ATE242234T1 - Bicyclische arylcarboxamide und ihre therapeutische verwendung - Google Patents
Bicyclische arylcarboxamide und ihre therapeutische verwendungInfo
- Publication number
- ATE242234T1 ATE242234T1 AT97912370T AT97912370T ATE242234T1 AT E242234 T1 ATE242234 T1 AT E242234T1 AT 97912370 T AT97912370 T AT 97912370T AT 97912370 T AT97912370 T AT 97912370T AT E242234 T1 ATE242234 T1 AT E242234T1
- Authority
- AT
- Austria
- Prior art keywords
- arylcarboxamides
- bicyclic
- therapeutic use
- phosphodiesterase
- tnf
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9623860.5A GB9623860D0 (en) | 1996-11-15 | 1996-11-15 | Novel compounds |
| GBGB9708062.6A GB9708062D0 (en) | 1997-04-22 | 1997-04-22 | Novel compounds |
| PCT/GB1997/003154 WO1998022460A1 (en) | 1996-11-15 | 1997-11-17 | Bicyclic aryl carboxamides and their therapeutic use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE242234T1 true ATE242234T1 (de) | 2003-06-15 |
Family
ID=26310411
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97912370T ATE242234T1 (de) | 1996-11-15 | 1997-11-17 | Bicyclische arylcarboxamide und ihre therapeutische verwendung |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US6353010B1 (de) |
| EP (1) | EP0944616B1 (de) |
| JP (1) | JP2001504479A (de) |
| KR (1) | KR20000053274A (de) |
| CN (1) | CN1114604C (de) |
| AT (1) | ATE242234T1 (de) |
| AU (1) | AU726590B2 (de) |
| BR (1) | BR9713507A (de) |
| CA (1) | CA2268037A1 (de) |
| CZ (1) | CZ158299A3 (de) |
| DE (1) | DE69722656T2 (de) |
| DK (1) | DK0944616T3 (de) |
| ES (1) | ES2200163T3 (de) |
| HU (1) | HUP0000189A3 (de) |
| ID (1) | ID21698A (de) |
| IL (1) | IL129337A0 (de) |
| NO (1) | NO992337L (de) |
| NZ (1) | NZ335197A (de) |
| RU (1) | RU2176642C2 (de) |
| SK (1) | SK283534B6 (de) |
| TR (1) | TR199901730T2 (de) |
| WO (1) | WO1998022460A1 (de) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000198734A (ja) * | 1998-12-30 | 2000-07-18 | Pfizer Inc | 胃運動性減弱および関連疾患の治療のための運動性増強薬 |
| GB0003254D0 (en) * | 2000-02-11 | 2000-04-05 | Darwin Discovery Ltd | Heterocyclic compounds and their therapeutic use |
| GB0003256D0 (en) | 2000-02-11 | 2000-04-05 | Darwin Discovery Ltd | Heterocyclic compounds and their therapeutic use |
| PL367205A1 (en) * | 2001-06-15 | 2005-02-21 | Yamanouchi Pharmaceutical Co, Ltd. | Phenylpyridine carbonyl piperazine derivative |
| EP2298810A3 (de) * | 2002-07-19 | 2011-08-03 | Abbott Biotechnology Ltd | Behandlung von Erkrankungen im Zusammenhang mit TNF-alpha |
| CA2548172A1 (en) | 2003-12-04 | 2005-06-23 | Vertex Pharmaceuticals Incorporated | Quinoxalines useful as inhibitors of protein kinases |
| JPWO2005087749A1 (ja) * | 2004-03-15 | 2007-08-09 | 協和醗酵工業株式会社 | ２−アミノキナゾリン誘導体 |
| NZ560969A (en) * | 2005-02-17 | 2010-08-27 | Albany Molecular Res Inc | Benzoxazole carboxamides for treating chemotherapy-induced vomiting and irritable bowel syndrome |
| EP2457901A1 (de) * | 2005-03-14 | 2012-05-30 | High Point Pharmaceuticals, LLC | Benzazolderivate, Zusammensetzungen und Verfahren zur Verwendung als b-Sekretase-Inhibitoren |
| CA2903138A1 (en) | 2005-05-16 | 2006-11-23 | Abbvie Biotechnology Ltd. | Use of tnfa inhibitor for treatment of erosive polyarthritis |
| CA2642610A1 (en) * | 2006-02-20 | 2007-08-30 | Astellas Pharma Inc. | Amide derivative or salt thereof |
| EP2007426A4 (de) | 2006-04-10 | 2010-06-16 | Abbott Biotech Ltd | Anwendungen und zusammensetzungen zur behandlung von psoriasis-arthritis |
| US9605064B2 (en) | 2006-04-10 | 2017-03-28 | Abbvie Biotechnology Ltd | Methods and compositions for treatment of skin disorders |
| US7553846B2 (en) * | 2006-08-07 | 2009-06-30 | Albany Molecular Research, Inc. | 2-alkylbenzoxazole carboxamides as 5-HT3 modulators |
| US20100056791A1 (en) * | 2006-09-01 | 2010-03-04 | Yasushi Kohno | Pyrazolopyridine carboxamide derivative and phosphodiesterase (pde) inhibitor containing the same |
| WO2008030584A2 (en) * | 2006-09-07 | 2008-03-13 | Biogen Idec Ma Inc. | Indazole derivatives as modulators of interleukin- 1 receptor-associated kinase |
| WO2008154543A2 (en) | 2007-06-11 | 2008-12-18 | Abbott Biotechnology Ltd. | Methods for treating juvenile idiopathic arthritis |
| TWI444379B (zh) | 2007-06-29 | 2014-07-11 | Sunesis Pharmaceuticals Inc | 有用於作為Ｒａｆ激酶抑制劑之化合物 |
| CN105837560A (zh) | 2009-02-27 | 2016-08-10 | 埃姆比特生物科学公司 | 调控jak激酶的喹唑啉衍生物和其使用方法 |
| MX2013002384A (es) | 2010-09-01 | 2013-07-05 | Ambit Biosciences Corp | Compuestos quinazolina y metodos para utilizarlos. |
| CN104428293B (zh) * | 2012-06-11 | 2018-06-08 | Ucb生物制药私人有限公司 | 调节TNFα的苯并咪唑类 |
| EA201590482A1 (ru) * | 2012-09-05 | 2015-07-30 | Байер Кропсайенс Аг | Применение замещенных 2-амидобензимидазолов, 2-амидобензоксазолов и 2-амидобензотиазолов или их солей в качестве биологически активных веществ против абиотического стресса растений |
| CN108440333A (zh) * | 2018-03-29 | 2018-08-24 | 江苏道博化工有限公司 | 分散染料中间体的合成方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS50140442A (de) | 1974-04-16 | 1975-11-11 | ||
| JPS59155357A (ja) | 1983-02-14 | 1984-09-04 | ユ−エスヴイ−・フア−マシユ−テイカル・コ−ポレ−シヨン | ベンゾ複素環状カルバメイト |
| DE3835660A1 (de) * | 1988-03-25 | 1989-10-12 | Bayer Ag | 7-substituierte 2-carbonamido-benzthiazol-3-oxide |
| DE4014937A1 (de) | 1990-05-10 | 1991-11-14 | Bayer Ag | 2,3-disubstituierte chinoxaline als leistungsfoerderer fuer tiere |
| GB9219632D0 (en) | 1992-09-16 | 1992-10-28 | Ici Plc | Heterocyclic compounds |
| GB9219634D0 (en) | 1992-09-16 | 1992-10-28 | Ici Plc | Heterocyclic compounds |
| DE69327536T2 (de) | 1992-10-14 | 2000-07-06 | Merck & Co Inc | Fibrinogenrezeptor-antagonisten |
| DE4237617A1 (de) | 1992-11-06 | 1994-05-11 | Bayer Ag | Verwendung von substituierten Benzimidazolen |
| GB9301660D0 (en) | 1993-01-28 | 1993-03-17 | Smithkline Beecham Plc | Pharmaceuticals |
| GB9306578D0 (en) | 1993-03-30 | 1993-05-26 | Merck Sharp & Dohme | Therapeutic agents |
| US6083961A (en) | 1994-08-03 | 2000-07-04 | Fujisawa Pharmaceutical Co., Ltd. | Benzimidazole compounds as bradykinin antagonists |
| US5665737B1 (en) | 1994-10-12 | 1999-02-16 | Euro Celtique Sa | Substituted benzoxazoles |
| AU699489B2 (en) * | 1994-10-12 | 1998-12-03 | Euro-Celtique S.A. | Novel benzoxazoles |
-
1997
- 1997-11-17 CZ CZ991582A patent/CZ158299A3/cs unknown
- 1997-11-17 HU HU0000189A patent/HUP0000189A3/hu unknown
- 1997-11-17 WO PCT/GB1997/003154 patent/WO1998022460A1/en not_active Application Discontinuation
- 1997-11-17 SK SK644-99A patent/SK283534B6/sk unknown
- 1997-11-17 JP JP52334598A patent/JP2001504479A/ja not_active Ceased
- 1997-11-17 CA CA002268037A patent/CA2268037A1/en not_active Abandoned
- 1997-11-17 AT AT97912370T patent/ATE242234T1/de not_active IP Right Cessation
- 1997-11-17 AU AU49602/97A patent/AU726590B2/en not_active Ceased
- 1997-11-17 EP EP97912370A patent/EP0944616B1/de not_active Expired - Lifetime
- 1997-11-17 IL IL12933797A patent/IL129337A0/xx not_active IP Right Cessation
- 1997-11-17 NZ NZ335197A patent/NZ335197A/xx unknown
- 1997-11-17 DK DK97912370T patent/DK0944616T3/da active
- 1997-11-17 RU RU99112569/04A patent/RU2176642C2/ru not_active IP Right Cessation
- 1997-11-17 ES ES97912370T patent/ES2200163T3/es not_active Expired - Lifetime
- 1997-11-17 DE DE69722656T patent/DE69722656T2/de not_active Expired - Fee Related
- 1997-11-17 TR TR1999/01730T patent/TR199901730T2/xx unknown
- 1997-11-17 CN CN97199650A patent/CN1114604C/zh not_active Expired - Fee Related
- 1997-11-17 ID IDW990356A patent/ID21698A/id unknown
- 1997-11-17 BR BR9713507-0A patent/BR9713507A/pt unknown
- 1997-11-17 KR KR1019990704253A patent/KR20000053274A/ko not_active Application Discontinuation
-
1999
- 1999-05-14 NO NO992337A patent/NO992337L/no not_active Application Discontinuation
- 1999-10-21 US US09/422,473 patent/US6353010B1/en not_active Expired - Fee Related
-
2002
- 2002-01-14 US US10/050,005 patent/US20020094987A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2268037A1 (en) | 1998-05-28 |
| RU2176642C2 (ru) | 2001-12-10 |
| NO992337D0 (no) | 1999-05-14 |
| US6353010B1 (en) | 2002-03-05 |
| NZ335197A (en) | 2000-11-24 |
| BR9713507A (pt) | 2000-02-29 |
| TR199901730T2 (xx) | 1999-09-21 |
| HUP0000189A2 (hu) | 2001-04-28 |
| IL129337A0 (en) | 2000-02-17 |
| AU726590B2 (en) | 2000-11-09 |
| CN1114604C (zh) | 2003-07-16 |
| EP0944616B1 (de) | 2003-06-04 |
| US20020094987A1 (en) | 2002-07-18 |
| CN1237168A (zh) | 1999-12-01 |
| JP2001504479A (ja) | 2001-04-03 |
| ID21698A (id) | 1999-07-15 |
| HUP0000189A3 (en) | 2002-01-28 |
| KR20000053274A (ko) | 2000-08-25 |
| DK0944616T3 (da) | 2003-09-29 |
| SK64499A3 (en) | 2000-03-13 |
| SK283534B6 (sk) | 2003-09-11 |
| DE69722656T2 (de) | 2004-05-13 |
| WO1998022460A1 (en) | 1998-05-28 |
| CZ158299A3 (cs) | 1999-09-15 |
| AU4960297A (en) | 1998-06-10 |
| ES2200163T3 (es) | 2004-03-01 |
| DE69722656D1 (de) | 2003-07-10 |
| EP0944616A1 (de) | 1999-09-29 |
| NO992337L (no) | 1999-05-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0944616 Country of ref document: EP |
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| REN | Ceased due to non-payment of the annual fee |