc1)=O Chemical compound CCOC(CN(CC1)CCN1C(CC(C1)C2CCCCC2)CC1[n]1c(ccc(-c2c[o]cc2)c2)c2nc1)=O SWUAUESANMWSRU-UHFFFAOYSA-N 0.000 description 1
- WRUQTHIYVYGQJX-UHFFFAOYSA-N Cc1n[o]c(CN(CC2)CCN2c2cc(-[n]3c(ccc(-c4c[o]cc4)c4)c4nc3)ccc2)n1 Chemical compound Cc1n[o]c(CN(CC2)CCN2c2cc(-[n]3c(ccc(-c4c[o]cc4)c4)c4nc3)ccc2)n1 WRUQTHIYVYGQJX-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA199900888 | 1999-06-22 | ||
| DKPA199900888 | 1999-06-22 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2001131104A RU2001131104A (ru) | 2003-07-20 |
| RU2243226C2 true RU2243226C2 (ru) | 2004-12-27 |
Family
ID=8098669
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2001131104/04A RU2243226C2 (ru) | 1999-06-22 | 2000-06-22 | Новые производные бензимидазола и содержащие эти соединения фармацевтические композиции |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US6649609B2 (enExample) |
| EP (1) | EP1194410B1 (enExample) |
| JP (1) | JP2003502405A (enExample) |
| CN (1) | CN1167686C (enExample) |
| AT (1) | ATE316076T1 (enExample) |
| AU (1) | AU777961B2 (enExample) |
| BR (1) | BR0011823A (enExample) |
| CA (1) | CA2373921A1 (enExample) |
| DE (1) | DE60025604T2 (enExample) |
| IL (2) | IL146403A0 (enExample) |
| MX (1) | MXPA02000107A (enExample) |
| NZ (1) | NZ515543A (enExample) |
| RU (1) | RU2243226C2 (enExample) |
| WO (1) | WO2000078728A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2435759C2 (ru) * | 2006-03-24 | 2011-12-10 | НьюроСёрч А/С | Производные бензимидазолов и их применение для модуляции гамка-рецепторного комплекса |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6489346B1 (en) * | 1996-01-04 | 2002-12-03 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and method of using same |
| US5840737A (en) | 1996-01-04 | 1998-11-24 | The Curators Of The University Of Missouri | Omeprazole solution and method for using same |
| JP2003502405A (ja) * | 1999-06-22 | 2003-01-21 | ニューロサーチ、アクティーゼルスカブ | 新規ベンズイミダゾール誘導体及びこれらの化合物を含有する薬学的に容認された塩 |
| SE9904724D0 (sv) | 1999-12-22 | 1999-12-22 | Carlsson A Research Ab | New modulators of dopamine neurotransmission I |
| SE9904723D0 (sv) | 1999-12-22 | 1999-12-22 | Carlsson A Research Ab | New modulators of dopamine neurotransmission II |
| USRE46117E1 (en) | 1999-12-22 | 2016-08-23 | Teva Pharmaceuticals International Gmbh | Modulators of dopamine neurotransmission |
| GB0117277D0 (en) * | 2001-07-16 | 2001-09-05 | Merck Sharp & Dohme | Therapeutic agents |
| DE60115282T2 (de) * | 2000-11-10 | 2006-08-10 | Merck Sharp & Dohme Ltd., Hoddesdon | Imidazotriazin-derivate als liganden für gaba-rezeptoren |
| WO2002050057A1 (en) * | 2000-12-20 | 2002-06-27 | Neurosearch A/S | Novel benzimidazole derivatives for the treatment of gaba-alpha mediated disorders |
| PA8535601A1 (es) | 2000-12-21 | 2002-11-28 | Pfizer | Derivados benzimidazol y piridilimidazol como ligandos para gabaa |
| US6743796B2 (en) * | 2001-05-07 | 2004-06-01 | Wyeth | Piperazinyl-isatins |
| AUPR625901A0 (en) * | 2001-07-10 | 2001-08-02 | Mcgregor, Neil | A method for treatment and/or prophylaxis |
| GB0212048D0 (en) | 2002-05-24 | 2002-07-03 | Merck Sharp & Dohme | Therapeutic agents |
| JP2006522069A (ja) | 2003-04-03 | 2006-09-28 | ニューロサーチ、アクティーゼルスカブ | ベンズイミダゾール誘導体及びこれをｇａｂａａ受容体複合体をモジュレートするために使用する方法 |
| NZ541544A (en) | 2003-04-03 | 2008-06-30 | Neurosearch As | Benzimidazole derivatives and their use for modulating the GABAA receptor complex |
| EP1615896B1 (en) * | 2003-04-10 | 2008-04-23 | Neurosearch A/S | Novel benzimidazole derivatives and pharmaceutical compositions comprising these compounds |
| EP1678144A1 (en) * | 2003-10-23 | 2006-07-12 | Akzo Nobel N.V. | 1,5,7-TRISUBSTITUTED BENZIMIDAZOLE DERIVATIVES AND THEIR USE FOR MODULATING THE GABA-a RECEPTOR COMPLEX |
| NZ547109A (en) | 2003-10-28 | 2010-03-26 | Vertex Pharma | Benzimidazoles useful as modulators of ion channels |
| ZA200603165B (en) * | 2003-11-03 | 2007-07-25 | Probiodrug Ag | Combinations useful for the treatment of neuronal disorders |
| US20060185357A1 (en) * | 2004-05-07 | 2006-08-24 | Kovacevich Ian D | Independently drawing and tensioning lines with bi-directional rotary device having two spools |
| MXPA06013944A (es) | 2004-06-08 | 2007-10-08 | Neurosearch Sweden Ab | Nuevas fenilpiperidinas/piperazinas disustituidas como moduladores de la neurotransmision de dopamina. |
| US7851629B2 (en) | 2004-06-08 | 2010-12-14 | Nsab, Filial Af Neurosearch Sweden Ab, Sverige | Disubstituted phenylpiperidines as modulators of dopamine and serotonin neurotransmission |
| AU2005293754B2 (en) | 2004-10-13 | 2011-07-21 | Teva Pharmaceuticals International Gmbh | Process for the synthesis of 4-(3-methanesulfonylphenyl)-1-N-propyl-piperidine |
| BRPI0606110A2 (pt) | 2005-01-25 | 2009-06-02 | Epix Delaware Inc | compostos de arilamina substituìdos e seu uso como 5 - ht6 moduladores |
| WO2006108800A1 (en) * | 2005-04-13 | 2006-10-19 | Neurosearch A/S | Benzimidazole derivatives and their use for modulating the gabaa receptor complex |
| US20090062304A1 (en) * | 2005-04-19 | 2009-03-05 | Lene Teuber | Benzimidazole derivatives and their use for modulating the gaba-alpha receptor complex |
| WO2006111516A1 (en) * | 2005-04-19 | 2006-10-26 | Neurosearch A/S | Benzimidazole derivatives and their use for modulating the gabaa receptor complex |
| EP1874735A1 (en) * | 2005-04-19 | 2008-01-09 | Neurosearch A/S | Benzimidazole derivatives and their use for modulating the gabaa receptor complex |
| SE529246C2 (sv) | 2005-10-13 | 2007-06-12 | Neurosearch Sweden Ab | Nya disubstituerade fenyl-piperidiner som modulatorer för dopaminneurotransmission |
| US7858649B2 (en) | 2005-10-14 | 2010-12-28 | Neurosearch A/S | Imidazole derivatives and their use for modulating the GABAA receptor complex |
| WO2007042545A1 (en) * | 2005-10-14 | 2007-04-19 | Neurosearch A/S | Imidazole derivatives and their use for modulating the gaba-a receptor complex |
| CA2632395A1 (en) * | 2005-12-05 | 2007-06-14 | Neurosearch A/S | Benzimidazole derivatives and their use for modulating the gabaa receptor complex |
| JO2972B1 (en) * | 2007-06-08 | 2016-03-15 | جانسين فارماسوتيكا ان. في | Piperidine / piperazine derivatives |
| JP5443342B2 (ja) | 2007-06-08 | 2014-03-19 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ピペリジン／ピペラジン誘導体 |
| AU2008258487B2 (en) * | 2007-06-08 | 2012-11-15 | Janssen Pharmaceutica N.V. | Piperidine/piperazine derivatives |
| JP5464709B2 (ja) * | 2007-06-08 | 2014-04-09 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ピペリジン／ピペラジン誘導体 |
| ES2617619T3 (es) * | 2008-06-05 | 2017-06-19 | Janssen Pharmaceutica, N.V. | Combinaciones de fármacos que comprenden un inhibidor de DGAT y un agonista de PPAR |
| CN102206204B (zh) * | 2011-04-08 | 2012-12-12 | 奇方(天津)医药科技有限公司 | 一种苯并咪唑类化合物及其医药用途 |
| US9012476B2 (en) | 2011-12-08 | 2015-04-21 | IVAX International GmbH | Hydrobromide salt of pridopidine |
| JP6177875B2 (ja) | 2012-04-04 | 2017-08-09 | テバ・ファーマシューティカルズ・インターナショナル・ゲーエムベーハーＴｅｖａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｔｅｒｎａｔｉｏｎａｌ ＧｍｂＨ | 併用療法のための医薬組成物 |
| KR20200023034A (ko) * | 2018-08-24 | 2020-03-04 | 일양약품주식회사 | 이속사졸 유도체 및 그의 제조방법 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2059623C1 (ru) * | 1989-02-02 | 1996-05-10 | Яманути Фармасьютикал Ко., Лтд. | Тетрагидробензимидазольное производное или его фармацевтически приемлемая соль и фармацевтическая композиция на его основе, проявляющая активность 5-ht3-антагониста |
| EP0616807B1 (en) * | 1993-03-24 | 1998-07-08 | Neurosearch A/S | Benzimidazole useful in the treatment of central nervous system disorders |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE788751A (fr) * | 1971-09-13 | 1973-01-02 | Teijin Ltd | Membranes polymeres permselectives |
| US5149814A (en) * | 1987-09-30 | 1992-09-22 | Pfizer Inc | Alkyl 2-benzylidene-4-(2-alkylimidazopyrid-1-yl) benzoylacetate esters as intermediate compounds |
| DE3928177A1 (de) * | 1989-04-08 | 1991-02-28 | Thomae Gmbh Dr K | Benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| JPH05507469A (ja) * | 1990-04-13 | 1993-10-28 | スミスクライン・ビーチャム・コーポレイション | 置換ベンズイミダゾール |
| US6034114A (en) * | 1990-12-14 | 2000-03-07 | Smithkline Beecham Plc | Medicament |
| DK40192D0 (da) * | 1992-03-26 | 1992-03-26 | Neurosearch As | Imidazolforbindelser, deres fremstilling og anvendelse |
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2000
- 2000-06-22 JP JP2001504895A patent/JP2003502405A/ja not_active Ceased
- 2000-06-22 AT AT00938584T patent/ATE316076T1/de not_active IP Right Cessation
- 2000-06-22 RU RU2001131104/04A patent/RU2243226C2/ru not_active IP Right Cessation
- 2000-06-22 AU AU53910/00A patent/AU777961B2/en not_active Ceased
- 2000-06-22 WO PCT/DK2000/000333 patent/WO2000078728A1/en not_active Ceased
- 2000-06-22 NZ NZ515543A patent/NZ515543A/en not_active IP Right Cessation
- 2000-06-22 EP EP00938584A patent/EP1194410B1/en not_active Expired - Lifetime
- 2000-06-22 CN CNB008091730A patent/CN1167686C/zh not_active Expired - Fee Related
- 2000-06-22 CA CA002373921A patent/CA2373921A1/en not_active Abandoned
- 2000-06-22 DE DE60025604T patent/DE60025604T2/de not_active Expired - Lifetime
- 2000-06-22 BR BR0011823-0A patent/BR0011823A/pt not_active Application Discontinuation
- 2000-06-22 IL IL14640300A patent/IL146403A0/xx active IP Right Grant
- 2000-06-22 MX MXPA02000107A patent/MXPA02000107A/es active IP Right Grant
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2001
- 2001-11-08 IL IL146403A patent/IL146403A/en not_active IP Right Cessation
- 2001-12-12 US US10/012,490 patent/US6649609B2/en not_active Expired - Fee Related
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2003
- 2003-07-15 US US10/618,727 patent/US6936613B2/en not_active Expired - Fee Related
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| Publication number | Priority date | Publication date | Assignee | Title |
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| RU2059623C1 (ru) * | 1989-02-02 | 1996-05-10 | Яманути Фармасьютикал Ко., Лтд. | Тетрагидробензимидазольное производное или его фармацевтически приемлемая соль и фармацевтическая композиция на его основе, проявляющая активность 5-ht3-антагониста |
| EP0616807B1 (en) * | 1993-03-24 | 1998-07-08 | Neurosearch A/S | Benzimidazole useful in the treatment of central nervous system disorders |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2435759C2 (ru) * | 2006-03-24 | 2011-12-10 | НьюроСёрч А/С | Производные бензимидазолов и их применение для модуляции гамка-рецепторного комплекса |
| US8288418B2 (en) | 2006-03-24 | 2012-10-16 | Neurosearch A/S | Benzimidazole derivatives and their use for modulating the GABAA receptor complex |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1194410A1 (en) | 2002-04-10 |
| EP1194410B1 (en) | 2006-01-18 |
| US6649609B2 (en) | 2003-11-18 |
| DE60025604D1 (de) | 2006-04-06 |
| AU5391000A (en) | 2001-01-09 |
| US6936613B2 (en) | 2005-08-30 |
| CA2373921A1 (en) | 2000-12-28 |
| IL146403A (en) | 2007-08-19 |
| US20040097570A1 (en) | 2004-05-20 |
| US20030055055A1 (en) | 2003-03-20 |
| AU777961B2 (en) | 2004-11-04 |
| IL146403A0 (en) | 2002-07-25 |
| BR0011823A (pt) | 2002-03-19 |
| ATE316076T1 (de) | 2006-02-15 |
| NZ515543A (en) | 2003-11-28 |
| CN1167686C (zh) | 2004-09-22 |
| CN1356987A (zh) | 2002-07-03 |
| MXPA02000107A (es) | 2002-07-02 |
| DE60025604T2 (de) | 2006-07-27 |
| JP2003502405A (ja) | 2003-01-21 |
| WO2000078728A1 (en) | 2000-12-28 |
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