RU2227749C2 - Комбинация ингибиторов fbpазы и сенсибилизаторов инсулина для лечения диабета - Google Patents

Комбинация ингибиторов fbpазы и сенсибилизаторов инсулина для лечения диабета

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Publication number
RU2227749C2
RU2227749C2 RU2001120726/15A RU2001120726A RU2227749C2 RU 2227749 C2 RU2227749 C2 RU 2227749C2 RU 2001120726/15 A RU2001120726/15 A RU 2001120726/15A RU 2001120726 A RU2001120726 A RU 2001120726A RU 2227749 C2 RU2227749 C2 RU 2227749C2
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Russia
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group
alkyl
aryl
aralkyl
cyclic
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RU2001120726/15A
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English (en)
Russian (ru)
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RU2001120726A (ru
Inventor
Марк Д. ЭРИОН (US)
Марк Д. ЭРИОН
ПУЛЬЕ Пауль ван (US)
ПУЛЬЕ Пауль Ван
Original Assignee
Метабэйсис Терапьютикс, Инк.
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Publication of RU2001120726A publication Critical patent/RU2001120726A/ru
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Reproductive Health (AREA)
  • Child & Adolescent Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
RU2001120726/15A 1998-12-24 1999-12-22 Комбинация ингибиторов fbpазы и сенсибилизаторов инсулина для лечения диабета RU2227749C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11471898P 1998-12-24 1998-12-24
US60/114,718 1998-12-24

Related Child Applications (1)

Application Number Title Priority Date Filing Date
RU2003132054/14A Division RU2003132054A (ru) 1998-12-24 2003-10-31 Комбинация ингибиторов fbpазы и сенсибилизаторов инсулина для лечения диабета

Publications (2)

Publication Number Publication Date
RU2001120726A RU2001120726A (ru) 2003-04-20
RU2227749C2 true RU2227749C2 (ru) 2004-04-27

Family

ID=22357016

Family Applications (2)

Application Number Title Priority Date Filing Date
RU2001120726/15A RU2227749C2 (ru) 1998-12-24 1999-12-22 Комбинация ингибиторов fbpазы и сенсибилизаторов инсулина для лечения диабета
RU2003132054/14A RU2003132054A (ru) 1998-12-24 2003-10-31 Комбинация ингибиторов fbpазы и сенсибилизаторов инсулина для лечения диабета

Family Applications After (1)

Application Number Title Priority Date Filing Date
RU2003132054/14A RU2003132054A (ru) 1998-12-24 2003-10-31 Комбинация ингибиторов fbpазы и сенсибилизаторов инсулина для лечения диабета

Country Status (25)

Country Link
EP (1) EP1143955B1 (enExample)
JP (1) JP2003515523A (enExample)
KR (3) KR20070046210A (enExample)
CN (3) CN101164618A (enExample)
AT (1) ATE300288T1 (enExample)
AU (1) AU771039B2 (enExample)
BR (1) BR9917005A (enExample)
CA (1) CA2354053A1 (enExample)
CZ (1) CZ20012353A3 (enExample)
DE (1) DE69926400T2 (enExample)
DK (1) DK1143955T3 (enExample)
ES (1) ES2246586T3 (enExample)
HK (1) HK1046863B (enExample)
HU (1) HUP0402506A3 (enExample)
ID (1) ID30237A (enExample)
IL (2) IL143569A0 (enExample)
MX (1) MXPA01006511A (enExample)
NO (1) NO20013115L (enExample)
NZ (1) NZ512219A (enExample)
PL (1) PL352756A1 (enExample)
PT (1) PT1143955E (enExample)
RU (2) RU2227749C2 (enExample)
SK (1) SK9172001A3 (enExample)
WO (1) WO2000038666A2 (enExample)
ZA (1) ZA200105016B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2328308C2 (ru) * 2000-07-06 2008-07-10 Метабэйсис Терапьютикс, Инк. Комбинирование ингибиторов fbp-азы и антидиабетических средств для лечения диабета

Families Citing this family (25)

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WO1998039344A1 (en) 1997-03-07 1998-09-11 Metabasis Therapeutics, Inc. Novel purine inhibitors of fructose-1,6-bisphosphatase
US6312662B1 (en) 1998-03-06 2001-11-06 Metabasis Therapeutics, Inc. Prodrugs phosphorus-containing compounds
HK1042496B (zh) 1998-09-09 2006-01-27 症变治疗公司 新的果糖1，6-二磷酸酶的杂芳族抑制剂
CA2396713A1 (en) 1999-12-22 2001-07-05 Metabasis Therapeutics, Inc. Novel bisamidate phosphonate prodrugs
EP1607401A1 (en) 2000-03-08 2005-12-21 Metabasis Therapeutics, Inc. Novel aryl fructose-1,6-Bisphosphatase inhibitors
US7563774B2 (en) 2000-06-29 2009-07-21 Metabasis Therapeutics, Inc. Combination of FBPase inhibitors and antidiabetic agents useful for the treatment of diabetes
WO2002040458A1 (en) * 2000-11-17 2002-05-23 Takeda Chemical Industries, Ltd. Isoxazole derivatives
EP1504014B1 (en) 2002-05-13 2015-12-02 Metabasis Therapeutics, Inc. Process for preparation of cyclic prodrugs of pmea and pmpa
IL164809A0 (en) 2002-05-13 2005-12-18 Metabasis Therapeutics Inc Novel phosphonic acid basdrugs of pmea and its analogues
AU2003264256A1 (en) * 2002-09-04 2004-03-29 Dsm Ip Assets B.V. A nutritional and therapeutic composition of an insulin sensitizer and a peptide fraction
UA80991C2 (en) 2002-10-07 2007-11-26 Solid preparation containing an insulin resistance improving drug and an active ingredient useful as a remedy for diabetes
SI1611112T1 (sl) * 2003-02-11 2012-12-31 Vernalis (R&D) Limited Izoksazolne spojine kot inhibitorji vroäśinskih ĺ ok proteinov
ES2629414T3 (es) * 2003-12-26 2017-08-09 Kyowa Hakko Kirin Co., Ltd. Derivados de tiazol
BRPI0514372A (pt) * 2004-08-18 2008-06-10 Metabasis Therapeutics Inc inibidores de tiazol de frutose 1, 6-bisfosfatase
WO2006064744A1 (ja) * 2004-12-13 2006-06-22 Daiichi Sankyo Company, Limited 糖尿病の治療のための医薬組成物
CN101115483A (zh) * 2004-12-15 2008-01-30 第一三共株式会社 含有FBPase抑制剂的药物组合物
US20090227493A1 (en) * 2005-05-27 2009-09-10 Daiichi Sankyo Company, Limited Combined drug for treating diabetes
WO2006137527A1 (ja) 2005-06-23 2006-12-28 Kyowa Hakko Kogyo Co., Ltd. チアゾール誘導体
EP2394647A1 (en) 2006-11-02 2011-12-14 Aestus Therapeutics, Inc. Methods of treating neuropathic pain by modulation of glycogenolysis or glycolysis pathways
CN107312039B (zh) 2012-08-30 2019-06-25 江苏豪森药业集团有限公司 一种替诺福韦前药的制备方法
US9631825B2 (en) 2012-12-18 2017-04-25 Nortek Air Solutions, Llc Air filter assembly
WO2015123352A1 (en) 2014-02-13 2015-08-20 Ligand Pharmaceuticals, Inc. Prodrug compounds and their uses
CN106687118A (zh) 2014-07-02 2017-05-17 配体药物公司 前药化合物及其用途
CN105481896A (zh) * 2015-12-03 2016-04-13 浙江大学 一种地马格列的制备方法
CN113416739B (zh) * 2021-06-24 2022-04-19 黑龙江八一农垦大学 鲁氏酵母菌基因在提高微生物产hdmf的产量中的应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4968790A (en) * 1988-08-12 1990-11-06 American Cyanamid Company Antidiabetic phosphates
JPH03157377A (ja) * 1988-11-18 1991-07-05 Takeda Chem Ind Ltd チオ尿素誘導体及びａｇｅ生成阻害剤
ATE114474T1 (de) * 1989-01-24 1994-12-15 Gensia Pharma Verfahren und verbindungen zur verabreichung von aica ribosiden und zur erniedrigung des blutglucose gehaltes.
TW438587B (en) * 1995-06-20 2001-06-07 Takeda Chemical Industries Ltd A pharmaceutical composition for prophylaxis and treatment of diabetes
US5859037A (en) * 1997-02-19 1999-01-12 Warner-Lambert Company Sulfonylurea-glitazone combinations for diabetes
WO1998039342A1 (en) * 1997-03-07 1998-09-11 Metabasis Therapeutics, Inc. Novel indole and azaindole inhibitors of fructose-1,6-bisphosphatase
ES2210728T3 (es) * 1997-03-07 2004-07-01 Metabasis Therapeutics, Inc. Nuevos inhibidores bencimidazol de la fructosa-1, 6-bifosfatasa.
WO1998039344A1 (en) * 1997-03-07 1998-09-11 Metabasis Therapeutics, Inc. Novel purine inhibitors of fructose-1,6-bisphosphatase

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2328308C2 (ru) * 2000-07-06 2008-07-10 Метабэйсис Терапьютикс, Инк. Комбинирование ингибиторов fbp-азы и антидиабетических средств для лечения диабета

Also Published As

Publication number Publication date
EP1143955A2 (en) 2001-10-17
WO2000038666A3 (en) 2001-11-29
ATE300288T1 (de) 2005-08-15
BR9917005A (pt) 2002-04-02
ZA200105016B (en) 2002-09-19
EP1143955A3 (en) 2002-08-28
DE69926400T2 (de) 2006-05-24
AU2058300A (en) 2000-07-31
PT1143955E (pt) 2005-11-30
JP2003515523A (ja) 2003-05-07
KR20060114724A (ko) 2006-11-07
WO2000038666A2 (en) 2000-07-06
CN100352505C (zh) 2007-12-05
NO20013115L (no) 2001-08-24
ID30237A (id) 2001-11-15
AU771039B2 (en) 2004-03-11
CA2354053A1 (en) 2000-07-06
DE69926400D1 (de) 2005-09-01
CN1714866A (zh) 2006-01-04
HK1046863B (zh) 2008-07-25
CN101164618A (zh) 2008-04-23
NZ512219A (en) 2004-12-24
IL143569A (en) 2006-06-11
HUP0402506A3 (en) 2007-05-29
CZ20012353A3 (cs) 2001-12-12
CN1350466A (zh) 2002-05-22
MXPA01006511A (es) 2004-03-19
KR20070046210A (ko) 2007-05-02
IL143569A0 (en) 2002-04-21
KR20010099942A (ko) 2001-11-09
KR100689943B1 (ko) 2007-03-08
SK9172001A3 (en) 2002-04-04
NO20013115D0 (no) 2001-06-21
EP1143955B1 (en) 2005-07-27
HK1046863A1 (zh) 2003-01-30
ES2246586T3 (es) 2006-02-16
RU2003132054A (ru) 2005-04-20
HUP0402506A2 (hu) 2005-04-28
DK1143955T3 (da) 2005-11-14
PL352756A1 (en) 2003-09-08

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MM4A The patent is invalid due to non-payment of fees

Effective date: 20111223