JP2003515523A - 糖尿病治療のためのｆｂｐアーゼ阻害物質とインスリンセンシタイザの組み合わせ - Google Patents
糖尿病治療のためのｆｂｐアーゼ阻害物質とインスリンセンシタイザの組み合わせInfo
- Publication number
- JP2003515523A JP2003515523A JP2000590620A JP2000590620A JP2003515523A JP 2003515523 A JP2003515523 A JP 2003515523A JP 2000590620 A JP2000590620 A JP 2000590620A JP 2000590620 A JP2000590620 A JP 2000590620A JP 2003515523 A JP2003515523 A JP 2003515523A
- Authority
- JP
- Japan
- Prior art keywords
- group
- alkyl
- aryl
- cyclic
- aralkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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Classifications
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- A61K31/425—Thiazoles
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
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- A—HUMAN NECESSITIES
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- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
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- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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Landscapes
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11471898P | 1998-12-24 | 1998-12-24 | |
| US60/114,718 | 1998-12-24 | ||
| PCT/US1999/030713 WO2000038666A2 (en) | 1998-12-24 | 1999-12-22 | A COMBINATION OF FBPase INHIBITORS AND INSULIN SENSITIZERS FOR THE TREATMENT OF DIABETES |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003515523A true JP2003515523A (ja) | 2003-05-07 |
| JP2003515523A5 JP2003515523A5 (enExample) | 2007-02-15 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| JP2000590620A Pending JP2003515523A (ja) | 1998-12-24 | 1999-12-22 | 糖尿病治療のためのｆｂｐアーゼ阻害物質とインスリンセンシタイザの組み合わせ |
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| EP (1) | EP1143955B1 (enExample) |
| JP (1) | JP2003515523A (enExample) |
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| ES (1) | ES2246586T3 (enExample) |
| HK (1) | HK1046863B (enExample) |
| HU (1) | HUP0402506A3 (enExample) |
| ID (1) | ID30237A (enExample) |
| IL (2) | IL143569A0 (enExample) |
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| WO2006064744A1 (ja) * | 2004-12-13 | 2006-06-22 | Daiichi Sankyo Company, Limited | 糖尿病の治療のための医薬組成物 |
| JP2006517572A (ja) * | 2003-02-11 | 2006-07-27 | ヴァーナリス（ケンブリッジ）リミテッド | 熱ショックタンパク質の阻害剤としてのイソオキサゾール化合物類 |
| WO2006126673A1 (ja) * | 2005-05-27 | 2006-11-30 | Daiichi Sankyo Company, Limited | 組み合わせによる糖尿病治療薬 |
| JP2008510018A (ja) * | 2004-08-18 | 2008-04-03 | メタバシス・セラピューティクス・インコーポレイテッド | フルクトース−１，６−ビスホスファターゼの新規チアゾール阻害物質 |
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| WO1998039344A1 (en) | 1997-03-07 | 1998-09-11 | Metabasis Therapeutics, Inc. | Novel purine inhibitors of fructose-1,6-bisphosphatase |
| US6312662B1 (en) | 1998-03-06 | 2001-11-06 | Metabasis Therapeutics, Inc. | Prodrugs phosphorus-containing compounds |
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| CN1740182A (zh) * | 1999-12-22 | 2006-03-01 | 症变治疗公司 | 新的双氨基化膦酸酯前药 |
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| US7563774B2 (en) | 2000-06-29 | 2009-07-21 | Metabasis Therapeutics, Inc. | Combination of FBPase inhibitors and antidiabetic agents useful for the treatment of diabetes |
| CN101301294A (zh) * | 2000-07-06 | 2008-11-12 | 症变治疗公司 | Fbp酶抑制剂与抗糖尿病药联合用于治疗糖尿病 |
| US7022725B2 (en) | 2000-11-17 | 2006-04-04 | Takeda Pharmaceutical Company Limited | Isoxazole derivatives |
| AU2003235501A1 (en) | 2002-05-13 | 2003-11-11 | Metabasis Therapeutics, Inc. | PMEA and PMPA cyclic producing synthesis |
| IL164809A0 (en) | 2002-05-13 | 2005-12-18 | Metabasis Therapeutics Inc | Novel phosphonic acid basdrugs of pmea and its analogues |
| WO2004022083A1 (en) * | 2002-09-04 | 2004-03-18 | Dsm Ip Assets B.V. | A nutritional and therapeutic composition of an insulin sensitizer and a peptide fraction |
| UA80991C2 (en) | 2002-10-07 | 2007-11-26 | Solid preparation containing an insulin resistance improving drug and an active ingredient useful as a remedy for diabetes | |
| TWI349550B (en) | 2003-12-26 | 2011-10-01 | A thiazole derivative and adenosine a2a receptor antagonist containing the same | |
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| CN107312039B (zh) | 2012-08-30 | 2019-06-25 | 江苏豪森药业集团有限公司 | 一种替诺福韦前药的制备方法 |
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| EP3623364A1 (en) | 2014-02-13 | 2020-03-18 | Ligand Pharmaceuticals, Inc. | Prodrug compounds and their uses |
| CN106687118A (zh) | 2014-07-02 | 2017-05-17 | 配体药物公司 | 前药化合物及其用途 |
| CN105481896A (zh) * | 2015-12-03 | 2016-04-13 | 浙江大学 | 一种地马格列的制备方法 |
| CN113416739B (zh) * | 2021-06-24 | 2022-04-19 | 黑龙江八一农垦大学 | 鲁氏酵母菌基因在提高微生物产hdmf的产量中的应用 |
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- 1999-12-22 CN CNB998163562A patent/CN100352505C/zh not_active Expired - Fee Related
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- 1999-12-22 PL PL99352756A patent/PL352756A1/xx not_active Application Discontinuation
- 1999-12-22 ES ES99964313T patent/ES2246586T3/es not_active Expired - Lifetime
- 1999-12-22 MX MXPA01006511A patent/MXPA01006511A/es active IP Right Grant
- 1999-12-22 DK DK99964313T patent/DK1143955T3/da active
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- 1999-12-22 KR KR1020077008649A patent/KR20070046210A/ko not_active Ceased
- 1999-12-22 RU RU2001120726/15A patent/RU2227749C2/ru not_active IP Right Cessation
- 1999-12-22 HK HK02108475.5A patent/HK1046863B/zh not_active IP Right Cessation
- 1999-12-22 SK SK917-2001A patent/SK9172001A3/sk unknown
- 1999-12-22 KR KR1020067022095A patent/KR20060114724A/ko not_active Ceased
- 1999-12-22 HU HU0402506A patent/HUP0402506A3/hu active IP Right Revival
- 1999-12-22 DE DE69926400T patent/DE69926400T2/de not_active Expired - Lifetime
- 1999-12-22 PT PT99964313T patent/PT1143955E/pt unknown
- 1999-12-22 AU AU20583/00A patent/AU771039B2/en not_active Ceased
- 1999-12-22 EP EP99964313A patent/EP1143955B1/en not_active Expired - Lifetime
- 1999-12-22 AT AT99964313T patent/ATE300288T1/de active
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- 1999-12-22 JP JP2000590620A patent/JP2003515523A/ja active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2006517572A (ja) * | 2003-02-11 | 2006-07-27 | ヴァーナリス（ケンブリッジ）リミテッド | 熱ショックタンパク質の阻害剤としてのイソオキサゾール化合物類 |
| JP4921162B2 (ja) * | 2003-02-11 | 2012-04-25 | ヴァーナリス（ケンブリッジ）リミテッド | 熱ショックタンパク質の阻害剤としてのイソオキサゾール化合物類 |
| JP2008510018A (ja) * | 2004-08-18 | 2008-04-03 | メタバシス・セラピューティクス・インコーポレイテッド | フルクトース−１，６−ビスホスファターゼの新規チアゾール阻害物質 |
| WO2006064744A1 (ja) * | 2004-12-13 | 2006-06-22 | Daiichi Sankyo Company, Limited | 糖尿病の治療のための医薬組成物 |
| WO2006064826A1 (ja) * | 2004-12-15 | 2006-06-22 | Daiichi Sankyo Company, Limited | FBPase阻害剤を含有する医薬組成物 |
| WO2006126673A1 (ja) * | 2005-05-27 | 2006-11-30 | Daiichi Sankyo Company, Limited | 組み合わせによる糖尿病治療薬 |
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