RU2160731C2 - Промежуточные продукты для получения 1-бензил-4-((5,6-диметокси-1-инданон)-2-ил)-метилпиперидина, способы их получения и способ получения 1-бензил-4-((5,6-диметокси-1-инданон)-2-ил)-метилпиперидина с их применением - Google Patents
Промежуточные продукты для получения 1-бензил-4-((5,6-диметокси-1-инданон)-2-ил)-метилпиперидина, способы их получения и способ получения 1-бензил-4-((5,6-диметокси-1-инданон)-2-ил)-метилпиперидина с их применением Download PDFInfo
- Publication number
- RU2160731C2 RU2160731C2 RU98111204/04A RU98111204A RU2160731C2 RU 2160731 C2 RU2160731 C2 RU 2160731C2 RU 98111204/04 A RU98111204/04 A RU 98111204/04A RU 98111204 A RU98111204 A RU 98111204A RU 2160731 C2 RU2160731 C2 RU 2160731C2
- Authority
- RU
- Russia
- Prior art keywords
- formula
- compound
- alkyl
- benzyl
- acid
- Prior art date
Links
- 0 COc(c(OC)c1)ccc1C(CCC1CCN(*I)CC1)=O Chemical compound COc(c(OC)c1)ccc1C(CCC1CCN(*I)CC1)=O 0.000 description 4
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
- C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US875395P | 1995-12-15 | 1995-12-15 | |
| US60/008,753 | 1995-12-15 | ||
| US60/008.753 | 1995-12-15 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU98111204A RU98111204A (ru) | 2000-05-20 |
| RU2160731C2 true RU2160731C2 (ru) | 2000-12-20 |
Family
ID=21733469
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU98111204/04A RU2160731C2 (ru) | 1995-12-15 | 1996-10-11 | Промежуточные продукты для получения 1-бензил-4-((5,6-диметокси-1-инданон)-2-ил)-метилпиперидина, способы их получения и способ получения 1-бензил-4-((5,6-диметокси-1-инданон)-2-ил)-метилпиперидина с их применением |
Country Status (33)
| Country | Link |
|---|---|
| EP (1) | EP0883607A1 (cs) |
| JP (1) | JP3066083B2 (cs) |
| KR (1) | KR20000064387A (cs) |
| AP (1) | AP708A (cs) |
| AR (1) | AR004368A1 (cs) |
| AU (1) | AU716462B2 (cs) |
| BG (1) | BG102525A (cs) |
| BR (1) | BR9612018A (cs) |
| CA (1) | CA2237647A1 (cs) |
| CO (1) | CO4750831A1 (cs) |
| CZ (1) | CZ180898A3 (cs) |
| DZ (1) | DZ2141A1 (cs) |
| GT (1) | GT199600092A (cs) |
| HN (1) | HN1996000065A (cs) |
| HR (1) | HRP960592A2 (cs) |
| HU (1) | HUP9904275A3 (cs) |
| IL (3) | IL136420A0 (cs) |
| IS (1) | IS4752A (cs) |
| MA (1) | MA24032A1 (cs) |
| NO (1) | NO982712L (cs) |
| NZ (1) | NZ318843A (cs) |
| OA (1) | OA10694A (cs) |
| PE (1) | PE25698A1 (cs) |
| PL (1) | PL197306B1 (cs) |
| RO (1) | RO121382B1 (cs) |
| RU (1) | RU2160731C2 (cs) |
| SK (1) | SK75498A3 (cs) |
| TN (1) | TNSN96153A1 (cs) |
| TW (1) | TW414787B (cs) |
| UY (1) | UY24401A1 (cs) |
| WO (1) | WO1997022584A1 (cs) |
| YU (1) | YU49486B (cs) |
| ZA (1) | ZA9610533B (cs) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6252081B1 (en) | 1998-01-16 | 2001-06-26 | Eisai Co., Ltd. | Process for production of donepezil derivative |
| IL125809A (en) * | 1998-08-17 | 2005-08-31 | Finetech Lab Ltd | Process and intermediates for production of donepezil and related compounds |
| US7148354B2 (en) * | 2002-07-24 | 2006-12-12 | Dr. Reddy's Laboratories Limited | Process for preparation of donepezil |
| IL150982A (en) | 2002-07-30 | 2007-02-11 | Ori Lerman | Process for making Donafzil |
| IL151253A0 (en) * | 2002-08-14 | 2003-04-10 | Finetech Lab Ltd | Process for production of highly pure donepezil hydrochloride |
| US6649765B1 (en) | 2003-02-12 | 2003-11-18 | Usv Limited, Bsd Marg. | Process for the preparation of 1-benzyl-4(5,6-dimethoxy-1-indanon)-2-yl) methyl piperidine hydrochloride (Donepezil HCL) |
| US6953856B2 (en) | 2003-02-12 | 2005-10-11 | Usv, Limited | Process for the preparation of 1-benzyl-4-(5,6-dimethoxy-1-indanon)-2-yl) methyl piperidine hydrochloride (Donepezil HCI) |
| US20070129549A1 (en) * | 2003-03-21 | 2007-06-07 | Yatendra Kumar | Stable lamotrigine pharmaceutical compositions and processes for their preparation |
| WO2004099142A1 (en) * | 2003-05-05 | 2004-11-18 | Ranbaxy Laboratories Limited | Hydrobromide salt of benzyl-piperidylmethyl-indanone and its polymorphs |
| WO2005003092A1 (en) | 2003-07-01 | 2005-01-13 | Hetero Drugs Limited | Preparation of intermediates for acetyl cholinesterase inhibitors |
| CN1280273C (zh) * | 2003-11-05 | 2006-10-18 | 天津和美生物技术有限公司 | 合成多奈哌齐及其衍生物的方法 |
| KR20070083679A (ko) | 2004-09-29 | 2007-08-24 | 케마지스 리미티드 | 약학적으로 순수한 비정질 도네페닐 염산염의 제조를 위한정제된 도네페질 말레산염의 용도 |
| CN100436416C (zh) * | 2005-07-29 | 2008-11-26 | 西南合成制药股份有限公司 | 盐酸多奈哌齐合成工艺 |
| GB0515803D0 (en) * | 2005-07-30 | 2005-09-07 | Pliva Hrvatska D O O | Intermediate compounds |
| AR057910A1 (es) | 2005-11-18 | 2007-12-26 | Synthon Bv | Proceso para preparar donepezilo |
| KR20080085195A (ko) * | 2006-01-04 | 2008-09-23 | 씨아이피엘에이 엘티디. | 도네페질의 제조방법 및 중간체 |
| US8247563B2 (en) | 2006-12-11 | 2012-08-21 | Reviva Pharmaceuticals, Inc. | Compositions, synthesis, and methods of using indanone based cholinesterase inhibitors |
| WO2013078608A1 (en) | 2011-11-29 | 2013-06-06 | Ziqiang Gu | Donepezil pamoate and methods of making and using the same |
| ES2888074T3 (es) | 2013-08-16 | 2021-12-30 | Univ Maastricht | Tratamiento del deterioro cognitivo con inhibidor de PDE4 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI95572C (fi) * | 1987-06-22 | 1996-02-26 | Eisai Co Ltd | Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi |
| FR2642069B1 (fr) * | 1989-01-20 | 1991-04-12 | Rhone Poulenc Sante | Nouveaux derives du benzopyranne, leur preparation et les compositions pharmaceutiques qui les contiennent |
| DE4439822A1 (de) * | 1994-11-08 | 1996-08-29 | Bayer Ag | Verfahren zur Herstellung von Benzyl-piperidylmethyl-indanonen |
-
1996
- 1996-10-11 SK SK754-98A patent/SK75498A3/sk unknown
- 1996-10-11 WO PCT/IB1996/001076 patent/WO1997022584A1/en not_active Application Discontinuation
- 1996-10-11 IL IL13642096A patent/IL136420A0/xx unknown
- 1996-10-11 CA CA002237647A patent/CA2237647A1/en not_active Abandoned
- 1996-10-11 PL PL327512A patent/PL197306B1/pl not_active IP Right Cessation
- 1996-10-11 HU HU9904275A patent/HUP9904275A3/hu unknown
- 1996-10-11 IL IL13642196A patent/IL136421A0/xx unknown
- 1996-10-11 NZ NZ318843A patent/NZ318843A/xx unknown
- 1996-10-11 KR KR1019980704423A patent/KR20000064387A/ko not_active Application Discontinuation
- 1996-10-11 JP JP9522607A patent/JP3066083B2/ja not_active Expired - Lifetime
- 1996-10-11 BR BR9612018A patent/BR9612018A/pt not_active Application Discontinuation
- 1996-10-11 RO RO98-01070A patent/RO121382B1/ro unknown
- 1996-10-11 CZ CZ981808A patent/CZ180898A3/cs unknown
- 1996-10-11 AU AU70925/96A patent/AU716462B2/en not_active Ceased
- 1996-10-11 IL IL12445296A patent/IL124452A0/xx unknown
- 1996-10-11 EP EP96931937A patent/EP0883607A1/en not_active Withdrawn
- 1996-10-11 RU RU98111204/04A patent/RU2160731C2/ru not_active IP Right Cessation
- 1996-10-14 TW TW085112515A patent/TW414787B/zh not_active IP Right Cessation
- 1996-10-15 HN HN1996000065A patent/HN1996000065A/es unknown
- 1996-11-18 GT GT199600092A patent/GT199600092A/es unknown
- 1996-12-09 PE PE1996000883A patent/PE25698A1/es not_active Application Discontinuation
- 1996-12-10 AR ARP960105577A patent/AR004368A1/es unknown
- 1996-12-11 TN TNTNSN96153A patent/TNSN96153A1/fr unknown
- 1996-12-11 DZ DZ960186A patent/DZ2141A1/fr active
- 1996-12-11 YU YU66096A patent/YU49486B/sh unknown
- 1996-12-11 MA MA24424A patent/MA24032A1/fr unknown
- 1996-12-12 AP APAP/P/1996/000892A patent/AP708A/en active
- 1996-12-12 UY UY24401A patent/UY24401A1/es not_active IP Right Cessation
- 1996-12-12 CO CO96065334A patent/CO4750831A1/es unknown
- 1996-12-13 HR HR60/008,753A patent/HRP960592A2/xx not_active Application Discontinuation
- 1996-12-13 ZA ZA9610533A patent/ZA9610533B/xx unknown
-
1998
- 1998-05-22 IS IS4752A patent/IS4752A/is unknown
- 1998-06-05 OA OA9800076A patent/OA10694A/en unknown
- 1998-06-09 BG BG102525A patent/BG102525A/xx unknown
- 1998-06-12 NO NO982712A patent/NO982712L/no not_active Application Discontinuation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2160731C2 (ru) | Промежуточные продукты для получения 1-бензил-4-((5,6-диметокси-1-инданон)-2-ил)-метилпиперидина, способы их получения и способ получения 1-бензил-4-((5,6-диметокси-1-инданон)-2-ил)-метилпиперидина с их применением | |
| JP3147906B2 (ja) | 神経栄養活性および神経保護活性を有する４−アリール−１−フェニルアルキル−１，２，３，６−テトラヒドロピリジン | |
| EP0080104B1 (en) | 3-(4-piperidyl)-1,2-benzisoxazoles, process for the preparation thereof, and a pharmaceutical composition comprising the same | |
| NZ333197A (en) | Polymorphs of donepezil hydrochloride | |
| HU222726B1 (hu) | Piperidinszármazékok, eljárás elżállításukra és az ezeket tartalmazó gyógyszerkészítmények | |
| JP2011522845A (ja) | アラルキルアルコールピペリジン誘導体及びその抗うつ病薬物としての使用 | |
| EP2261209A1 (en) | Novel crystalline forms of 4-[4-[4- hydroxydiphenylmethyl)-1-piperidinyl]-1-hydroxybutyl]-alpha, alpha-dimethylbenene acetic acid and its hydrochloride | |
| AU2001278094A1 (en) | Novel crystalline forms of 4-[4-[4-(hydroxydiphenylmethyl)-1-piperindinyl]-1-hydroxybutyl]-alpha, alpha-dimethylbenzene acetic acid and its hydrochloride | |
| JP2002506059A (ja) | （Ｒ）−α−（２，３−ジメトキシフェニル）−１−［２−（４−フルオロフェニル）エチル］−４−ピペリジンメタノールの製造方法 | |
| EP0470686A2 (en) | (Benzhydryloxyethylpiperidyl)aliphatic acid derivatives and their use in the treatment of allergies and asthma | |
| DE60012355T2 (de) | Phenyl- und pyridyl-tetrahydro-pyridine mit tnf inhibitorischer wirkung | |
| SI21232A (sl) | Postopek za pripravo izredno čiste farmacevtske vmesne spojine, 4-(ciklopropilkarbonil)-alfa, alfa-dimetilfenilocetne kisline | |
| US6803468B2 (en) | Process for the synthesis of n-(5-methylnicontinoyl)-4 hydroxypiperidine, a key intermediate of rupatadine | |
| JP4324381B2 (ja) | Ｔｎｆ活性を有するフェニル−およびピリジル−ピペリジン類 | |
| MXPA98004820A (en) | Procedures and intermediates for preparing 1-bencil-4 - ((5,6-dimetoxi-1-indanon) -2-il) metilpiperid | |
| KR820001835B1 (ko) | 4-아미노-2-피페리디노퀴나졸린 유도체의 제조방법 | |
| JPH05255308A (ja) | ピペリジン誘導体 | |
| SA96170395B1 (ar) | عمليات ومركبات وسطية لتحضير 1- بنزيل - 4 - ((5.6-ثنائي ميثوكسي -1- إندانون) -2- يل) ميثيل بيبريدين 1-benzy1-4-((5.6-dimethoxy -1-Indanon)-2-y1)methy1piperidine | |
| WO2001002357A2 (en) | Process for the synthesis of 4-(4'-fluorophenyl)-piperidines | |
| AU6995994A (en) | N-substituted azaheterocyclic carboxylic acids and esters thereof | |
| CS205086B2 (cs) | Způsob výroby hydroxyderivátů aryloxy- a arylthioperhydroazaheterocyklů | |
| JPS6346755B2 (cs) |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20081012 |