RU2176642C2 - Бициклические карбоксамиды и их фармацевтически приемлемые соли и фармацевтическая композиция на их основе - Google Patents
Бициклические карбоксамиды и их фармацевтически приемлемые соли и фармацевтическая композиция на их основе Download PDFInfo
- Publication number
- RU2176642C2 RU2176642C2 RU99112569/04A RU99112569A RU2176642C2 RU 2176642 C2 RU2176642 C2 RU 2176642C2 RU 99112569/04 A RU99112569/04 A RU 99112569/04A RU 99112569 A RU99112569 A RU 99112569A RU 2176642 C2 RU2176642 C2 RU 2176642C2
- Authority
- RU
- Russia
- Prior art keywords
- alkyl
- carboxamide
- optionally substituted
- methoxy
- ethyl acetate
- Prior art date
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- -1 Bicyclic carboxamides Chemical class 0.000 title claims abstract description 31
- 150000003839 salts Chemical class 0.000 title claims abstract description 24
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 4
- 150000001875 compounds Chemical class 0.000 claims abstract description 129
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 38
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims abstract description 19
- 125000003118 aryl group Chemical group 0.000 claims abstract description 14
- 125000001072 heteroaryl group Chemical group 0.000 claims abstract description 13
- 125000003710 aryl alkyl group Chemical group 0.000 claims abstract description 10
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims abstract description 10
- 125000000623 heterocyclic group Chemical group 0.000 claims abstract description 10
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims abstract description 9
- 230000002401 inhibitory effect Effects 0.000 claims abstract description 9
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 9
- 125000000753 cycloalkyl group Chemical group 0.000 claims abstract description 8
- 102000004861 Phosphoric Diester Hydrolases Human genes 0.000 claims abstract description 7
- 108090001050 Phosphoric Diester Hydrolases Proteins 0.000 claims abstract description 7
- 229910052717 sulfur Inorganic materials 0.000 claims abstract description 7
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 4
- 125000005843 halogen group Chemical group 0.000 claims abstract 7
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract 2
- 229910002091 carbon monoxide Inorganic materials 0.000 claims description 14
- 229910052736 halogen Inorganic materials 0.000 claims description 9
- 125000004122 cyclic group Chemical group 0.000 claims description 7
- 229910052739 hydrogen Inorganic materials 0.000 claims description 6
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 5
- 125000003545 alkoxy group Chemical group 0.000 claims description 4
- 150000003857 carboxamides Chemical class 0.000 claims description 4
- 125000004217 4-methoxybenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])* 0.000 claims description 3
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- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 2
- 239000001257 hydrogen Substances 0.000 claims description 2
- 102100040247 Tumor necrosis factor Human genes 0.000 claims 2
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- NKESBLJNJIVASL-UHFFFAOYSA-N n-(3,5-dichloropyridin-4-yl)-7-methoxy-2-(trifluoromethyl)-1h-benzimidazole-4-carboxamide Chemical compound C1=2NC(C(F)(F)F)=NC=2C(OC)=CC=C1C(=O)NC1=C(Cl)C=NC=C1Cl NKESBLJNJIVASL-UHFFFAOYSA-N 0.000 claims 1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- General Chemical & Material Sciences (AREA)
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- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9623860.5A GB9623860D0 (en) | 1996-11-15 | 1996-11-15 | Novel compounds |
| GB9623860.5 | 1996-11-15 | ||
| GBGB9708062.6A GB9708062D0 (en) | 1997-04-22 | 1997-04-22 | Novel compounds |
| GB9708062.6 | 1997-04-22 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU99112569A RU99112569A (ru) | 2001-04-10 |
| RU2176642C2 true RU2176642C2 (ru) | 2001-12-10 |
Family
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| RU99112569/04A RU2176642C2 (ru) | 1996-11-15 | 1997-11-17 | Бициклические карбоксамиды и их фармацевтически приемлемые соли и фармацевтическая композиция на их основе |
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| EP (1) | EP0944616B1 (enExample) |
| JP (1) | JP2001504479A (enExample) |
| KR (1) | KR20000053274A (enExample) |
| CN (1) | CN1114604C (enExample) |
| AT (1) | ATE242234T1 (enExample) |
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| BR (1) | BR9713507A (enExample) |
| CA (1) | CA2268037A1 (enExample) |
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| DK (1) | DK0944616T3 (enExample) |
| ES (1) | ES2200163T3 (enExample) |
| HU (1) | HUP0000189A3 (enExample) |
| ID (1) | ID21698A (enExample) |
| IL (1) | IL129337A0 (enExample) |
| NO (1) | NO992337D0 (enExample) |
| NZ (1) | NZ335197A (enExample) |
| RU (1) | RU2176642C2 (enExample) |
| SK (1) | SK283534B6 (enExample) |
| TR (1) | TR199901730T2 (enExample) |
| WO (1) | WO1998022460A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2459821C2 (ru) * | 2006-09-07 | 2012-08-27 | Байоджен Айдек Ма Инк. | Модуляторы киназы, ассоциированной с рецептором интерлейкина-1 |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000198734A (ja) * | 1998-12-30 | 2000-07-18 | Pfizer Inc | 胃運動性減弱および関連疾患の治療のための運動性増強薬 |
| GB0003254D0 (en) * | 2000-02-11 | 2000-04-05 | Darwin Discovery Ltd | Heterocyclic compounds and their therapeutic use |
| GB0003256D0 (en) * | 2000-02-11 | 2000-04-05 | Darwin Discovery Ltd | Heterocyclic compounds and their therapeutic use |
| WO2002102778A1 (en) * | 2001-06-15 | 2002-12-27 | Yamanouchi Pharmaceutical Co., Ltd. | Phenylpyridine carbonyl piperazine derivative |
| CN101745112A (zh) * | 2002-07-19 | 2010-06-23 | 艾博特生物技术有限公司 | TNFα相关疾病的治疗 |
| CA2548172A1 (en) | 2003-12-04 | 2005-06-23 | Vertex Pharmaceuticals Incorporated | Quinoxalines useful as inhibitors of protein kinases |
| JPWO2005087749A1 (ja) * | 2004-03-15 | 2007-08-09 | 協和醗酵工業株式会社 | ２−アミノキナゾリン誘導体 |
| KR20070114748A (ko) * | 2005-02-17 | 2007-12-04 | 에이엠알 테크놀로지, 인크. | Ｃｉｎｖ 및 ｉｂｓｄ를 치료하기 위한 벤족사졸카복스아미드 |
| US7893267B2 (en) * | 2005-03-14 | 2011-02-22 | High Point Pharmaceuticals, Llc | Benzazole derivatives, compositions, and methods of use as β-secretase inhibitors |
| BRPI0610058A2 (pt) | 2005-05-16 | 2010-05-25 | Abbott Biotech Ltd | uso de inibidor de tnf para tratamento da poliartrite erosiva |
| CA2642610A1 (en) * | 2006-02-20 | 2007-08-30 | Astellas Pharma Inc. | Amide derivative or salt thereof |
| US9605064B2 (en) | 2006-04-10 | 2017-03-28 | Abbvie Biotechnology Ltd | Methods and compositions for treatment of skin disorders |
| US9624295B2 (en) | 2006-04-10 | 2017-04-18 | Abbvie Biotechnology Ltd. | Uses and compositions for treatment of psoriatic arthritis |
| WO2008019363A2 (en) * | 2006-08-07 | 2008-02-14 | Albany Molecular Research, Inc. | 2-alkylbenzoxazole carboxamides as 5ht3 modulators |
| JPWO2008026687A1 (ja) | 2006-09-01 | 2010-01-21 | 杏林製薬株式会社 | ピラゾロピリジンカルボキサミド誘導体及びそれらを含有するホスホジエステラーゼ（ｐｄｅ）阻害剤 |
| WO2008154543A2 (en) | 2007-06-11 | 2008-12-18 | Abbott Biotechnology Ltd. | Methods for treating juvenile idiopathic arthritis |
| CL2008001933A1 (es) | 2007-06-29 | 2009-09-25 | Millennium Pharm Inc | Compuestos derivados de pirimidina, inhibidores de la raf quinasa; compuestos intermediarios; procedimiento de preparacion; composicion farmaceutica; y su uso para tratar trastornos proliferativos, cardiacos, neurodegenerativos, inflamatorios, oseos, inmunologicos enfermedad viral, entre otros. |
| RU2529019C2 (ru) | 2009-02-27 | 2014-09-27 | Эмбит Байосайенсиз Корпорейшн | Модулирующие jak киназу хиназолиновые производные и способы их применения |
| CA2810024A1 (en) | 2010-09-01 | 2012-03-08 | Ambit Biosciences Corporation | Quinazoline compounds and methods of use thereof |
| CN104428293B (zh) * | 2012-06-11 | 2018-06-08 | Ucb生物制药私人有限公司 | 调节TNFα的苯并咪唑类 |
| CN104780764A (zh) * | 2012-09-05 | 2015-07-15 | 拜尔农作物科学股份公司 | 取代的2-酰氨基苯并咪唑、2-酰氨基苯并噁唑和2-酰氨基苯并噻唑或其盐作为活性物质对抗非生物植物胁迫的用途 |
| CN108440333A (zh) * | 2018-03-29 | 2018-08-24 | 江苏道博化工有限公司 | 分散染料中间体的合成方法 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996003399A1 (de) * | 1994-07-22 | 1996-02-08 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Dihydrobenzofurane |
| WO1996011917A1 (en) * | 1994-10-12 | 1996-04-25 | Euro-Celtique, S.A. | Novel benzoxazoles |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS50140442A (enExample) | 1974-04-16 | 1975-11-11 | ||
| JPS59155357A (ja) | 1983-02-14 | 1984-09-04 | ユ−エスヴイ−・フア−マシユ−テイカル・コ−ポレ−シヨン | ベンゾ複素環状カルバメイト |
| DE3835660A1 (de) * | 1988-03-25 | 1989-10-12 | Bayer Ag | 7-substituierte 2-carbonamido-benzthiazol-3-oxide |
| DE4014937A1 (de) | 1990-05-10 | 1991-11-14 | Bayer Ag | 2,3-disubstituierte chinoxaline als leistungsfoerderer fuer tiere |
| GB9219634D0 (en) | 1992-09-16 | 1992-10-28 | Ici Plc | Heterocyclic compounds |
| GB9219632D0 (en) | 1992-09-16 | 1992-10-28 | Ici Plc | Heterocyclic compounds |
| CA2144763A1 (en) | 1992-10-14 | 1994-04-28 | George D. Hartman | Fibrinogen receptor antagonists |
| DE4237617A1 (de) | 1992-11-06 | 1994-05-11 | Bayer Ag | Verwendung von substituierten Benzimidazolen |
| GB9301660D0 (en) | 1993-01-28 | 1993-03-17 | Smithkline Beecham Plc | Pharmaceuticals |
| GB9306578D0 (en) | 1993-03-30 | 1993-05-26 | Merck Sharp & Dohme | Therapeutic agents |
| US6083961A (en) | 1994-08-03 | 2000-07-04 | Fujisawa Pharmaceutical Co., Ltd. | Benzimidazole compounds as bradykinin antagonists |
| US5665737B1 (en) | 1994-10-12 | 1999-02-16 | Euro Celtique Sa | Substituted benzoxazoles |
-
1997
- 1997-11-17 IL IL12933797A patent/IL129337A0/xx not_active IP Right Cessation
- 1997-11-17 TR TR1999/01730T patent/TR199901730T2/xx unknown
- 1997-11-17 AU AU49602/97A patent/AU726590B2/en not_active Ceased
- 1997-11-17 ID IDW990356A patent/ID21698A/id unknown
- 1997-11-17 HU HU0000189A patent/HUP0000189A3/hu unknown
- 1997-11-17 NZ NZ335197A patent/NZ335197A/xx unknown
- 1997-11-17 CZ CZ991582A patent/CZ158299A3/cs unknown
- 1997-11-17 ES ES97912370T patent/ES2200163T3/es not_active Expired - Lifetime
- 1997-11-17 EP EP97912370A patent/EP0944616B1/en not_active Expired - Lifetime
- 1997-11-17 AT AT97912370T patent/ATE242234T1/de not_active IP Right Cessation
- 1997-11-17 DK DK97912370T patent/DK0944616T3/da active
- 1997-11-17 KR KR1019990704253A patent/KR20000053274A/ko not_active Withdrawn
- 1997-11-17 JP JP52334598A patent/JP2001504479A/ja not_active Ceased
- 1997-11-17 DE DE69722656T patent/DE69722656T2/de not_active Expired - Fee Related
- 1997-11-17 WO PCT/GB1997/003154 patent/WO1998022460A1/en not_active Ceased
- 1997-11-17 SK SK644-99A patent/SK283534B6/sk unknown
- 1997-11-17 CA CA002268037A patent/CA2268037A1/en not_active Abandoned
- 1997-11-17 RU RU99112569/04A patent/RU2176642C2/ru not_active IP Right Cessation
- 1997-11-17 CN CN97199650A patent/CN1114604C/zh not_active Expired - Fee Related
- 1997-11-17 BR BR9713507-0A patent/BR9713507A/pt unknown
-
1999
- 1999-05-14 NO NO992337A patent/NO992337D0/no not_active Application Discontinuation
- 1999-10-21 US US09/422,473 patent/US6353010B1/en not_active Expired - Fee Related
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2002
- 2002-01-14 US US10/050,005 patent/US20020094987A1/en not_active Abandoned
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996003399A1 (de) * | 1994-07-22 | 1996-02-08 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Dihydrobenzofurane |
| WO1996011917A1 (en) * | 1994-10-12 | 1996-04-25 | Euro-Celtique, S.A. | Novel benzoxazoles |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2459821C2 (ru) * | 2006-09-07 | 2012-08-27 | Байоджен Айдек Ма Инк. | Модуляторы киназы, ассоциированной с рецептором интерлейкина-1 |
Also Published As
| Publication number | Publication date |
|---|---|
| NO992337L (no) | 1999-05-14 |
| AU4960297A (en) | 1998-06-10 |
| EP0944616A1 (en) | 1999-09-29 |
| DE69722656T2 (de) | 2004-05-13 |
| CA2268037A1 (en) | 1998-05-28 |
| US20020094987A1 (en) | 2002-07-18 |
| CN1237168A (zh) | 1999-12-01 |
| AU726590B2 (en) | 2000-11-09 |
| CZ158299A3 (cs) | 1999-09-15 |
| DK0944616T3 (da) | 2003-09-29 |
| ES2200163T3 (es) | 2004-03-01 |
| DE69722656D1 (de) | 2003-07-10 |
| SK64499A3 (en) | 2000-03-13 |
| NO992337D0 (no) | 1999-05-14 |
| ID21698A (id) | 1999-07-15 |
| EP0944616B1 (en) | 2003-06-04 |
| KR20000053274A (ko) | 2000-08-25 |
| WO1998022460A1 (en) | 1998-05-28 |
| ATE242234T1 (de) | 2003-06-15 |
| US6353010B1 (en) | 2002-03-05 |
| JP2001504479A (ja) | 2001-04-03 |
| NZ335197A (en) | 2000-11-24 |
| SK283534B6 (sk) | 2003-09-11 |
| TR199901730T2 (xx) | 1999-09-21 |
| HUP0000189A2 (hu) | 2001-04-28 |
| CN1114604C (zh) | 2003-07-16 |
| HUP0000189A3 (en) | 2002-01-28 |
| IL129337A0 (en) | 2000-02-17 |
| BR9713507A (pt) | 2000-02-29 |
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| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20031118 |