ATE242234T1 - Bicyclische arylcarboxamide und ihre therapeutische verwendung - Google Patents
Bicyclische arylcarboxamide und ihre therapeutische verwendungInfo
- Publication number
- ATE242234T1 ATE242234T1 AT97912370T AT97912370T ATE242234T1 AT E242234 T1 ATE242234 T1 AT E242234T1 AT 97912370 T AT97912370 T AT 97912370T AT 97912370 T AT97912370 T AT 97912370T AT E242234 T1 ATE242234 T1 AT E242234T1
- Authority
- AT
- Austria
- Prior art keywords
- arylcarboxamides
- bicyclic
- therapeutic use
- phosphodiesterase
- tnf
- Prior art date
Links
- 230000001225 therapeutic effect Effects 0.000 title abstract 2
- 102000004861 Phosphoric Diester Hydrolases Human genes 0.000 abstract 1
- 108090001050 Phosphoric Diester Hydrolases Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Psychiatry (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Communicable Diseases (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9623860.5A GB9623860D0 (en) | 1996-11-15 | 1996-11-15 | Novel compounds |
| GBGB9708062.6A GB9708062D0 (en) | 1997-04-22 | 1997-04-22 | Novel compounds |
| PCT/GB1997/003154 WO1998022460A1 (en) | 1996-11-15 | 1997-11-17 | Bicyclic aryl carboxamides and their therapeutic use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE242234T1 true ATE242234T1 (de) | 2003-06-15 |
Family
ID=26310411
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97912370T ATE242234T1 (de) | 1996-11-15 | 1997-11-17 | Bicyclische arylcarboxamide und ihre therapeutische verwendung |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US6353010B1 (de) |
| EP (1) | EP0944616B1 (de) |
| JP (1) | JP2001504479A (de) |
| KR (1) | KR20000053274A (de) |
| CN (1) | CN1114604C (de) |
| AT (1) | ATE242234T1 (de) |
| AU (1) | AU726590B2 (de) |
| BR (1) | BR9713507A (de) |
| CA (1) | CA2268037A1 (de) |
| CZ (1) | CZ158299A3 (de) |
| DE (1) | DE69722656T2 (de) |
| DK (1) | DK0944616T3 (de) |
| ES (1) | ES2200163T3 (de) |
| HU (1) | HUP0000189A3 (de) |
| ID (1) | ID21698A (de) |
| IL (1) | IL129337A0 (de) |
| NO (1) | NO992337D0 (de) |
| NZ (1) | NZ335197A (de) |
| RU (1) | RU2176642C2 (de) |
| SK (1) | SK283534B6 (de) |
| TR (1) | TR199901730T2 (de) |
| WO (1) | WO1998022460A1 (de) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000198734A (ja) * | 1998-12-30 | 2000-07-18 | Pfizer Inc | 胃運動性減弱および関連疾患の治療のための運動性増強薬 |
| GB0003256D0 (en) | 2000-02-11 | 2000-04-05 | Darwin Discovery Ltd | Heterocyclic compounds and their therapeutic use |
| GB0003254D0 (en) * | 2000-02-11 | 2000-04-05 | Darwin Discovery Ltd | Heterocyclic compounds and their therapeutic use |
| US7196080B2 (en) * | 2001-06-15 | 2007-03-27 | Astellas Pharma Inc. | Phenylpyridinecarbonylpiperazinederivative |
| AR040603A1 (es) * | 2002-07-19 | 2005-04-13 | Abbott Lab S A | El uso de un anticuerpo anti-tnfalfa neutralizador de alta afinidad en la fabricacion de un medicamento y conjunto de elementos |
| JP2007513184A (ja) | 2003-12-04 | 2007-05-24 | バーテックス ファーマシューティカルズ インコーポレイテッド | プロテインキナーゼのインヒビターとして有用なキノキサリン |
| WO2005087749A1 (ja) * | 2004-03-15 | 2005-09-22 | Kyowa Hakko Kogyo Co., Ltd. | ２−アミノキナゾリン誘導体 |
| US7307094B2 (en) | 2005-02-17 | 2007-12-11 | Amr Technology, Inc. | Benzoxazole carboxamides for treating CINV and IBS-D |
| CA2600570C (en) * | 2005-03-14 | 2011-12-06 | Transtech Pharma, Inc. | Benzazole derivatives, compositions, and methods of use as .beta.-secretase inhibitors |
| AU2006246721B2 (en) | 2005-05-16 | 2012-12-13 | Abbvie Biotechnology Ltd | Use of TNF inhibitor for treatment of erosive polyarthritis |
| CN101384550B (zh) * | 2006-02-20 | 2011-08-31 | 安斯泰来制药株式会社 | 酰胺衍生物或其盐 |
| EP2666472A3 (de) | 2006-04-10 | 2014-04-02 | Abbott Biotechnology Ltd | Anwendungen und Zusammensetzungen zur Behandlung von Psoriasis-Arthritis |
| US9605064B2 (en) | 2006-04-10 | 2017-03-28 | Abbvie Biotechnology Ltd | Methods and compositions for treatment of skin disorders |
| WO2008019363A2 (en) * | 2006-08-07 | 2008-02-14 | Albany Molecular Research, Inc. | 2-alkylbenzoxazole carboxamides as 5ht3 modulators |
| CA2661850A1 (en) * | 2006-09-01 | 2008-03-06 | Kyorin Pharmaceutical Co., Ltd. | Pyrazolopyridine carboxamide derivative and phosphodiesterase (pde) inhibitor containing the same |
| MX2009002377A (es) * | 2006-09-07 | 2009-03-13 | Biogen Idec Inc | Derivados de indazol como moduladores de cinasa asociados con el receptor de interleucina-1. |
| WO2008154543A2 (en) | 2007-06-11 | 2008-12-18 | Abbott Biotechnology Ltd. | Methods for treating juvenile idiopathic arthritis |
| TWI444379B (zh) | 2007-06-29 | 2014-07-11 | Sunesis Pharmaceuticals Inc | 有用於作為Ｒａｆ激酶抑制劑之化合物 |
| PL2401267T3 (pl) | 2009-02-27 | 2014-06-30 | Ambit Biosciences Corp | Pochodne chinazoliny modulujące kinazę JAK i ich zastosowanie w metodach |
| CN103298805A (zh) | 2010-09-01 | 2013-09-11 | 埃姆比特生物科学公司 | 喹唑啉化合物及其使用方法 |
| US9550737B2 (en) * | 2012-06-11 | 2017-01-24 | Ucb Biopharma Sprl | TNF -α modulating benzimidazoles |
| AU2013311826A1 (en) * | 2012-09-05 | 2015-03-26 | Bayer Cropscience Ag | Use of substituted 2-amidobenzimidazoles, 2-amidobenzoxazoles and 2-amidobenzothiazoles or salts thereof as active substances against abiotic plant stress |
| CN108440333A (zh) * | 2018-03-29 | 2018-08-24 | 江苏道博化工有限公司 | 分散染料中间体的合成方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS50140442A (de) | 1974-04-16 | 1975-11-11 | ||
| EP0116938A1 (de) | 1983-02-14 | 1984-08-29 | Usv Pharmaceutical Corporation | Benzoheterocyclische Carbamate |
| DE3835660A1 (de) * | 1988-03-25 | 1989-10-12 | Bayer Ag | 7-substituierte 2-carbonamido-benzthiazol-3-oxide |
| DE4014937A1 (de) | 1990-05-10 | 1991-11-14 | Bayer Ag | 2,3-disubstituierte chinoxaline als leistungsfoerderer fuer tiere |
| GB9219632D0 (en) | 1992-09-16 | 1992-10-28 | Ici Plc | Heterocyclic compounds |
| GB9219634D0 (en) | 1992-09-16 | 1992-10-28 | Ici Plc | Heterocyclic compounds |
| CA2144763A1 (en) | 1992-10-14 | 1994-04-28 | George D. Hartman | Fibrinogen receptor antagonists |
| DE4237617A1 (de) | 1992-11-06 | 1994-05-11 | Bayer Ag | Verwendung von substituierten Benzimidazolen |
| GB9301660D0 (en) | 1993-01-28 | 1993-03-17 | Smithkline Beecham Plc | Pharmaceuticals |
| GB9306578D0 (en) | 1993-03-30 | 1993-05-26 | Merck Sharp & Dohme | Therapeutic agents |
| EP0772610B9 (de) * | 1994-07-22 | 2001-07-25 | Byk Gulden Lomberg Chemische Fabrik GmbH | Dihydrobenzofurane |
| EP0774462A4 (de) | 1994-08-03 | 1997-10-29 | Fujisawa Pharmaceutical Co | Heterocyclische verbindungen |
| US5665737B1 (en) | 1994-10-12 | 1999-02-16 | Euro Celtique Sa | Substituted benzoxazoles |
| EP0785927B1 (de) * | 1994-10-12 | 2003-08-27 | Euroceltique S.A. | Neue benzoxazole |
-
1997
- 1997-11-17 AT AT97912370T patent/ATE242234T1/de not_active IP Right Cessation
- 1997-11-17 ID IDW990356A patent/ID21698A/id unknown
- 1997-11-17 WO PCT/GB1997/003154 patent/WO1998022460A1/en not_active Ceased
- 1997-11-17 IL IL12933797A patent/IL129337A0/xx not_active IP Right Cessation
- 1997-11-17 TR TR1999/01730T patent/TR199901730T2/xx unknown
- 1997-11-17 AU AU49602/97A patent/AU726590B2/en not_active Ceased
- 1997-11-17 JP JP52334598A patent/JP2001504479A/ja not_active Ceased
- 1997-11-17 CA CA002268037A patent/CA2268037A1/en not_active Abandoned
- 1997-11-17 CN CN97199650A patent/CN1114604C/zh not_active Expired - Fee Related
- 1997-11-17 RU RU99112569/04A patent/RU2176642C2/ru not_active IP Right Cessation
- 1997-11-17 HU HU0000189A patent/HUP0000189A3/hu unknown
- 1997-11-17 ES ES97912370T patent/ES2200163T3/es not_active Expired - Lifetime
- 1997-11-17 SK SK644-99A patent/SK283534B6/sk unknown
- 1997-11-17 NZ NZ335197A patent/NZ335197A/xx unknown
- 1997-11-17 CZ CZ991582A patent/CZ158299A3/cs unknown
- 1997-11-17 DE DE69722656T patent/DE69722656T2/de not_active Expired - Fee Related
- 1997-11-17 DK DK97912370T patent/DK0944616T3/da active
- 1997-11-17 KR KR1019990704253A patent/KR20000053274A/ko not_active Withdrawn
- 1997-11-17 BR BR9713507-0A patent/BR9713507A/pt unknown
- 1997-11-17 EP EP97912370A patent/EP0944616B1/de not_active Expired - Lifetime
-
1999
- 1999-05-14 NO NO992337A patent/NO992337D0/no not_active Application Discontinuation
- 1999-10-21 US US09/422,473 patent/US6353010B1/en not_active Expired - Fee Related
-
2002
- 2002-01-14 US US10/050,005 patent/US20020094987A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2001504479A (ja) | 2001-04-03 |
| HUP0000189A3 (en) | 2002-01-28 |
| ID21698A (id) | 1999-07-15 |
| IL129337A0 (en) | 2000-02-17 |
| DE69722656T2 (de) | 2004-05-13 |
| ES2200163T3 (es) | 2004-03-01 |
| US6353010B1 (en) | 2002-03-05 |
| DK0944616T3 (da) | 2003-09-29 |
| NZ335197A (en) | 2000-11-24 |
| CA2268037A1 (en) | 1998-05-28 |
| CZ158299A3 (cs) | 1999-09-15 |
| CN1237168A (zh) | 1999-12-01 |
| AU726590B2 (en) | 2000-11-09 |
| EP0944616B1 (de) | 2003-06-04 |
| US20020094987A1 (en) | 2002-07-18 |
| SK64499A3 (en) | 2000-03-13 |
| KR20000053274A (ko) | 2000-08-25 |
| NO992337L (no) | 1999-05-14 |
| TR199901730T2 (xx) | 1999-09-21 |
| DE69722656D1 (de) | 2003-07-10 |
| NO992337D0 (no) | 1999-05-14 |
| WO1998022460A1 (en) | 1998-05-28 |
| SK283534B6 (sk) | 2003-09-11 |
| EP0944616A1 (de) | 1999-09-29 |
| AU4960297A (en) | 1998-06-10 |
| CN1114604C (zh) | 2003-07-16 |
| BR9713507A (pt) | 2000-02-29 |
| HUP0000189A2 (hu) | 2001-04-28 |
| RU2176642C2 (ru) | 2001-12-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0944616 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |